Predicted to enable death domain binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of DNA-templated transcription; and negative regulation of autophagy. Predicted to act upstream of or within apoptotic process. Orthologous to human DAP (death associated protein); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DAP mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DAP gene]
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA and [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAP mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAP mRNA
[Clofibrate co-treated with Acetaminophen] affects the expression of DAP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DAP mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAP mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DAP mRNA
[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of DAP mRNA and [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of DAP mRNA
[Clofibrate co-treated with Acetaminophen] affects the expression of DAP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DAP mRNA]
Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively.