Metap2 (methionyl aminopeptidase 2)

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Gene: Metap2 (methionyl aminopeptidase 2) Rattus norvegicus

Analyze

Symbol:

Metap2

Name:

methionyl aminopeptidase 2

RGD ID:

70995

Description:

Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein initiator methionine removal involved in protein maturation. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human METAP2 (methionyl aminopeptidase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Amp2; initiation factor 2 associated 67 kDa protein; initiation factor 2-associated 67 kDa glycoprotein; MAP 2; metAP 2; methionine aminopeptidase; methionine aminopeptidase 2; Mnpep; p67; p67eIF2; peptidase M 2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	METAP2 (methionyl aminopeptidase 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Metap2 (methionine aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Metap2 (methionyl aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	METAP2 (methionyl aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	METAP2 (methionyl aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Metap2 (methionyl aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	METAP2 (methionyl aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	METAP2 (methionyl aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Metap2 (methionyl aminopeptidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	METAP2 (methionyl aminopeptidase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Metap2 (methionine aminopeptidase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	metap2a (methionyl aminopeptidase 2a)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	metap2b (methionyl aminopeptidase 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F53B6.5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	MAP2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	und	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T27A8.3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	map-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	metap2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Metap2-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	28,412,771 - 28,440,458 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	28,411,608 - 28,440,434 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	30,402,812 - 30,430,792 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	32,565,048 - 32,593,032 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	32,342,482 - 32,370,504 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	34,762,241 - 34,789,456 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	34,762,231 - 34,789,479 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	34,821,214 - 34,848,430 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	30,974,071 - 31,001,641 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	30,994,341 - 31,021,912 (-)	NCBI
Celera	7	25,509,781 - 25,535,670 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

2-methylcholine (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

5-fluorouracil (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

Allylamine (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

carbon nanotube (ISO)

chloropicrin (ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

coumarin (ISO)

coumestrol (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

dioxygen (ISO)

diuron (EXP)

doxorubicin (ISO)

elemental selenium (ISO)

Enterolactone (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

fumagillin (EXP,ISO)

furan (EXP)

gold atom (ISO)

gold(0) (ISO)

ivermectin (ISO)

L-ethionine (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (ISO)

methylparaben (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nitroxoline (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

pinosylvin (ISO)

progesterone (ISO)

resveratrol (ISO)

rotenone (EXP)

selenium atom (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

tetrahydropalmatine (ISO)

thioacetamide (EXP)

topotecan (EXP)

trans-pinosylvin (ISO)

triazoles (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trimellitic anhydride (ISO)

troglitazone (ISO)

uranium atom (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

N-terminal protein amino acid modification (ISO,ISS)

obsolete protein initiator methionine removal (IEA)

obsolete protein initiator methionine removal involved in protein maturation (IBA)

peptidyl-methionine modification (ISO,ISS)

protein processing (ISO,ISS)

proteolysis (IEA)

Cellular Component

cytoplasm (IBA,IEA,ISO,ISS)

cytosol (ISO)

plasma membrane (ISO)

Molecular Function

aminopeptidase activity (IBA,ISO,ISS)

metal ion binding (IEA)

metalloaminopeptidase activity (IEA)

metalloexopeptidase activity (IBA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Gene Data Set	MGD Curation, June 12, 2002
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9.	Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67).	Wu S, etal., J Biol Chem 1993 May 25;268(15):10796-81.

Additional References at PubMed

PMID:7644482	PMID:8858118	PMID:12581743	PMID:15102683	PMID:17446530	PMID:21033716	PMID:22658674

Genomics

Comparative Map Data

Metap2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	28,412,771 - 28,440,458 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	28,411,608 - 28,440,434 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	30,402,812 - 30,430,792 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	32,565,048 - 32,593,032 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	32,342,482 - 32,370,504 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	34,762,241 - 34,789,456 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	34,762,231 - 34,789,479 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	34,821,214 - 34,848,430 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	30,974,071 - 31,001,641 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	30,994,341 - 31,021,912 (-)	NCBI
Celera	7	25,509,781 - 25,535,670 (-)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

METAP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	95,474,152 - 95,515,839 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	95,473,520 - 95,515,839 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	95,867,928 - 95,909,615 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	94,391,953 - 94,433,746 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	94,370,389 - 94,410,587	NCBI
Celera	12	95,538,718 - 95,580,736 (+)	NCBI		Celera
Cytogenetic Map	12	q22	NCBI
HuRef	12	92,936,350 - 92,977,989 (+)	NCBI		HuRef
CHM1_1	12	95,833,252 - 95,875,049 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	95,455,178 - 95,496,879 (+)	NCBI		T2T-CHM13v2.0

Metap2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	93,694,351 - 93,732,952 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	93,694,351 - 93,732,955 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	93,858,489 - 93,897,090 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	93,858,489 - 93,897,093 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	93,321,234 - 93,353,947 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	93,288,288 - 93,321,001 (-)	NCBI		MGSCv36	mm8
Celera	10	95,828,659 - 95,861,285 (-)	NCBI		Celera
Cytogenetic Map	10	C2	NCBI

Metap2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955405	31,942,427 - 31,976,678 (+)	NCBI	ChiLan1.0	ChiLan1.0

METAP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	103,545,904 - 103,586,912 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	93,068,921 - 93,109,098 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	96,461,418 - 96,503,087 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	96,461,549 - 96,503,508 (+)	Ensembl	panpan1.1		panPan2

METAP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	35,363,494 - 35,398,926 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	35,363,528 - 35,398,168 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	35,750,123 - 35,785,289 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	36,028,074 - 36,063,311 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	36,028,136 - 36,064,772 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	35,301,082 - 35,336,182 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	35,395,570 - 35,430,722 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	35,658,719 - 35,693,877 (+)	NCBI		UU_Cfam_GSD_1.0

Metap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	24,573,140 - 24,610,683 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936507	11,624,060 - 11,660,875 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936507	11,624,696 - 11,661,632 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

METAP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	87,888,674 - 87,926,148 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	87,890,821 - 87,926,155 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	92,091,623 - 92,127,676 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

METAP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	90,872,672 - 90,914,257 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	90,872,699 - 90,912,499 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	154,255,439 - 154,297,723 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Metap2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624750	11,726,303 - 11,756,671 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Metap2
63 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	288
Count of miRNA genes:	172
Interacting mature miRNAs:	186
Transcripts:	ENSRNOT00000030056, ENSRNOT00000031571
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	15795565	38073970	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	19032807	35526300	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	19654317	49753746	Rat
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	19654317	49753746	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	19654317	52888450	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	20555705	29891047	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat

Markers in Region

AW529792

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	28,412,512 - 28,412,671 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	34,761,972 - 34,762,130	NCBI	Rnor6.0
Rnor_5.0	7	34,820,945 - 34,821,103	UniSTS	Rnor5.0
RGSC_v3.4	7	30,973,802 - 30,973,960	UniSTS	RGSC3.4
Celera	7	25,509,512 - 25,509,670	UniSTS
RH 3.4 Map	7	192.1	UniSTS
Cytogenetic Map	7	q13	UniSTS

RH143662

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	7	q13	UniSTS

RH135833

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	49,612,619 - 49,612,738 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	233,108,263 - 233,108,380 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	254,019,891 - 254,020,007	NCBI	Rnor6.0
Rnor_6.0	18	51,219,309 - 51,219,427	NCBI	Rnor6.0
Rnor_5.0	18	50,418,025 - 50,418,143	UniSTS	Rnor5.0
Rnor_5.0	1	261,237,751 - 261,237,867	UniSTS	Rnor5.0
RGSC_v3.4	1	239,602,208 - 239,602,324	UniSTS	RGSC3.4
RGSC_v3.4	18	51,879,290 - 51,879,408	UniSTS	RGSC3.4
Celera	18	47,760,366 - 47,760,484	UniSTS
Celera	1	230,211,792 - 230,211,908	UniSTS
Cytogenetic Map	7	q13	UniSTS
Cytogenetic Map	1	q53	UniSTS
Cytogenetic Map	18	q12.1	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC070892	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L10652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000030056 ⟹ ENSRNOP00000032680

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	28,412,781 - 28,440,434 (-)	Ensembl
Rnor_6.0 Ensembl	7	34,762,656 - 34,789,370 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000031571 ⟹ ENSRNOP00000030415

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	28,412,773 - 28,440,434 (-)	Ensembl
Rnor_6.0 Ensembl	7	34,762,231 - 34,789,479 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000110473 ⟹ ENSRNOP00000087571

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	28,411,608 - 28,440,434 (-)	Ensembl

RefSeq Acc Id:

NM_022539 ⟹ NP_071984

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	28,412,782 - 28,440,408 (-)	NCBI
Rnor_6.0	7	34,762,241 - 34,789,456 (-)	NCBI
Rnor_5.0	7	34,821,214 - 34,848,430 (-)	NCBI
RGSC_v3.4	7	30,974,071 - 31,001,641 (-)	RGD
Celera	7	25,509,781 - 25,535,670 (-)	RGD

Sequence:

show sequence

GGTGAAGAAGGAGCGGGCCCTCGCCGCTCGTTCTCGCTCCCTCTTTCTCTCTCTCTTCTTCTCT
CTCTCTTTCCCTCTCGGGCAACATGGCGGGCGTGGAAGAGGCATCGTCTTTCGGGGGCCACCTG
AATCGCGACCTGGATCCAGACGACAGGGAAGAGGGAACCTCCAGCACGGCCGAGGAAGCCGCCA
AGAAGAAAAGACGGAAGAAGAAGAAGGGCAAAGGGGCTGTGTCAGCAGGGCAACAAGAACTTGA
TAAAGAATCGGGAACCTCAGTGGACGAAGTAGCAAAACAGTTGGAGAGACAAGCACTGGAGGAG
AAAGAGAAAGATGATGACGATGAAGATGGAGATGGTGATGGTGATGGTGCAGCTGGGAAGAAGA
AGAAAAAGAAGAAGAAGAAGAGAGGACCAAGAGTTCAAACAGACCCTCCCTCAGTTCCAATATG
TGACCTGTATCCTAATGGTGTATTTCCCAAAGGACAAGAGTGTGAATACCCACCCACCCAAGAT
GGGCGGACAGCTGCTTGGAGAACCACAAGTGAAGAGAAAAAGGCGCTAGACCAGGCTAGTGAGG
AGATTTGGAACGACTTCCGAGAAGCTGCCGAAGCACACCGGCAAGTTAGGAAATACGTCATGAG
CTGGATCAAGCCTGGGATGACAATGATAGAAATATGTGAGAAGTTGGAAGACTGTTCCCGAAAG
CTCATAAAGGAGAATGGGTTAAATGCAGGCCTGGCCTTTCCCACTGGGTGTTCTCTCAACAACT
GTGCTGCACATTACACTCCCAATGCTGGTGACACGACAGTCTTACAGTACGACGACATCTGTAA
GATCGACTTTGGAACGCATATAAGTGGTAGAATAATTGATTGTGCTTTTACTGTTACTTTTAAT
CCCAAATATGACATATTATTAAAAGCTGTAAAAGATGCCACCAATACTGGAATAAAGTGTGCGG
GGATTGACGTCCGTCTCTGTGATGTCGGCGAGGCCATTCAAGAAGTTATGGAGTCCTATGAAGT
GGAAATAGATGGGAAGACCTACCAAGTGAAACCCATACGTAACTTAAATGGACATTCAATTGGG
CCATATAGAATTCATGCTGGAAAAACAGTGCCCATTGTGAAAGGAGGGGAAGCTACAAGGATGG
AGGAAGGAGAGGTGTATGCCATTGAGACCTTTGGTAGCACAGGGAAGGGCGTGGTTCATGACGA
TATGGAATGTTCACACTACATGAAAAATTTTGATGTGGGACACGTGCCAATAAGGCTTCCAAGA
ACAAAACACTTGTTGAATGTCATCAATGAAAACTTTGGTACCCTTGCCTTCTGCCGAAGGTGGC
TGGATCGCTTGGGAGAAAGTAAATACTTAATGGCTCTGAAGAACCTGTGTGACTTGGGCATTGT
AGATCCATATCCACCACTCTGTGACATTAAAGGATCATACACAGCACAGTTTGAACATACCATA
CTCTGCGCCCAACCTGTAAAGAAGTTGTCAGCAGAGGAGATGACTATTAAAACTTAGTCCAAAG
CCAACTCAACGTCTTTATTTTCTAAGCTTTGTTGGAACACATTATACCACAAGTAATTTGCAAC
ATGTCTGTTTTAACAGTGGACCTGTGTAATGCCGTTATCCATGTTTAAAGGAGTTTGATCAAAG
CCAAACTGTCTACATGTAATTAACCAAGGAAAAGGCTTTCAAGACTTTACTGTTAACTGTTTCT
CCCGTCTAGGAAATGCTGTACTGCTCACTAGTTAGGAATTACTTAAACGTTTTGTTTTGAAGAC
CTAAGAGATGCTTTTTGGATATTTATATTGCCATATTCTTACTTGGATGCTTTGAATGACTACA
TACATCCAGTTCTGCACCTATGCCCTCTGGTATTGCTTTTTAACCTTCCTGGAATCCATTTTCT
AAAAAATAAAGACATTTTCAGATC

hide sequence

RefSeq Acc Id:

XM_039079852 ⟹ XP_038935780

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	28,412,771 - 28,440,457 (-)	NCBI

RefSeq Acc Id:

XM_039079853 ⟹ XP_038935781

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	28,412,771 - 28,440,458 (-)	NCBI

RefSeq Acc Id:

XM_039079854 ⟹ XP_038935782

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	28,412,771 - 28,440,458 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_071984	(Get FASTA)	NCBI Sequence Viewer
	XP_038935780	(Get FASTA)	NCBI Sequence Viewer
	XP_038935781	(Get FASTA)	NCBI Sequence Viewer
	XP_038935782	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41111	(Get FASTA)	NCBI Sequence Viewer
	AAH70892	(Get FASTA)	NCBI Sequence Viewer
	AAH91150	(Get FASTA)	NCBI Sequence Viewer
	P38062	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_071984 ⟸ NM_022539

- UniProtKB:

Q5BKA1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAGVEEASSFGGHLNRDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAGQQELDKESGTSV
DEVAKQLERQALEEKEKDDDDEDGDGDGDGAAGKKKKKKKKKRGPRVQTDPPSVPICDLYPNGV
FPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMT
MIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHI
SGRIIDCAFTVTFNPKYDILLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTY
QVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYM
KNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLC
DIKGSYTAQFEHTILCAQPVKKLSAEEMTIKT

hide sequence

RefSeq Acc Id:

ENSRNOP00000030415 ⟸ ENSRNOT00000031571

RefSeq Acc Id:

ENSRNOP00000032680 ⟸ ENSRNOT00000030056

RefSeq Acc Id:	XP_038935782 ⟸ XM_039079854
- Peptide Label:	isoform X3
- UniProtKB:	F7FJ19 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038935781 ⟸ XM_039079853
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038935780 ⟸ XM_039079852
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000087571 ⟸ ENSRNOT00000110473

Protein Domains

Peptidase M24

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P38062-F1-model_v2	AlphaFold	P38062	1-478	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695150

Promoter ID:

EPDNEW_R5675

Type:

initiation region

Name:

Metap2_1

Description:

methionyl aminopeptidase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	34,789,488 - 34,789,548	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70995	AgrOrtholog
BioCyc Gene	G2FUF-34381	BioCyc
BioCyc Pathway	PWY-7799 [Arg/N-end rule pathway (eukaryotic)]	BioCyc
	PWY-7800 [Ac/N-end rule pathway]	BioCyc
Ensembl Genes	ENSRNOG00000021881	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000030415	ENTREZGENE
	ENSRNOP00000030415.5	UniProtKB/TrEMBL
	ENSRNOP00000032680	ENTREZGENE
	ENSRNOP00000032680.7	UniProtKB/TrEMBL
	ENSRNOP00000087571.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000030056	ENTREZGENE
	ENSRNOT00000030056.7	UniProtKB/TrEMBL
	ENSRNOT00000031571	ENTREZGENE
	ENSRNOT00000031571.7	UniProtKB/TrEMBL
	ENSRNOT00000110473.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.230.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7099147	IMAGE-MGC_LOAD
	IMAGE:7122560	IMAGE-MGC_LOAD
InterPro	Creatinase/aminopeptidase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M24	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M24_MAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M24A_MAP2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pept_M24A_MAP2_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64370	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:108689	IMAGE-MGC_LOAD
	MGC:91685	IMAGE-MGC_LOAD
NCBI Gene	64370	ENTREZGENE
PANTHER	METHIONINE AMINOPEPTIDASE 2	UniProtKB/Swiss-Prot
	METHIONINE AMINOPEPTIDASE 2	UniProtKB/Swiss-Prot
	METHIONINE AMINOPEPTIDASE 2	UniProtKB/TrEMBL
	METHIONINE AMINOPEPTIDASE 2	UniProtKB/TrEMBL
Pfam	Peptidase_M24	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Metap2	PhenoGen
PRINTS	MAPEPTIDASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MAP_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55920	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	met_pdase_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A902_RAT	UniProtKB/TrEMBL
	F1LRI8_RAT	UniProtKB/TrEMBL
	F7FJ19	ENTREZGENE
	MAP2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5BKA1	ENTREZGENE, UniProtKB/TrEMBL
	Q6IRK1_RAT	UniProtKB/TrEMBL
UniProt Secondary	F7FJ19	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-24	Metap2	methionyl aminopeptidase 2	Metap2	methionine aminopeptidase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Metap2	methionine aminopeptidase 2			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains a highly charged N-terminal region with two basic polylysine blocks and an acidic aspartic acid block	70793
gene_protein	480 amino acids	70793

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar