Limk2 (LIM domain kinase 2) - Rat Genome Database

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Gene: Limk2 (LIM domain kinase 2) Rattus norvegicus
Analyze
Symbol: Limk2
Name: LIM domain kinase 2
RGD ID: 62056
Description: Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in nucleus. Orthologous to human LIMK2 (LIM domain kinase 2); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LIM motif-containing protein kinase 2; LIMK-2; Limk2b; Link2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21478,208,182 - 78,286,106 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1478,218,063 - 78,286,007 (-)Ensembl
Rnor_6.01483,564,048 - 83,641,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,573,928 - 83,641,892 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,253,114 - 84,330,159 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41483,969,282 - 84,037,218 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11483,988,426 - 84,056,363 (-)NCBI
Celera1477,131,523 - 77,199,230 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO,ISS)
cis-Golgi network  (ISO)
cytoplasm  (IBA,ISO)
cytosol  (TAS)
mitotic spindle  (ISO,ISS)
nucleus  (IBA,IDA,ISO)
perinuclear region of cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505. Amano T, etal., Biochem J 2001 Feb 15;354(Pt 1):149-59.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Comparison of tissue distribution of two novel serine/threonine kinase genes containing the LIM motif (LIMK-1 and LIMK-2) in the developing rat. Mori T, etal., Brain Res Mol Brain Res 1997 May;45(2):247-54.
6. LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family. Nunoue K, etal., Oncogene 1995 Aug 17;11(4):701-10.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Rosok O, etal., Genomics 1999 Oct 1;61(1):44-54.
11. Cloning and biochemical characterization of LIMK-2, a protein kinase containing two LIM domains. Smolich B, etal., J Biochem (Tokyo) 1997 Feb;121(2):382-8.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho- and Cdc42-activated LIM-kinase 2. Sumi T, etal., J Cell Biol 1999 Dec 27;147(7):1519-32.
Additional References at PubMed
PMID:11784110   PMID:16399995   PMID:22328514   PMID:22405825   PMID:24561342   PMID:24962708   PMID:26234751   PMID:26438559   PMID:30870492  


Genomics

Comparative Map Data
Limk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21478,208,182 - 78,286,106 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1478,218,063 - 78,286,007 (-)Ensembl
Rnor_6.01483,564,048 - 83,641,996 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,573,928 - 83,641,892 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,253,114 - 84,330,159 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41483,969,282 - 84,037,218 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11483,988,426 - 84,056,363 (-)NCBI
Celera1477,131,523 - 77,199,230 (-)NCBICelera
Cytogenetic Map14q21NCBI
LIMK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,212,298 - 31,280,080 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2231,212,239 - 31,280,080 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,608,284 - 31,676,066 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,938,250 - 30,006,066 (+)NCBINCBI36hg18NCBI36
Build 342229,968,941 - 30,000,618NCBI
Celera2215,408,353 - 15,476,551 (+)NCBI
Cytogenetic Map22q12.2NCBI
HuRef2214,569,980 - 14,637,678 (+)NCBIHuRef
CHM1_12231,568,095 - 31,635,881 (+)NCBICHM1_1
T2T-CHM13v2.02231,675,859 - 31,744,063 (+)NCBI
Limk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,293,297 - 3,359,249 (-)NCBIGRCm39mm39
GRCm39 Ensembl113,294,256 - 3,359,189 (-)Ensembl
GRCm38113,343,297 - 3,409,276 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,344,256 - 3,409,189 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,243,300 - 3,309,238 (-)NCBIGRCm37mm9NCBIm37
MGSCv36113,243,300 - 3,309,238 (-)NCBImm8
Celera113,834,265 - 3,899,342 (-)NCBICelera
Cytogenetic Map11A1NCBI
Limk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,405,940 - 5,473,418 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554555,406,085 - 5,473,418 (+)NCBIChiLan1.0ChiLan1.0
LIMK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12230,071,574 - 30,139,821 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2230,071,574 - 30,139,821 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02212,235,611 - 12,304,013 (+)NCBIMhudiblu_PPA_v0panPan3
LIMK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,182,595 - 24,242,429 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,146,005 - 24,240,653 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2624,052,624 - 24,112,447 (+)NCBI
ROS_Cfam_1.02624,565,985 - 24,625,824 (+)NCBI
ROS_Cfam_1.0 Ensembl2624,527,922 - 24,624,066 (+)Ensembl
UMICH_Zoey_3.12624,269,022 - 24,329,024 (+)NCBI
UNSW_CanFamBas_1.02624,530,984 - 24,590,898 (+)NCBI
UU_Cfam_GSD_1.02624,592,678 - 24,652,526 (+)NCBI
Limk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,116,743 - 117,185,723 (+)NCBI
SpeTri2.0NW_004936755374,279 - 443,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIMK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,983,975 - 48,040,821 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,983,984 - 48,039,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,094,927 - 51,150,601 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIMK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,101,051 - 14,168,210 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,101,054 - 14,166,570 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045111,949,015 - 112,016,137 (-)NCBIVero_WHO_p1.0
Limk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247477,700,411 - 7,766,713 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247477,700,996 - 7,766,713 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127162  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,218,067 - 78,218,316 (+)MAPPERmRatBN7.2
Rnor_6.01483,573,933 - 83,574,181NCBIRnor6.0
Rnor_5.01484,262,205 - 84,262,453UniSTSRnor5.0
RGSC_v3.41483,969,287 - 83,969,535UniSTSRGSC3.4
Celera1477,131,528 - 77,131,776UniSTS
Cytogenetic Map14q21UniSTS
AI058790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,218,082 - 78,218,191 (+)MAPPERmRatBN7.2
Rnor_6.01483,573,948 - 83,574,056NCBIRnor6.0
Rnor_5.01484,262,220 - 84,262,328UniSTSRnor5.0
RGSC_v3.41483,969,302 - 83,969,410UniSTSRGSC3.4
Celera1477,131,543 - 77,131,651UniSTS
RH 3.4 Map14532.3UniSTS
Cytogenetic Map14q21UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:409
Count of miRNA genes:172
Interacting mature miRNAs:202
Transcripts:ENSRNOT00000026032, ENSRNOT00000050005, ENSRNOT00000057673
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 19 12 11 12 74 30 32 11
Low 17 38 29 8 29 8 11 5 9 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_595861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY489563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D31877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000026032   ⟹   ENSRNOP00000026032
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1478,218,063 - 78,286,007 (-)Ensembl
Rnor_6.0 Ensembl1483,573,928 - 83,641,892 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000050005   ⟹   ENSRNOP00000044951
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1478,218,063 - 78,247,186 (-)Ensembl
Rnor_6.0 Ensembl1483,573,931 - 83,603,003 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000057673   ⟹   ENSRNOP00000054482
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1478,218,063 - 78,271,530 (-)Ensembl
Rnor_6.0 Ensembl1483,573,928 - 83,603,047 (-)Ensembl
RefSeq Acc Id: NM_024135   ⟹   NP_077049
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,218,063 - 78,286,007 (-)NCBI
Rnor_6.01483,573,928 - 83,641,892 (-)NCBI
Rnor_5.01484,253,114 - 84,330,159 (-)NCBI
RGSC_v3.41483,969,282 - 84,037,218 (-)RGD
Celera1477,131,523 - 77,199,230 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251236   ⟹   XP_006251298
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,218,061 - 78,247,219 (-)NCBI
Rnor_6.01483,573,926 - 83,604,140 (-)NCBI
Rnor_5.01484,253,114 - 84,330,159 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770275   ⟹   XP_008768497
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,211,720 - 78,286,105 (-)NCBI
Rnor_6.01483,567,569 - 83,641,996 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770276   ⟹   XP_008768498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,211,720 - 78,247,227 (-)NCBI
Rnor_6.01483,567,569 - 83,604,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770277   ⟹   XP_008768499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,211,721 - 78,247,224 (-)NCBI
Rnor_6.01483,567,569 - 83,604,141 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770278   ⟹   XP_008768500
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,211,720 - 78,286,104 (-)NCBI
Rnor_6.01483,567,569 - 83,641,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770279   ⟹   XP_008768501
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,221,134 - 78,286,104 (-)NCBI
Rnor_6.01483,576,999 - 83,641,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091790   ⟹   XP_038947718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,211,719 - 78,233,774 (-)NCBI
RefSeq Acc Id: XR_005492924
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,219,575 - 78,286,106 (-)NCBI
RefSeq Acc Id: XR_005492925
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,218,061 - 78,247,226 (-)NCBI
RefSeq Acc Id: XR_595861
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21478,208,182 - 78,286,105 (-)NCBI
Rnor_6.01483,564,048 - 83,641,996 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077049   ⟸   NM_024135
- UniProtKB: P53670 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006251298   ⟸   XM_006251236
- Peptide Label: isoform X5
- UniProtKB: P53670 (UniProtKB/Swiss-Prot),   Q5D047 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768497   ⟸   XM_008770275
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008768500   ⟸   XM_008770278
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008768498   ⟸   XM_008770276
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008768499   ⟸   XM_008770277
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008768501   ⟸   XM_008770279
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000054482   ⟸   ENSRNOT00000057673
RefSeq Acc Id: ENSRNOP00000026032   ⟸   ENSRNOT00000026032
RefSeq Acc Id: ENSRNOP00000044951   ⟸   ENSRNOT00000050005
RefSeq Acc Id: XP_038947718   ⟸   XM_039091790
- Peptide Label: isoform X7
Protein Domains
LIM zinc-binding   PDZ   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53670-F1-model_v2 AlphaFold P53670 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699443
Promoter ID:EPDNEW_R9948
Type:initiation region
Name:Limk2_1
Description:LIM domain kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9949  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01483,603,015 - 83,603,075EPDNEW
RGD ID:13699424
Promoter ID:EPDNEW_R9949
Type:initiation region
Name:Limk2_2
Description:LIM domain kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9948  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01483,641,951 - 83,642,011EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 83579132 83579133 G A snv M520/N (MCW)


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 83974486 83974487 G A snv M520/N (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62056 AgrOrtholog
BioCyc Gene G2FUF-15229 BioCyc
Ensembl Genes ENSRNOG00000019000 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000026032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000044951 ENTREZGENE
  ENSRNOP00000044951.2 UniProtKB/TrEMBL
  ENSRNOP00000054482.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026032 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000050005 ENTREZGENE
  ENSRNOT00000050005.4 UniProtKB/TrEMBL
  ENSRNOT00000057673.4 UniProtKB/TrEMBL
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623751 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29524 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72430 IMAGE-MGC_LOAD
NCBI Gene 29524 ENTREZGENE
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Limk2 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QN67_RAT UniProtKB/TrEMBL
  A0A8L2QS45_RAT UniProtKB/TrEMBL
  LIMK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5D047 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Limk2  LIM domain kinase 2  Limk2  LIM motif-containing protein kinase 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Limk2  LIM motif-containing protein kinase 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two repeats of the LIM motif at the N-terminus and a protein kinase consensus sequence at the C-terminus 61653
gene_transcript has several alternative splicing forms 61653