Gene: Eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1) Rattus norvegicus
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Symbol: Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Description: ENCODES a protein that exhibits eukaryotic translation initiation factor 2alpha kinase activity; heme binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN acute inflammatory response (ortholog); iron ion homeostasis (ortholog); macrophage differentiation (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C virus infection pathway; influenza A virus infection pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Anemia, Hemolytic (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: eukaryotic translation initiation factor 2-alpha kinase 1; HCR; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; hemin-sensitive initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2a kinase; Hri
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01212,749,026 - 12,782,078 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01214,792,379 - 14,825,284 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,039,139 - 11,072,708 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11210,969,549 - 11,102,636 (-)NCBI
Celera1212,508,244 - 12,541,227 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Eif2ak1
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70883
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE