Grpel1 (GrpE-like 1, mitochondrial)

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Gene: Grpel1 (GrpE-like 1, mitochondrial) Rattus norvegicus

Analyze

Symbol:

Grpel1

Name:

GrpE-like 1, mitochondrial

RGD ID:

70947

Description:

Enables ATPase activator activity; ATPase binding activity; and identical protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be part of PAM complex, Tim23 associated import motor. Biomarker of middle cerebral artery infarction. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial); PARTICIPATES IN presequence pathway of mitochondrial protein import; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2-nitrofluorene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

grpE protein homolog 1, mitochondrial; GrpE#1; GrpE1; mt-GrpE#1; stress-inducible chaperone mt-GrpE#1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GRPEL1 (GrpE like 1, mitochondrial)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Grpel1 (GrpE-like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Grpel1 (GrpE like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GRPEL1 (GrpE like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GRPEL1 (GrpE like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Grpel1 (GrpE like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GRPEL1 (GrpE like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GRPEL1 (GrpE like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Grpel1 (GrpE like 1, mitochondrial)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	LAMB3 (laminin subunit beta 3)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Grpel1 (GrpE-like 1, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GRPEL1 (GrpE like 1, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grpel1 (GrpE-like 1, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C34C12.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MGE1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Roe1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	grpel1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	74,292,023 - 74,298,243 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	74,292,023 - 74,298,200 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	78,734,419 - 78,740,226 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	79,975,292 - 79,981,099 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	76,420,265 - 76,426,072 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	79,458,951 - 79,464,782 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	79,458,963 - 79,464,770 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	79,097,953 - 79,103,777 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	79,873,191 - 79,878,998 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	79,875,225 - 79,881,387 (-)	NCBI
Celera	14	73,230,590 - 73,236,397 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

human immunodeficiency virus infectious disease (ISO)

middle cerebral artery infarction (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-colchicine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2-hydroxypropanoic acid (ISO)

2-nitrofluorene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

adenine (ISO)

aflatoxin B1 (EXP)

amiodarone (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

Bisphenol B (ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

cisplatin (EXP,ISO)

clofibrate (EXP)

clofibric acid (EXP)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diethylstilbestrol (EXP)

dimethylarsinic acid (EXP)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

hydroxyurea (ISO)

isobutanol (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-ethionine (EXP)

limonene (EXP)

methapyrilene (EXP)

methidathion (ISO)

methyl methanesulfonate (ISO)

mitomycin C (ISO)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

omeprazole (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP,ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

senecionine (ISO)

sodium dichromate (ISO)

tert-butyl hydroperoxide (ISO)

thapsigargin (EXP,ISO)

thioacetamide (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

protein folding (IEA)

protein import into mitochondrial matrix (IBA)

Cellular Component

mitochondrial matrix (IEA,ISO)

mitochondrion (ISO)

nucleoplasm (IEA,ISO)

PAM complex, Tim23 associated import motor (IBA)

Molecular Function

adenyl-nucleotide exchange factor activity (IBA,IEA)

ATPase activator activity (IDA)

ATPase binding (IPI)

identical protein binding (IPI,ISO)

protein binding (ISO)

protein homodimerization activity (IEA)

protein-folding chaperone binding (IEA)

unfolded protein binding (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

presequence pathway of mitochondrial protein import (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE.	Choglay AA, etal., Gene 2001 Apr 4;267(1):125-34.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Gene Data Set	MGD Curation, June 12, 2002
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Isolation and characterisation of a cDNA encoding rat mitochondrial GrpE, a stress-inducible nucleotide-exchange factor of ubiquitous appearance in mammalian organs.	Naylor DJ, etal., FEBS Lett 1996 Nov 4;396(2-3):181-8.
7.	Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members.	Naylor DJ, etal., J Biol Chem. 1998 Aug 14;273(33):21169-77.
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	Unlocking the presequence import pathway.	Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
13.	Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.	Tamura S, etal., Brain Res 2003 Jan 17;960(1-2):277-81.

Additional References at PubMed

PMID:11311562	PMID:12477932	PMID:14651853	PMID:18614015	PMID:25002582

Genomics

Comparative Map Data

Grpel1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	74,292,023 - 74,298,243 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	74,292,023 - 74,298,200 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	78,734,419 - 78,740,226 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	79,975,292 - 79,981,099 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	76,420,265 - 76,426,072 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	79,458,951 - 79,464,782 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	79,458,963 - 79,464,770 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	79,097,953 - 79,103,777 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	79,873,191 - 79,878,998 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	79,875,225 - 79,881,387 (-)	NCBI
Celera	14	73,230,590 - 73,236,397 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

GRPEL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	7,058,895 - 7,068,064 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	7,058,671 - 7,068,085 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	7,060,622 - 7,069,791 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	7,112,681 - 7,120,701 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	7,179,851 - 7,187,872	NCBI
Celera	4	6,965,198 - 6,973,219 (-)	NCBI		Celera
Cytogenetic Map	4	p16.1	NCBI
HuRef	4	6,989,046 - 6,997,061 (-)	NCBI		HuRef
CHM1_1	4	7,060,163 - 7,068,180 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	7,030,735 - 7,039,901 (-)	NCBI		T2T-CHM13v2.0

Grpel1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	36,622,529 - 36,631,421 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	36,622,342 - 36,631,424 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	36,465,185 - 36,474,077 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	36,464,998 - 36,474,080 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	36,807,834 - 36,816,726 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	36,782,280 - 36,791,172 (+)	NCBI		MGSCv36	mm8
Celera	5	33,946,160 - 33,955,052 (+)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI

Grpel1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	3,459,774 - 3,467,279 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	3,459,774 - 3,467,279 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRPEL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	7,255,405 - 7,263,644 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	4	7,126,043 - 7,135,388 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	7,126,043 - 7,135,388 (-)	Ensembl	panpan1.1		panPan2

GRPEL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	59,124,116 - 59,131,541 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	59,124,613 - 59,131,977 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	61,770,979 - 61,778,423 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	59,595,959 - 59,603,388 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	59,595,274 - 59,603,595 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	59,093,027 - 59,100,454 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	59,294,915 - 59,302,364 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	59,649,262 - 59,656,689 (-)	NCBI		UU_Cfam_GSD_1.0

Grpel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	65,181,864 - 65,189,477 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	18,880,736 - 18,891,110 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936477	18,883,556 - 18,891,108 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRPEL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	8	3,797,310 - 3,813,725 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	3,397,261 - 3,413,692 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRPEL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	43,173,664 - 43,182,015 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	43,174,467 - 43,181,783 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	90,028,597 - 90,036,905 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grpel1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	23,270,910 - 23,280,264 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	23,273,253 - 23,280,328 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Grpel1
21 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	462
Count of miRNA genes:	245
Interacting mature miRNAs:	292
Transcripts:	ENSRNOT00000008932
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	37669719	82669719	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	37669719	82669719	Rat
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	37669719	82669719	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	37669719	82669719	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39057237	83368335	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39998251	75582726	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	40793460	98037301	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42262529	95023211	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	50023211	95023211	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	55147478	100147478	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	55624247	100624247	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	55624247	100624247	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	56631369	101631369	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	58184885	103184885	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	68757796	83368335	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	73415323	92554092	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	92554092	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	73415323	92554092	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	73415323	95876975	Rat

Markers in Region

RH129769

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	74,292,066 - 74,292,260 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	79,458,650 - 79,458,843	NCBI	Rnor6.0
Rnor_5.0	14	79,097,652 - 79,097,845	UniSTS	Rnor5.0
RGSC_v3.4	14	79,872,878 - 79,873,071	UniSTS	RGSC3.4
Celera	14	73,230,277 - 73,230,470	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_024487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006251142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U62940	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000008932 ⟹ ENSRNOP00000008930

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	74,292,023 - 74,298,200 (-)	Ensembl
Rnor_6.0 Ensembl	14	79,458,963 - 79,464,770 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000082180 ⟹ ENSRNOP00000070967

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	74,292,371 - 74,298,180 (-)	Ensembl
Rnor_6.0 Ensembl	14	79,459,057 - 79,462,080 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104564 ⟹ ENSRNOP00000093798

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	74,292,023 - 74,295,055 (-)	Ensembl

RefSeq Acc Id:

NM_024487 ⟹ NP_077813

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	74,292,380 - 74,298,187 (-)	NCBI
Rnor_6.0	14	79,458,963 - 79,464,770 (-)	NCBI
Rnor_5.0	14	79,097,953 - 79,103,777 (-)	NCBI
RGSC_v3.4	14	79,873,191 - 79,878,998 (-)	RGD
Celera	14	73,230,590 - 73,236,397 (-)	RGD

Sequence:

show sequence

CCCGGGGGTAGTCATGGCGGCTCGGTGCGTGAGGCTGGCGCGGCGCAGCCTCCCGGCTTTGGCG
CTGTCGTTCAGGCCTTCTCCTCGCTTGTTGTGCACAGCTACAAAACAAAAGAACAATGGCCAGA
ACCTGGAAGAGGACTTGGGGCATTGTGAGCCAAAGACAGATCCATCCTCTGCAGACAAGACCCT
CCTGGAAGAGAAGGTGAAGCTGGAAGAGCAGCTGAAGGAGACCATGGAAAAATACAAACGTGCT
TTGGCAGATACCGAGAATCTACGGCAGAGAAGCCAGAAGCTGGTAGAAGAGGCCAAGTTATATG
GCATCCAGGGTTTCTGCAAGGACTTGCTGGAGGTTGCAGACATCCTAGAGAAGGCAACCCAGAG
TGTTCCAAAGGAGGAGGTCAGCAACAACAACCCTCACCTGAAGAGTCTTTATGAAGGGCTCGTG
ATGACTGAAGTCCAGATTCAGAAGGTGTTCACAAAACACGGCTTGCTCAGGCTTGACCCCATTG
GGGCAAAGTTCGACCCTTATGAACATGAGGCCTTGTTCCACACCCCTGTGGAGGGGAAAGAACC
AGGCACTGTGGCACTAGTTAGTAAGGTGGGCTACAAGCTGCATGGACGCACCCTGAGGCCAGCT
TTGGTGGGGGTGGTGAAGGACGCTTAGCTCTCTCCCTCAAGGCTCTGGACTTTGTAGGTCACTT
GCTAGAACTCAAAGGGTGGGCGGGCTTGTAATTTCTCATCTGTGAACACATCTGACCCTTGCCC
AGCCTTGTTGGAAATCTTAAGTAAGCTAAGCAGAACATGAAGCTGCTTGCACACTGTGTCAGAG
ACTCTGGGAGTCTGGTCATTGAGTTTAGCATTACCTACTTCAGAAGAGGGCCAGCAGGGCCTCA
GGAGTAGCATGCTAACGTTGTATCTGTTCCACCTTGTGATTAAGTACTTTACACAAATAAAAGG

hide sequence

RefSeq Acc Id:

XM_006251142 ⟹ XP_006251204

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	74,292,023 - 74,298,243 (-)	NCBI
Rnor_6.0	14	79,458,951 - 79,464,782 (-)	NCBI
Rnor_5.0	14	79,097,953 - 79,103,777 (-)	NCBI

Sequence:

show sequence

CAGTGACGCGACCCCGGGGGTAGTCATGGCGGCTCGGTGCGTGAGGCTGGCGCGGCGCAGCCTC
CCGGCTTTGGCGCTGTCGTTCAGGACCCAAGCTCATATTGGACAGTTTACAACCACCTGTAATT
CCAGCTCCAGGGCATCCCTCTTCTGGTCTCCTCGGACACTGCACTCATGTGGCATACACTCATA
CTGACACACCTAAAAAGGCATCCACATTCTTTGGGTGGTGTATGTGATGTGAGCACATTGGGAA
GGCCCAAGGTCAACATCAGGCCTTCTCCTCGCTTGTTGTGCACAGCTACAAAACAAAAGAACAA
TGGCCAGAACCTGGAAGAGGACTTGGGGCATTGTGAGCCAAAGACAGATCCATCCTCTGCAGAC
AAGACCCTCCTGGAAGAGAAGGTGAAGCTGGAAGAGCAGCTGAAGGAGACCATGGAAAAATACA
AACGTGCTTTGGCAGATACCGAGAATCTACGGCAGAGAAGCCAGAAGCTGGTAGAAGAGGCCAA
GTTATATGGCATCCAGGGTTTCTGCAAGGACTTGCTGGAGGTTGCAGACATCCTAGAGAAGGCA
ACCCAGAGTGTTCCAAAGGAGGAGGTCAGCAACAACAACCCTCACCTGAAGAGTCTTTATGAAG
GGCTCGTGATGACTGAAGTCCAGATTCAGAAGGTGTTCACAAAACACGGCTTGCTCAGGCTTGA
CCCCATTGGGGCAAAGTTCGACCCTTATGAACATGAGGCCTTGTTCCACACCCCTGTGGAGGGG
AAAGAACCAGGCACTGTGGCACTAGTTAGTAAGGTGGGCTACAAGCTGCATGGACGCACCCTGA
GGCCAGCTTTGGTGGGGGTGGTGAAGGACGCTTAGCTCTCTCCCTCAAGGCTCTGGACTTTGTA
GGTCACTTGCTAGAACTCAAAGGGTGGGCGGGCTTGTAATTTCTCATCTGTGAACACATCTGAC
CCTTGCCCAGCCTTGTTGGAAATCTTAAGTAAGCTAAGCAGAACATGAAGCTGCTTGCACACTG
TGTCAGAGACTCTGGGAGTCTGGTCATTGAGTTTAGCATTACCTACTTCAGAAGAGGGCCAGCA
GGGCCTCAGGAGTAGCATGCTAACGTTGTATCTGTTCCACCTTGTGATTAAGTACTTTACACAA
ATAAAAGGTCTTTGGCTACA

hide sequence

Protein Sequences


Protein RefSeqs	NP_077813	(Get FASTA)	NCBI Sequence Viewer
	XP_006251204	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53534	(Get FASTA)	NCBI Sequence Viewer
	AAH97312	(Get FASTA)	NCBI Sequence Viewer
	EDM00047	(Get FASTA)	NCBI Sequence Viewer
	P97576	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_077813 ⟸ NM_024487
- Peptide Label:	precursor
- UniProtKB:	Q4QRA3 (UniProtKB/Swiss-Prot), P97576 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLEEDLGHCEPKTDPSSADKTLLEEK VKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKE EVSNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVA LVSKVGYKLHGRTLRPALVGVVKDA hide sequence

RefSeq Acc Id:	XP_006251204 ⟸ XM_006251142
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JZA2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWHTLILTHLKRHPHSLGGVCDVSTLGRPKVNIRPSPRLLCTATKQKNNGQNLEEDLGHCEPKT DPSSADKTLLEEKVKLEEQLKETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVA DILEKATQSVPKEEVSNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALF HTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA hide sequence

RefSeq Acc Id:

ENSRNOP00000008930 ⟸ ENSRNOT00000008932

RefSeq Acc Id:

ENSRNOP00000070967 ⟸ ENSRNOT00000082180

RefSeq Acc Id:

ENSRNOP00000093798 ⟸ ENSRNOT00000104564

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97576-F1-model_v2	AlphaFold	P97576	1-217	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699384

Promoter ID:

EPDNEW_R9909

Type:

multiple initiation site

Name:

Grpel1_1

Description:

GrpE-like 1, mitochondrial

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	79,464,781 - 79,464,841	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70947	AgrOrtholog
Ensembl Genes	ENSRNOG00000006593	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000008930	ENTREZGENE
	ENSRNOP00000008930.3	UniProtKB/Swiss-Prot
	ENSRNOP00000070967	ENTREZGENE
	ENSRNOP00000070967.1	UniProtKB/TrEMBL
	ENSRNOP00000093798.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008932	ENTREZGENE
	ENSRNOT00000008932.6	UniProtKB/Swiss-Prot
	ENSRNOT00000082180	ENTREZGENE
	ENSRNOT00000082180.2	UniProtKB/TrEMBL
	ENSRNOT00000104564.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.22.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.20.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7387647	IMAGE-MGC_LOAD
InterPro	GrpE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GrpE_coiled_coil	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GrpE_head	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:79563	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114309	IMAGE-MGC_LOAD
NCBI Gene	79563	ENTREZGENE
PANTHER	GRPE PROTEIN HOMOLOG 1, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR21237	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	GrpE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Grpel1	PhenoGen
PRINTS	GRPEPROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	GRPE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51064	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF58014	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JZA2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AMG9_RAT	UniProtKB/TrEMBL
	GRPE1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q4QRA3	ENTREZGENE
UniProt Secondary	Q4QRA3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-07-09	Grpel1	GrpE-like 1, mitochondrial			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_process	enhances the ATPase activity of the mitochondrial Hsp70	68707
gene_regulation	expression only marginally increased in response to the proline analog L-azetidine 2-carboxylic acid	70756

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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