Predicted to enable several functions, including GTP binding activity; GTPase activity; and preribosome binding activity. Predicted to be involved in several processes, including negative regulation of nitrogen compound metabolic process; protein stabilization; and ribosomal large subunit biogenesis. Predicted to act upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Predicted to be active in nucleolus. Used to study end stage renal disease. Orthologous to human GTPBP4 (GTP binding protein 4); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
chronic renal failure gene protein; Crfg; G protein-binding protein CRFG; GTP-binding protein 4; LOC498786; LOC683324; LOC689822; nucleolar GTP-binding protein 1; RGD1563564; similar to GTP-binding protein NGB; similar to Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB)
Cisplatin promotes the reaction [jinfukang results in decreased expression of GTPBP4 mRNA] and jinfukang promotes the reaction [Cisplatin results in decreased expression of GTPBP4 mRNA]
[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of GTPBP4 mRNA and [sulforaphane affects the susceptibility to Oxygen] which affects the expression of GTPBP4 mRNA
[[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of GTPBP4 mRNA
[LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of GTPBP4 protein