Ago2 (argonaute RISC catalytic component 2) - Rat Genome Database

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Gene: Ago2 (argonaute RISC catalytic component 2) Rattus norvegicus
Analyze
Symbol: Ago2
Name: argonaute RISC catalytic component 2
RGD ID: 621255
Description: Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and RISC complex binding activity. Involved in several processes, including cellular response to calcium ion; regulation of macromolecule biosynthetic process; and response to alkaloid. Located in several cellular components, including Golgi apparatus; cytoplasmic ribonucleoprotein granule; and dendrite. Part of RISC complex. Biomarker of morphine dependence and withdrawal disorder. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2); PARTICIPATES IN microRNA pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: argonaute 2, RISC catalytic component; argonaute2; eIF-2C 2; eIF2C 2; Eif2c2; eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 2; Gerp95; golgi ER protein 95 kDa; protein argonaute-2; protein slicer
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87106,907,209 - 106,994,124 (-)NCBIGRCr8
mRatBN7.27105,018,202 - 105,105,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7105,029,120 - 105,104,974 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07114,339,607 - 114,377,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,339,434 - 114,380,613 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07114,274,582 - 114,312,135 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,827,857 - 110,865,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17110,862,086 - 110,899,819 (-)NCBI
Celera7101,439,261 - 101,476,737 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butyric acid  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
excitatory amino acid agonist  (EXP)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucaric acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nicotinamide  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (NAS)
cellular response to calcium ion  (IEP)
miRNA metabolic process  (IEA,ISO)
miRNA processing  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (IEA,ISO,ISS)
miRNA-mediated gene silencing by mRNA destabilization  (IEA,ISO,ISS)
negative regulation of amyloid precursor protein biosynthetic process  (IMP)
negative regulation of translational initiation  (IEA,ISO,ISS)
P-body assembly  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IEA,ISO,ISS)
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  (IEA,ISO,ISS)
positive regulation of post-transcriptional gene silencing by RNA  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of translation  (IEA,ISO)
positive regulation of trophoblast cell migration  (IEA,ISO)
post-embryonic development  (IEA,ISO)
pre-miRNA processing  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (IEA)
regulation of mRNA stability  (IMP)
regulation of synapse maturation  (ISO)
regulation of translation  (IEA)
regulatory ncRNA-mediated gene silencing  (IEA,ISO,ISS)
regulatory ncRNA-mediated post-transcriptional gene silencing  (IBA)
response to cocaine  (IEP)
response to hypoxia  (IEP)
response to morphine  (IEP)
RISC complex assembly  (IEA,ISO)
RNA secondary structure unwinding  (IEA,ISO)
siRNA processing  (IEA,ISO)
siRNA-mediated gene silencing by mRNA destabilization  (IEA,ISO)
spermatogenesis  (IEP)

Cellular Component
chromatoid body  (IDA)
cytoplasm  (IBA,IDA,ISO,ISS)
cytoplasmic ribonucleoprotein granule  (IBA,ISO)
cytoplasmic stress granule  (IDA)
cytosol  (IDA,IEA,ISO,TAS)
dendrite  (IDA,IEA,ISO)
extracellular exosome  (IEA,ISO)
glutamatergic synapse  (ISO)
Golgi apparatus  (IDA)
membrane  (IDA)
mitochondrion  (IDA)
nucleus  (IBA,IEA,ISO)
P granule  (IDA)
P-body  (IEA,ISO)
pi-body  (IDA)
postsynapse  (ISO)
ribonucleoprotein complex  (IDA,IEA,ISO)
RISC complex  (IBA,IDA,IEA,ISO,ISS)
RISC-loading complex  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation. Cikaluk DE, etal., Mol Biol Cell 1999 Oct;10(10):3357-72.
2. Nuclear miRNA regulates the mitochondrial genome in the heart. Das S, etal., Circ Res. 2012 Jun 8;110(12):1596-603. doi: 10.1161/CIRCRESAHA.112.267732. Epub 2012 Apr 19.
3. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
4. Argonaute2 Protein in Rat Spermatogenic Cells Is Localized to Nuage Structures and LAMP2-Positive Vesicles Surrounding Chromatoid Bodies. Fujii Y, etal., J Histochem Cytochem. 2016 Apr;64(4):268-79. doi: 10.1369/0022155416638840.
5. Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. García-Pérez D, etal., Addict Biol. 2015 Jan;20(1):104-19. doi: 10.1111/adb.12083. Epub 2013 Aug 8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. Gedik H, etal., DNA Cell Biol. 2015 Mar;34(3):220-6. doi: 10.1089/dna.2014.2549. Epub 2014 Dec 11.
8. Non-equivalent Roles of AGO1 and AGO2 in mRNA Turnover and Translation of Cyclin D1 mRNA. Ghosh U and Adhya S, J Biol Chem. 2016 Mar 25;291(13):7119-27. doi: 10.1074/jbc.M115.696377. Epub 2016 Feb 4.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. RNA interference may suppress stress granule formation by preventing argonaute 2 recruitment. Lou Q, etal., Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C81-C91. doi: 10.1152/ajpcell.00251.2018. Epub 2018 Nov 7.
11. Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Neuroprotection in Rodent Models of Glaucoma. Mead B, etal., Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):702-714. doi: 10.1167/iovs.17-22855.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Next generation sequencing of the Ago2 interacting transcriptome identified chemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells. Noetel A, etal., J Hepatol. 2013 Feb;58(2):335-41. doi: 10.1016/j.jhep.2012.09.024. Epub 2012 Oct 4.
16. The PICK1 Ca2+ sensor modulates N-methyl-d-aspartate (NMDA) receptor-dependent microRNA-mediated translational repression in neurons. Rajgor D, etal., J Biol Chem. 2017 Jun 9;292(23):9774-9786. doi: 10.1074/jbc.M117.776302. Epub 2017 Apr 12.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. Sadakierska-Chudy A, etal., Mol Neurobiol. 2017 Apr;54(3):2241-2254. doi: 10.1007/s12035-016-9817-2. Epub 2016 Mar 5.
22. GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization. Tahbaz N, etal., J Biol Chem 2001 Nov 16;276(46):43294-9.
23. Characterization of RNA interference in rat PC12 cells: requirement of GERp95. Thonberg H, etal., Biochem Biophys Res Commun. 2004 Jun 11;318(4):927-34. doi: 10.1016/j.bbrc.2004.04.119.
24. MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons. Vilardo E, etal., J Biol Chem. 2010 Jun 11;285(24):18344-51. doi: 10.1074/jbc.M110.112664. Epub 2010 Apr 15.
25. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Wu C, etal., Mol Cell Biol. 2011 Dec;31(23):4760-74. doi: 10.1128/MCB.05776-11. Epub 2011 Oct 3.
Additional References at PubMed
PMID:15260970   PMID:15973356   PMID:16271386   PMID:16357216   PMID:16424907   PMID:17495927   PMID:17524464   PMID:17531811   PMID:17671087   PMID:17728463   PMID:17932509   PMID:18178619  
PMID:18771919   PMID:19536157   PMID:19701182   PMID:19716330   PMID:19801630   PMID:19820710   PMID:19826008   PMID:19898466   PMID:19946888   PMID:19966796   PMID:20014101   PMID:20424607  
PMID:20616046   PMID:20975942   PMID:22022532   PMID:22053081   PMID:22503104   PMID:22658674   PMID:22681889   PMID:22795694   PMID:22915799   PMID:23125361   PMID:23185045   PMID:23409027  
PMID:23661684   PMID:23985560   PMID:24101522   PMID:24427314   PMID:25336585   PMID:25724380   PMID:26858302   PMID:27208409   PMID:28159509   PMID:29735530   PMID:30207314   PMID:30470799  
PMID:31012336   PMID:31152866   PMID:31362482   PMID:31507089   PMID:32923478  


Genomics

Comparative Map Data
Ago2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87106,907,209 - 106,994,124 (-)NCBIGRCr8
mRatBN7.27105,018,202 - 105,105,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7105,029,120 - 105,104,974 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07114,339,607 - 114,377,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,339,434 - 114,380,613 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07114,274,582 - 114,312,135 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,827,857 - 110,865,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17110,862,086 - 110,899,819 (-)NCBI
Celera7101,439,261 - 101,476,737 (-)NCBICelera
Cytogenetic Map7q34NCBI
AGO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388140,520,156 - 140,642,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8140,520,156 - 140,635,633 (-)EnsemblGRCh38hg38GRCh38
GRCh378141,530,255 - 141,645,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,610,446 - 141,714,827 (-)NCBINCBI36Build 36hg18NCBI36
Build 348141,610,446 - 141,714,827NCBI
Celera8137,710,380 - 137,814,765 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8136,853,198 - 136,907,219 (-)NCBIHuRef
CHM1_18141,581,910 - 141,685,882 (-)NCBICHM1_1
T2T-CHM13v2.08141,640,512 - 141,762,332 (-)NCBIT2T-CHM13v2.0
Ago2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391572,967,693 - 73,056,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1572,967,693 - 73,056,784 (-)EnsemblGRCm39 Ensembl
GRCm381573,101,625 - 73,184,947 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,095,844 - 73,184,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371572,932,055 - 73,015,377 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361572,934,117 - 73,012,065 (-)NCBIMGSCv36mm8
Celera1574,601,857 - 74,646,651 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1533.92NCBI
Ago2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546114,205,748 - 14,253,861 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546114,194,268 - 14,260,949 (-)NCBIChiLan1.0ChiLan1.0
AGO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27157,913,911 - 158,030,054 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18133,444,339 - 133,560,536 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08137,192,037 - 137,308,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18140,278,610 - 140,361,124 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8140,287,647 - 140,361,125 (-)Ensemblpanpan1.1panPan2
AGO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,169,243 - 35,230,252 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,180,912 - 35,268,577 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1335,028,442 - 35,140,440 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01335,564,998 - 35,666,115 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1335,565,198 - 35,666,187 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11335,274,354 - 35,386,196 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01335,364,327 - 35,476,164 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01335,795,131 - 35,895,912 (-)NCBIUU_Cfam_GSD_1.0
Ago2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053033,202,184 - 3,264,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647010,628,128 - 10,680,106 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647010,641,109 - 10,690,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl42,919,511 - 3,015,334 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.142,966,794 - 3,012,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.242,362,700 - 2,405,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18134,761,651 - 134,855,971 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8134,767,182 - 134,823,070 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660395,263,683 - 5,390,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473515,785,114 - 15,842,435 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473515,785,831 - 15,853,854 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ago2
402 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:116
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000011898
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 38 22 19 22 8 8 72 28 38 9 8
Low 3 9 19 19 19 3 2 7 3 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011898   ⟹   ENSRNOP00000011898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,029,120 - 105,104,974 (-)Ensembl
Rnor_6.0 Ensembl7114,339,434 - 114,380,613 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098774   ⟹   ENSRNOP00000081910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,029,120 - 105,053,798 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109078   ⟹   ENSRNOP00000095871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,029,120 - 105,067,774 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113680   ⟹   ENSRNOP00000079608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,029,120 - 105,070,099 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120018   ⟹   ENSRNOP00000095405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7105,029,120 - 105,070,099 (-)Ensembl
RefSeq Acc Id: NM_001408918   ⟹   NP_001395847
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87106,907,209 - 106,994,124 (-)NCBI
mRatBN7.27105,018,203 - 105,105,118 (-)NCBI
RefSeq Acc Id: XM_039080221   ⟹   XP_038936149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87106,909,887 - 106,956,560 (-)NCBI
mRatBN7.27105,018,202 - 105,067,583 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000011898   ⟸   ENSRNOT00000011898
RefSeq Acc Id: XP_038936149   ⟸   XM_039080221
- Peptide Label: isoform X1
- UniProtKB: Q9QZ81 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000079608   ⟸   ENSRNOT00000113680
RefSeq Acc Id: ENSRNOP00000095405   ⟸   ENSRNOT00000120018
RefSeq Acc Id: ENSRNOP00000081910   ⟸   ENSRNOT00000098774
RefSeq Acc Id: ENSRNOP00000095871   ⟸   ENSRNOT00000109078
RefSeq Acc Id: NP_001395847   ⟸   NM_001408918
- UniProtKB: F1LRP7 (UniProtKB/TrEMBL)
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZ81-F1-model_v2 AlphaFold Q9QZ81 1-860 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621255 AgrOrtholog
BioCyc Gene G2FUF-33064 BioCyc
Ensembl Genes ENSRNOG00000008533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011898 ENTREZGENE
  ENSRNOT00000011898.5 UniProtKB/TrEMBL
  ENSRNOT00000098774.1 UniProtKB/TrEMBL
  ENSRNOT00000109078.1 UniProtKB/TrEMBL
  ENSRNOT00000113680.1 UniProtKB/TrEMBL
  ENSRNOT00000120018.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  paz domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGO2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argonaute_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 59117 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ArgoL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoMid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ago2 PhenoGen
PROSITE PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIWI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008533 RatGTEx
SMART DUF1785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZN55_RAT UniProtKB/TrEMBL
  A0A8I5ZTX6_RAT UniProtKB/TrEMBL
  A0A8I6ANG4_RAT UniProtKB/TrEMBL
  A0A8I6ANZ1_RAT UniProtKB/TrEMBL
  AGO2_RAT UniProtKB/Swiss-Prot
  F1LRP7 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZ81 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Ago2  argonaute RISC catalytic component 2  Ago2  argonaute 2, RISC catalytic component  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-02 Ago2  argonaute 2, RISC catalytic component  Ago2  argonaute RISC catalytic component 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-22 Ago2  argonaute RISC catalytic component 2  Eif2c2  eukaryotic translation initiation factor 2C, 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Eif2c2  eukaryotic translation initiation factor 2C, 2    GERp95  Name updated 1299863 APPROVED
2004-09-10 Eif2c2  GERp95  Gerp95    Symbol and Name updated 1299863 APPROVED
2002-08-07 Gerp95  GERp95      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the Golgi complex or the endoplasmic reticulum (ER) 632717
gene_product belongs to a family of proteins involved in stem cell differentiation, highly conserved in metazoans and Schizosaccharomyces pombe 632717
gene_protein 97.6 kDa 632717