Akt3 (AKT serine/threonine kinase 3) - Rat Genome Database

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Gene: Akt3 (AKT serine/threonine kinase 3) Rattus norvegicus
Analyze
Symbol: Akt3
Name: AKT serine/threonine kinase 3
RGD ID: 62390
Description: Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Acts upstream of or within cellular response to insulin stimulus and positive regulation of sodium ion transport. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3); PARTICIPATES IN altered phosphatidylinositol 3-kinase-Akt signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; sphingosine 1-phosphate signaling pathway; INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AKT3 kinase; PKB gamma; Pkbg; protein kinase Akt-3; protein kinase B gamma; protein kinase B, gamma; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma); v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81391,475,839 - 91,758,060 (-)NCBIGRCr8
mRatBN7.21388,943,708 - 89,225,831 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1388,946,091 - 89,225,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1391,448,976 - 91,721,092 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01392,849,190 - 93,121,303 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01390,036,538 - 90,308,696 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01395,076,308 - 95,348,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1395,081,390 - 95,348,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01399,527,953 - 99,800,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41392,802,390 - 93,110,704 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11393,002,743 - 93,299,588 (-)NCBI
Celera1388,523,410 - 88,791,412 (-)NCBICelera
Cytogenetic Map13q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clenbuterol  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
Di-n-octyl phthalate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dobutamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
hydroquinone  (ISO)
insulin  (ISO)
lead(0)  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
nitenpyram  (ISO)
oxidopamine  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
PhIP  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
thimerosal  (ISO)
topotecan  (ISO)
torcetrapib  (ISO)
trametinib  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
xanthohumol  (ISO)
zearalenone  (ISO)
zebularine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (TAS)
membrane  (IEA)
nucleoplasm  (TAS)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer. Al-Saad S, etal., Anticancer Res. 2009 Oct;29(10):4175-83.
2. PI3K/Akt: getting it right matters. Franke TF Oncogene. 2008 Oct 27;27(50):6473-88.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
6. The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression. Joy A, etal., J Neurooncol. 2016 Oct;130(1):43-52. doi: 10.1007/s11060-016-2220-z. Epub 2016 Jul 15.
7. Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells. Kageyama K, etal., J Biol Chem 2002 May 31;277(22):19255-64.
8. Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Konishi H, etal., Biochem Biophys Res Commun 1995 Nov 13;216(2):526-34.
9. Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer. Lavender NA, etal., BMC Med Genomics. 2012 Apr 30;5:11. doi: 10.1186/1755-8794-5-11.
10. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Lee IH, etal., J Biol Chem. 2007 Oct 12;282(41):29866-73. Epub 2007 Aug 22.
11. The use of protein array to identify targetable receptor tyrosine kinases for treatment of human colon cancer. Morishita A, etal., Int J Oncol. 2010 Oct;37(4):829-35.
12. Akt2 and Akt3 play a pivotal role in malignant gliomas. Mure H, etal., Neuro Oncol. 2010 Mar;12(3):221-32. doi: 10.1093/neuonc/nop026. Epub 2009 Dec 21.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer. Pectasides D, etal., Anticancer Res. 2016 Dec;36(12):6347-6356.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Knockdown of Akt isoforms by RNA silencing suppresses the growth of human prostate cancer cells in vitro and in vivo. Sasaki T, etal., Biochem Biophys Res Commun. 2010 Aug 13;399(1):79-83. doi: 10.1016/j.bbrc.2010.07.045. Epub 2010 Jul 16.
22. Energy balance, polymorphisms in the mTOR pathway, and renal cell carcinoma risk. Shu X, etal., J Natl Cancer Inst. 2013 Mar 20;105(6):424-32. doi: 10.1093/jnci/djt005. Epub 2013 Feb 2.
23. Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise. Turinsky J and Damrau-Abney A, Am J Physiol. 1999 Jan;276(1 Pt 2):R277-82.
24. Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. Webster CR, etal., J Biol Chem 2002 Aug 9;277(32):28578-83.
Additional References at PubMed
PMID:12767043   PMID:15057822   PMID:15713641   PMID:16540465   PMID:18524868   PMID:18535289   PMID:22391142   PMID:25323119   PMID:27821807   PMID:28254819   PMID:30053369   PMID:31376943  
PMID:34402705   PMID:34663861   PMID:34953897   PMID:35833537   PMID:36752556   PMID:38267920  


Genomics

Comparative Map Data
Akt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81391,475,839 - 91,758,060 (-)NCBIGRCr8
mRatBN7.21388,943,708 - 89,225,831 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1388,946,091 - 89,225,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1391,448,976 - 91,721,092 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01392,849,190 - 93,121,303 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01390,036,538 - 90,308,696 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01395,076,308 - 95,348,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1395,081,390 - 95,348,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01399,527,953 - 99,800,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41392,802,390 - 93,110,704 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11393,002,743 - 93,299,588 (-)NCBI
Celera1388,523,410 - 88,791,412 (-)NCBICelera
Cytogenetic Map13q25NCBI
AKT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381243,488,233 - 243,851,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1243,488,233 - 243,851,079 (-)EnsemblGRCh38hg38GRCh38
GRCh371243,651,535 - 244,014,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361241,718,158 - 242,073,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341239,977,575 - 240,332,594NCBI
Celera1216,939,341 - 217,293,898 (-)NCBICelera
Cytogenetic Map1q43-q44NCBI
HuRef1214,031,579 - 214,386,139 (-)NCBIHuRef
CHM1_11244,924,165 - 245,279,192 (-)NCBICHM1_1
T2T-CHM13v2.01242,900,035 - 243,266,582 (-)NCBIT2T-CHM13v2.0
Akt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391176,847,642 - 177,091,688 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1176,847,639 - 177,085,769 (-)EnsemblGRCm39 Ensembl
GRCm381177,020,076 - 177,261,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1177,020,073 - 177,258,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,952,246 - 179,178,898 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,858,791 - 179,085,442 (-)NCBIMGSCv36mm8
Celera1184,083,831 - 184,309,489 (-)NCBICelera
Cytogenetic Map1H4NCBI
cM Map182.66NCBI
Akt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554066,907,876 - 7,163,672 (-)NCBIChiLan1.0ChiLan1.0
AKT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215,291,732 - 5,644,689 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan115,511,179 - 5,864,762 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01219,107,482 - 219,463,140 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11224,480,762 - 224,824,950 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1224,480,784 - 224,824,838 (-)Ensemblpanpan1.1panPan2
AKT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1734,633,064 - 34,931,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl734,636,124 - 34,931,112 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha734,110,532 - 34,416,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0734,462,499 - 34,769,046 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl734,458,304 - 34,769,283 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1734,299,283 - 34,606,536 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0734,316,186 - 34,622,902 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0734,580,988 - 34,887,190 (-)NCBIUU_Cfam_GSD_1.0
Akt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934447,546,714 - 47,803,867 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365266,944,005 - 7,200,583 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365266,944,056 - 7,201,226 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1016,441,447 - 16,741,337 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11016,441,465 - 16,741,745 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21017,966,073 - 18,268,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12580,509,701 - 80,878,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2580,515,168 - 80,816,018 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605582,702,263 - 83,063,037 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477115,648,638 - 15,896,590 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477115,639,018 - 15,896,590 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akt3
1076 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:110
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000057879
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH128880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,946,144 - 88,946,355 (+)MAPPERmRatBN7.2
Rnor_6.01395,078,658 - 95,078,868NCBIRnor6.0
Rnor_5.01399,530,303 - 99,530,513UniSTSRnor5.0
RGSC_v3.41392,804,740 - 92,804,950UniSTSRGSC3.4
Celera1388,525,760 - 88,525,970UniSTS
Cytogenetic Map13q24-q26UniSTS
RH132276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25117,927,238 - 117,927,436 (-)MAPPERmRatBN7.2
mRatBN7.25117,927,238 - 117,927,436 (+)MAPPERmRatBN7.2
mRatBN7.21388,998,731 - 88,998,929 (-)MAPPERmRatBN7.2
mRatBN7.21388,998,731 - 88,998,929 (+)MAPPERmRatBN7.2
Rnor_6.01395,130,485 - 95,130,682NCBIRnor6.0
Rnor_6.05122,693,285 - 122,693,482NCBIRnor6.0
Rnor_5.05126,558,805 - 126,559,002UniSTSRnor5.0
Rnor_5.01399,582,128 - 99,582,325UniSTSRnor5.0
RGSC_v3.45124,100,522 - 124,100,719UniSTSRGSC3.4
RGSC_v3.41392,859,717 - 92,859,914UniSTSRGSC3.4
Celera1388,578,423 - 88,578,620UniSTS
Celera5116,498,997 - 116,499,194UniSTS
RH 3.4 Map13601.4UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map13q24-q26UniSTS
RH133674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,943,493 - 88,943,684 (+)MAPPERmRatBN7.2
Rnor_6.01395,076,007 - 95,076,197NCBIRnor6.0
Rnor_5.01399,527,652 - 99,527,842UniSTSRnor5.0
RGSC_v3.41392,802,089 - 92,802,279UniSTSRGSC3.4
Celera1388,523,109 - 88,523,299UniSTS
RH 3.4 Map13592.5UniSTS
Cytogenetic Map13q25UniSTS
Cytogenetic Map13q24-q26UniSTS
RH134046  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,945,795 - 88,945,995 (+)MAPPERmRatBN7.2
Rnor_6.01395,078,309 - 95,078,508NCBIRnor6.0
Rnor_5.01399,529,954 - 99,530,153UniSTSRnor5.0
RGSC_v3.41392,804,391 - 92,804,590UniSTSRGSC3.4
Celera1388,525,411 - 88,525,610UniSTS
RH 3.4 Map13593.4UniSTS
Cytogenetic Map13q24-q26UniSTS
BI301874  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21389,196,220 - 89,196,424 (+)MAPPERmRatBN7.2
Rnor_6.01395,329,297 - 95,329,500NCBIRnor6.0
Rnor_5.01399,780,686 - 99,780,889UniSTSRnor5.0
RGSC_v3.41393,091,088 - 93,091,291UniSTSRGSC3.4
Celera1388,771,798 - 88,772,001UniSTS
RH 3.4 Map13601.9UniSTS
Cytogenetic Map13q24-q26UniSTS
BF416653  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1388,559,379 - 88,559,547UniSTS
RH 3.4 Map13592.5UniSTS
Cytogenetic Map13q24-q26UniSTS
AI413057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21388,959,407 - 88,959,568 (+)MAPPERmRatBN7.2
Rnor_6.01395,091,908 - 95,092,068NCBIRnor6.0
Rnor_5.01399,543,180 - 99,543,340UniSTSRnor5.0
RGSC_v3.41392,819,304 - 92,819,464UniSTSRGSC3.4
Celera1388,539,037 - 88,539,197UniSTS
RH 3.4 Map13593.0UniSTS
Cytogenetic Map13q24-q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 34 22 6 19 6 2 2 74 26 41 11 2
Low 1 9 35 35 35 6 9 9 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000057879   ⟹   ENSRNOP00000054688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1388,953,995 - 89,225,708 (-)Ensembl
Rnor_6.0 Ensembl1395,087,450 - 95,348,913 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085648   ⟹   ENSRNOP00000070231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1388,946,091 - 89,225,708 (-)Ensembl
Rnor_6.0 Ensembl1395,081,390 - 95,250,235 (-)Ensembl
RefSeq Acc Id: NM_031575   ⟹   NP_113763
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,747,949 (-)NCBI
mRatBN7.21388,943,708 - 89,215,836 (-)NCBI
Rnor_6.01395,076,308 - 95,348,913 (-)NCBI
Rnor_5.01399,527,953 - 99,800,302 (-)NCBI
RGSC_v3.41392,802,390 - 93,110,704 (-)RGD
Celera1388,523,410 - 88,791,412 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090628   ⟹   XP_038946556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,758,060 (-)NCBI
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090629   ⟹   XP_038946557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,757,030 (-)NCBI
mRatBN7.21388,943,708 - 89,224,805 (-)NCBI
RefSeq Acc Id: XM_039090630   ⟹   XP_038946558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,758,060 (-)NCBI
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090631   ⟹   XP_038946559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,758,060 (-)NCBI
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090632   ⟹   XP_038946560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,758,060 (-)NCBI
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090633   ⟹   XP_038946561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,758,060 (-)NCBI
mRatBN7.21388,943,708 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090634   ⟹   XP_038946562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,648,794 (-)NCBI
mRatBN7.21388,943,708 - 89,116,690 (-)NCBI
RefSeq Acc Id: XM_039090635   ⟹   XP_038946563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,607,520 (-)NCBI
mRatBN7.21388,943,708 - 89,075,404 (-)NCBI
RefSeq Acc Id: XM_039090636   ⟹   XP_038946564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,511,064 - 91,758,060 (-)NCBI
mRatBN7.21388,975,566 - 89,225,831 (-)NCBI
RefSeq Acc Id: XM_039090637   ⟹   XP_038946565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,748,000 (-)NCBI
mRatBN7.21388,943,708 - 89,182,119 (-)NCBI
RefSeq Acc Id: XM_063272204   ⟹   XP_063128274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,757,036 (-)NCBI
RefSeq Acc Id: XM_063272205   ⟹   XP_063128275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,678,579 (-)NCBI
RefSeq Acc Id: XM_063272206   ⟹   XP_063128276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,475,839 - 91,648,133 (-)NCBI
RefSeq Acc Id: XM_063272207   ⟹   XP_063128277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81391,511,064 - 91,758,060 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113763   ⟸   NM_031575
- UniProtKB: Q63484 (UniProtKB/Swiss-Prot),   A0A0G2JXD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054688   ⟸   ENSRNOT00000057879
RefSeq Acc Id: ENSRNOP00000070231   ⟸   ENSRNOT00000085648
RefSeq Acc Id: XP_038946560   ⟸   XM_039090632
- Peptide Label: isoform X4
- UniProtKB: A6JGD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946561   ⟸   XM_039090633
- Peptide Label: isoform X5
- UniProtKB: Q63484 (UniProtKB/Swiss-Prot),   A0A0G2JXD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946556   ⟸   XM_039090628
- Peptide Label: isoform X1
- UniProtKB: A6JGD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946559   ⟸   XM_039090631
- Peptide Label: isoform X3
- UniProtKB: F1M6A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946558   ⟸   XM_039090630
- Peptide Label: isoform X2
- UniProtKB: Q63484 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038946557   ⟸   XM_039090629
- Peptide Label: isoform X1
- UniProtKB: A6JGD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946565   ⟸   XM_039090637
- Peptide Label: isoform X8
- UniProtKB: A6JGD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946562   ⟸   XM_039090634
- Peptide Label: isoform X6
- UniProtKB: A6JGD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946563   ⟸   XM_039090635
- Peptide Label: isoform X7
- UniProtKB: A6JGD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946564   ⟸   XM_039090636
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063128274   ⟸   XM_063272204
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JXD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128275   ⟸   XM_063272205
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063128276   ⟸   XM_063272206
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063128277   ⟸   XM_063272207
- Peptide Label: isoform X10
Protein Domains
AGC-kinase C-terminal   PH   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63484-F1-model_v2 AlphaFold Q63484 1-479 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62390 AgrOrtholog
BioCyc Gene G2FUF-17206 BioCyc
Ensembl Genes ENSRNOG00000021497 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057879.5 UniProtKB/TrEMBL
  ENSRNOT00000085648 ENTREZGENE
  ENSRNOT00000085648.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Akt3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_PKB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29414 UniProtKB/Swiss-Prot
NCBI Gene 29414 ENTREZGENE
PANTHER PTHR24351:SF199 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB AKT3 RGD
PhenoGen Akt3 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021497 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JXD7 ENTREZGENE, UniProtKB/TrEMBL
  A6JGD0 ENTREZGENE, UniProtKB/TrEMBL
  AKT3_RAT UniProtKB/Swiss-Prot
  F1M6A8 ENTREZGENE, UniProtKB/TrEMBL
  Q63484 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Akt3  AKT serine/threonine kinase 3  Akt3  v-akt murine thymoma viral oncogene homolog 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Akt3  v-akt murine thymoma viral oncogene homolog 3  Akt3  v-akt murine thymoma viral oncogene 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Akt3  v-akt murine thymoma viral oncogene 3  Akt3  v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akt3  v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)  Akt3  thymoma viral proto-oncogene 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Akt3  thymoma viral proto-oncogene 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function capable of phosphorylating several known proteins 724707
gene_regulation activated by igf-1, which may play a role in regulating cell survival. 724707