Mx2 (MX dynamin like GTPase 2) - Rat Genome Database

Name: Mx2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Mx2 (MX dynamin like GTPase 2) Rattus norvegicus

Analyze

Symbol:

Mx2

Name:

MX dynamin like GTPase 2

RGD ID:

628821

Description:

Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Involved in response to virus. Located in cytoplasm. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1); PARTICIPATES IN influenza A pathway; measles pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

interferon-induced GTP-binding protein Mx2; interferon-induced GTP-binding protein Mx3; Mx3; myxovirus (influenza virus) resistance 2; myxovirus (influenza virus) resistance 3; myxovirus resistance protein 2; myxovirus resistance protein 3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MX2 (MX dynamin like GTPase 2)	HGNC	OrthoDB
Pan paniscus (bonobo/pygmy chimpanzee):	MX2 (MX dynamin like GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MX2 (MX dynamin like GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MX2 (MX dynamin like GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MX2 (MX dynamin like GTPase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	MX1 (MX dynamin like GTPase 1)	HGNC	Ensembl, HomoloGene, OrthoDB, Panther
Homo sapiens (human):	VPS29 (VPS29 retromer complex component)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	MX1 (MX dynamin like GTPase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mx2 (MX dynamin-like GTPase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mxc (myxovirus (influenza virus) resistance C)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	mxa (myxovirus (influenza) resistance A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	mxb (myxovirus (influenza) resistance B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	mxe (myxovirus (influenza virus) resistance E)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	VPS1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	mx1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	50,375,101 - 50,399,373 (+)	NCBI		GRCr8
mRatBN7.2	11	36,905,698 - 36,936,308 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	36,906,111 - 36,930,342 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	45,604,887 - 45,630,454 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	38,276,267 - 38,301,834 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	37,436,195 - 37,461,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	38,035,306 - 38,066,185 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	38,035,450 - 38,059,950 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	41,545,958 - 41,570,577 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	37,548,650 - 37,572,717 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	37,608,291 - 37,630,303 (+)	NCBI
Celera	11	36,790,647 - 36,814,700 (+)	NCBI		Celera
RH 3.4 Map	11	263.01	RGD
Cytogenetic Map	11	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

genetic disease (ISO)

Human Influenza (ISO)

melanoma (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

(-)-epigallocatechin 3-gallate (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aconitine (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-phellandrene (ISO)

amitrole (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

amphotericin B (ISO)

atrazine (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

CGP 52608 (ISO)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

corn oil (EXP)

cyclophosphamide (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

diazinon (ISO)

dieldrin (EXP)

diethyl maleate (EXP)

diethylstilbestrol (EXP)

dioxygen (EXP)

doxorubicin (ISO)

endosulfan (EXP)

formaldehyde (ISO)

gentamycin (EXP)

irinotecan (ISO)

lead diacetate (EXP)

lipopolysaccharide (ISO)

metformin (EXP)

methimazole (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

orphenadrine (EXP)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

PCB138 (EXP)

perfluorooctanoic acid (ISO)

phenformin (EXP)

phenobarbital (EXP)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propiconazole (EXP)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

tamibarotene (ISO)

tauroursodeoxycholic acid (EXP)

temozolomide (ISO)

testosterone (EXP)

testosterone enanthate (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

tofacitinib (ISO)

topotecan (EXP)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zidovudine (ISO)

zinc atom (EXP)

zinc sulfate (ISO)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to type I interferon (ISO)

defense response to virus (IBA,IEA,ISO)

endosomal transport (ISO)

innate immune response (IEA)

negative regulation of intracellular transport of viral material (ISO)

negative regulation of viral genome replication (ISO)

regulation of cell cycle (ISO)

regulation of nucleocytoplasmic transport (ISO)

response to interferon-alpha (ISO)

response to virus (IDA,IEA,ISO)

Cellular Component

cytoplasm (IBA,IDA,IEA,ISO)

exocytic vesicle (ISO)

membrane (IBA,IEA)

microtubule (IBA,IEA)

nuclear pore (ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

GTP binding (IEA,ISO)

GTPase activity (IBA,IEA,ISO)

microtubule binding (IBA,IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

influenza A pathway (IEA)

measles pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
3.	Activity of rat Mx proteins against a rhabdovirus.	Meier E, etal., J Virol 1990 Dec;64(12):6263-9.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9371647	PMID:12477932	PMID:14687945	PMID:15047845	PMID:15767791	PMID:16202617	PMID:16780588	PMID:18504258	PMID:20167191	PMID:20428112	PMID:21478870	PMID:21859714
PMID:24500530	PMID:25295396	PMID:25416956	PMID:28064310	PMID:31505169

Genomics

Comparative Map Data

Mx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	50,375,101 - 50,399,373 (+)	NCBI		GRCr8
mRatBN7.2	11	36,905,698 - 36,936,308 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	36,906,111 - 36,930,342 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	45,604,887 - 45,630,454 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	38,276,267 - 38,301,834 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	37,436,195 - 37,461,762 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	38,035,306 - 38,066,185 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	38,035,450 - 38,059,950 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	41,545,958 - 41,570,577 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	37,548,650 - 37,572,717 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	37,608,291 - 37,630,303 (+)	NCBI
Celera	11	36,790,647 - 36,814,700 (+)	NCBI		Celera
RH 3.4 Map	11	263.01	RGD
Cytogenetic Map	11	q12	NCBI

MX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	41,362,027 - 41,409,393 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	41,361,999 - 41,409,393 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	42,733,954 - 42,781,320 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	41,655,820 - 41,702,739 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	41,655,819 - 41,702,739	NCBI
Celera	21	27,932,197 - 27,979,096 (+)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	28,202,853 - 28,249,753 (+)	NCBI		HuRef
CHM1_1	21	42,294,753 - 42,341,669 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	39,750,638 - 39,798,083 (+)	NCBI		T2T-CHM13v2.0

MX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	37,443,072 - 37,490,730 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	32,297,379 - 32,344,569 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	27,696,457 - 27,744,105 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	41,024,562 - 41,071,653 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	41,032,681 - 41,071,653 (+)	Ensembl	panpan1.1		panPan2

MX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	35,860,596 - 35,883,607 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	35,860,590 - 35,951,350 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	35,005,886 - 35,038,055 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	35,368,501 - 35,400,678 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	35,367,708 - 35,468,668 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	35,264,320 - 35,296,463 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	35,242,367 - 35,274,518 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	35,736,514 - 35,768,675 (+)	NCBI		UU_Cfam_GSD_1.0

MX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	204,798,629 - 204,831,957 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	204,798,633 - 204,821,612 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	215,036,188 - 215,059,001 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	85,281,752 - 85,326,736 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	85,289,689 - 85,326,735 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	13,133,992 - 13,178,868 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Mx2
2254 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	236
Count of miRNA genes:	176
Interacting mature miRNAs:	194
Transcripts:	ENSRNOT00000002695
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	8436674	53436674	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16472047	44285911	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	29528418	60324829	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat

Markers in Region

RH94601

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	11	263.01	UniSTS
Cytogenetic Map	11	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	6	30	14	19	14			21	14	16	11
Low	2	29	27	27		27	8	11	51	21	25		8
Below cutoff		8							2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_134350	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270316	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063270318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X52712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X52713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002695 ⟹ ENSRNOP00000002695

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	11	38,035,696 - 38,059,577 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083067 ⟹ ENSRNOP00000075302

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	36,906,111 - 36,930,342 (+)	Ensembl
Rnor_6.0 Ensembl	11	38,035,450 - 38,059,312 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087603 ⟹ ENSRNOP00000075496

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	36,906,111 - 36,930,342 (+)	Ensembl
Rnor_6.0 Ensembl	11	38,035,611 - 38,059,950 (+)	Ensembl

RefSeq Acc Id:

NM_134350 ⟹ NP_599177

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	50,375,306 - 50,399,373 (+)	NCBI
mRatBN7.2	11	36,905,903 - 36,929,972 (+)	NCBI
Rnor_6.0	11	38,035,513 - 38,059,580 (+)	NCBI
Rnor_5.0	11	41,545,958 - 41,570,577 (+)	NCBI
RGSC_v3.4	11	37,548,650 - 37,572,717 (+)	RGD
Celera	11	36,790,647 - 36,814,700 (+)	RGD

Sequence:

show sequence

CCCAGGAGCTTTCTCTCTGGGAAGGGGTGGAGACAGCTGTTTAAAGACACTGCAACCAGAAAGC
CAAGCATTCTGTCACTAAGCAGGAGACTGAGTGCCCACTTGGAAGAAGAAATAAAAGATGGTTC
TTAGCACAGAGGAAAACAGGAGTGTTGATTTAGTCAACTTACCCAGTGTCCCACTGCCCGATGG
AGAGGCTGGCGTAGGGGAGAACAACAAGGATTCCTTGAACAACCTCTGCAGTCAGTATGAGGAG
AAGGTGCGGCCCTGCATTGACCTCATCGACTCCCTGCGAGCTCTGGGTGTGGAGCAAGACCTGG
CCCTGCCTGCCATCGCTGTCATCGGGGACCAGAGTTCAGGGAAGAGCTCTGTGCTGGAAGCACT
GTCTGGAGTGGCCCTCCCCAGAGGCAGTGGTATTGTCACCAGATGTCCCCTGGTGCTGAAATTG
AAGAAGCTGAATCAGGGAGAGGAGTGGAAAGGCAAAGTCACCTATGATGACATCGAAGTGGAGC
TCTCTGATCCTTCAGAGGTGGAAGAGGCCATCAACACAGGTCAGAACCATATTGCTGGGGTAGG
GCTGGGGATCAGTGATAAACTCATTAGCCTGGATGTCAGCTCCCCACACGTCCCAGACCTGACT
CTGATTGACCTTCCTGGAATCACCAGGGTGGCTGTAGGCAACCAGCCTGCAGACATAGGACGGC
AGATCAAGAGACTTATCACTAACTACATCCAAAAACAAGAGACCATCAACCTGGTGGTGGTCCC
CAGCAATGTGGACATTGCCACCACAGAGGCCCTGAGCATGGCTCAGAAGGTGGACCCTGATGGG
GATAGGACCATAGGGATCTTGACCAAGCCTGATCTGGTGGACAGAGGGACTGAAGACAAGGTCG
TGGATGTGGTGAGGAACCTCGTGTGCCACCTGAAGAAGGGCTACATGATAGTCAAGTGCAGGGG
TCAGCAGGACATCCAGGAGCAGCTGAGCCTGGCTGAGGCTCTTCAGAAGGAGCAAGTCTTCTTC
AAGGAACACCCTCAATTCAGAGCTCTTCTGGAGGATGGGAAGGCCACAGTGCCCTGCCTGGCAG
AGAGGCTGACCATGGAGCTCATCTCACACATCTGTAAATCTCTTCCTTTGTTAGAAAATCAAAT
AAAGGAAAGTCACCAGAGTACAAGTGAGGAGCTGCAGAAGTATGGTGCAGACATACCAGAAGAT
GAGAATGAAAAAACTCTCTTCCTGATTGAAAAAATCAATGCTTTTAACCAGGACATCACTGCCA
TAGTAGAAGGGGAAGAGATTGTGAGGGAGAAAGAATGTCGCCTATTCACCAAGCTCCGTAAAGA
GTTCTTCTTGTGGAGTGAGGAGATCGAAAGGAATTTCCAAAAAGGTTCTGATGCTTTATATAAA
GAAGTCTACACATTCGAAATGCAGTATCGTGGCCGAGAACTACCAGGGTTTGTGAATTACAAAA
CATTTGAGAACATCATAAGAAGACAAATCAAAACCCTGGAAGAACCAGCTATGGAAATGCTTCA
CAAGGTCACTGAAATTGTACGGGCTGCCTTTACAACGGTTTCTGAGAAAAATTTCTCTGAGTTT
TTTAATCTCCACAGAACTACCAAGTCCAAACTTGAAGACATCAGATTAGAACAGGAAACGGAAG
CAGAGAAGGCGATCCGGCTTCACTTCCAGATGGAACAAATCATCTACTGCCAGGACCAAATTTA
TAGGAAAGCCTTGCAGAAGGTGAGAGAGGAGGAAGCTGAGGAGGAGGAGAGGAAGCATGGCAAA
AGCAGGTCCGCTCAGTCCCCAAATTTACAGACCTCATCCATGGATGAAATCTTCCAGCATCTGA
ATGCCTACCGCCAGGAGGCTCACAACTGCATCTCCAGCCACATTCCATTGATCATCCAGTATTT
CATCTTGAAGATGTTTGCTGAGAAGCTGCAGAAGGGCATGCTCCAGCTCCTGCAGGACAAGGAT
TCCTGCAGCTGGCTCCTGAAGGAAAAGAGTGACACCAGTGAGAAGAGGAGATTCCTGAAGGAGC
GGTTGGCAAGGCTGGCCCAAGCTCAGCGCAGGCTAGCCAAATTCCCTGGTTAAGCTGGCCCTGT
CCTTTCCTGTGTCTCCTGGATAATTAAATATTCAGGGACAGAAGGGTTCCAGCCTTGTTGTGGT
TTGCCCTAAGATATCTGTATTTTGATGCTAATTCCACTGCCCCAGGGACAGCTGCCTAGTCCTG
TACTCAGGAATCAGGTGACTTCACCAGAAACTTCTCCCCATTGAATTTGTAAAATACAGGTGAG
GGGCACATAGAGGATAGAAAGAGGCCTGTAATTGGACCAGAAGTAAGGATTGGTGGGAGAGAAG
TTTAAAGGAAGGGGAGGATACTGGAAGGGAAAGAAGGAGAGGAGAGAGATAGAGAGAAGCCATG
GCAGGACAATATGGCAGGTGACATTAAGATTCCATGCTGTACCTTTACAGGTTGTTACAAATGT
TCTTAAGGGATGGATGGTACTGGGCTTTGTATGTTTAGGTGGGCAATTATATCTTACCAATTGG
GTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039088055 ⟹ XP_038943983

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	50,375,101 - 50,399,373 (+)	NCBI
mRatBN7.2	11	36,905,698 - 36,930,468 (+)	NCBI

RefSeq Acc Id:

XM_063270316 ⟹ XP_063126386

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	50,375,245 - 50,399,373 (+)	NCBI

RefSeq Acc Id:

XM_063270317 ⟹ XP_063126387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	50,375,245 - 50,399,373 (+)	NCBI

RefSeq Acc Id:

XM_063270318 ⟹ XP_063126388

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	50,375,298 - 50,399,373 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_599177	(Get FASTA)	NCBI Sequence Viewer
	XP_038943983	(Get FASTA)	NCBI Sequence Viewer
	XP_063126386	(Get FASTA)	NCBI Sequence Viewer
	XP_063126387	(Get FASTA)	NCBI Sequence Viewer
	XP_063126388	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99808	(Get FASTA)	NCBI Sequence Viewer
	CAA36936	(Get FASTA)	NCBI Sequence Viewer
	CAA36937	(Get FASTA)	NCBI Sequence Viewer
	EDM10969	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075302.2
	ENSRNOP00000075496
	ENSRNOP00000075496.1
GenBank Protein	P18589	(Get FASTA)	NCBI Sequence Viewer
	P18590	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_599177 ⟸ NM_134350

- UniProtKB:

Q499Q3 (UniProtKB/TrEMBL), A6IQG6 (UniProtKB/TrEMBL), A0A0G2KA85 (UniProtKB/TrEMBL), A0A0G2KAR4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLSTEENRSVDLVNLPSVPLPDGEAGVGENNKDSLNNLCSQYEEKVRPCIDLIDSLRALGVEQ
DLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLNQGEEWKGKVTYDDIE
VELSDPSEVEEAINTGQNHIAGVGLGISDKLISLDVSSPHVPDLTLIDLPGITRVAVGNQPADI
GRQIKRLITNYIQKQETINLVVVPSNVDIATTEALSMAQKVDPDGDRTIGILTKPDLVDRGTED
KVVDVVRNLVCHLKKGYMIVKCRGQQDIQEQLSLAEALQKEQVFFKEHPQFRALLEDGKATVPC
LAERLTMELISHICKSLPLLENQIKESHQSTSEELQKYGADIPEDENEKTLFLIEKINAFNQDI
TAIVEGEEIVREKECRLFTKLRKEFFLWSEEIERNFQKGSDALYKEVYTFEMQYRGRELPGFVN
YKTFENIIRRQIKTLEEPAMEMLHKVTEIVRAAFTTVSEKNFSEFFNLHRTTKSKLEDIRLEQE
TEAEKAIRLHFQMEQIIYCQDQIYRKALQKVREEEAEEEERKHGKSRSAQSPNLQTSSMDEIFQ
HLNAYRQEAHNCISSHIPLIIQYFILKMFAEKLQKGMLQLLQDKDSCSWLLKEKSDTSEKRRFL
KERLARLAQAQRRLAKFPG

hide sequence

RefSeq Acc Id:

ENSRNOP00000075496 ⟸ ENSRNOT00000087603

RefSeq Acc Id:

ENSRNOP00000002695 ⟸ ENSRNOT00000002695

RefSeq Acc Id:

ENSRNOP00000075302 ⟸ ENSRNOT00000083067

RefSeq Acc Id:	XP_038943983 ⟸ XM_039088055
- Peptide Label:	isoform X1
- UniProtKB:	Q499Q3 (UniProtKB/TrEMBL), A6IQG6 (UniProtKB/TrEMBL), A0A0G2KA85 (UniProtKB/TrEMBL), A0A0G2KAR4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063126386 ⟸ XM_063270316
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAR4 (UniProtKB/TrEMBL), A6IQG6 (UniProtKB/TrEMBL), Q499Q3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063126387 ⟸ XM_063270317
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAR4 (UniProtKB/TrEMBL), A6IQG6 (UniProtKB/TrEMBL), Q499Q3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063126388 ⟸ XM_063270318
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAR4 (UniProtKB/TrEMBL), A6IQG6 (UniProtKB/TrEMBL), Q499Q3 (UniProtKB/TrEMBL)

Protein Domains

Dynamin-type G GED

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P18589-F1-model_v2	AlphaFold	P18589	1-659	view protein structure
AF-P18590-F1-model_v2	AlphaFold	P18590	1-659	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698098

Promoter ID:

EPDNEW_R8618

Type:

multiple initiation site

Name:

Mx2_1

Description:

MX dynamin like GTPase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	38,035,498 - 38,035,558	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628821	AgrOrtholog
BioCyc Gene	G2FUF-21683	BioCyc
Ensembl Genes	ENSRNOG00000001963	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000083067.2	UniProtKB/TrEMBL
	ENSRNOT00000087603	ENTREZGENE
	ENSRNOT00000087603.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin, middle domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7938638	IMAGE-MGC_LOAD
InterPro	Dynamin_central	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_GTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_GTPase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_SF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_DYNAMIN_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GED_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:286918	UniProtKB/TrEMBL
MGC_CLONE	MGC:124566	IMAGE-MGC_LOAD
NCBI Gene	286918	ENTREZGENE
PANTHER	INTERFERON-INDUCED GTP-BINDING PROTEIN MX1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11566	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Dynamin_M	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Dynamin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mx2	PhenoGen
PRINTS	DYNAMIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_DYNAMIN_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_DYNAMIN_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001963	RatGTEx
SMART	DYNc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2KA85	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2KAR4	ENTREZGENE, UniProtKB/TrEMBL
	A6IQG6	ENTREZGENE, UniProtKB/TrEMBL
	MX2_RAT	UniProtKB/Swiss-Prot
	MX3_RAT	UniProtKB/Swiss-Prot
	P18589	ENTREZGENE
	P18590	ENTREZGENE
	Q499Q3	ENTREZGENE
UniProt Secondary	Q499Q3	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-29	Mx2	MX dynamin like GTPase 2	Mx2	myxovirus (influenza virus) resistance 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-04-21	Mx2	myxovirus (influenza virus) resistance 2	Mx3	myxovirus (influenza virus) resistance 3	Data merged from RGD:621298	737654	APPROVED
2003-02-27	Mx2	myxovirus (influenza virus) resistance 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-08-07	Mx3	myxovirus (influenza virus) resistance 3			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression stimulated by alpha/beta interferon	728936

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)