Epha5 (EPH receptor A5) - Rat Genome Database

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Pathways
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Gene: Epha5 (EPH receptor A5) Rattus norvegicus
Analyze
Symbol: Epha5
Name: EPH receptor A5
RGD ID: 620831
Description: Enables ephrin receptor activity and growth factor binding activity. Involved in cAMP-mediated signaling; dendritic spine morphogenesis; and ephrin receptor signaling pathway. Acts upstream of or within negative regulation of cell adhesion. Located in axon and plasma membrane. Orthologous to human EPHA5 (EPH receptor A5); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eck-like sequence 1; EHK-1; Els1; Els1.; EPH homology kinase 1; ephrin type-A receptor 5; tyrosine-protein kinase receptor EHK-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81424,007,400 - 24,374,854 (+)NCBIGRCr8
mRatBN7.21423,653,393 - 24,020,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1423,653,393 - 24,017,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1423,956,543 - 24,317,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01425,268,992 - 25,630,263 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01423,801,211 - 24,162,478 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01425,589,312 - 25,958,258 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1425,589,762 - 25,958,227 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01425,417,590 - 25,788,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41425,524,170 - 25,896,798 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11425,256,413 - 25,884,513 (+)NCBI
Celera1423,059,394 - 23,424,647 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development. Akaneya Y, etal., PLoS One. 2010 Aug 31;5(8):e12486. doi: 10.1371/journal.pone.0012486.
2. The ephrin signaling pathway regulates morphology and adhesion of mouse granulosa cells in vitro. Buensuceso AV and Deroo BJ, Biol Reprod. 2013 Jan 31;88(1):25. doi: 10.1095/biolreprod.112.100123. Print 2013 Jan.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. Maisonpierre PC, etal., Oncogene 1993 Dec;8(12):3277-88.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Noberini R, etal., Cell Adh Migr. 2012 Mar-Apr;6(2):102-12. doi: 10.4161/cam.19620. Epub 2012 Mar 1.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain. Taylor V, etal., Neuroscience 1994 Nov;63(1):163-78.
12. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Winslow JW, etal., Neuron 1995 May;14(5):973-81.
Additional References at PubMed
PMID:9191074   PMID:10064801   PMID:10375373   PMID:12124402   PMID:17448994   PMID:19036963   PMID:24222347   PMID:26109526   PMID:29237529   PMID:29330744  


Genomics

Comparative Map Data
Epha5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81424,007,400 - 24,374,854 (+)NCBIGRCr8
mRatBN7.21423,653,393 - 24,020,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1423,653,393 - 24,017,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1423,956,543 - 24,317,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01425,268,992 - 25,630,263 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01423,801,211 - 24,162,478 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01425,589,312 - 25,958,258 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1425,589,762 - 25,958,227 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01425,417,590 - 25,788,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41425,524,170 - 25,896,798 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11425,256,413 - 25,884,513 (+)NCBI
Celera1423,059,394 - 23,424,647 (+)NCBICelera
Cytogenetic Map14p21NCBI
EPHA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38465,319,567 - 65,670,489 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl465,319,563 - 65,670,495 (-)EnsemblGRCh38hg38GRCh38
GRCh37466,185,285 - 66,536,207 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36465,872,241 - 66,218,104 (-)NCBINCBI36Build 36hg18NCBI36
Celera463,644,911 - 63,993,769 (-)NCBICelera
Cytogenetic Map4q13.1-q13.2NCBI
HuRef462,095,699 - 62,445,869 (-)NCBIHuRef
CHM1_1466,222,199 - 66,573,162 (-)NCBICHM1_1
T2T-CHM13v2.0468,756,500 - 69,108,844 (-)NCBIT2T-CHM13v2.0
Epha5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39584,199,024 - 84,565,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl584,202,620 - 84,565,241 (-)EnsemblGRCm39 Ensembl
GRCm38584,054,761 - 84,417,818 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl584,054,761 - 84,417,382 (-)EnsemblGRCm38mm10GRCm38
MGSCv37584,483,786 - 84,846,407 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36585,132,352 - 85,491,482 (-)NCBIMGSCv36mm8
Celera581,291,528 - 81,651,176 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.0NCBI
Epha5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554477,066,111 - 7,382,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554477,066,111 - 7,382,046 (+)NCBIChiLan1.0ChiLan1.0
EPHA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2364,222,358 - 64,574,467 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1464,447,417 - 64,799,360 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0458,392,771 - 58,743,604 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1464,767,083 - 65,113,510 (+)NCBIpanpan1.1PanPan1.1panPan2
EPHA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11356,054,247 - 56,402,583 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1356,058,800 - 56,383,301 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1355,969,239 - 56,314,376 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01356,669,158 - 57,015,552 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1356,671,834 - 57,016,808 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11356,388,025 - 56,733,358 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01355,892,815 - 56,238,437 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01356,885,964 - 57,231,303 (-)NCBIUU_Cfam_GSD_1.0
Epha5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528519,941,499 - 20,271,236 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365822,505,145 - 2,830,014 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365822,503,546 - 2,832,950 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl863,287,711 - 63,604,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1863,285,006 - 63,604,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2867,246,392 - 67,540,677 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.173,219,396 - 3,564,416 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl73,219,449 - 3,559,854 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660663,415,672 - 3,777,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247613,693,540 - 4,048,953 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247613,693,462 - 4,050,426 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epha5
2564 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1701
Count of miRNA genes:263
Interacting mature miRNAs:320
Transcripts:ENSRNOT00000002793, ENSRNOT00000042149, ENSRNOT00000043938, ENSRNOT00000047290, ENSRNOT00000065394, ENSRNOT00000067439
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat

Markers in Region
D14Hmgc6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21423,685,571 - 23,685,694 (+)MAPPERmRatBN7.2
mRatBN7.21423,685,539 - 23,685,694 (+)MAPPERmRatBN7.2
mRatBN7.21423,685,539 - 23,685,855 (+)MAPPERmRatBN7.2
Rnor_6.01425,622,244 - 25,622,398NCBIRnor6.0
Rnor_6.01425,622,244 - 25,622,682NCBIRnor6.0
Rnor_5.01425,451,582 - 25,452,020UniSTSRnor5.0
Rnor_5.01425,451,582 - 25,451,736UniSTSRnor5.0
RGSC_v3.41425,556,517 - 25,556,671UniSTSRGSC3.4
RGSC_v3.41425,556,516 - 25,556,671RGDRGSC3.4
Celera1423,091,473 - 23,091,627UniSTS
Cytogenetic Map14p21UniSTS
RH131857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21423,654,973 - 23,655,193 (+)MAPPERmRatBN7.2
Rnor_6.01425,591,348 - 25,591,567NCBIRnor6.0
Rnor_5.01425,419,680 - 25,419,899UniSTSRnor5.0
RGSC_v3.41425,525,751 - 25,525,970UniSTSRGSC3.4
Celera1423,060,975 - 23,061,194UniSTS
Cytogenetic Map14p21UniSTS
AW531504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21423,948,852 - 23,949,029 (+)MAPPERmRatBN7.2
Rnor_6.01425,886,078 - 25,886,254NCBIRnor6.0
Rnor_5.01425,715,317 - 25,715,493UniSTSRnor5.0
RGSC_v3.41425,825,316 - 25,825,492UniSTSRGSC3.4
Celera1423,353,273 - 23,353,449UniSTS
Cytogenetic Map14p21UniSTS
BE110064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21424,018,345 - 24,018,512 (+)MAPPERmRatBN7.2
Rnor_6.01425,956,469 - 25,956,635NCBIRnor6.0
Rnor_5.01425,786,237 - 25,786,403UniSTSRnor5.0
RGSC_v3.41425,895,010 - 25,895,176UniSTSRGSC3.4
Celera1423,422,858 - 23,423,024UniSTS
Cytogenetic Map14p21UniSTS
UniSTS:266988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21424,007,760 - 24,007,912 (+)MAPPERmRatBN7.2
Rnor_6.01425,945,114 - 25,945,265NCBIRnor6.0
Rnor_5.01425,774,882 - 25,775,033UniSTSRnor5.0
RGSC_v3.41425,884,209 - 25,884,360UniSTSRGSC3.4
Celera1423,412,268 - 23,412,419UniSTS
Cytogenetic Map14p21UniSTS
UniSTS:495883  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21423,653,448 - 23,653,687 (+)MAPPERmRatBN7.2
Rnor_6.01425,589,823 - 25,590,061NCBIRnor6.0
Rnor_5.01425,418,155 - 25,418,393UniSTSRnor5.0
RGSC_v3.41425,524,226 - 25,524,464UniSTSRGSC3.4
Celera1423,059,450 - 23,059,688UniSTS
Cytogenetic Map14p21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64
Low 15 6 4 6 10 2 31 7
Below cutoff 3 19 17 10 14 10 5 5 18 10 3 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001169137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002793   ⟹   ENSRNOP00000002793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1423,653,393 - 24,017,317 (+)Ensembl
Rnor_6.0 Ensembl1425,589,767 - 25,958,227 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000043938   ⟹   ENSRNOP00000043926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1423,653,393 - 24,017,317 (+)Ensembl
Rnor_6.0 Ensembl1425,589,762 - 25,945,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067439   ⟹   ENSRNOP00000062326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1423,653,393 - 24,008,122 (+)Ensembl
Rnor_6.0 Ensembl1425,589,767 - 25,945,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100109   ⟹   ENSRNOP00000085420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1423,653,393 - 24,017,317 (+)Ensembl
RefSeq Acc Id: NM_001169137   ⟹   NP_001162608
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,008,122 - 24,374,848 (+)NCBI
mRatBN7.21423,653,393 - 24,020,129 (+)NCBI
Rnor_6.01425,589,767 - 25,958,258 (+)NCBI
Rnor_5.01425,417,590 - 25,788,026 (+)NCBI
RGSC_v3.41425,524,170 - 25,896,798 (+)RGD
Celera1423,059,394 - 23,424,647 (+)NCBI
Sequence:
RefSeq Acc Id: NM_024367   ⟹   NP_077343
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,008,122 - 24,362,841 (+)NCBI
mRatBN7.21423,653,393 - 24,008,122 (+)NCBI
Rnor_6.01425,589,767 - 25,945,423 (+)NCBI
Rnor_5.01425,417,590 - 25,788,026 (+)NCBI
RGSC_v3.41425,524,170 - 25,896,798 (+)RGD
Celera1423,059,394 - 23,412,577 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063273652   ⟹   XP_063129722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,374,854 (+)NCBI
RefSeq Acc Id: XM_063273653   ⟹   XP_063129723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,374,854 (+)NCBI
RefSeq Acc Id: XM_063273654   ⟹   XP_063129724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,374,854 (+)NCBI
RefSeq Acc Id: XM_063273655   ⟹   XP_063129725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,374,854 (+)NCBI
RefSeq Acc Id: XM_063273656   ⟹   XP_063129726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,374,854 (+)NCBI
RefSeq Acc Id: XM_063273657   ⟹   XP_063129727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,374,854 (+)NCBI
RefSeq Acc Id: XM_063273659   ⟹   XP_063129729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,374,854 (+)NCBI
RefSeq Acc Id: XM_063273660   ⟹   XP_063129730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81424,007,400 - 24,363,979 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001162608   ⟸   NM_001169137
- Peptide Label: isoform 1 precursor
- UniProtKB: P54757 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_077343   ⟸   NM_024367
- Peptide Label: isoform 2
- UniProtKB: D3ZCV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000062326   ⟸   ENSRNOT00000067439
RefSeq Acc Id: ENSRNOP00000002793   ⟸   ENSRNOT00000002793
RefSeq Acc Id: ENSRNOP00000043926   ⟸   ENSRNOT00000043938
RefSeq Acc Id: ENSRNOP00000085420   ⟸   ENSRNOT00000100109
RefSeq Acc Id: XP_063129722   ⟸   XM_063273652
- Peptide Label: isoform X1
- UniProtKB: F1M7W0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129723   ⟸   XM_063273653
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A019 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129724   ⟸   XM_063273654
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063129725   ⟸   XM_063273655
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063129726   ⟸   XM_063273656
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063129727   ⟸   XM_063273657
- Peptide Label: isoform X6
- UniProtKB: D3ZBZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129729   ⟸   XM_063273659
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063129730   ⟸   XM_063273660
- Peptide Label: isoform X8
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54757-F1-model_v2 AlphaFold P54757 1-1005 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620831 AgrOrtholog
BioCyc Gene G2FUF-16048 BioCyc
Ensembl Genes ENSRNOG00000002024 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002793 ENTREZGENE
  ENSRNOT00000002793.6 UniProtKB/TrEMBL
  ENSRNOT00000043938.6 UniProtKB/TrEMBL
  ENSRNOT00000067439 ENTREZGENE
  ENSRNOT00000067439.5 UniProtKB/TrEMBL
  ENSRNOT00000100109.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79208 UniProtKB/Swiss-Prot
NCBI Gene 79208 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Epha5 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/Swiss-Prot
  EPH_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002024 RatGTEx
SMART EPH_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A019 ENTREZGENE, UniProtKB/TrEMBL
  A6JCS4_RAT UniProtKB/TrEMBL
  A6JCS5_RAT UniProtKB/TrEMBL
  A6JCS6_RAT UniProtKB/TrEMBL
  D3ZBZ7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCV9 ENTREZGENE, UniProtKB/TrEMBL
  EPHA5_RAT UniProtKB/Swiss-Prot
  F1M7W0 ENTREZGENE, UniProtKB/TrEMBL
  P54757 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-16 Epha5  EPH receptor A5  Epha5  EphA5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Epha5  EphA5  Els1  eck-like sequence 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Els1  eck-like sequence 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression early in development expression is prominent in the periventricular germinal layers of the brain 632543