Nampt (nicotinamide phosphoribosyltransferase) - Rat Genome Database
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Gene: Nampt (nicotinamide phosphoribosyltransferase) Rattus norvegicus
Analyze
Symbol: Nampt
Name: nicotinamide phosphoribosyltransferase
RGD ID: 631365
Description: Exhibits several functions, including cytokine activity; identical protein binding activity; and nicotinamide phosphoribosyltransferase activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to oxygen-glucose deprivation; and negative regulation of cellular senescence. Localizes to cytoplasm; nucleus; and plasma membrane. Used to study middle cerebral artery infarction and transient cerebral ischemia. Biomarker of kidney failure; periodontitis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in transient cerebral ischemia. Orthologous to human NAMPT (nicotinamide phosphoribosyltransferase); PARTICIPATES IN niacin metabolic pathway; nicotinamide adenine dinucleotide biosynthesis, the salvage pathway; monoterpenoid biosynthetic pathway; INTERACTS WITH (S)-nicotine; 1-methylnicotinamide; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: NAmPRTase; Pbef; Pbef1; pre-B-cell colony enhancing factor 1; pre-B-cell colony-enhancing factor; pre-B-cell colony-enhancing factor 1 homolog; visfatin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0652,122,085 - 52,156,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,753,125 - 61,787,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4651,129,160 - 51,166,514 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1651,132,285 - 51,169,639 (+)NCBI
Celera648,619,485 - 48,654,540 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methylnicotinamide  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
acetic acid  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP)
bromobenzene  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chlorendic acid  (EXP)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
estriol  (ISO)
ethylbenzene  (ISO)
eugenol  (ISO)
fenofibrate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
glucose  (ISO)
hydralazine  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (EXP)
mitoxantrone  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (EXP)
nevirapine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP)
nifedipine  (ISO)
nimesulide  (EXP)
NMN zwitterion  (EXP,ISO)
p-anisidine  (ISO)
paclitaxel  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
progesterone  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
toluene  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell junction  (IEA,ISO)
cytoplasm  (IDA,IEA,ISO)
extracellular space  (IEA)
nuclear speck  (IEA,ISO)
nucleus  (IDA,IEA)
plasma membrane  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Baburski AZ, etal., Exp Gerontol. 2016 Jan;73:5-13. doi: 10.1016/j.exger.2015.11.002. Epub 2015 Nov 4.
2. Chen CX, etal., Neuroscience. 2017 Jul 25;356:193-206. doi: 10.1016/j.neuroscience.2017.05.022. Epub 2017 May 19.
3. Chen J, etal., Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15.
4. Choi KC, etal., Biochem Biophys Res Commun. 2007 May 25;357(1):62-7. Epub 2007 Mar 28.
5. Dahl TB, etal., Circulation. 2007 Feb 27;115(8):972-80. Epub 2007 Feb 5.
6. Dietrich LS and Muniz O, Biochemistry. 1972 Apr 25;11(9):1691-5.
7. Erfani S, etal., J Mol Neurosci. 2015 May;56(1):237-43. doi: 10.1007/s12031-014-0486-1. Epub 2015 Jan 22.
8. Filippatos TD, etal., J Endocrinol Invest. 2007 Apr;30(4):323-6.
9. GOA data from the GO Consortium
10. Houtkooper RH, etal., Endocr Rev. 2010 Apr;31(2):194-223. doi: 10.1210/er.2009-0026. Epub 2009 Dec 9.
11. Hu Q, etal., Stroke. 2017 Jun;48(6):1655-1664. doi: 10.1161/STROKEAHA.116.015753. Epub 2017 May 11.
12. Huang X, etal., Mol Med Rep. 2017 Sep;16(3):2700-2706. doi: 10.3892/mmr.2017.6931. Epub 2017 Jul 5.
13. Jeremy M, etal., Ann Anat. 2017 May;211:46-54. doi: 10.1016/j.aanat.2017.01.009. Epub 2017 Feb 3.
14. Josephs T, etal., J Endocrinol. 2007 Aug;194(2):305-12.
15. Kim MK, etal., J Mol Biol. 2006 Sep 8;362(1):66-77. Epub 2006 Aug 9.
16. Kitani T, etal., FEBS Lett 2003 Jun 5;544(1-3):74-8.
17. Kloting N and Kloting I, Biochem Biophys Res Commun. 2005 Jul 15;332(4):1070-2.
18. Kowalska I, etal., Hum Reprod. 2007 Jul;22(7):1824-9.
19. Luo S, etal., J Periodontal Res. 2016 Aug;51(4):453-61. doi: 10.1111/jre.12322. Epub 2015 Oct 12.
20. Ma C, etal., PLoS One. 2017 Jan 26;12(1):e0170930. doi: 10.1371/journal.pone.0170930. eCollection 2017.
21. MGD data from the GO Consortium
22. Oku H, etal., Jpn J Ophthalmol. 2017 Mar;61(2):195-203. doi: 10.1007/s10384-016-0493-6. Epub 2016 Dec 28.
23. Pipeline to import KEGG annotations from KEGG into RGD
24. Pipeline to import SMPDB annotations from SMPDB into RGD
25. Retnakaran R, etal., Clin Endocrinol (Oxf). 2008 Dec;69(6):885-93. Epub 2008 Apr 10.
26. RGD automated data pipeline
27. RGD automated import pipeline for gene-chemical interactions
28. Sengupta A, etal., Int J Biochem Cell Biol. 2017 Dec;93:129-135. doi: 10.1016/j.biocel.2017.08.014. Epub 2017 Aug 30.
29. Song HK, etal., Am J Physiol Renal Physiol. 2008 Nov;295(5):F1485-94. Epub 2008 Sep 3.
30. Ugur S, etal., Ren Fail. 2015 Mar;37(2):332-6. doi: 10.3109/0886022X.2014.986005. Epub 2015 Jan 16.
31. Wang P, etal., Cardiovasc Res. 2009 Feb 1;81(2):370-80. Epub 2008 Oct 24.
32. Wu GC, etal., Respir Res. 2017 Apr 24;18(1):71. doi: 10.1186/s12931-017-0557-2.
33. Xiang B, etal., Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):538-46. doi: 10.1016/j.ijrobp.2016.06.2442. Epub 2016 Jul 1.
34. Yang P, etal., Pharmazie. 2015 Oct;70(10):650-5.
35. Zahorska-Markiewicz B, etal., Metabolism. 2007 Aug;56(8):1131-4.
36. Zou XD, etal., Mol Med Rep. 2016 May;13(5):4058-64. doi: 10.3892/mmr.2016.5034. Epub 2016 Mar 21.
Additional References at PubMed
PMID:12477932   PMID:15381699   PMID:15489334   PMID:16783373   PMID:16783377   PMID:17889652   PMID:17983582   PMID:18401839   PMID:19263259   PMID:19299583   PMID:19533035   PMID:19661458  
PMID:19666527   PMID:19727662   PMID:19751774   PMID:19913571   PMID:19929131   PMID:20456420   PMID:20458337   PMID:20658215   PMID:21246601   PMID:21664630   PMID:21841463   PMID:22113203  
PMID:23001182   PMID:23065734   PMID:23533145   PMID:23831038   PMID:23946338   PMID:24287278   PMID:24304571   PMID:24332931   PMID:24667915   PMID:25351242   PMID:25358398   PMID:25505128  
PMID:25645057   PMID:26051626   PMID:26694625   PMID:26857566   PMID:27083000   PMID:28478801   PMID:29663373   PMID:29772226  


Genomics

Comparative Map Data
Nampt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0652,122,085 - 52,156,473 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0661,753,125 - 61,787,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4651,129,160 - 51,166,514 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1651,132,285 - 51,169,639 (+)NCBI
Celera648,619,485 - 48,654,540 (+)NCBICelera
Cytogenetic Map6q16NCBI
NAMPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7106,248,298 - 106,286,326 (-)EnsemblGRCh38hg38GRCh38
GRCh387106,248,298 - 106,284,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377105,888,731 - 105,926,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367105,675,967 - 105,712,874 (-)NCBINCBI36hg18NCBI36
Build 347105,495,899 - 105,519,318NCBI
Celera7100,694,260 - 100,731,169 (-)NCBI
Cytogenetic Map7q22.3NCBI
HuRef7100,248,062 - 100,285,253 (-)NCBIHuRef
CHM1_17105,822,212 - 105,859,137 (-)NCBICHM1_1
CRA_TCAGchr7v27105,249,752 - 105,286,646 (-)NCBI
Nampt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391232,870,334 - 32,903,368 (+)NCBIGRCm39mm39
GRCm381232,820,335 - 32,853,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1232,819,545 - 32,853,349 (+)EnsemblGRCm38mm10GRCm38
MGSCv371233,505,200 - 33,538,234 (+)NCBIGRCm37mm9NCBIm37
MGSCv361233,405,722 - 33,436,855 (+)NCBImm8
Celera1234,264,778 - 34,297,952 (+)NCBICelera
Cytogenetic Map12A3NCBI
Nampt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541010,717,664 - 10,751,177 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541010,717,664 - 10,742,109 (-)NCBIChiLan1.0ChiLan1.0
NAMPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17110,952,876 - 110,989,233 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0798,227,071 - 98,262,254 (-)NCBIMhudiblu_PPA_v0panPan3
NAMPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1813,993,022 - 14,208,657 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11814,110,045 - 14,211,268 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nampt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647917,682,070 - 17,716,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAMPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9106,119,899 - 106,294,587 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19106,119,896 - 106,162,126 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29116,889,082 - 116,932,047 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NAMPT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12175,160,748 - 75,195,781 (-)NCBI
ChlSab1.1 Ensembl2175,158,596 - 75,196,025 (-)Ensembl
Nampt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473923,411,478 - 23,444,590 (+)NCBI

Position Markers
AI314458  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0652,156,088 - 52,156,213NCBIRnor6.0
Rnor_5.0661,787,190 - 61,787,315UniSTSRnor5.0
RGSC_v3.4651,166,129 - 51,166,254UniSTSRGSC3.4
Celera648,654,155 - 48,654,280UniSTS
Cytogenetic Map6q16UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)71017386255173862Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295857516539Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)61941788764417887Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62151530265784818Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)63425776653855198Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63436743680490628Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63499565675623393Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63626028860606186Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63626028884763275Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63760898075023446Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63810630883106308Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63819641260606431Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64167904686679046Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:600
Count of miRNA genes:289
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000013043
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013043   ⟹   ENSRNOP00000013043
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl652,122,085 - 52,156,472 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086432   ⟹   ENSRNOP00000071458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl652,122,318 - 52,155,611 (+)Ensembl
RefSeq Acc Id: NM_177928   ⟹   NP_808789
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0652,122,085 - 52,156,473 (+)NCBI
Rnor_5.0661,753,125 - 61,787,575 (+)NCBI
RGSC_v3.4651,129,160 - 51,166,514 (+)RGD
Celera648,619,485 - 48,654,540 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_808789 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85681 (Get FASTA)   NCBI Sequence Viewer  
  AAX49410 (Get FASTA)   NCBI Sequence Viewer  
  BAC66022 (Get FASTA)   NCBI Sequence Viewer  
  EDM03273 (Get FASTA)   NCBI Sequence Viewer  
  Q80Z29 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_808789   ⟸   NM_177928
- UniProtKB: Q80Z29 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071458   ⟸   ENSRNOT00000086432
RefSeq Acc Id: ENSRNOP00000013043   ⟸   ENSRNOT00000013043
Protein Domains
DUF5598   NAPRTase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694548
Promoter ID:EPDNEW_R5073
Type:initiation region
Name:Nampt_1
Description:nicotinamide phosphoribosyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0652,122,055 - 52,122,115EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631365 AgrOrtholog
Ensembl Genes ENSRNOG00000009754 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013043 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000071458 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013043 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000086432 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192109 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N/Namide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinamide_PRibTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nicotinate_pribotase-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:297508 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93053 IMAGE-MGC_LOAD
NCBI Gene 297508 ENTREZGENE
PANTHER PTHR43816 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF5598 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAPRTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NAMPT RGD
PhenoGen Nampt PhenoGen
PIRSF NMPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.203508 ENTREZGENE
UniProt A0A0G2K0I3_RAT UniProtKB/TrEMBL
  NAMPT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q2VT47 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-25 Nampt  nicotinamide phosphoribosyltransferase  Pbef1  pre-B-cell colony enhancing factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pbef1  pre-B-cell colony enhancing factor 1  Pbef  pre-B-cell colony-enhancing factor  Symbol and Name updated 1299863 APPROVED