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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:62348 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of LIMK2 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of LIMK2 mRNA | CTD | PMID:25380136, PMID:30723492 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of LIMK2 mRNA | CTD | PMID:17557909 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of LIMK2 mRNA | CTD | PMID:20170705, PMID:26865667 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:733238 | 6480464 | Ethinyl Estradiol affects the expression of LIMK2 mRNA | CTD | PMID:20170705, PMID:26865667 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:733238 | 6480464 | Ethinyl Estradiol results in decreased expression of LIMK2 mRNA | CTD | PMID:18936297 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of LIMK2 mRNA | CTD | PMID:21215274 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:19692669 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of LIMK2 mRNA | CTD | PMID:25380136 | 5-fluorouracil | affects response to substance | ISO | RGD:733238 | 6480464 | LIMK2 protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LIMK2 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of LIMK2 mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects expression | ISO | RGD:733238 | 6480464 | Aflatoxin B1 affects the expression of LIMK2 protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of LIMK2 mRNA | CTD | PMID:33354967 | aflatoxin B1 | increases expression | ISO | RGD:733238 | 6480464 | Aflatoxin B1 results in increased expression of LIMK2 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | increases expression | ISO | RGD:733238 | 6480464 | Tretinoin results in increased expression of LIMK2 mRNA | CTD | PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of LIMK2 mRNA | CTD | PMID:16483693 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of LIMK2 mRNA | CTD | PMID:30779732 | aristolochic acid | increases expression | ISO | RGD:733238 | 6480464 | aristolochic acid I results in increased expression of LIMK2 mRNA | CTD | PMID:33212167 | benzo[a]pyrene | affects methylation | ISO | RGD:733238 | 6480464 | Benzo(a)pyrene affects the methylation of LIMK2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:733238 | 6480464 | Benzo(a)pyrene results in increased expression of LIMK2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | decreases methylation | ISO | RGD:733238 | 6480464 | Benzo(a)pyrene results in decreased methylation of LIMK2 exon | CTD | PMID:27901495 | bisphenol A | affects expression | ISO | RGD:733238 | 6480464 | bisphenol A affects the expression of LIMK2 mRNA | CTD | PMID:20170705 | bisphenol A | affects methylation | ISO | RGD:733238 | 6480464 | bisphenol A affects the methylation of LIMK2 gene | CTD | PMID:31601247 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of LIMK2 mRNA | CTD | PMID:25181051 | cannabidiol | affects methylation | EXP | | 6480464 | Cannabidiol affects the methylation of LIMK2 gene | CTD | PMID:30521419 | CGP 52608 | multiple interactions | ISO | RGD:733238 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to LIMK2 gene] | CTD | PMID:28238834 | cisplatin | increases expression | ISO | RGD:733238 | 6480464 | Cisplatin results in increased expression of LIMK2 mRNA | CTD | PMID:27594783 | copper(II) sulfate | decreases expression | ISO | RGD:733238 | 6480464 | Copper Sulfate results in decreased expression of LIMK2 mRNA | CTD | PMID:19549813 | CU-O LINKAGE | decreases expression | ISO | RGD:733238 | 6480464 | cupric oxide results in decreased expression of LIMK2 mRNA | CTD | PMID:22077320 | cyclosporin A | increases expression | ISO | RGD:733238 | 6480464 | Cyclosporine results in increased expression of LIMK2 mRNA | CTD | PMID:20106945 | dexamethasone | increases expression | ISO | RGD:62348 | 6480464 | Dexamethasone results in increased expression of LIMK2 mRNA | CTD | PMID:22733784 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of LIMK2 mRNA | CTD | PMID:21551480 | doxorubicin | affects expression | ISO | RGD:733238 | 6480464 | Doxorubicin affects the expression of LIMK2 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of LIMK2 mRNA | CTD | PMID:29391264 | ethanol | affects splicing | ISO | RGD:62348 | 6480464 | Ethanol affects the splicing of LIMK2 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | RGD:733238 | 6480464 | Ethyl Methanesulfonate results in increased expression of LIMK2 mRNA | CTD | PMID:23649840 | fasudil | multiple interactions | EXP | | 6480464 | fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] | CTD | PMID:22062134 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of LIMK2 mRNA | CTD | PMID:24136188 | formaldehyde | increases expression | ISO | RGD:733238 | 6480464 | Formaldehyde results in increased expression of LIMK2 mRNA | CTD | PMID:23649840 | genistein | affects expression | ISO | RGD:733238 | 6480464 | Genistein affects the expression of LIMK2 mRNA | CTD | PMID:26865667 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of LIMK2 mRNA | CTD | PMID:24136188 | leflunomide | increases expression | ISO | RGD:733238 | 6480464 | leflunomide results in increased expression of LIMK2 mRNA | CTD | PMID:28988120 | lidocaine | increases expression | EXP | | 6480464 | Lidocaine results in increased expression of LIMK2 mRNA | CTD | PMID:35283115 | maneb | multiple interactions | ISO | RGD:62348 | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA | CTD | PMID:18386188 | methyl methanesulfonate | increases expression | ISO | RGD:733238 | 6480464 | Methyl Methanesulfonate results in increased expression of LIMK2 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | RGD:733238 | 6480464 | methylmercuric chloride results in decreased expression of LIMK2 mRNA | CTD | PMID:28001369 | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of LIMK2 mRNA | CTD | PMID:25380136 | paracetamol | decreases expression | ISO | RGD:62348 | 6480464 | Acetaminophen results in decreased expression of LIMK2 mRNA | CTD | PMID:17585979 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of LIMK2 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | RGD:733238 | 6480464 | Acetaminophen results in increased expression of LIMK2 mRNA | CTD | PMID:25704631 | paracetamol | affects expression | ISO | RGD:62348 | 6480464 | Acetaminophen affects the expression of LIMK2 mRNA | CTD | PMID:17562736 | paraquat | multiple interactions | ISO | RGD:62348 | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA | CTD | PMID:18386188 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of LIMK2 mRNA | CTD | PMID:19162173 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of LIMK2 mRNA | CTD | PMID:19162173 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of LIMK2 mRNA | CTD | PMID:19162173 | sevoflurane | affects expression | EXP | | 6480464 | sevoflurane affects the expression of LIMK2 mRNA | CTD | PMID:15967596 | streptozocin | increases phosphorylation | EXP | | 6480464 | Streptozocin results in increased phosphorylation of LIMK2 protein | CTD | PMID:22062134 | streptozocin | multiple interactions | EXP | | 6480464 | fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] | CTD | PMID:22062134 | sunitinib | increases expression | ISO | RGD:733238 | 6480464 | Sunitinib results in increased expression of LIMK2 mRNA | CTD | PMID:31533062 | tauroursodeoxycholic acid | decreases expression | EXP | | 6480464 | ursodoxicoltaurine results in decreased expression of LIMK2 mRNA | CTD | PMID:15885361 | testosterone | multiple interactions | ISO | RGD:62348 | 6480464 | 1 more ... | CTD | PMID:33848595 | testosterone | increases expression | ISO | RGD:62348 | 6480464 | Testosterone deficiency results in increased expression of LIMK2 mRNA | CTD | PMID:33848595 | testosterone enanthate | affects expression | ISO | RGD:733238 | 6480464 | testosterone enanthate affects the expression of LIMK2 mRNA | CTD | PMID:17440010 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of LIMK2 mRNA | CTD | PMID:34492290 | topotecan | affects response to substance | ISO | RGD:733238 | 6480464 | LIMK2 protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | triptonide | increases expression | ISO | RGD:62348 | 6480464 | triptonide results in increased expression of LIMK2 mRNA | CTD | PMID:33045310 | undecane | decreases expression | EXP | | 6480464 | undecane results in decreased expression of LIMK2 protein | CTD | PMID:17337753 | valproic acid | increases expression | ISO | RGD:62348 | 6480464 | Valproic Acid results in increased expression of LIMK2 mRNA | CTD | PMID:20546886 | valproic acid | affects expression | ISO | RGD:733238 | 6480464 | Valproic Acid affects the expression of LIMK2 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | RGD:733238 | 6480464 | Valproic Acid results in decreased expression of LIMK2 mRNA | CTD | PMID:28001369 | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of LIMK2 gene | CTD | PMID:31079544 | |