Ogg1 (8-oxoguanine DNA glycosylase) - Rat Genome Database

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Gene: Ogg1 (8-oxoguanine DNA glycosylase) Rattus norvegicus
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Symbol: Ogg1
Name: 8-oxoguanine DNA glycosylase
RGD ID: 621168
Description: Enables damaged DNA binding activity and oxidized purine nucleobase lesion DNA N-glycosylase activity. Involved in several processes, including cellular response to cadmium ion; response to estradiol; and response to folic acid. Predicted to be located in mitochondrion; nuclear matrix; and nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Biomarker of hepatitis; middle cerebral artery infarction; renal cell carcinoma; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); carcinoma (multiple); eye disease (multiple); and reproductive organ cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase); PARTICIPATES IN base excision repair pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; N-glycosylase/DNA lyase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,030,237 - 148,037,599 (+)NCBIGRCr8
mRatBN7.24146,474,701 - 146,481,959 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,474,750 - 146,484,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,859,153 - 151,865,412 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,639,996 - 147,646,255 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,261,532 - 146,267,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,282,828 - 145,289,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,282,797 - 145,289,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,580,193 - 208,586,457 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,209,745 - 149,219,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,454,585 - 149,463,922 (+)NCBI
Celera4135,032,266 - 135,038,520 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
adenocarcinoma  (ISO)
allergic contact dermatitis  (ISO)
angiomyolipoma  (ISO)
Atrioventricular Septal Defect 2  (ISO)
basal cell carcinoma  (ISO)
brain disease  (ISO)
breast cancer  (ISO)
cataract  (ISO)
cholangiocarcinoma  (ISO)
Chromosome Aberrations  (ISO)
clear cell renal cell carcinoma  (ISO)
coronary artery disease  (ISO)
developmental coordination disorder  (ISO)
Discoid Lupus Erythematosus  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IEP)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heart disease  (ISO)
hepatitis  (IEP)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Kidney Reperfusion Injury  (IEP)
long QT syndrome  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
male infertility  (ISO)
middle cerebral artery infarction  (IEP)
Nerve Degeneration  (ISO)
Neurodevelopmental Disorders  (ISO)
nonpapillary renal cell carcinoma  (ISO)
obesity  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
pre-eclampsia  (ISO)
Premature Birth  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Prenatal Injuries  (ISO)
primary open angle glaucoma  (ISO)
progressive supranuclear palsy  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pterygium  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (IEP,ISO)
sarcoma  (ISO)
senile cataract  (ISO)
skin disease  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (IEP)
Tongue Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IEP)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
Urologic Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-diamino-5-formamido-4-hydroxypyrimidine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7,8-dihydro-8-oxoguanine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aurintricarboxylic acid  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beryllium dichloride  (ISO)
bezafibrate  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camphene  (EXP)
carbon atom  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diethyl maleate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental carbon  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
geraniol  (EXP)
glutathione  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydralazine  (ISO)
hydrazine  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
idarubicin  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lupeol  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methyl methanesulfonate  (ISO)
methyl tert-butyl ether  (EXP)
methylarsonic acid  (EXP)
miconazole  (EXP)
mitomycin C  (ISO)
monocrotophos  (ISO)
myristicin  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
O-methyleugenol  (EXP)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
oxirane  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
phenobarbital  (EXP)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirfenidone  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
pristane  (ISO)
procyanidin B1  (ISO)
quartz  (ISO)
quercetin  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
styrene  (ISO)
tamibarotene  (ISO)
tert-butyl ethyl ether  (EXP)
tetrachloromethane  (ISO)
Thiotepa  (ISO)
Thymidine glycol  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trimethylarsine oxide  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (ISO)
nuclear matrix  (ISO,ISS)
nuclear speck  (ISO,ISS)
nucleoplasm  (ISO,ISS)
nucleus  (IBA,ISO)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. 8-oxoguanine DNA glycosylase, but not Kin17 protein, is translocated and differentially regulated by estrogens in rat brain cells. Araneda S, etal., Neuroscience. 2005;136(1):135-46. Epub 2005 Sep 21.
2. Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney. Audebert M, etal., Cancer Res. 2000 Sep 1;60(17):4740-4.
3. Dietary fish oil reduces oxidative DNA damage in rat colonocytes. Bancroft LK, etal., Free Radic Biol Med. 2003 Jul 15;35(2):149-59.
4. Two functional variations in 5'-UTR of hoGG1 gene associated with the risk of breast cancer in Chinese. Chen X, etal., Breast Cancer Res Treat. 2011 Jun;127(3):795-803. doi: 10.1007/s10549-010-1284-2. Epub 2010 Dec 14.
5. Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats. Choudhury S, etal., Cancer Res. 2003 Nov 15;63(22):7704-7.
6. DNA repair gene variants in endometrial carcinoma. Cincin ZB, etal., Med Oncol. 2012 Dec;29(4):2949-54. doi: 10.1007/s12032-012-0162-7. Epub 2012 Jan 22.
7. Zhonghua bing li xue za zhi Chinese journal of pathology Cong W, etal., Zhonghua Bing Li Xue Za Zhi. 2001 Jun;30(3):183-7.
8. Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study. Cong WM, etal., J Cancer Res Clin Oncol. 2001;127(3):187-92.
9. Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Cortina MS, etal., Exp Eye Res. 2005 Dec;81(6):742-50. Epub 2005 Jun 24.
10. DNA repair gene polymorphisms and prostate cancer risk in South Australia--results of a pilot study. Dhillon VS, etal., Urol Oncol. 2011 Nov-Dec;29(6):641-6. doi: 10.1016/j.urolonc.2009.08.013. Epub 2009 Nov 13.
11. Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death. Dobson AW, etal., Am J Physiol Lung Cell Mol Physiol 2002 Jul;283(1):L205-10.
12. Detecting pathway-based gene-gene and gene-environment interactions in pancreatic cancer. Duell EJ, etal., Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1470-9.
13. Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Duthie SJ, etal., Cancer Prev Res (Phila Pa). 2010 Jan;3(1):92-100.
14. Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients. Fleischer T, etal., Int J Cancer. 2014 Jun 1;134(11):2615-25. doi: 10.1002/ijc.28606. Epub 2014 Jan 6.
15. Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. Fukae J, etal., Acta Neuropathol. 2005 Mar;109(3):256-62. Epub 2004 Nov 17.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Polymorphisms of DNA repair genes OGG1 and XPD and the risk of age-related cataract in Egyptians. Gharib AF, etal., Mol Vis. 2014 May 21;20:661-9. eCollection 2014.
18. Association between genetic variants of DNA repair genes and coronary artery disease. Gokkusu C, etal., Genet Test Mol Biomarkers. 2013 Apr;17(4):307-13. doi: 10.1089/gtmb.2012.0383. Epub 2013 Jan 31.
19. Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients. Habib SL Mol Cancer. 2009 Mar 5;8:13. doi: 10.1186/1476-4598-8-13.
20. Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis. Habib SL, etal., Cancer Biol Ther. 2008 Jan;7(1):23-7. Epub 2007 Oct 8.
21. Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors. Habib SL, etal., Mol Cancer. 2008 Jan 24;7:10.
22. Ebselen attenuates oxidative DNA damage and enhances its repair activity in the thalamus after focal cortical infarction in hypertensive rats. He M, etal., Brain Res. 2007 Nov 21;1181:83-92. Epub 2007 Sep 8.
23. Human 8-oxoguanine-DNA glycosylase-1 is downregulated in human basal cell carcinoma. Huang XX, etal., Mol Genet Metab. 2012 May;106(1):127-30. doi: 10.1016/j.ymgme.2012.02.017. Epub 2012 Mar 3.
24. Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. Hung RJ, etal., Am J Epidemiol. 2005 Nov 15;162(10):925-42. Epub 2005 Oct 12.
25. Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride. Ichikawa K, etal., Mol Biol Rep. 2012 Dec;39(12):10803-10. doi: 10.1007/s11033-012-1974-4. Epub 2012 Oct 9.
26. Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. Jarrett SG, etal., Neurobiol Dis. 2008 Apr;30(1):130-8. Epub 2008 Jan 5.
27. Genetic polymorphism of hOGG1 and risk of pterygium in Chinese. Kau HC, etal., Eye (Lond). 2004 Jun;18(6):635-9.
28. Impact of genetic polymorphisms in base excision repair genes on the risk of breast cancer in a Korean population. Kim KY, etal., Gene. 2013 Dec 15;532(2):192-6. doi: 10.1016/j.gene.2013.09.069. Epub 2013 Sep 25.
29. Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1. Kinoshita A, etal., Carcinogenesis. 2002 Feb;23(2):341-9.
30. Immunolocalization of 8-OHdG and OGG1 in pancreatic islets of streptozotocin-induced diabetic rats. Ku YP, etal., Acta Histochem. 2009;111(2):138-44. Epub 2008 Aug 3.
31. Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India. Kumar A, etal., Tumour Biol. 2012 Feb;33(1):111-9. doi: 10.1007/s13277-011-0253-7. Epub 2011 Nov 15.
32. 8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Kunisada M, etal., Cancer Res. 2005 Jul 15;65(14):6006-10.
33. Inducible repair of oxidative DNA lesions in the rat brain after transient focal ischemia and reperfusion. Lan J, etal., J Cereb Blood Flow Metab. 2003 Nov;23(11):1324-39.
34. Effects of base excision repair gene polymorphisms on pancreatic cancer survival. Li D, etal., Int J Cancer. 2007 Apr 15;120(8):1748-54.
35. Oxidative DNA damage and 8-hydroxy-2-deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer. Li D, etal., Mol Carcinog. 2001 Aug;31(4):214-23.
36. Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a Chinese population. Luo H, etal., Asian Pac J Cancer Prev. 2014;15(3):1133-40.
37. Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation. Mabley JG, etal., FASEB J. 2005 Feb;19(2):290-2. Epub 2004 Dec 1.
38. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
39. Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk. Ming-Shiean H, etal., Ann Surg Oncol. 2010 Mar;17(3):760-71.
40. Protective association exhibited by the single nucleotide polymorphism (SNP) rs1052133 in the gene human 8-oxoguanine DNA glycosylase (hOGG1) with the risk of squamous cell carcinomas of the head & neck (SCCHN) among north Indians. Mitra AK, etal., Indian J Med Res. 2011 Jun;133:605-12.
41. Ethanol modulates rat hepatic DNA repair functions. Navasumrit P, etal., Alcohol Alcohol. 2001 Sep-Oct;36(5):369-76.
42. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers. Osorio A, etal., PLoS Genet. 2014 Apr 3;10(4):e1004256. doi: 10.1371/journal.pgen.1004256. eCollection 2014 Apr.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells. Potts RJ, etal., Toxicology. 2003 Mar 3;184(2-3):189-202.
47. Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site. Prieto Alamo MJ, etal., Nucleic Acids Res 1998 Nov 15;26(22):5199-202.
48. Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity. Radak Z, etal., Free Radic Biol Med. 2009 Jan 15;46(2):238-43. doi: 10.1016/j.freeradbiomed.2008.10.022. Epub 2008 Oct 18.
49. GOA pipeline RGD automated data pipeline
50. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
51. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
52. OGG1 polymorphisms and breast cancer risk. Rossner P Jr, etal., Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):811-5.
53. The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells. Ruchko MV, etal., Free Radic Biol Med. 2011 May 1;50(9):1107-13. doi: 10.1016/j.freeradbiomed.2010.10.692. Epub 2010 Oct 20.
54. A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population. Shen H, etal., PLoS One. 2014 Mar 5;9(3):e89662. doi: 10.1371/journal.pone.0089662. eCollection 2014.
55. Salivary analysis of oral cancer biomarkers. Shpitzer T, etal., Br J Cancer. 2009 Oct 6;101(7):1194-8. doi: 10.1038/sj.bjc.6605290.
56. Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase. Simone S, etal., Diabetes. 2008 Oct;57(10):2626-36. doi: 10.2337/db07-1579. Epub 2008 Jul 3.
57. Polymorphisms of DNA repair genes in endometrial cancer. Sobczuk A, etal., Pathol Oncol Res. 2012 Oct;18(4):1015-20. Epub 2012 Apr 28.
58. Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population. Srivastava A, etal., Ann Surg Oncol. 2009 Jun;16(6):1695-703. Epub 2009 Mar 6.
59. Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India. Srivastava K, etal., Cancer. 2010 Jul 1;116(13):3160-9. doi: 10.1002/cncr.25063.
60. Study of DNA damage via the comet assay and base excision repair activities in rat brain neurons and astrocytes during aging. Swain U and Subba Rao K, Mech Ageing Dev. 2011 Aug;132(8-9):374-81. doi: 10.1016/j.mad.2011.04.012. Epub 2011 May 11.
61. Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients. Synowiec E, etal., Mutat Res. 2008 Dec 15;648(1-2):65-72. doi: 10.1016/j.mrfmmm.2008.09.014. Epub 2008 Oct 10.
62. Association of the 399Arg/Gln XRCC1, the 194 Arg/Trp XRCC1, the 326Ser/Cys OGG1, and the 324Gln/His MUTYH gene polymorphisms with clinical parameters and the risk for development of primary open-angle glaucoma. Szaflik JP, etal., Mutat Res. 2013 Apr 30;753(1):12-22. doi: 10.1016/j.mrgentox.2012.12.019. Epub 2013 Mar 7.
63. The 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease. Tanrikulu S, etal., Cell Biochem Funct. 2011 Apr;29(3):244-8. doi: 10.1002/cbf.1742. Epub 2011 Feb 24.
64. Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney. Tsuruya K, etal., DNA Repair (Amst). 2003 Feb 3;2(2):211-29.
65. Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. Tyrberg B, etal., BMC Endocr Disord. 2002 Apr 25;2(1):2.
66. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
67. No association between OGG1 Ser326Cys and risk of basal cell carcinoma. Vogel U, etal., Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1680-1.
68. Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells. Wan J, etal., Exp Mol Med. 2004 Feb 29;36(1):71-7.
69. Association of hOGG1 and XPD polymorphisms with urothelial carcinoma in Taiwan. Wang YH, etal., Anticancer Res. 2011 Nov;31(11):3939-44.
70. Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer. Zhang Y, etal., Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):353-8.
71. Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens. Zhang Y, etal., Mol Vis. 2010 Aug 27;16:1754-63.
72. Genetic polymorphisms in DNA repair genes OGG1, APE1, XRCC1, and XPD and the risk of age-related cataract. Zhang Y, etal., Ophthalmology. 2012 May;119(5):900-6. doi: 10.1016/j.ophtha.2011.11.004. Epub 2012 Feb 4.
73. Susceptibility of XPD and hOGG1 genetic variants to prostate cancer. Zhou C, etal., Biomed Rep. 2013 Jul;1(4):679-683. Epub 2013 May 30.
Additional References at PubMed
PMID:8621488   PMID:9207108   PMID:10557315   PMID:10570187   PMID:11454679   PMID:11532868   PMID:12447686   PMID:12477932   PMID:12874039   PMID:14651853   PMID:14706345   PMID:15725623  
PMID:15811855   PMID:16001017   PMID:17148573   PMID:17213818   PMID:18614015   PMID:19506022   PMID:22564741   PMID:23697596   PMID:23973402   PMID:24429287   PMID:24907397   PMID:25672835  
PMID:27091693   PMID:28758699   PMID:28882450   PMID:33471970  


Genomics

Comparative Map Data
Ogg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84148,030,237 - 148,037,599 (+)NCBIGRCr8
mRatBN7.24146,474,701 - 146,481,959 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4146,474,750 - 146,484,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,859,153 - 151,865,412 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,639,996 - 147,646,255 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04146,261,532 - 146,267,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04145,282,828 - 145,289,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4145,282,797 - 145,289,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04208,580,193 - 208,586,457 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,209,745 - 149,219,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14149,454,585 - 149,463,922 (+)NCBI
Celera4135,032,266 - 135,038,520 (+)NCBICelera
Cytogenetic Map4q42NCBI
OGG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3839,749,952 - 9,783,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl39,749,944 - 9,788,219 (+)EnsemblGRCh38hg38GRCh38
GRCh3739,791,636 - 9,808,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3639,765,705 - 9,783,342 (+)NCBINCBI36Build 36hg18NCBI36
Build 3439,766,653 - 9,783,311NCBI
Celera39,726,330 - 9,743,054 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef39,727,975 - 9,744,701 (+)NCBIHuRef
CHM1_139,741,823 - 9,758,548 (+)NCBICHM1_1
T2T-CHM13v2.039,741,907 - 9,758,605 (+)NCBIT2T-CHM13v2.0
Ogg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396113,303,959 - 113,311,149 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6113,303,933 - 113,312,029 (+)EnsemblGRCm39 Ensembl
GRCm386113,326,972 - 113,334,877 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6113,326,972 - 113,335,068 (+)EnsemblGRCm38mm10GRCm38
MGSCv376113,276,970 - 113,284,182 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366113,292,788 - 113,299,961 (+)NCBIMGSCv36mm8
Celera6115,153,980 - 115,161,188 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.75NCBI
Ogg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555611,277,365 - 1,282,793 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555611,277,362 - 1,282,949 (+)NCBIChiLan1.0ChiLan1.0
OGG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v229,761,821 - 9,801,743 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan139,766,593 - 9,806,794 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v039,702,311 - 9,742,283 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,940,955 - 9,972,658 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,940,955 - 9,947,335 (+)Ensemblpanpan1.1panPan2
OGG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,486,150 - 8,491,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,480,005 - 8,491,264 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,519,224 - 8,524,513 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,515,436 - 8,520,730 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,515,437 - 8,520,524 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,237,911 - 8,243,202 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,582,435 - 8,587,727 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,556,049 - 8,561,340 (-)NCBIUU_Cfam_GSD_1.0
Ogg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494215,490,887 - 15,501,164 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,413,282 - 3,418,831 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,411,106 - 3,418,826 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11366,038,669 - 66,045,478 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21373,102,660 - 73,108,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OGG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12245,757,414 - 45,763,690 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041120,772,448 - 120,811,082 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ogg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247314,383,434 - 4,388,196 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247314,383,000 - 4,388,486 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ogg1
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:40
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000011352
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat

Markers in Region
RH128087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,480,937 - 146,481,139 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,042 - 145,289,243NCBIRnor6.0
Rnor_5.04208,586,192 - 208,586,392UniSTSRnor5.0
Celera4135,038,254 - 135,038,455UniSTS
RH 3.4 Map4937.4UniSTS
Cytogenetic Map4q42UniSTS
AI505105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,481,267 - 146,481,394 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,372 - 145,289,498NCBIRnor6.0
Rnor_5.04208,586,521 - 208,586,647UniSTSRnor5.0
Celera4135,038,584 - 135,038,710UniSTS
Cytogenetic Map4q42UniSTS
D6Ertd263e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,481,234 - 146,481,453 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,339 - 145,289,557NCBIRnor6.0
Rnor_5.04208,586,488 - 208,586,706UniSTSRnor5.0
Celera4135,038,551 - 135,038,769UniSTS
Cytogenetic Map4q42UniSTS
RH137514  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,481,260 - 146,481,393 (+)MAPPERmRatBN7.2
Rnor_6.04145,289,365 - 145,289,497NCBIRnor6.0
Rnor_5.04208,586,514 - 208,586,646UniSTSRnor5.0
Celera4135,038,577 - 135,038,709UniSTS
Cytogenetic Map4q42UniSTS
Ogg1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24146,478,876 - 146,480,164 (+)MAPPERmRatBN7.2
Rnor_6.04145,286,983 - 145,288,270NCBIRnor6.0
Rnor_5.04208,584,133 - 208,585,420UniSTSRnor5.0
RGSC_v3.44149,216,891 - 149,218,178UniSTSRGSC3.4
Celera4135,036,195 - 135,037,482UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 24 18 17 18 53 20 35 5
Low 1 17 33 23 2 23 8 11 21 15 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000085766   ⟹   ENSRNOP00000070483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4146,474,750 - 146,484,766 (+)Ensembl
Rnor_6.0 Ensembl4145,282,797 - 145,289,326 (+)Ensembl
RefSeq Acc Id: NM_030870   ⟹   NP_110497
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,030,586 - 148,036,851 (+)NCBI
mRatBN7.24146,474,936 - 146,481,204 (+)NCBI
Rnor_6.04145,283,043 - 145,289,308 (+)NCBI
Rnor_5.04208,580,193 - 208,586,457 (+)NCBI
RGSC_v3.44149,209,745 - 149,219,081 (+)RGD
Celera4135,032,266 - 135,038,520 (+)RGD
Sequence:
RefSeq Acc Id: XM_017592906   ⟹   XP_017448395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,030,640 - 148,037,599 (+)NCBI
mRatBN7.24146,474,966 - 146,481,959 (+)NCBI
Rnor_6.04145,283,120 - 145,289,367 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108420   ⟹   XP_038964348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,030,620 - 148,037,599 (+)NCBI
mRatBN7.24146,474,749 - 146,481,956 (+)NCBI
RefSeq Acc Id: XM_063286744   ⟹   XP_063142814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,030,237 - 148,035,936 (+)NCBI
RefSeq Acc Id: XM_063286745   ⟹   XP_063142815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84148,030,237 - 148,036,675 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_110497   ⟸   NM_030870
- UniProtKB: O70249 (UniProtKB/Swiss-Prot),   A6IBQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448395   ⟸   XM_017592906
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000070483   ⟸   ENSRNOT00000085766
RefSeq Acc Id: XP_038964348   ⟸   XM_039108420
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142815   ⟸   XM_063286745
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063142814   ⟸   XM_063286744
- Peptide Label: isoform X2
Protein Domains
8-oxoguanine DNA glycosylase N-terminal   HhH-GPD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70249-F1-model_v2 AlphaFold O70249 1-345 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693295
Promoter ID:EPDNEW_R3819
Type:multiple initiation site
Name:Ogg1_1
Description:8-oxoguanine DNA glycosylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04145,282,840 - 145,282,900EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621168 AgrOrtholog
BioCyc Gene G2FUF-43395 BioCyc
Ensembl Genes ENSRNOG00000052140 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055007846 UniProtKB/Swiss-Prot
  ENSRNOG00060013588 UniProtKB/Swiss-Prot
  ENSRNOG00065027639 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085766 ENTREZGENE
  ENSRNOT00000085766.2 UniProtKB/Swiss-Prot
  ENSRNOT00055013181 UniProtKB/Swiss-Prot
  ENSRNOT00060023192 UniProtKB/Swiss-Prot
  ENSRNOT00065047651 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1670.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.310.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNA_glycosylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HhH-GPD_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HhH_base_excis_C UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Ogg1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OGG_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81528 ENTREZGENE
PANTHER 8-OXOGUANINE DNA GLYCOSYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  N-GLYCOSYLASE/DNA LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HhH-GPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OGG_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB OGG1 RGD
PhenoGen Ogg1 PhenoGen
RatGTEx ENSRNOG00000052140 RatGTEx
  ENSRNOG00055007846 RatGTEx
  ENSRNOG00060013588 RatGTEx
  ENSRNOG00065027639 RatGTEx
SMART ENDO3c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP DNA-glycosylase UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  TATA-box binding protein-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IBQ2 ENTREZGENE, UniProtKB/TrEMBL
  A6IBQ3_RAT UniProtKB/TrEMBL
  A6IBQ4_RAT UniProtKB/TrEMBL
  B2RYK1_RAT UniProtKB/TrEMBL
  O70249 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Ogg1  8-oxoguanine DNA glycosylase  Ogg1  8-oxoguanine DNA-glycosylase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ogg1  8-oxoguanine DNA-glycosylase 1    8-oxoguanine-DNA-glycosylase  Name updated 1299863 APPROVED
2002-08-07 Ogg1  8-oxoguanine-DNA-glycosylase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function excises 8-oxoG from DNA with preference for duplex DNA containing 8-oxoG:C base pairs 729091
gene_process protected against Xanthine Oxidase-induced mtDNA damage 628343