Gene: Egln1 (egl-9 family hypoxia-inducible factor 1) Rattus norvegicus
Symbol: Egln1
Name: egl-9 family hypoxia-inducible factor 1
Description: ENCODES a protein that exhibits enzyme binding; peptidyl-proline dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (ortholog); INVOLVED IN negative regulation of CAMKK-AMPK signaling cascade; negative regulation of cAMP catabolic process; negative regulation of cyclic-nucleotide phosphodiesterase activity; PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; ASSOCIATED WITH increased systemic arterial systolic blood pressure; ASSOCIATED WITH Acute Kidney Injury; Hypertension; Kidney Reperfusion Injury; FOUND IN cytosol; cytoplasm (ortholog); INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; astemizole
Type: protein-coding
RefSeq Status: MODEL
Also known as: egl nine homolog 1; EGL nine homolog 1 (C. elegans); HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; hypoxia-inducible factor prolyl hydroxylase 2; LOW QUALITY PROTEIN: egl nine homolog 1; PHD-2; PHD2; prolyl hydroxylase domain-containing protein 2
Homo sapiens (human) : EGLN1 (egl-9 family hypoxia inducible factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Egln1 (egl-9 family hypoxia-inducible factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln1 (egl-9 family hypoxia inducible factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Canis lupus familiaris (dog) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln1 (egl-9 family hypoxia inducible factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01957,660,194 - 57,701,158 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01968,373,433 - 68,412,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,080,670 - 55,118,226 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11955,086,125 - 55,122,813 (-)NCBI
Celera1952,235,066 - 52,273,829 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Egln1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631375
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2018-04-10
Status: ACTIVE