Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4) - Rat Genome Database

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Gene: Hsd17b4 (hydroxysteroid (17-beta) dehydrogenase 4) Rattus norvegicus
Analyze
Symbol: Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
RGD ID: 621806
Description: Enables 3-hydroxyacyl-CoA dehydratase activity; identical protein binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in cellular response to organic cyclic compound; response to steroid hormone; and response to xenobiotic stimulus. Located in peroxisome. Biomarker of hypertension. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; MFP-2; MPF-2; multifunctional protein 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type II
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21843,328,903 - 43,417,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1843,328,824 - 43,417,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1845,372,258 - 45,461,303 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01846,093,452 - 46,184,056 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01843,878,165 - 43,967,210 (+)NCBIRnor_WKY
Rnor_6.01844,810,462 - 44,897,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1844,810,388 - 44,897,640 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01844,032,347 - 44,119,545 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41845,157,435 - 45,251,606 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11845,194,975 - 45,281,963 (+)NCBI
Celera1841,553,644 - 41,635,741 (+)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trichlorophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dibromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-bromophenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-dihydrocoumarin  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
aminoglutethimide  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
androst-5-ene-3beta,17beta-diol  (ISO)
aniline  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzofurans  (ISO)
betamethasone  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carboplatin  (EXP)
CGP 52608  (ISO)
chlorothalonil  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
entacapone  (EXP)
estrone  (ISO)
ethanol  (EXP)
fenofibrate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gallic acid  (ISO)
gemfibrozil  (EXP)
glafenine  (EXP)
haloperidol  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Muraglitazar  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
Propiverine  (EXP)
quercetin  (ISO)
raloxifene  (EXP)
Rebamipide  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
tolcapone  (EXP)
trichloroethene  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
peroxisome  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Prolonged in vivo administration of testosterone-enanthate, the widely used and abused anabolic androgenic steroid, disturbs prolactin and cAMP signaling in Leydig cells of adult rats. Bjelic MM, etal., J Steroid Biochem Mol Biol. 2015 May;149:58-69. doi: 10.1016/j.jsbmb.2015.01.012. Epub 2015 Jan 17.
2. Peroxisome proliferators alter the expression of estrogen-metabolizing enzymes. Corton JC, etal., Biochimie. 1997 Feb-Mar;79(2-3):151-62.
3. Rat 17 beta-hydroxysteroid dehydrogenase type IV is a novel peroxisome proliferator-inducible gene. Corton JC, etal., Mol Pharmacol 1996 Nov;50(5):1157-66.
4. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins. Dieuaide-Noubhani M, etal., Eur J Biochem 1996 Sep 15;240(3):660-6.
5. Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen. Dinkel K, etal., J Neuroimmunol. 2002 Sep;130(1-2):184-93.
6. Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis. Ferdinandusse S, etal., Am J Hum Genet. 2006 Jan;78(1):112-24. Epub 2005 Nov 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice. Huyghe S, etal., Endocrinology. 2006 May;147(5):2228-36. Epub 2006 Feb 16.
10. Purification and properties of rat D-3-hydroxyacyl-CoA dehydratase: D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein. Jiang LL, etal., J Biochem. 1996 Sep;120(3):633-41.
11. Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative. Kashiwayama Y, etal., J Biol Chem. 2010 Aug 20;285(34):26315-25. doi: 10.1074/jbc.M110.104547. Epub 2010 Jun 21.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
14. Stereospecific formation of (24R,25R)-3 alpha,7 alpha,12 alpha,24-tetrahydroxy-5 beta-cholestan-26-oic acid catalyzed with a peroxisomal bifunctional D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase. Kurosawa T, etal., Biol Pharm Bull. 1997 Mar;20(3):295-7.
15. Molecular Networks in Dahl Salt-Sensitive Hypertension Based on Transcriptome Analysis of a Panel of Consomic Rats. Liang M, etal., Physiol Genomics. 2008 Apr 22;.
16. Dual activation of PPARalpha and PPARgamma by mono-(2-ethylhexyl) phthalate in rat ovarian granulosa cells. Lovekamp-Swan T, etal., Mol Cell Endocrinol. 2003 Mar 28;201(1-2):133-41.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. [Relationship between the increase of hepatic D-bifunctional protein activity and bile acid biosynthesis in rats]. Shi RL, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Jun;27(3):321-4.
26. Age related changes of cAMP and MAPK signaling in Leydig cells of Wistar rats. Sokanovic SJ, etal., Exp Gerontol. 2014 Oct;58:19-29. doi: 10.1016/j.exger.2014.07.004. Epub 2014 Jul 12.
27. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
28. D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder. Suzuki Y, etal., Am J Hum Genet. 1997 Nov;61(5):1153-62.
Additional References at PubMed
PMID:7487879   PMID:8889548   PMID:9089413   PMID:9482850   PMID:10400999   PMID:10706581   PMID:12517343   PMID:12897163   PMID:14651853   PMID:15060085   PMID:15599942   PMID:15644212  
PMID:16210410   PMID:17442273   PMID:18614015   PMID:20178365   PMID:21525035   PMID:26316108   PMID:29867124   PMID:29917219  


Genomics

Comparative Map Data
Hsd17b4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21843,328,903 - 43,417,950 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1843,328,824 - 43,417,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1845,372,258 - 45,461,303 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01846,093,452 - 46,184,056 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01843,878,165 - 43,967,210 (+)NCBIRnor_WKY
Rnor_6.01844,810,462 - 44,897,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1844,810,388 - 44,897,640 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01844,032,347 - 44,119,545 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41845,157,435 - 45,251,606 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11845,194,975 - 45,281,963 (+)NCBI
Celera1841,553,644 - 41,635,741 (+)NCBICelera
Cytogenetic Map18q11NCBI
HSD17B4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385119,452,497 - 119,542,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5119,452,465 - 119,637,199 (+)EnsemblGRCh38hg38GRCh38
GRCh375118,788,192 - 118,878,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365118,816,122 - 118,905,923 (+)NCBINCBI36Build 36hg18NCBI36
Build 345118,816,123 - 118,905,923NCBI
Celera5114,741,869 - 114,831,759 (+)NCBICelera
Cytogenetic Map5q23.1NCBI
HuRef5113,983,371 - 114,073,268 (+)NCBIHuRef
CHM1_15118,221,090 - 118,311,127 (+)NCBICHM1_1
T2T-CHM13v2.05119,973,333 - 120,063,188 (+)NCBIT2T-CHM13v2.0
Hsd17b4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391850,261,268 - 50,329,337 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1850,261,268 - 50,329,336 (+)EnsemblGRCm39 Ensembl
GRCm381850,128,201 - 50,196,270 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1850,128,201 - 50,196,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv371850,287,986 - 50,355,920 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361850,253,673 - 50,321,596 (+)NCBIMGSCv36mm8
Celera1851,460,559 - 51,528,691 (+)NCBICelera
Cytogenetic Map18D1NCBI
Hsd17b4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540839,040,840 - 39,138,338 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540839,041,028 - 39,136,867 (+)NCBIChiLan1.0ChiLan1.0
HSD17B4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan15112,882,983 - 112,970,447 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05114,842,892 - 114,928,559 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15120,628,605 - 120,713,859 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5120,628,605 - 120,713,860 (+)Ensemblpanpan1.1panPan2
HSD17B4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1118,717,182 - 8,810,716 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl118,717,349 - 8,824,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha119,845,728 - 9,939,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0118,803,421 - 8,896,940 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl118,803,454 - 8,911,864 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1118,674,773 - 8,768,177 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0118,731,175 - 8,824,571 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0118,988,828 - 9,082,305 (+)NCBIUU_Cfam_GSD_1.0
Hsd17b4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213131,797,848 - 131,887,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367152,357,274 - 2,446,271 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367152,357,215 - 2,446,601 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2123,313,448 - 123,402,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12123,313,445 - 123,401,386 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22128,752,284 - 128,841,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12322,674,059 - 22,761,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2322,674,072 - 22,762,056 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603455,546,291 - 55,636,123 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247332,124,825 - 2,205,378 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247332,126,124 - 2,204,966 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hsd17b4
331 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:138
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000021646
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021646   ⟹   ENSRNOP00000021646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1843,340,861 - 43,417,952 (+)Ensembl
Rnor_6.0 Ensembl1844,810,388 - 44,897,640 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089750   ⟹   ENSRNOP00000070792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1843,340,861 - 43,417,853 (+)Ensembl
Rnor_6.0 Ensembl1844,810,472 - 44,897,580 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097573   ⟹   ENSRNOP00000078701
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1843,328,824 - 43,410,159 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115693   ⟹   ENSRNOP00000081103
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1843,352,663 - 43,417,952 (+)Ensembl
RefSeq Acc Id: NM_024392   ⟹   NP_077368
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21843,328,903 - 43,417,950 (+)NCBI
Rnor_6.01844,810,462 - 44,897,677 (+)NCBI
Rnor_5.01844,032,347 - 44,119,545 (+)NCBI
RGSC_v3.41845,157,435 - 45,251,606 (+)RGD
Celera1841,553,644 - 41,635,741 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077368   ⟸   NM_024392
- UniProtKB: P70540 (UniProtKB/Swiss-Prot),   P97852 (UniProtKB/Swiss-Prot),   Q6IN39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021646   ⟸   ENSRNOT00000021646
RefSeq Acc Id: ENSRNOP00000070792   ⟸   ENSRNOT00000089750
RefSeq Acc Id: ENSRNOP00000081103   ⟸   ENSRNOT00000115693
RefSeq Acc Id: ENSRNOP00000078701   ⟸   ENSRNOT00000097573
Protein Domains
MaoC-like   SCP2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97852-F1-model_v2 AlphaFold P97852 1-735 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700774
Promoter ID:EPDNEW_R11298
Type:initiation region
Name:Hsd17b4_1
Description:hydroxysteroid (17-beta) dehydrogenase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01844,810,448 - 44,810,508EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621806 AgrOrtholog
BioCyc Gene G2FUF-7548 BioCyc
Ensembl Genes ENSRNOG00000015840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021646 ENTREZGENE
  ENSRNOP00000021646.5 UniProtKB/TrEMBL
  ENSRNOP00000070792.2 UniProtKB/TrEMBL
  ENSRNOP00000078701.1 UniProtKB/TrEMBL
  ENSRNOP00000081103.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021646 ENTREZGENE
  ENSRNOT00000021646.6 UniProtKB/TrEMBL
  ENSRNOT00000089750.2 UniProtKB/TrEMBL
  ENSRNOT00000097573.1 UniProtKB/TrEMBL
  ENSRNOT00000115693.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.4290 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hotdog Thioesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100430 IMAGE-MGC_LOAD
InterPro HotDog_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MaoC-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP2_sterol-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP2_sterol-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79244 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91668 IMAGE-MGC_LOAD
NCBI Gene 79244 ENTREZGENE
PANTHER DEHYDROGENASES, SHORT CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2 UniProtKB/TrEMBL
  PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED UniProtKB/TrEMBL
  SCP2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MaoC_dehydratas UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SCP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hsd17b4 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PKS_KR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54637 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55718 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYU4_RAT UniProtKB/TrEMBL
  A0A8I5ZS89_RAT UniProtKB/TrEMBL
  A0A8I6G270_RAT UniProtKB/TrEMBL
  A0A8L2QCC3_RAT UniProtKB/TrEMBL
  DHB4_RAT UniProtKB/Swiss-Prot
  P70540 ENTREZGENE
  P97852 ENTREZGENE
  Q6IN39 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P70523 UniProtKB/Swiss-Prot
  P70540 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hsd17b4  hydroxysteroid (17-beta) dehydrogenase 4    peroxisomal multifunctional enzyme type II  Name updated 1299863 APPROVED
2002-08-07 Hsd17b4  peroxisomal multifunctional enzyme type II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is induced by peroxisome proliferator-activated receptor alpha 632889