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Gene: Pdia3 (protein disulfide isomerase family A, member 3) Rattus norvegicus
Symbol: Pdia3
Name: protein disulfide isomerase family A, member 3
RGD ID: 68430
Description: Exhibits MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Localizes to several cellular components, including acrosomal vesicle; endoplasmic reticulum; and mitochondrial intermembrane space. Used to study autoimmune hepatitis and irritable bowel syndrome. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3); PARTICIPATES IN antigen processing and presentation pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
Also known as: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; ER protein 57; ER protein 60; ER-60 protease; ER60; ERp57; ERp60; glucose regulated protein, 58 kDa; Grp58; HIP-70; oxidoreductase ERp57; p58; protein disulfide isomerase associated 3; protein disulfide-isomerase A3; Q-2
Homo sapiens (human) : PDIA3 (protein disulfide isomerase family A member 3)  HGNC  Alliance
Mus musculus (house mouse) : Pdia3 (protein disulfide isomerase associated 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdia3 (protein disulfide isomerase family A member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PDIA3 (protein disulfide isomerase family A member 3)
Canis lupus familiaris (dog) : PDIA3 (protein disulfide isomerase family A member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdia3 (protein disulfide isomerase family A member 3)
Sus scrofa (pig) : PDIA3 (protein disulfide isomerase family A member 3)
Chlorocebus sabaeus (African green monkey) : PDIA3 (protein disulfide isomerase family A member 3)
Heterocephalus glaber (naked mole-rat) : Pdia3 (protein disulfide isomerase family A member 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03113,376,983 - 113,400,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,376,983 - 113,400,707 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03119,916,772 - 119,940,826 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43108,216,414 - 108,240,138 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13108,117,203 - 108,140,928 (+)NCBI
Celera3107,289,603 - 107,313,229 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pdia3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68430
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.