Scn3b (sodium voltage-gated channel beta subunit 3) - Rat Genome Database

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Gene: Scn3b (sodium voltage-gated channel beta subunit 3) Rattus norvegicus
Analyze
Symbol: Scn3b
Name: sodium voltage-gated channel beta subunit 3
RGD ID: 621657
Description: Predicted to enable sodium channel inhibitor activity; transmembrane transporter binding activity; and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in nervous system development and sodium ion transport. Predicted to be located in Z disc and plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Scnb3; sodium channel beta 3 subunit; sodium channel subunit beta-3; sodium channel, voltage-gated, type III, beta; sodium channel, voltage-gated, type III, beta subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8849,527,529 - 49,550,019 (+)NCBIGRCr8
mRatBN7.2840,630,372 - 40,652,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl840,630,455 - 40,652,868 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx846,138,136 - 46,160,555 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0844,416,727 - 44,439,130 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,284,327 - 42,306,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0844,136,413 - 44,159,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl844,136,496 - 44,159,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0861,379,751 - 61,402,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,231,453 - 43,254,066 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1843,240,218 - 43,262,831 (+)NCBI
Celera840,246,442 - 40,268,779 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
cypermethrin  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenpropathrin  (EXP)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pirinixic acid  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium atom  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Morgan K, etal., Proc Natl Acad Sci U S A 2000 Feb 29;97(5):2308-13.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits. Qu Y, etal., Mol Cell Neurosci 2001 Nov;18(5):570-80.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Expression of auxiliary beta subunits of sodium channels in primary afferent neurons and the effect of nerve injury. Takahashi N, etal., Neuroscience. 2003;121(2):441-50.
15. Differential expression of neuronal voltage-gated sodium channel mRNAs during the development of the rat trigeminal ganglion. Thun J, etal., Brain Res. 2009 May 7;1269:11-22. Epub 2009 Mar 6.
Additional References at PubMed
PMID:11470829   PMID:15178439   PMID:15489334   PMID:17884088   PMID:18158113   PMID:19351516   PMID:19796257   PMID:20042427   PMID:20226894   PMID:20675377   PMID:21051419   PMID:22871113  
PMID:26528804  


Genomics

Comparative Map Data
Scn3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8849,527,529 - 49,550,019 (+)NCBIGRCr8
mRatBN7.2840,630,372 - 40,652,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl840,630,455 - 40,652,868 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx846,138,136 - 46,160,555 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0844,416,727 - 44,439,130 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,284,327 - 42,306,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0844,136,413 - 44,159,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl844,136,496 - 44,159,010 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0861,379,751 - 61,402,348 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,231,453 - 43,254,066 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1843,240,218 - 43,262,831 (+)NCBI
Celera840,246,442 - 40,268,779 (+)NCBICelera
Cytogenetic Map8q22NCBI
SCN3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811123,629,188 - 123,654,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11123,629,187 - 123,655,244 (-)EnsemblGRCh38hg38GRCh38
GRCh3711123,499,896 - 123,525,332 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611123,005,105 - 123,030,525 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411123,007,132 - 123,030,522NCBI
Celera11120,659,315 - 120,684,712 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11119,441,120 - 119,466,515 (-)NCBIHuRef
CHM1_111123,386,094 - 123,411,515 (-)NCBICHM1_1
T2T-CHM13v2.011123,658,164 - 123,683,597 (-)NCBIT2T-CHM13v2.0
Scn3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,180,512 - 40,202,914 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,180,513 - 40,202,914 (+)EnsemblGRCm39 Ensembl
GRCm38940,269,216 - 40,291,618 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,269,217 - 40,291,618 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,076,801 - 40,099,203 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36940,019,969 - 40,041,678 (+)NCBIMGSCv36mm8
Celera937,506,998 - 37,529,283 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.42NCBI
Scn3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541224,388,366 - 24,412,604 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541224,391,764 - 24,412,912 (-)NCBIChiLan1.0ChiLan1.0
SCN3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29124,329,243 - 124,354,342 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111125,433,875 - 125,458,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011118,460,860 - 118,486,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111122,377,643 - 122,403,065 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11122,377,643 - 122,403,063 (-)Ensemblpanpan1.1panPan2
SCN3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1510,783,235 - 10,808,342 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl510,783,325 - 10,804,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha510,839,227 - 10,864,324 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0510,733,388 - 10,758,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl510,734,206 - 10,759,133 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1510,837,530 - 10,862,647 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0510,768,079 - 10,793,209 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0510,814,475 - 10,839,652 (+)NCBIUU_Cfam_GSD_1.0
Scn3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947105,161,078 - 105,184,745 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365428,086,702 - 8,105,372 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365428,082,487 - 8,106,154 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl950,508,880 - 50,583,712 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1950,508,194 - 50,532,432 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,796,544 - 55,873,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCN3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,031,634 - 115,057,829 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,034,508 - 115,057,787 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604311,051,460 - 11,079,632 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248801,496,634 - 1,516,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248801,496,571 - 1,519,728 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scn3b
165 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:410
Count of miRNA genes:223
Interacting mature miRNAs:301
Transcripts:ENSRNOT00000009367
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83084815440713225Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat

Markers in Region
RH133093  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2840,652,644 - 40,652,834 (+)MAPPERmRatBN7.2
Rnor_6.0844,158,787 - 44,158,976NCBIRnor6.0
Rnor_5.0861,379,786 - 61,379,975UniSTSRnor5.0
RGSC_v3.4843,253,842 - 43,254,031UniSTSRGSC3.4
Celera840,268,555 - 40,268,744UniSTS
RH 3.4 Map8361.92UniSTS
Cytogenetic Map8q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 1 64 3 9
Low 3 39 21 14 15 14 8 11 10 17 35 2 8
Below cutoff 2 25 25 3 25 14 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087022   ⟹   ENSRNOP00000071448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl840,630,455 - 40,652,868 (+)Ensembl
Rnor_6.0 Ensembl844,136,496 - 44,159,010 (+)Ensembl
RefSeq Acc Id: NM_139097   ⟹   NP_620797
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,527,612 - 49,550,019 (+)NCBI
mRatBN7.2840,630,455 - 40,652,869 (+)NCBI
Rnor_6.0844,136,496 - 44,159,011 (+)NCBI
Rnor_5.0861,379,751 - 61,402,348 (-)NCBI
RGSC_v3.4843,231,453 - 43,254,066 (+)RGD
Celera840,246,442 - 40,268,779 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243102   ⟹   XP_006243164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,527,529 - 49,550,019 (+)NCBI
mRatBN7.2840,630,372 - 40,652,381 (+)NCBI
Rnor_6.0844,136,413 - 44,158,527 (+)NCBI
Rnor_5.0861,379,751 - 61,402,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006243103   ⟹   XP_006243165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,527,529 - 49,550,019 (+)NCBI
mRatBN7.2840,630,372 - 40,652,381 (+)NCBI
Rnor_6.0844,136,413 - 44,158,527 (+)NCBI
Rnor_5.0861,379,751 - 61,402,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595466   ⟹   XP_017450955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,527,529 - 49,550,019 (+)NCBI
mRatBN7.2840,630,372 - 40,652,381 (+)NCBI
Rnor_6.0844,136,413 - 44,158,527 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080819   ⟹   XP_038936747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,527,529 - 49,550,019 (+)NCBI
mRatBN7.2840,630,372 - 40,652,381 (+)NCBI
RefSeq Acc Id: XM_063264913   ⟹   XP_063120983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,527,529 - 49,550,019 (+)NCBI
RefSeq Acc Id: XM_063264914   ⟹   XP_063120984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,527,529 - 49,550,019 (+)NCBI
RefSeq Acc Id: XM_063264915   ⟹   XP_063120985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8849,534,869 - 49,550,019 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_620797   ⟸   NM_139097
- Peptide Label: precursor
- UniProtKB: Q9JK00 (UniProtKB/Swiss-Prot),   A6J3Q2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243165   ⟸   XM_006243103
- Peptide Label: isoform X1
- UniProtKB: Q9JK00 (UniProtKB/Swiss-Prot),   A6J3Q2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243164   ⟸   XM_006243102
- Peptide Label: isoform X1
- UniProtKB: Q9JK00 (UniProtKB/Swiss-Prot),   A6J3Q2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450955   ⟸   XM_017595466
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000071448   ⟸   ENSRNOT00000087022
RefSeq Acc Id: XP_038936747   ⟸   XM_039080819
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120983   ⟸   XM_063264913
- Peptide Label: isoform X1
- UniProtKB: Q9JK00 (UniProtKB/Swiss-Prot),   A6J3Q2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120984   ⟸   XM_063264914
- Peptide Label: isoform X1
- UniProtKB: Q9JK00 (UniProtKB/Swiss-Prot),   A6J3Q2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120985   ⟸   XM_063264915
- Peptide Label: isoform X2
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JK00-F1-model_v2 AlphaFold Q9JK00 1-215 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621657 AgrOrtholog
BioCyc Gene G2FUF-30844 BioCyc
Ensembl Genes ENSRNOG00000057221 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018065 UniProtKB/Swiss-Prot
  ENSRNOG00060020755 UniProtKB/Swiss-Prot
  ENSRNOG00065026353 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087022 ENTREZGENE
  ENSRNOT00000087022.2 UniProtKB/Swiss-Prot
  ENSRNOT00055030605 UniProtKB/Swiss-Prot
  ENSRNOT00060035949 UniProtKB/Swiss-Prot
  ENSRNOT00065045481 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100476 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_channel_b1/b3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:245956 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91409 IMAGE-MGC_LOAD
NCBI Gene 245956 ENTREZGENE
PANTHER PTHR10546 UniProtKB/Swiss-Prot
  PTHR10546:SF1 UniProtKB/Swiss-Prot
  SODIUM CHANNEL SUBUNIT BETA-1 AND 3 UniProtKB/TrEMBL
  SODIUM CHANNEL SUBUNIT BETA-3 UniProtKB/TrEMBL
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SCN3B RGD
PhenoGen Scn3b PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057221 RatGTEx
  ENSRNOG00055018065 RatGTEx
  ENSRNOG00060020755 RatGTEx
  ENSRNOG00065026353 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6J3Q2 ENTREZGENE, UniProtKB/TrEMBL
  Q9JK00 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Scn3b  sodium voltage-gated channel beta subunit 3  Scn3b  sodium channel, voltage-gated, type III, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-13 Scn3b  sodium channel, voltage-gated, type III, beta subunit  Scn3b  sodium channel, voltage-gated, type III, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Scn3b  sodium channel, voltage-gated, type III, beta  Scnb3  sodium channel beta 3 subunit  Symbol and Name updated 1299863 APPROVED
2002-08-07 Scnb3  sodium channel beta 3 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process inactivates sodium channel opening more slowly than beta 1 subunit 633985