Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Rattus norvegicus
Symbol: Wfs1
Name: wolframin ER transmembrane glycoprotein
Description: ENCODES a protein that exhibits activating transcription factor binding; calcium-dependent protein binding; calmodulin binding; INVOLVED IN negative regulation of ATF6-mediated unfolded protein response; negative regulation of DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH Seizures; Stress Disorders, Post-Traumatic; Autistic Disorder (ortholog); FOUND IN proteasome complex; endoplasmic reticulum (ortholog); integral component of endoplasmic reticulum membrane (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride
Type: protein-coding
Also known as: Wolfram syndrome 1; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); wolframin
Homo sapiens (human) : WFS1 (wolframin ER transmembrane glycoprotein)  HGNC  AGR
Mus musculus (house mouse) : Wfs1 (wolframin ER transmembrane glycoprotein)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Wfs1 (wolframin ER transmembrane glycoprotein)
Pan paniscus (bonobo/pygmy chimpanzee) : WFS1 (wolframin ER transmembrane glycoprotein)
Canis lupus familiaris (dog) : WFS1 (wolframin ER transmembrane glycoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wfs1 (wolframin ER transmembrane glycoprotein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Celera1472,756,725 - 72,781,236 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Wfs1
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68954
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE