Hsf2 (heat shock transcription factor 2) - Rat Genome Database

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Gene: Hsf2 (heat shock transcription factor 2) Rattus norvegicus
Analyze
Symbol: Hsf2
Name: heat shock transcription factor 2
RGD ID: 68395
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human HSF2 (heat shock transcription factor 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; allethrin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heat shock factor 2; heat shock factor protein 2; heat shock transcription factor hsf2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22036,819,864 - 36,847,490 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2036,819,864 - 36,850,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2037,839,384 - 37,867,393 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02037,230,068 - 37,258,090 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02037,957,121 - 37,985,145 (+)NCBIRnor_WKY
Rnor_6.02038,935,820 - 38,963,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2038,935,820 - 38,963,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02040,673,635 - 40,701,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42036,520,685 - 36,538,506 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12036,534,484 - 36,552,286 (+)NCBI
Celera2038,134,605 - 38,162,082 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Regulation of rat heat shock factor 2 expression during the early organogenic phase of embryogenesis. Min JN, etal., Biochim Biophys Acta 2000 Dec 1;1494(3):256-62.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10561509   PMID:11032181   PMID:12477932   PMID:14994269   PMID:16889897   PMID:17536178   PMID:18434628   PMID:18755693   PMID:21480429   PMID:28295305   PMID:28796250   PMID:35182974  


Genomics

Comparative Map Data
Hsf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22036,819,864 - 36,847,490 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2036,819,864 - 36,850,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2037,839,384 - 37,867,393 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02037,230,068 - 37,258,090 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02037,957,121 - 37,985,145 (+)NCBIRnor_WKY
Rnor_6.02038,935,820 - 38,963,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2038,935,820 - 38,963,309 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02040,673,635 - 40,701,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42036,520,685 - 36,538,506 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12036,534,484 - 36,552,286 (+)NCBI
Celera2038,134,605 - 38,162,082 (+)NCBICelera
Cytogenetic Map20q12NCBI
HSF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386122,399,551 - 122,433,119 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6122,399,551 - 122,433,119 (+)EnsemblGRCh38hg38GRCh38
GRCh376122,720,696 - 122,754,264 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366122,762,494 - 122,795,810 (+)NCBINCBI36Build 36hg18NCBI36
Build 346122,762,493 - 122,795,810NCBI
Celera6123,464,983 - 123,498,552 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6120,297,677 - 120,331,266 (+)NCBIHuRef
CHM1_16122,984,511 - 123,018,082 (+)NCBICHM1_1
T2T-CHM13v2.06123,587,813 - 123,621,398 (+)NCBIT2T-CHM13v2.0
Hsf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391057,359,862 - 57,389,239 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1057,362,481 - 57,389,231 (+)EnsemblGRCm39 Ensembl
GRCm381057,483,766 - 57,513,143 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1057,486,385 - 57,513,135 (+)EnsemblGRCm38mm10GRCm38
MGSCv371057,206,191 - 57,232,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361057,174,901 - 57,201,550 (+)NCBIMGSCv36mm8
Celera1058,304,915 - 58,331,733 (+)NCBICelera
Cytogenetic Map10B4NCBI
Hsf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554364,387,495 - 4,408,497 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554364,387,498 - 4,406,719 (+)NCBIChiLan1.0ChiLan1.0
HSF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan16140,292,704 - 140,326,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06120,187,898 - 120,221,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16124,312,458 - 124,345,913 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6124,312,353 - 124,348,628 (+)Ensemblpanpan1.1panPan2
HSF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,777,297 - 61,809,208 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,789,720 - 61,808,793 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha162,586,078 - 62,626,997 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,980,494 - 62,021,429 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,980,455 - 62,022,669 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,915,228 - 61,956,121 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0161,702,424 - 61,743,310 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0162,351,349 - 62,392,345 (+)NCBIUU_Cfam_GSD_1.0
Hsf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946112,680,808 - 112,706,663 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368021,369,956 - 1,394,033 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049368021,369,232 - 1,396,722 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl140,147,164 - 40,180,297 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1140,147,267 - 40,180,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2144,452,505 - 44,545,206 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11351,363,650 - 51,401,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1351,364,389 - 51,401,640 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604023,663,584 - 23,701,505 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247988,647,893 - 8,674,082 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247988,646,936 - 8,674,181 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsf2
87 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:317
Count of miRNA genes:189
Interacting mature miRNAs:212
Transcripts:ENSRNOT00000001059
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
D6S2058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22036,846,633 - 36,846,772 (+)MAPPERmRatBN7.2
Rnor_6.02038,962,588 - 38,962,726NCBIRnor6.0
Rnor_5.02040,700,403 - 40,700,541UniSTSRnor5.0
RGSC_v3.42036,537,765 - 36,537,903UniSTSRGSC3.4
Celera2038,161,341 - 38,161,479UniSTS
Cytogenetic Map20q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 39 39 25 11 25 8 10 74 34 41 11 8
Low 3 4 18 16 8 16 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001059   ⟹   ENSRNOP00000001059
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2036,819,864 - 36,847,355 (+)Ensembl
Rnor_6.0 Ensembl2038,935,820 - 38,963,309 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101061   ⟹   ENSRNOP00000085150
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2036,819,941 - 36,847,375 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119675   ⟹   ENSRNOP00000084598
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2036,819,969 - 36,850,174 (+)Ensembl
RefSeq Acc Id: NM_031694   ⟹   NP_113882
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22036,819,864 - 36,847,375 (+)NCBI
Rnor_6.02038,935,820 - 38,963,329 (+)NCBI
Rnor_5.02040,673,635 - 40,701,259 (+)NCBI
RGSC_v3.42036,520,685 - 36,538,506 (+)RGD
Celera2038,134,605 - 38,162,082 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256505   ⟹   XP_006256567
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22036,819,887 - 36,847,490 (+)NCBI
Rnor_6.02038,935,895 - 38,963,444 (+)NCBI
Rnor_5.02040,673,635 - 40,701,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256506   ⟹   XP_006256568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22036,820,290 - 36,847,490 (+)NCBI
Rnor_6.02038,936,168 - 38,963,444 (+)NCBI
Rnor_5.02040,673,635 - 40,701,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601769   ⟹   XP_017457258
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22036,819,995 - 36,847,490 (+)NCBI
Rnor_6.02038,943,130 - 38,963,444 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113882   ⟸   NM_031694
- UniProtKB: Q9R120 (UniProtKB/TrEMBL),   F1LQD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256567   ⟸   XM_006256505
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZYL7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256568   ⟸   XM_006256506
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017457258   ⟸   XM_017601769
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000001059   ⟸   ENSRNOT00000001059
RefSeq Acc Id: ENSRNOP00000084598   ⟸   ENSRNOT00000119675
RefSeq Acc Id: ENSRNOP00000085150   ⟸   ENSRNOT00000101061
Protein Domains
HSF-type DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R120-F1-model_v2 AlphaFold Q9R120 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701634
Promoter ID:EPDNEW_R12158
Type:initiation region
Name:Hsf2_1
Description:heat shock transcription factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02038,935,903 - 38,935,963EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68395 AgrOrtholog
BioCyc Gene G2FUF-3588 BioCyc
Ensembl Genes ENSRNOG00000000808 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001059 ENTREZGENE
  ENSRNOP00000001059.4 UniProtKB/TrEMBL
  ENSRNOP00000084598.1 UniProtKB/TrEMBL
  ENSRNOP00000085150 ENTREZGENE
  ENSRNOP00000085150.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001059 ENTREZGENE
  ENSRNOT00000001059.5 UniProtKB/TrEMBL
  ENSRNOT00000101061 ENTREZGENE
  ENSRNOT00000101061.1 UniProtKB/TrEMBL
  ENSRNOT00000119675.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302950 IMAGE-MGC_LOAD
InterPro HSF_DNA-bd UniProtKB/TrEMBL
  HSF_fam UniProtKB/TrEMBL
  Vert_HS_TF UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:64441 UniProtKB/TrEMBL
MGC_CLONE MGC:105394 IMAGE-MGC_LOAD
NCBI Gene 64441 ENTREZGENE
PANTHER PTHR10015 UniProtKB/TrEMBL
  PTHR10015:SF185 UniProtKB/TrEMBL
Pfam HSF_DNA-bind UniProtKB/TrEMBL
  Vert_HS_TF UniProtKB/TrEMBL
PhenoGen Hsf2 PhenoGen
PRINTS HSFDOMAIN UniProtKB/TrEMBL
PROSITE HSF_DOMAIN UniProtKB/TrEMBL
SMART HSF UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
TIGR TC205519
UniProt A0A8I5ZYL7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GAQ4_RAT UniProtKB/TrEMBL
  F1LQD4 ENTREZGENE
  Q9R120 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LQD4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-06 Hsf2  heat shock transcription factor 2  Hsf2  heat shock factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hsf2  heat shock factor 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has 96.3% amino acid identity with the mouse homolog 68263