H2az1 (H2A.Z variant histone 1) - Rat Genome Database

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Gene: H2az1 (H2A.Z variant histone 1) Rattus norvegicus
Analyze
Symbol: H2az1
Name: H2A.Z variant histone 1
RGD ID: 621464
Description: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Involved in cellular response to insulin stimulus. Predicted to be part of euchromatin; heterochromatin; and nucleosome. Predicted to be active in nucleus. Orthologous to human H2AZ1 (H2A.Z variant histone 1); PARTICIPATES IN histone modification pathway; systemic lupus erythematosus pathway; INTERACTS WITH 17beta-estradiol; 2-nitrofluorene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H2A histone family, member Z; H2A.Z-1; H2A/z; H2afz; histone H2A.Z; MGC105426; MGC72814
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,026,464 - 229,031,411 (+)NCBIGRCr8
mRatBN7.22226,355,668 - 226,357,984 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,355,708 - 226,358,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,110,339 - 234,112,450 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,010,121 - 232,012,232 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02226,874,738 - 226,876,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,105,224 - 243,107,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,105,674 - 243,106,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02261,653,464 - 261,655,573 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,353,027 - 235,355,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,339,772 - 235,341,875 (+)NCBI
Celera2218,522,206 - 218,524,315 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-nitrofluorene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aminoglutethimide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
diuron  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycine betaine  (EXP)
leflunomide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
pyrimidifen  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Barr body  (ISO)
euchromatin  (ISO)
heterochromatin  (ISO)
nucleosome  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species. Hatch CL and Bonner WM, Nucleic Acids Res 1988 Feb 11;16(3):1113-24.
3. Identification of ADP-ribosylated histones by the combined use of high-performance liquid chromatography and electrophoresis. Lindner H, etal., J Chromatogr. 1989 Jun 9;472(1):243-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Histone variants: dynamic punctuation in transcription. Weber CM and Henikoff S, Genes Dev. 2014 Apr 1;28(7):672-82. doi: 10.1101/gad.238873.114.
11. Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site. Zerzaihi O, etal., Biochem Cell Biol. 2014 Feb;92(1):61-7. doi: 10.1139/bcb-2013-0071. Epub 2013 Nov 4.
Additional References at PubMed
PMID:10716735   PMID:11331621   PMID:12477932   PMID:15489334   PMID:16319397   PMID:16457589   PMID:16687393   PMID:19633671   PMID:19834540   PMID:20003410   PMID:21630459   PMID:22720776  
PMID:22871113   PMID:23533145   PMID:23637611   PMID:28856239   PMID:29476059   PMID:29871976   PMID:37175793  


Genomics

Comparative Map Data
H2az1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,026,464 - 229,031,411 (+)NCBIGRCr8
mRatBN7.22226,355,668 - 226,357,984 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,355,708 - 226,358,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,110,339 - 234,112,450 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,010,121 - 232,012,232 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02226,874,738 - 226,876,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,105,224 - 243,107,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,105,674 - 243,106,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02261,653,464 - 261,655,573 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,353,027 - 235,355,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,339,772 - 235,341,875 (+)NCBI
Celera2218,522,206 - 218,524,315 (+)NCBICelera
Cytogenetic Map2q43NCBI
H2AZ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,948,088 - 99,950,275 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,948,086 - 99,950,355 (-)EnsemblGRCh38hg38GRCh38
GRCh374100,869,245 - 100,871,432 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364101,088,267 - 101,090,535 (-)NCBINCBI36Build 36hg18NCBI36
Build 344101,226,421 - 101,228,690NCBI
Celera498,166,664 - 98,168,932 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef496,607,568 - 96,609,836 (-)NCBIHuRef
CHM1_14100,845,766 - 100,848,034 (-)NCBICHM1_1
T2T-CHM13v2.04103,263,572 - 103,265,759 (-)NCBIT2T-CHM13v2.0
H2az1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393137,570,248 - 137,572,683 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3137,570,248 - 137,572,683 (+)EnsemblGRCm39 Ensembl
GRCm383137,864,487 - 137,866,922 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3137,864,487 - 137,866,922 (+)EnsemblGRCm38mm10GRCm38
MGSCv373137,527,563 - 137,529,886 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363138,361,991 - 138,368,602 (+)NCBIMGSCv36mm8
MGSCv363137,801,986 - 137,804,309 (+)NCBIMGSCv36mm8
Celera6118,011,137 - 118,011,992 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map363.94NCBI
LOC102021365
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554967,733,918 - 7,735,525 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554967,733,910 - 7,735,525 (+)NCBIChiLan1.0ChiLan1.0
LOC100974973
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2398,029,591 - 98,032,659 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1498,313,384 - 98,316,452 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0492,371,150 - 92,373,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14103,031,339 - 103,033,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4103,030,469 - 103,033,397 (-)Ensemblpanpan1.1panPan2
H2AZ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,889,890 - 21,892,165 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,889,877 - 21,892,102 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,004,606 - 20,006,940 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03222,110,961 - 22,113,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3222,110,948 - 22,113,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13222,087,386 - 22,089,720 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,874,328 - 21,876,660 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03217,991,798 - 17,994,133 (+)NCBIUU_Cfam_GSD_1.0
LOC101974663
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530119,716,171 - 19,718,489 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365203,059,623 - 3,061,941 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
H2AZ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8120,563,752 - 120,566,177 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18120,563,752 - 120,566,023 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28129,744,062 - 129,745,412 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103236032
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1748,079,894 - 48,082,147 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603726,551,875 - 26,554,212 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701243
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248307,238,929 - 7,240,563 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248307,238,897 - 7,240,566 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in H2az1
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:107
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000013919
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat

Markers in Region
GDB:451604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2156,812,333 - 6,812,460 (-)MAPPERmRatBN7.2
mRatBN7.21666,654,574 - 66,654,726 (+)MAPPERmRatBN7.2
Rnor_6.01671,438,822 - 71,438,973NCBIRnor6.0
Rnor_6.0158,610,179 - 8,610,305NCBIRnor6.0
Rnor_5.01671,095,779 - 71,095,930UniSTSRnor5.0
Rnor_5.01512,672,624 - 12,672,750UniSTSRnor5.0
RGSC_v3.4158,380,818 - 8,380,944UniSTSRGSC3.4
RGSC_v3.41671,035,515 - 71,035,666UniSTSRGSC3.4
Celera1664,562,244 - 64,562,395UniSTS
Celera156,872,660 - 6,872,786UniSTS
Cytogenetic Map15p16UniSTS
Cytogenetic Map2q44UniSTS
MARC_31601-31602:1045759847:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,654,584 - 66,654,955 (+)MAPPERmRatBN7.2
mRatBN7.22226,357,039 - 226,357,678 (+)MAPPERmRatBN7.2
Rnor_6.02243,106,495 - 243,107,133NCBIRnor6.0
Rnor_6.01671,438,832 - 71,439,202NCBIRnor6.0
Rnor_5.01671,095,789 - 71,096,159UniSTSRnor5.0
Rnor_5.02261,654,735 - 261,655,373UniSTSRnor5.0
RGSC_v3.42235,354,298 - 235,354,936UniSTSRGSC3.4
RGSC_v3.41671,035,525 - 71,035,895UniSTSRGSC3.4
Celera1664,562,254 - 64,562,624UniSTS
Celera2218,523,477 - 218,524,115UniSTS
Cytogenetic Map2q44UniSTS
ksks443  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22226,357,085 - 226,357,512 (+)MAPPERmRatBN7.2
mRatBN7.21666,654,630 - 66,654,789 (+)MAPPERmRatBN7.2
Rnor_6.02243,106,541 - 243,106,967NCBIRnor6.0
Rnor_6.01671,438,878 - 71,439,036NCBIRnor6.0
Rnor_5.01671,095,835 - 71,095,993UniSTSRnor5.0
Rnor_5.02261,654,781 - 261,655,207UniSTSRnor5.0
Cytogenetic Map2q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 4 4
Medium 3 43 57 41 19 41 8 11 62 31 37 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M37584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013919   ⟹   ENSRNOP00000013919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2226,355,708 - 226,358,485 (+)Ensembl
Rnor_6.0 Ensembl2243,105,674 - 243,106,956 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098112   ⟹   ENSRNOP00000083876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2226,356,315 - 226,358,485 (+)Ensembl
RefSeq Acc Id: NM_022674   ⟹   NP_073165
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,029,095 - 229,031,411 (+)NCBI
mRatBN7.22226,355,668 - 226,357,984 (+)NCBI
Rnor_6.02243,105,224 - 243,107,333 (+)NCBI
Rnor_5.02261,653,464 - 261,655,573 (+)NCBI
RGSC_v3.42235,353,027 - 235,355,136 (+)RGD
Celera2218,522,206 - 218,524,315 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282425   ⟹   XP_063138495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,026,464 - 229,031,305 (+)NCBI
RefSeq Acc Id: XM_063282426   ⟹   XP_063138496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82229,028,451 - 229,031,305 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_073165   ⟸   NM_022674
- UniProtKB: Q5U5H6 (UniProtKB/Swiss-Prot),   P0C0S7 (UniProtKB/Swiss-Prot),   A6HW07 (UniProtKB/TrEMBL),   A0A0A0MXW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013919   ⟸   ENSRNOT00000013919
RefSeq Acc Id: ENSRNOP00000083876   ⟸   ENSRNOT00000098112
RefSeq Acc Id: XP_063138495   ⟸   XM_063282425
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063138496   ⟸   XM_063282426
- Peptide Label: isoform X2
- UniProtKB: Q5U5H6 (UniProtKB/Swiss-Prot),   P0C0S7 (UniProtKB/Swiss-Prot),   A6HW07 (UniProtKB/TrEMBL)
Protein Domains
Histone H2A C-terminal   Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C0S7-F1-model_v2 AlphaFold P0C0S7 1-128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621464 AgrOrtholog
BioCyc Gene G2FUF-51106 BioCyc
Ensembl Genes ENSRNOG00000010306 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010753 UniProtKB/Swiss-Prot
  ENSRNOG00060023034 UniProtKB/Swiss-Prot
  ENSRNOG00065025820 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013919 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000013919.7 UniProtKB/Swiss-Prot
  ENSRNOT00000098112.1 UniProtKB/TrEMBL
  ENSRNOT00055018174 UniProtKB/Swiss-Prot
  ENSRNOT00060039905 UniProtKB/Swiss-Prot
  ENSRNOT00065044525 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922321 IMAGE-MGC_LOAD
  IMAGE:7302603 IMAGE-MGC_LOAD
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105426 IMAGE-MGC_LOAD
  MGC:72814 IMAGE-MGC_LOAD
NCBI Gene 58940 ENTREZGENE
PANTHER HISTONE H2A.Z UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Histone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen H2az1 PhenoGen
PRINTS HISTONEH2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010306 RatGTEx
  ENSRNOG00055010753 RatGTEx
  ENSRNOG00060023034 RatGTEx
  ENSRNOG00065025820 RatGTEx
SMART H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MXW3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWU4_RAT UniProtKB/TrEMBL
  A6HW07 ENTREZGENE, UniProtKB/TrEMBL
  H2AZ_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U5H6 ENTREZGENE
UniProt Secondary P17317 UniProtKB/Swiss-Prot
  Q5U5H6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 H2az1  H2A.Z variant histone 1  H2az1  H2A.Z variant histone 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-09-13 H2az1  H2A.Z variant histone 1  H2afz  H2A histone family, member Z  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 H2afz  H2A histone family, member Z      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 H2afz  H2A histone family, member Z      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology cDNA has 94% nucleotide positional identity to human ortholog in the coding region 728561