Nkain2 (sodium/potassium transporting ATPase interacting 2) - Rat Genome Database

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Gene: Nkain2 (sodium/potassium transporting ATPase interacting 2) Rattus norvegicus
Analyze
Symbol: Nkain2
Name: sodium/potassium transporting ATPase interacting 2
RGD ID: 7740967
Description: Predicted to be involved in regulation of sodium ion transport. Predicted to be located in plasma membrane. Orthologous to human NKAIN2 (sodium/potassium transporting ATPase interacting 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; N,N-diethyl-m-toluamide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC102551716; Na+/K+ transporting ATPase interacting 2; NKAIN2 transcript-like; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2; sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,488,381 - 27,696,134 (+)NCBIGRCr8
mRatBN7.2124,668,627 - 25,877,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl124,669,462 - 25,877,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0127,473,251 - 28,161,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl127,476,375 - 28,159,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,926,594 - 29,615,541 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera123,895,595 - 24,572,547 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17606467  


Genomics

Comparative Map Data
Nkain2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,488,381 - 27,696,134 (+)NCBIGRCr8
mRatBN7.2124,668,627 - 25,877,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl124,669,462 - 25,877,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0127,473,251 - 28,161,521 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl127,476,375 - 28,159,290 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,926,594 - 29,615,541 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera123,895,595 - 24,572,547 (+)NCBICelera
Cytogenetic Map1p11NCBI
NKAIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386123,803,865 - 124,825,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6123,803,865 - 124,825,640 (+)EnsemblGRCh38hg38GRCh38
GRCh376124,125,010 - 125,146,786 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366124,166,768 - 125,188,485 (+)NCBINCBI36Build 36hg18NCBI36
Build 346124,166,987 - 125,188,485NCBI
Celera6124,869,958 - 125,891,802 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6121,702,429 - 122,723,736 (+)NCBIHuRef
CHM1_16124,388,612 - 125,410,248 (+)NCBICHM1_1
T2T-CHM13v2.06124,991,747 - 126,013,690 (+)NCBIT2T-CHM13v2.0
Nkain2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391031,565,314 - 32,773,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1031,565,306 - 32,766,458 (-)EnsemblGRCm39 Ensembl
GRCm381031,689,310 - 32,897,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1031,689,310 - 32,890,462 (-)EnsemblGRCm38mm10GRCm38
MGSCv371031,409,125 - 32,609,721 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361031,378,735 - 32,579,264 (-)NCBIMGSCv36mm8
Celera1032,612,553 - 33,799,322 (-)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1017.56NCBI
Nkain2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554365,407,773 - 6,343,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554365,407,642 - 6,345,015 (+)NCBIChiLan1.0ChiLan1.0
NKAIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25143,793,042 - 144,817,344 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16141,700,135 - 142,776,468 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06121,590,732 - 122,611,445 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16125,713,030 - 126,732,080 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6125,713,247 - 126,729,668 (+)Ensemblpanpan1.1panPan2
NKAIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1163,091,956 - 63,857,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl162,910,841 - 63,858,164 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha163,719,503 - 64,668,404 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0163,115,179 - 64,065,713 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl163,115,326 - 64,065,725 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1163,047,299 - 63,997,590 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0162,836,039 - 63,786,131 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0163,484,826 - 64,435,218 (+)NCBIUU_Cfam_GSD_1.0
NKAIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl138,014,255 - 39,040,605 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1138,014,252 - 39,040,215 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2142,053,739 - 42,198,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NKAIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11348,876,514 - 50,121,382 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604021,185,910 - 22,296,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nkain2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247986,687,807 - 7,619,303 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247986,685,647 - 7,619,436 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nkain2
6468 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000047224
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 58
Low 4 7 2 5 2 2 2 10 16 19 1 2
Below cutoff 1 28 16 6 5 6 5 6 6 4 17 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047224   ⟹   ENSRNOP00000047346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl124,669,462 - 25,877,064 (+)Ensembl
Rnor_6.0 Ensembl127,476,375 - 28,155,831 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075427   ⟹   ENSRNOP00000067471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl124,669,462 - 25,877,064 (+)Ensembl
Rnor_6.0 Ensembl127,476,375 - 28,159,290 (+)Ensembl
RefSeq Acc Id: XM_063276503   ⟹   XP_063132573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,488,411 - 27,691,143 (+)NCBI
RefSeq Acc Id: XM_063276506   ⟹   XP_063132576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,488,396 - 27,696,134 (+)NCBI
RefSeq Acc Id: XM_063276515   ⟹   XP_063132585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,488,388 - 27,696,134 (+)NCBI
RefSeq Acc Id: XR_005499794
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,488,412 - 27,696,134 (+)NCBI
mRatBN7.2124,669,286 - 25,877,051 (+)NCBI
RefSeq Acc Id: XR_010058891
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,488,381 - 27,696,134 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063132573 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132576 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132585 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047346.6
  ENSRNOP00000067471.3
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000067471   ⟸   ENSRNOT00000075427
RefSeq Acc Id: ENSRNOP00000047346   ⟸   ENSRNOT00000047224
RefSeq Acc Id: XP_063132585   ⟸   XM_063276515
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132576   ⟸   XM_063276506
- Peptide Label: isoform X2
- UniProtKB: F1M3X2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132573   ⟸   XM_063276503
- Peptide Label: isoform X1
- UniProtKB: M0RCY3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M3X2-F1-model_v2 AlphaFold F1M3X2 1-188 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7740967 AgrOrtholog
BioCyc Gene G2FUF-61998 BioCyc
Ensembl Genes ENSRNOG00000029608 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047224.6 UniProtKB/TrEMBL
  ENSRNOT00000075427.3 UniProtKB/TrEMBL
InterPro Na/K-Atpase_Interacting UniProtKB/TrEMBL
NCBI Gene LOC102551716 ENTREZGENE
PANTHER PTHR13084 UniProtKB/TrEMBL
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 2 UniProtKB/TrEMBL
Pfam NKAIN UniProtKB/TrEMBL
PhenoGen Nkain2 PhenoGen
RatGTEx ENSRNOG00000029608 RatGTEx
UniProt F1M3X2 ENTREZGENE, UniProtKB/TrEMBL
  M0RCY3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-09 Nkain2  sodium/potassium transporting ATPase interacting 2  LOC102551716  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-04-09 LOC102551716  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like  Nkain2  Na+/K+ transporting ATPase interacting 2  Data merged from RGD:2323702 737654 PROVISIONAL
2013-12-18 LOC102551716  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-08-30 Nkain2  Na+/K+ transporting ATPase interacting 2  LOC100362992  NKAIN2 transcript-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100362992  NKAIN2 transcript-like      Symbol and Name status set to provisional 70820 PROVISIONAL