Atp6ap1 (ATPase H+ transporting accessory protein 1) - Rat Genome Database

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Gene: Atp6ap1 (ATPase H+ transporting accessory protein 1) Rattus norvegicus
Analyze
Symbol: Atp6ap1
Name: ATPase H+ transporting accessory protein 1
RGD ID: 620423
Description: Predicted to enable ATPase activator activity; small GTPase binding activity; and transporter activator activity. Predicted to be involved in several processes, including endosome to plasma membrane protein transport; intracellular monoatomic cation homeostasis; and synaptic vesicle lumen acidification. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Atp6s1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; C7-1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; V-type proton ATPase subunit S1; vacuolar proton pump subunit S1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,231,243 - 157,238,323 (+)NCBIGRCr8
mRatBN7.2X152,079,954 - 152,087,034 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,079,865 - 152,087,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX154,221,080 - 154,228,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,784,313 - 157,791,393 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,456,112 - 155,463,192 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,407,973 - 156,415,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,407,937 - 156,415,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,148,120 - 152,155,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,306,354 - 160,313,434 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X160,382,734 - 160,389,815 (-)NCBI
Celera1135,809,720 - 135,816,800 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structure of V-ATPase from the mammalian brain. Abbas YM, etal., Science. 2020 Mar 13;367(6483):1240-1246. doi: 10.1126/science.aaz2924.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction. Hodi FS, etal., Proc Natl Acad Sci U S A 2002 May 14;99(10):6919-24.
5. Age-dependent increase in C7-1 gene expression in rat frontal cortex. Hung H, etal., Brain Res Mol Brain Res. 2000 Feb 22;75(2):330-6.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19056867   PMID:22467241   PMID:23376485   PMID:28296633   PMID:29476059  


Genomics

Comparative Map Data
Atp6ap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,231,243 - 157,238,323 (+)NCBIGRCr8
mRatBN7.2X152,079,954 - 152,087,034 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,079,865 - 152,087,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX154,221,080 - 154,228,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,784,313 - 157,791,393 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,456,112 - 155,463,192 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,407,973 - 156,415,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,407,937 - 156,415,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,148,120 - 152,155,200 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,306,354 - 160,313,434 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X160,382,734 - 160,389,815 (-)NCBI
Celera1135,809,720 - 135,816,800 (-)NCBICelera
Cytogenetic MapXq37NCBI
ATP6AP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,428,677 - 154,436,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,428,633 - 154,436,516 (+)EnsemblGRCh38hg38GRCh38
GRCh37X153,657,023 - 153,664,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,310,172 - 153,318,056 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X153,177,867 - 153,183,641NCBI
CeleraX153,818,024 - 153,825,908 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,234,564 - 142,269,596 (+)NCBIHuRef
CHM1_1X153,568,616 - 153,576,500 (+)NCBICHM1_1
T2T-CHM13v2.0X152,665,185 - 152,673,024 (+)NCBIT2T-CHM13v2.0
Atp6ap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,340,753 - 73,348,297 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,340,703 - 73,348,327 (+)EnsemblGRCm39 Ensembl
GRCm38X74,297,097 - 74,304,721 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,297,097 - 74,304,721 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,542,436 - 71,550,060 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,549,866 - 70,557,411 (+)NCBIMGSCv36mm8
CeleraX65,550,888 - 65,558,512 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.96NCBI
Atp6ap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580927,114 - 934,734 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580927,546 - 934,633 (+)NCBIChiLan1.0ChiLan1.0
ATP6AP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,402,930 - 154,410,908 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,406,616 - 154,414,513 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,870,421 - 143,878,288 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,740,751 - 153,748,621 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,740,751 - 153,748,621 (+)Ensemblpanpan1.1panPan2
ATP6AP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,133,314 - 122,140,949 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,133,325 - 122,140,447 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X125,274,997 - 125,282,640 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX125,275,036 - 125,282,639 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,044,023 - 121,051,666 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,559,169 - 123,566,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,320,845 - 123,328,488 (+)NCBIUU_Cfam_GSD_1.0
Atp6ap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,441,750 - 119,450,401 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368091,179,464 - 1,188,283 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368091,179,507 - 1,188,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP6AP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,952,500 - 124,960,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,952,532 - 124,960,344 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,693,025 - 143,696,039 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATP6AP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606566,657,080 - 66,664,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp6ap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946884,685 - 902,365 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946885,400 - 902,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atp6ap1
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:79
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000056294
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat

Markers in Region
RH128191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,086,738 - 152,086,948 (-)MAPPERmRatBN7.2
Rnor_6.0X156,408,059 - 156,408,268NCBIRnor6.0
Rnor_5.01152,148,206 - 152,148,415UniSTSRnor5.0
RGSC_v3.4X160,306,440 - 160,306,649UniSTSRGSC3.4
Celera1135,809,806 - 135,810,015UniSTS
Cytogenetic MapXq37UniSTS
Cytogenetic MapXq37.1-q37.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000081914   ⟹   ENSRNOP00000069530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,079,874 - 152,087,034 (+)Ensembl
Rnor_6.0 EnsemblX156,407,937 - 156,415,145 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113494   ⟹   ENSRNOP00000090467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,079,865 - 152,087,034 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117428   ⟹   ENSRNOP00000091970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX152,079,917 - 152,087,034 (+)Ensembl
RefSeq Acc Id: NM_031785   ⟹   NP_113973
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,231,243 - 157,238,323 (+)NCBI
mRatBN7.2X152,079,954 - 152,087,034 (+)NCBI
Rnor_6.0X156,407,973 - 156,415,053 (-)NCBI
Rnor_5.01152,148,120 - 152,155,200 (-)NCBI
RGSC_v3.4X160,306,354 - 160,313,434 (-)RGD
Celera1135,809,720 - 135,816,800 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113973 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB88008 (Get FASTA)   NCBI Sequence Viewer  
  AAH70937 (Get FASTA)   NCBI Sequence Viewer  
  EDL84979 (Get FASTA)   NCBI Sequence Viewer  
  EDL84980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069530
  ENSRNOP00000069530.1
  ENSRNOP00000090467.1
  ENSRNOP00000091970.1
GenBank Protein O54715 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113973   ⟸   NM_031785
- Peptide Label: precursor
- UniProtKB: O54715 (UniProtKB/Swiss-Prot),   Q6IRF8 (UniProtKB/TrEMBL),   A6KRR4 (UniProtKB/TrEMBL),   A0A0G2JVL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069530   ⟸   ENSRNOT00000081914
RefSeq Acc Id: ENSRNOP00000090467   ⟸   ENSRNOT00000113494
RefSeq Acc Id: ENSRNOP00000091970   ⟸   ENSRNOT00000117428
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54715-F1-model_v2 AlphaFold O54715 1-463 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702045
Promoter ID:EPDNEW_R12569
Type:multiple initiation site
Name:Atp6ap1_1
Description:ATPase H+ transporting accessory protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,415,067 - 156,415,127EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620423 AgrOrtholog
BioCyc Gene G2FUF-630 BioCyc
Ensembl Genes ENSRNOG00000054352 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081914 ENTREZGENE
  ENSRNOT00000081914.2 UniProtKB/TrEMBL
  ENSRNOT00000113494.1 UniProtKB/TrEMBL
  ENSRNOT00000117428.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099117 IMAGE-MGC_LOAD
InterPro ATPase_V1-cplx_s1su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VAS1/VOA1_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VAS1_LD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83615 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91619 IMAGE-MGC_LOAD
NCBI Gene 83615 ENTREZGENE
PANTHER PTHR12471 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-TYPE PROTON ATPASE SUBUNIT S1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ac45-VOA1_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-synt_S1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp6ap1 PhenoGen
RatGTEx ENSRNOG00000054352 RatGTEx
UniProt A0A0G2JVL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AD46_RAT UniProtKB/TrEMBL
  A0A8I6ADV4_RAT UniProtKB/TrEMBL
  A6KRR3_RAT UniProtKB/TrEMBL
  A6KRR4 ENTREZGENE, UniProtKB/TrEMBL
  O54715 ENTREZGENE
  Q6IRF8 ENTREZGENE
  VAS1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6IRF8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Atp6ap1  ATPase H+ transporting accessory protein 1  Atp6ap1  ATPase, H+ transporting, lysosomal accessory protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Atp6ap1  ATPase, H+ transporting, lysosomal accessory protein 1    ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1  Name updated 1299863 APPROVED
2004-09-10 Atp6ap1  ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1  Atp6s1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Atp6s1  ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease increased antibody response to human homolog is associated with immune mediated response to tumors and tumor destruction 634610