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Gene: Adam17 (ADAM metallopeptidase domain 17) Rattus norvegicus
Symbol: Adam17
Name: ADAM metallopeptidase domain 17
RGD ID: 620404
Description: Predicted to have PDZ domain binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of signal transduction; and response to antineoplastic agent. Localizes to several cellular components, including apical part of cell; cell surface; and cytoplasmic vesicle. Predicted to colocalize with cell-cell junction; focal adhesion; and ruffle membrane. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; Notch signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM 17; disintegrin and metalloproteinase domain-containing protein 17; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
Homo sapiens (human) : ADAM17 (ADAM metallopeptidase domain 17)  HGNC  Alliance
Mus musculus (house mouse) : Adam17 (a disintegrin and metallopeptidase domain 17)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adam17 (ADAM metallopeptidase domain 17)
Pan paniscus (bonobo/pygmy chimpanzee) : ADAM17 (ADAM metallopeptidase domain 17)
Canis lupus familiaris (dog) : ADAM17 (ADAM metallopeptidase domain 17)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adam17 (ADAM metallopeptidase domain 17)
Sus scrofa (pig) : ADAM17 (ADAM metallopeptidase domain 17)
Chlorocebus sabaeus (African green monkey) : ADAM17 (ADAM metallopeptidase domain 17)
Heterocephalus glaber (naked mole-rat) : Adam17 (ADAM metallopeptidase domain 17)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Adam17
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620404
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.