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Gene: Kcnk1 (potassium two pore domain channel subfamily K member 1) Rattus norvegicus
Symbol: Kcnk1
Name: potassium two pore domain channel subfamily K member 1
RGD ID: 621447
Description: Exhibits potassium ion leak channel activity. Involved in potassium ion transmembrane transport and response to nicotine. Localizes to several cellular components, including apical plasma membrane; brush border membrane; and integral component of plasma membrane. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: inward rectifying potassium channel protein TWIK-1; potassium channel K2P1; potassium channel subfamily K member 1; potassium channel, subfamily K, member 1; potassium channel, two pore domain subfamily K, member 1; putative potassium channel TWIK; rTWIK; Twik
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01958,823,836 - 58,862,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1958,823,814 - 58,862,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01969,519,015 - 69,556,610 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41956,216,600 - 56,255,299 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11956,221,480 - 56,260,178 (+)NCBI
Celera1953,319,777 - 53,357,303 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Kcnk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621447
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.