Exoc5 (exocyst complex component 5) - Rat Genome Database

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Gene: Exoc5 (exocyst complex component 5) Rattus norvegicus
Analyze
Symbol: Exoc5
Name: exocyst complex component 5
RGD ID: 708408
Description: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; exocytosis; and protein localization to plasma membrane. Predicted to act upstream of or within with a negative effect on epithelial cell apoptotic process. Predicted to act upstream of or within establishment of planar polarity; negative regulation of apoptotic process; and non-motile cilium assembly. Predicted to be located in cytoplasm and midbody. Predicted to be part of exocyst. Orthologous to human EXOC5 (exocyst complex component 5); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH ammonium chloride; bisphenol A; flavonoids.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 71 kDa component of rsec6/8 secretory complex; component of rsec6/8 secretory complex p71 (71 kDa); exocyst complex component Sec10; LOC60627; p71 component of rsec6/8 secretory complex; SEC10-like 1; SEC10-like 1 (S. cerevisiae); Sec10l1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81524,788,738 - 24,834,941 (-)NCBIGRCr8
mRatBN7.21522,310,682 - 22,355,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1522,308,946 - 22,355,335 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1525,085,965 - 25,130,482 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01526,049,400 - 26,093,947 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01524,294,462 - 24,338,978 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01525,888,757 - 25,933,302 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1525,887,070 - 25,933,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01529,811,327 - 29,855,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41525,008,521 - 25,053,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11525,024,574 - 25,068,570 (-)NCBI
Celera1522,687,639 - 22,732,184 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
exocyst  (IBA,IEA)
midbody  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Characterization of a cDNA encoding a subunit of the rat brain rsec6/8 complex. Hazuka CD, etal., Gene 1997 Mar 10;187(1):67-73.
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18480549   PMID:24056301   PMID:26040895   PMID:26046524   PMID:26582389   PMID:31593505  


Genomics

Comparative Map Data
Exoc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81524,788,738 - 24,834,941 (-)NCBIGRCr8
mRatBN7.21522,310,682 - 22,355,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1522,308,946 - 22,355,335 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1525,085,965 - 25,130,482 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01526,049,400 - 26,093,947 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01524,294,462 - 24,338,978 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01525,888,757 - 25,933,302 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1525,887,070 - 25,933,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01529,811,327 - 29,855,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41525,008,521 - 25,053,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11525,024,574 - 25,068,570 (-)NCBI
Celera1522,687,639 - 22,732,184 (-)NCBICelera
Cytogenetic Map15p14NCBI
EXOC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381457,200,507 - 57,268,905 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1457,200,507 - 57,268,905 (-)EnsemblGRCh38hg38GRCh38
GRCh371457,667,225 - 57,735,623 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361456,738,947 - 56,805,370 (-)NCBINCBI36Build 36hg18NCBI36
Build 341456,739,867 - 56,805,376NCBI
Celera1437,719,278 - 37,785,703 (-)NCBICelera
Cytogenetic Map14q22.3NCBI
HuRef1437,833,989 - 37,900,415 (-)NCBIHuRef
CHM1_11457,607,847 - 57,674,254 (-)NCBICHM1_1
T2T-CHM13v2.01451,406,949 - 51,475,352 (-)NCBIT2T-CHM13v2.0
Exoc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391449,249,379 - 49,304,124 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1449,241,547 - 49,304,110 (-)EnsemblGRCm39 Ensembl
GRCm381449,011,922 - 49,066,667 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1449,004,090 - 49,066,653 (-)EnsemblGRCm38mm10GRCm38
MGSCv371449,631,819 - 49,686,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361447,934,094 - 47,988,618 (-)NCBIMGSCv36mm8
Celera1445,212,944 - 45,267,371 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1425.36NCBI
Exoc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546611,116,907 - 11,191,911 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546611,115,902 - 11,191,353 (-)NCBIChiLan1.0ChiLan1.0
EXOC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21558,311,238 - 58,375,449 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11457,527,752 - 57,591,954 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01437,775,555 - 37,839,751 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11456,046,142 - 56,110,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1456,050,175 - 56,089,615 (-)Ensemblpanpan1.1panPan2
EXOC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1832,789,311 - 32,848,045 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl832,778,715 - 32,848,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha832,556,919 - 32,615,671 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0833,039,719 - 33,098,885 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl833,043,978 - 33,098,848 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1832,642,956 - 32,702,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0832,718,881 - 32,777,624 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0833,094,536 - 33,153,654 (-)NCBIUU_Cfam_GSD_1.0
Exoc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864072,329,052 - 72,401,349 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364951,790,285 - 1,863,273 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364951,790,357 - 1,862,647 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXOC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1186,377,458 - 186,529,728 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11186,376,134 - 186,430,206 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21206,958,653 - 206,996,493 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EXOC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12434,388,155 - 34,449,832 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2434,388,119 - 34,450,442 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605322,607,944 - 22,672,732 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exoc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248842,242,040 - 2,312,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248842,239,614 - 2,311,500 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Exoc5
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:35
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000067735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15226636822711984Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 52 36 19 36 8 10 74 35 39 11 8
Low 3 5 5 5 1 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067735   ⟹   ENSRNOP00000062799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1522,308,946 - 22,355,322 (-)Ensembl
Rnor_6.0 Ensembl1525,887,070 - 25,933,268 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095143   ⟹   ENSRNOP00000079183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1522,310,700 - 22,355,335 (-)Ensembl
RefSeq Acc Id: NM_022204   ⟹   NP_071540
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81524,790,396 - 24,834,941 (-)NCBI
mRatBN7.21522,310,759 - 22,355,306 (-)NCBI
Rnor_6.01525,888,757 - 25,933,302 (-)NCBI
Rnor_5.01529,811,327 - 29,855,874 (-)NCBI
RGSC_v3.41525,008,521 - 25,053,098 (-)RGD
Celera1522,687,639 - 22,732,184 (-)RGD
Sequence:
RefSeq Acc Id: XM_039093635   ⟹   XP_038949563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81524,788,738 - 24,834,825 (-)NCBI
mRatBN7.21522,310,682 - 22,355,332 (-)NCBI
RefSeq Acc Id: XM_063274610   ⟹   XP_063130680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81524,797,666 - 24,834,825 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_071540   ⟸   NM_022204
- UniProtKB: A1A5N5 (UniProtKB/Swiss-Prot),   P97878 (UniProtKB/Swiss-Prot),   A6KE83 (UniProtKB/TrEMBL),   A0A8I5ZM73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062799   ⟸   ENSRNOT00000067735
RefSeq Acc Id: XP_038949563   ⟸   XM_039093635
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZM73 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079183   ⟸   ENSRNOT00000095143
RefSeq Acc Id: XP_063130680   ⟸   XM_063274610
- Peptide Label: isoform X2
Protein Domains
Exocyst complex component Sec10 N-terminal   Exocyst complex component Sec10-like alpha-helical

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97878-F1-model_v2 AlphaFold P97878 1-708 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699617
Promoter ID:EPDNEW_R10141
Type:initiation region
Name:Exoc5_1
Description:exocyst complex component 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01525,933,272 - 25,933,332EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708408 AgrOrtholog
BioCyc Gene G2FUF-14111 BioCyc
Ensembl Genes ENSRNOG00000013804 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024977 UniProtKB/Swiss-Prot
  ENSRNOG00060031019 UniProtKB/Swiss-Prot
  ENSRNOG00065031194 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067735 ENTREZGENE
  ENSRNOT00000067735.4 UniProtKB/Swiss-Prot
  ENSRNOT00000095143.1 UniProtKB/TrEMBL
  ENSRNOT00055043110 UniProtKB/Swiss-Prot
  ENSRNOT00060053945 UniProtKB/Swiss-Prot
  ENSRNOT00065053819 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8362342 IMAGE-MGC_LOAD
InterPro Sec10-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec10_HB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec10_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60627 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156649 IMAGE-MGC_LOAD
NCBI Gene 60627 ENTREZGENE
PANTHER EXOCYST COMPLEX COMPONENT 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sec10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec10_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Exoc5 PhenoGen
RatGTEx ENSRNOG00000013804 RatGTEx
  ENSRNOG00055024977 RatGTEx
  ENSRNOG00060031019 RatGTEx
  ENSRNOG00065031194 RatGTEx
UniProt A0A8I5ZM73 ENTREZGENE, UniProtKB/TrEMBL
  A1A5N5 ENTREZGENE
  A6KE83 ENTREZGENE, UniProtKB/TrEMBL
  EXOC5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1A5N5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Exoc5  exocyst complex component 5  Sec10l1  SEC10-like 1 (S. cerevisiae)  Symbol and Name updated 1299863 APPROVED
2005-07-08 Sec10l1  SEC10-like 1 (S. cerevisiae)  LOC60627  component of rsec6/8 secretory complex p71 (71 kDa)  Symbol and Name updated 1299863 APPROVED