Dctn1 (dynactin subunit 1) - Rat Genome Database

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Gene: Dctn1 (dynactin subunit 1) Rattus norvegicus
Analyze
Symbol: Dctn1
Name: dynactin subunit 1
RGD ID: 62038
Description: Enables identical protein binding activity; microtubule binding activity; and molecular adaptor activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; plasma membrane bounded cell projection organization; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within melanosome transport. Part of cytoplasmic dynein complex. Biomarker of synucleinopathy. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1); PARTICIPATES IN mitochondria transport pathway; N-cadherin signaling pathway; Huntington's disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 150 kDa dynein-associated polypeptide; DAP-150; DP-150; dynactin 1; p150-glued
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,671,024 - 115,703,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,661,638 - 115,703,815 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,160,751 - 121,180,548 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04116,935,930 - 116,955,727 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04115,550,197 - 115,569,992 (+)NCBIRnor_WKY
Rnor_6.04114,876,770 - 114,896,567 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,876,770 - 114,896,573 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,465,836 - 179,485,633 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,390,323 - 117,410,119 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,634,803 - 117,654,601 (+)NCBI
Celera4104,678,158 - 104,697,955 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IBA)
cell cortex  (IEA,ISO,ISS)
cell leading edge  (IEA,ISO)
centriolar subdistal appendage  (IEA,ISO)
centriole  (IEA,ISO,ISS)
centrosome  (IEA,ISO,ISS)
ciliary basal body  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoplasmic dynein complex  (IDA)
cytosol  (IEA)
dynein complex  (IEA)
intercellular bridge  (IEA,ISO)
kinetochore  (IBA,IEA,ISO,ISS)
microtubule  (IEA,ISO,ISS)
microtubule associated complex  (IBA,ISO)
microtubule cytoskeleton  (ISO)
microtubule plus-end  (IEA,ISO,ISS)
mitotic spindle  (IEA,ISO)
neuron projection  (IEA,ISO)
neuronal cell body  (IEA,ISO)
nuclear envelope  (IEA,ISO,ISS)
protein-containing complex  (ISO)
retromer complex  (IEA,ISO)
spindle  (ISO,ISS)
spindle pole  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin. Chevalier-Larsen ES, etal., Hum Mol Genet. 2008 Jul 1;17(13):1946-55. Epub 2008 Mar 25.
2. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. Chung CY, etal., J Neurosci. 2009 Mar 18;29(11):3365-73. doi: 10.1523/JNEUROSCI.5427-08.2009.
3. Human DCTN1: genomic structure and evaluation as a candidate for Alstrom syndrome. Collin GB, etal., Genomics 1998 Nov 1;53(3):359-64.
4. DCTN1 mutations in Perry syndrome. Farrer MJ, etal., Nat Genet. 2009 Feb;41(2):163-5. Epub 2009 Jan 11.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Conformational Flexibility of p150Glued(1-191) Subunit of Dynactin Assembled with Microtubules. Guo C, etal., Biophys J. 2019 Sep 3;117(5):938-949. doi: 10.1016/j.bpj.2019.07.036. Epub 2019 Jul 30.
7. Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued. Holzbaur EL, etal., Nature 1991 Jun 13;351(6327):579-83.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Autonomic failures in Perry syndrome with DCTN1 mutation. Ohshima S, etal., Parkinsonism Relat Disord. 2010 Nov;16(9):612-4. Epub 2010 Aug 11.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Dynactin. Schroer TA, Annu Rev Cell Dev Biol. 2004;20:759-79.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport. Tripathy SK, etal., Nat Cell Biol. 2014 Dec;16(12):1192-201. doi: 10.1038/ncb3063. Epub 2014 Nov 24.
23. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Waterman-Storer CM, etal., Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1634-8.
Additional References at PubMed
PMID:14718566   PMID:16505168   PMID:16954346   PMID:17139249   PMID:17600711   PMID:18305234   PMID:18331715   PMID:19468067   PMID:19619496   PMID:19946888   PMID:20679239   PMID:20719959  
PMID:21399614   PMID:21525035   PMID:21911489   PMID:22275436   PMID:22327364   PMID:22728878   PMID:22777741   PMID:22871113   PMID:23027904   PMID:23213374   PMID:23386061   PMID:23509069  
PMID:23523350   PMID:23874158   PMID:23985322   PMID:24625528   PMID:25774020   PMID:26296893   PMID:26765568   PMID:26972003   PMID:28000671   PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Dctn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24115,671,024 - 115,703,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,661,638 - 115,703,815 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,160,751 - 121,180,548 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04116,935,930 - 116,955,727 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04115,550,197 - 115,569,992 (+)NCBIRnor_WKY
Rnor_6.04114,876,770 - 114,896,567 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,876,770 - 114,896,573 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,465,836 - 179,485,633 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,390,323 - 117,410,119 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,634,803 - 117,654,601 (+)NCBI
Celera4104,678,158 - 104,697,955 (+)NCBICelera
Cytogenetic Map4q34NCBI
DCTN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,361,155 - 74,391,866 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl274,361,154 - 74,392,087 (-)EnsemblGRCh38hg38GRCh38
GRCh37274,588,282 - 74,618,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,441,790 - 74,461,472 (-)NCBINCBI36Build 36hg18NCBI36
Celera274,419,471 - 74,450,404 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,324,594 - 74,355,527 (-)NCBIHuRef
CHM1_1274,517,708 - 74,548,641 (-)NCBICHM1_1
T2T-CHM13v2.0274,369,715 - 74,400,439 (-)NCBIT2T-CHM13v2.0
Dctn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,142,702 - 83,177,103 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,142,902 - 83,177,099 (+)EnsemblGRCm39 Ensembl
GRCm38683,165,909 - 83,200,118 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,165,920 - 83,200,117 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,129,583 - 83,150,112 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,145,512 - 83,165,628 (+)NCBIMGSCv36mm8
Celera685,162,534 - 85,183,062 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Dctn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,392,812 - 11,413,140 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,362,240 - 11,413,140 (+)NCBIChiLan1.0ChiLan1.0
DCTN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12A51,999,894 - 52,032,281 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,428,060 - 74,458,574 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,934,408 - 75,965,012 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,934,752 - 75,953,296 (-)Ensemblpanpan1.1panPan2
DCTN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,728,096 - 48,759,187 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,728,270 - 48,759,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,369,513 - 48,400,598 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,587,461 - 49,618,608 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,599,639 - 49,618,608 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,604,305 - 48,635,379 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,670,770 - 48,701,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,229,002 - 49,260,088 (+)NCBIUU_Cfam_GSD_1.0
Dctn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,105,790 - 10,136,346 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556601,548 - 621,609 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936556601,550 - 632,321 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCTN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,643,247 - 68,673,604 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,642,562 - 68,673,605 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,751,232 - 71,779,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCTN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,885,483 - 32,916,491 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,885,623 - 32,916,145 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,251,156 - 79,282,059 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dctn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,115,561 - 29,137,276 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474929,105,310 - 29,135,124 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dctn1
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000068102
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat

Markers in Region
MARC_6321-6322:992007238:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,703,010 - 115,703,422 (+)MAPPERmRatBN7.2
Rnor_6.04114,895,762 - 114,896,173NCBIRnor6.0
Rnor_5.04179,484,828 - 179,485,239UniSTSRnor5.0
RGSC_v3.44117,409,315 - 117,409,726UniSTSRGSC3.4
Celera4104,697,150 - 104,697,561UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 40 19 40 8 11 74 35 41 11 8
Low 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013312   ⟹   ENSRNOP00000013311
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,661,705 - 115,667,928 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000068102   ⟹   ENSRNOP00000059076
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,684,021 - 115,703,815 (+)Ensembl
Rnor_6.0 Ensembl4114,876,770 - 114,896,566 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078175   ⟹   ENSRNOP00000072880
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,684,021 - 115,703,815 (+)Ensembl
Rnor_6.0 Ensembl4114,876,833 - 114,896,573 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099116   ⟹   ENSRNOP00000080290
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,671,043 - 115,703,813 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099394   ⟹   ENSRNOP00000085656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,672,998 - 115,703,813 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100284   ⟹   ENSRNOP00000095934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,686,230 - 115,703,815 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107740   ⟹   ENSRNOP00000082429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,661,638 - 115,703,813 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110975   ⟹   ENSRNOP00000080377
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,689,749 - 115,703,815 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119334   ⟹   ENSRNOP00000094269
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,665,569 - 115,667,928 (+)Ensembl
RefSeq Acc Id: NM_024130   ⟹   NP_077044
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,684,021 - 115,703,824 (+)NCBI
Rnor_6.04114,876,770 - 114,896,567 (+)NCBI
Rnor_5.04179,465,836 - 179,485,633 (+)NCBI
RGSC_v3.44117,390,323 - 117,410,119 (+)RGD
Celera4104,678,158 - 104,697,955 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107180   ⟹   XP_038963108
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,686,678 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107181   ⟹   XP_038963109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,686,678 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107182   ⟹   XP_038963110
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,684,032 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107183   ⟹   XP_038963111
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,671,024 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107184   ⟹   XP_038963112
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,671,617 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107185   ⟹   XP_038963113
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,684,033 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107186   ⟹   XP_038963114
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,671,024 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107187   ⟹   XP_038963115
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,671,024 - 115,703,819 (+)NCBI
RefSeq Acc Id: XM_039107188   ⟹   XP_038963116
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24115,671,024 - 115,703,819 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_077044   ⟸   NM_024130
- UniProtKB: A0A0G2K428 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072880   ⟸   ENSRNOT00000078175
RefSeq Acc Id: ENSRNOP00000059076   ⟸   ENSRNOT00000068102
RefSeq Acc Id: XP_038963111   ⟸   XM_039107183
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038963114   ⟸   XM_039107186
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038963115   ⟸   XM_039107187
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038963116   ⟸   XM_039107188
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038963112   ⟸   XM_039107184
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038963110   ⟸   XM_039107182
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038963113   ⟸   XM_039107185
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038963108   ⟸   XM_039107180
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038963109   ⟸   XM_039107181
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000013311   ⟸   ENSRNOT00000013312
RefSeq Acc Id: ENSRNOP00000082429   ⟸   ENSRNOT00000107740
RefSeq Acc Id: ENSRNOP00000095934   ⟸   ENSRNOT00000100284
RefSeq Acc Id: ENSRNOP00000085656   ⟸   ENSRNOT00000099394
RefSeq Acc Id: ENSRNOP00000080377   ⟸   ENSRNOT00000110975
RefSeq Acc Id: ENSRNOP00000080290   ⟸   ENSRNOT00000099116
RefSeq Acc Id: ENSRNOP00000094269   ⟸   ENSRNOT00000119334
Protein Domains
CAP-Gly   Dynein associated protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28023-F1-model_v2 AlphaFold P28023 1-1280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693174
Promoter ID:EPDNEW_R3699
Type:multiple initiation site
Name:Dctn1_1
Description:dynactin subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04114,876,778 - 114,876,838EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62038 AgrOrtholog
BioCyc Gene G2FUF-44016 BioCyc
Ensembl Genes ENSRNOG00000010048 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059076 ENTREZGENE
  ENSRNOP00000059076.3 UniProtKB/TrEMBL
  ENSRNOP00000072880 ENTREZGENE
  ENSRNOP00000072880.2 UniProtKB/TrEMBL
  ENSRNOP00000080290 ENTREZGENE
  ENSRNOP00000080290.1 UniProtKB/TrEMBL
  ENSRNOP00000080377 ENTREZGENE
  ENSRNOP00000080377.1 UniProtKB/TrEMBL
  ENSRNOP00000082429.1 UniProtKB/TrEMBL
  ENSRNOP00000085656.1 UniProtKB/TrEMBL
  ENSRNOP00000094269.1 UniProtKB/TrEMBL
  ENSRNOP00000095934.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068102 ENTREZGENE
  ENSRNOT00000068102.4 UniProtKB/TrEMBL
  ENSRNOT00000078175 ENTREZGENE
  ENSRNOT00000078175.2 UniProtKB/TrEMBL
  ENSRNOT00000099116 ENTREZGENE
  ENSRNOT00000099116.1 UniProtKB/TrEMBL
  ENSRNOT00000099394.1 UniProtKB/TrEMBL
  ENSRNOT00000100284.1 UniProtKB/TrEMBL
  ENSRNOT00000107740.1 UniProtKB/TrEMBL
  ENSRNOT00000110975 ENTREZGENE
  ENSRNOT00000110975.1 UniProtKB/TrEMBL
  ENSRNOT00000119334.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CAP-Gly_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP-Gly_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4639 UniProtKB/TrEMBL
  Dynactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29167 UniProtKB/Swiss-Prot
NCBI Gene 29167 ENTREZGENE
PANTHER CHROMOSOME A3 C2ORF81 HOMOLOG UniProtKB/TrEMBL
  DYNACTIN 1-RELATED MICROTUBULE-BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DYNACTIN SUBUNIT 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR34438 UniProtKB/TrEMBL
Pfam CAP_GLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4639 UniProtKB/TrEMBL
  Dynactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dctn1 PhenoGen
PROSITE CAP_GLY_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAP_GLY_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CAP_GLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF74924 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217509
UniProt A0A0G2K428 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPT7_RAT UniProtKB/TrEMBL
  A0A8I5ZQJ2_RAT UniProtKB/TrEMBL
  A0A8I5ZUH0_RAT UniProtKB/TrEMBL
  A0A8I6A3U0_RAT UniProtKB/TrEMBL
  A0A8I6AQ46_RAT UniProtKB/TrEMBL
  A0A8I6ASG8_RAT UniProtKB/TrEMBL
  D4A8U7_RAT UniProtKB/TrEMBL
  DCTN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V7A8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Dctn1  dynactin subunit 1  Dctn1  dynactin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dctn1  dynactin 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog may be a candidate gene for neuromuscular diseases Alstrom syndrome, limb-girdle muscle dystrophpy, and Miyoshi myopathy 728226