Bp286 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Bp286 (Blood pressure QTL 286) Rattus norvegicus

Symbol: Bp286
Name: Blood pressure QTL 286
RGD ID: 1598875
Previously known as: QTL2
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: systolic blood pressure   (CMO:0000004)    
LOD Score: 2.0
P Value: 9.0E-4
Variance: Not Available
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4265,484,323 - 110,484,323RGDRGSC3.4
RGSC_v3.1265,429,285 - 110,429,285RGD
Cross Type: Not Available
Strains Crossed: SS.SR-(D3Mco36-D3Got166)/Jr SS.SR-(D3Mco36-D3Mco46)/Jr 

Candidate Gene Status
Oprl1 is a candidate Gene for Bp286
Rgs19 is a candidate Gene for Bp286
Rtel1 is a candidate Gene for Bp286

Disease Annotations     Click to see Annotation Detail View
Hypotension  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain


References - curated
# Reference Title Reference Citation
1. Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model. Cicila GT, etal., Hypertension. 2009 Apr;53(4):725-32. Epub 2009 Mar 2.
2. Substitution Mapping in Dahl Rats Identifies Two Distinct Blood Pressure Quantitative Trait Loci within 1.12 Mb and 1.25 Mb Intervals on Chromosome 3. Lee SJ, etal., Genetics. 2006 Oct 8;.
Related QTLs

Related QTL Description Reference
Bp335 interacts with RGD:2306800


Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
Position Markers

Flank 1: (D3Mco44)
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,830,297 - 167,830,544 (+)MAPPER
Rnor_6.03176,221,290 - 176,221,536NCBI
Rnor_5.03179,920,355 - 179,920,601UniSTS
RGSC_v3.43169,811,454 - 169,811,700UniSTS
Celera3164,752,309 - 164,752,555UniSTS
Cytogenetic Map3q43UniSTS
Flank 2: (D2Mco36)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22107,641,164 - 107,641,424 (+)MAPPER
Rnor_6.02110,428,205 - 110,428,464NCBI
Rnor_5.02130,145,998 - 130,146,257UniSTS
RGSC_v3.42110,484,063 - 110,484,323RGD
RGSC_v3.42110,484,064 - 110,484,323UniSTS
RGSC_v3.12110,429,025 - 110,429,285RGD
Celera2102,907,364 - 102,907,623UniSTS
Cytogenetic Map2 RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general this QTL is 0.71-1.25 Mb and does not carry the low kidney weight allele 1581650
qtl_general 30 days old male rats were kept on low salt diet (0.4% NaCl) after 10-12 days they were given 2% NaCl diet and the blood pressure was measured 1581650
qtl_general tail-cuff microphonic method was used to determine the systolic blood pressure; heart weight and kidney weight was measured after the animals were sacrificed by pentobarbital overdosage 1581650