F8 (coagulation factor VIII) - Rat Genome Database

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Gene: F8 (coagulation factor VIII) Rattus norvegicus
Analyze
Symbol: F8
Name: coagulation factor VIII
RGD ID: 727845
Description: Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coagulation factor VIII, procoagulant component
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: F8m1Ycb   F8em1Sage   F8em1Mcwi  
Genetic Models: SD-F8em1Sage-/-/Novo SD-F8em1Sage/Novo SD-F8em1Sage+/-/Novo SS-F8em1Mcwi WAG-F8m1Ycb
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818155,237 - 187,186 (+)NCBIGRCr8
mRatBN7.218140,848 - 172,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18140,955 - 171,857 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18158,788 - 190,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018946,627 - 978,133 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018160,695 - 192,201 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018367,862 - 399,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18367,862 - 399,242 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018413,447 - 444,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418121,134 - 162,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.118121,133 - 162,008 (+)NCBI
Celera18135,235 - 166,779 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amphibole asbestos  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Ethyl icosapentate  (EXP)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (ISO)
gestodene  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
irinotecan  (ISO)
levonorgestrel  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
norgestimate  (ISO)
orphenadrine  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
sodium dodecyl sulfate  (ISO)
tamoxifen  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations of the factor VIII gene in thai hemophilia A patients. Akkarapatumwong V, etal., Hum Mutat. 2000 Jan;15(1):117-8.
2. Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis. Bank I, etal., J Thromb Haemost. 2005 Jan;3(1):79-84.
3. WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Booth CJ, etal., J Thromb Haemost. 2010 Nov;8(11):2472-7. doi: 10.1111/j.1538-7836.2010.03978.x.
4. Effect of factor VIIIc levels in pediatric stroke patients. Cangoz E, etal., Pediatr Hematol Oncol. 2004 Apr-May;21(3):255-60.
5. Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II. Ebbesen LS and Ingerslev J, J Nutr. 2005 Aug;135(8):1836-40.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Detection of 95 novel mutations in coagulation factor VIII gene F8 responsible for hemophilia A: results from a single institution. Guillet B, etal., Hum Mutat. 2006 Jul;27(7):676-85.
8. Secretion of coagulant factor VIII activity and antigen by in vitro cultivated rat liver sinusoidal endothelial cells. Hellman L, etal., Br J Haematol. 1989 Nov;73(3):348-55.
9. Haemostatic abnormalities persist despite glycaemic improvement by insulin therapy in lean type 2 diabetic patients. Knobl P, etal., Thromb Haemost. 1994 Jun;71(6):692-7.
10. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
13. A novel F8 -/- rat as a translational model of human hemophilia A. Nielsen LN, etal., J Thromb Haemost. 2014 Aug;12(8):1274-82. doi: 10.1111/jth.12635.
14. Effect of dienogest on bleeding time, coagulation, fibrinolysis, and platelet aggregation in female rats. Nobukata H, etal., Toxicol Lett. 1999 Jan 11;104(1-2):93-101.
15. Blood coagulation. Norris LA, Best Pract Res Clin Obstet Gynaecol. 2003 Jun;17(3):369-83.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. Shi Q, etal., Blood Adv. 2020 Jan 14;4(1):55-65. doi: 10.1182/bloodadvances.2019000944.
23. How it all starts: Initiation of the clotting cascade. Smith SA, etal., Crit Rev Biochem Mol Biol. 2015;50(4):326-36. doi: 10.3109/10409238.2015.1050550. Epub 2015 May 28.
24. The F8(-/-) rat as a model of hemophilic arthropathy. Sørensen KR, etal., J Thromb Haemost. 2016 Jun;14(6):1216-25. doi: 10.1111/jth.13328. Epub 2016 May 10.
25. Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice. VandenDriessche T, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10379-84.
26. Sequence of the rat factor VIII cDNA. Watzka M, etal., Thromb Haemost 2004 Jan;91(1):38-42.
27. Preferential consumption of coagulation factors I, V, and VIII in rat endotoxemia. Yamaguchi K, etal., Shock. 2000 Nov;14(5):535-43.
28. [Study on changes of blood coagulation factors in rats with hemorrhagic shock]. Zhang YJ, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Feb;13(1):110-3.
Additional References at PubMed
PMID:27681457  


Genomics

Comparative Map Data
F8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818155,237 - 187,186 (+)NCBIGRCr8
mRatBN7.218140,848 - 172,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18140,955 - 171,857 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18158,788 - 190,293 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018946,627 - 978,133 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018160,695 - 192,201 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018367,862 - 399,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18367,862 - 399,242 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018413,447 - 444,491 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418121,134 - 162,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.118121,133 - 162,008 (+)NCBI
Celera18135,235 - 166,779 (+)NCBICelera
Cytogenetic Map18p13NCBI
F8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,835,792 - 155,022,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,835,788 - 155,026,940 (-)EnsemblGRCh38hg38GRCh38
GRCh37X154,064,067 - 154,250,998 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,717,260 - 153,904,192 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X153,627,773 - 153,678,176NCBI
CeleraX154,222,608 - 154,409,733 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,607,715 - 142,796,096 (-)NCBIHuRef
CHM1_1X153,975,773 - 154,162,623 (-)NCBICHM1_1
T2T-CHM13v2.0X153,072,193 - 153,259,125 (-)NCBIT2T-CHM13v2.0
F8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,213,950 - 74,426,342 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,216,321 - 74,426,221 (-)EnsemblGRCm39 Ensembl
GRCm38X75,170,344 - 75,382,738 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,172,715 - 75,382,615 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X72,418,054 - 72,625,380 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,425,450 - 71,632,761 (-)NCBIMGSCv36mm8
CeleraX66,576,966 - 66,780,957 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.17NCBI
F8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594658,523 - 802,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955594658,686 - 800,101 (+)NCBIChiLan1.0ChiLan1.0
F8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,815,145 - 155,000,578 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,820,124 - 155,004,186 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,316,192 - 144,505,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,156,864 - 154,345,635 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,156,873 - 154,341,317 (-)Ensemblpanpan1.1panPan2
F8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,894,974 - 123,046,343 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,885,162 - 123,043,414 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,890,270 - 108,036,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,024,520 - 126,170,925 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX126,011,129 - 126,170,899 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,771,228 - 121,918,614 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,294,452 - 124,441,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,987,629 - 124,161,753 (-)NCBIUU_Cfam_GSD_1.0
F8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,830,886 - 119,943,339 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927190,111 - 301,609 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927189,359 - 301,791 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,229,450 - 125,350,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,265,330 - 125,350,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,132,160 - 143,217,828 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,090,140 - 129,315,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,088,611 - 129,312,909 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,072,999 - 67,292,423 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624963252,943 - 424,718 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F8
304 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:138
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000045926
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat

Markers in Region
RH139018  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218148,461 - 148,669 (-)MAPPERmRatBN7.2
Rnor_6.018391,522 - 391,729NCBIRnor6.0
Rnor_5.018437,107 - 437,314UniSTSRnor5.0
RGSC_v3.418137,921 - 138,128UniSTSRGSC3.4
Celera18142,944 - 143,151UniSTS
RH 3.4 Map101072.6UniSTS
Cytogenetic Map18p13UniSTS
BI275668  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218172,547 - 172,637 (-)MAPPERmRatBN7.2
Rnor_6.018367,555 - 367,644NCBIRnor6.0
Rnor_5.018413,140 - 413,229UniSTSRnor5.0
RGSC_v3.418162,226 - 162,315UniSTSRGSC3.4
Celera18166,997 - 167,086UniSTS
RH 3.4 Map1835.0UniSTS
Cytogenetic Map18p13UniSTS
AI234173  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218172,613 - 172,776 (-)MAPPERmRatBN7.2
Rnor_6.018367,416 - 367,578NCBIRnor6.0
Rnor_5.018413,001 - 413,163UniSTSRnor5.0
RGSC_v3.418162,292 - 162,454UniSTSRGSC3.4
Celera18167,063 - 167,225UniSTS
RH 3.4 Map1835.0UniSTS
Cytogenetic Map18p13UniSTS


Genetic Models
This gene F8 is modified in the following models/strains:
SD-F8em1Sage-/-/Novo     SD-F8em1Sage/Novo     SD-F8em1Sage+/-/Novo     SS-F8em1Mcwi     WAG-F8m1Ycb    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 10 2 12 2 20 18 32 11
Low 3 41 47 39 7 39 8 11 54 17 9 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045926   ⟹   ENSRNOP00000050792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18140,955 - 171,857 (+)Ensembl
Rnor_6.0 Ensembl18367,862 - 399,242 (-)Ensembl
RefSeq Acc Id: NM_183331   ⟹   NP_899160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818155,309 - 186,683 (+)NCBI
mRatBN7.218140,955 - 172,330 (+)NCBI
Rnor_6.018367,862 - 399,242 (-)NCBI
Rnor_5.018413,447 - 444,491 (-)NCBI
RGSC_v3.418121,134 - 162,008 (+)RGD
Celera18135,235 - 166,779 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096756   ⟹   XP_038952684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818155,237 - 181,884 (+)NCBI
mRatBN7.218140,848 - 167,529 (+)NCBI
RefSeq Acc Id: XM_039096757   ⟹   XP_038952685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818155,237 - 178,772 (+)NCBI
mRatBN7.218140,848 - 164,418 (+)NCBI
RefSeq Acc Id: XM_063277282   ⟹   XP_063133352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818155,237 - 183,312 (+)NCBI
RefSeq Acc Id: XM_063277283   ⟹   XP_063133353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818155,237 - 183,307 (+)NCBI
RefSeq Acc Id: XM_063277284   ⟹   XP_063133354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818177,262 - 187,186 (+)NCBI
RefSeq Acc Id: XM_063277285   ⟹   XP_063133355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818180,044 - 187,186 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_899160   ⟸   NM_183331
- Peptide Label: precursor
- UniProtKB: D3ZEB1 (UniProtKB/TrEMBL),   Q7TN96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050792   ⟸   ENSRNOT00000045926
RefSeq Acc Id: XP_038952684   ⟸   XM_039096756
- Peptide Label: isoform X3
- UniProtKB: Q7TN96 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952685   ⟸   XM_039096757
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133352   ⟸   XM_063277282
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133353   ⟸   XM_063277283
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133354   ⟸   XM_063277284
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063133355   ⟸   XM_063277285
- Peptide Label: isoform X6
Protein Domains
F5/8 type C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEB1-F1-model_v2 AlphaFold D3ZEB1 1-2257 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700623
Promoter ID:EPDNEW_R11147
Type:initiation region
Name:F8_1
Description:coagulation factor VIII
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.018399,292 - 399,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727845 AgrOrtholog
BioCyc Gene G2FUF-8440 BioCyc
Ensembl Genes ENSRNOG00000031197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045926 ENTREZGENE
  ENSRNOT00000045926.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
InterPro Coagulation_factor_5/8-type_C UniProtKB/TrEMBL
  Cu-oxidase_2 UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/TrEMBL
  Cu_oxidase_CS UniProtKB/TrEMBL
  Cupredoxin UniProtKB/TrEMBL
  Factor_5/8_like UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
KEGG Report rno:302470 UniProtKB/TrEMBL
NCBI Gene 302470 ENTREZGENE
PANTHER COAGULATION FACTOR VIII UniProtKB/TrEMBL
  F5/8 TYPE C DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Cu-oxidase_2 UniProtKB/TrEMBL
  Cu-oxidase_3 UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
PharmGKB F8 RGD
PhenoGen F8 PhenoGen
PIRSF Factors_V_VIII UniProtKB/TrEMBL
PROSITE FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
  MULTICOPPER_OXIDASE1 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031197 RatGTEx
SMART FA58C UniProtKB/TrEMBL
Superfamily-SCOP Cupredoxin UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
UniProt D3ZEB1 ENTREZGENE, UniProtKB/TrEMBL
  Q7TN96 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 F8  coagulation factor VIII  F8  coagulation factor VIII, procoagulant component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-17 F8  coagulation factor VIII, procoagulant component  F8  coagulation factor VIII  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED