Gls2 (glutaminase 2) - Rat Genome Database

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Gene: Gls2 (glutaminase 2) Rattus norvegicus
Analyze
Symbol: Gls2
Name: glutaminase 2
RGD ID: 620359
Description: Predicted to have glutaminase activity. Predicted to be involved in glutamine family amino acid metabolic process; reactive oxygen species metabolic process; and regulation of apoptotic process. Predicted to localize to mitochondrion. Orthologous to human GLS2 (glutaminase 2); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ga; GLS; glutaminase 2 (liver, mitochondrial); glutaminase liver isoform, mitochondrial; glutaminase variant 2; glutaminase variant 3; glutaminase variant 4; glutaminase variant 5; glutaminase variant 6; glutaminase variant 8; L-glutaminase; L-glutamine amidohydrolase; liver mitochondrial glutaminase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27617,252 - 633,424 (+)NCBI
Rnor_6.0 Ensembl72,605,719 - 2,621,852 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.072,605,679 - 2,621,853 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.072,584,594 - 2,600,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,484,397 - 1,495,283 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,484,396 - 1,495,283 (+)NCBI
Celera7495,890 - 511,971 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clomipramine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
imipramine  (EXP)
ketoconazole  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18614015   PMID:20351271   PMID:22679499   PMID:24270810   PMID:25065305   PMID:25297978   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Gls2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27617,252 - 633,424 (+)NCBI
Rnor_6.0 Ensembl72,605,719 - 2,621,852 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.072,605,679 - 2,621,853 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.072,584,594 - 2,600,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,484,397 - 1,495,283 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,484,396 - 1,495,283 (+)NCBI
Celera7495,890 - 511,971 (+)NCBICelera
Cytogenetic Map7q11NCBI
GLS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1256,470,944 - 56,488,414 (-)EnsemblGRCh38hg38GRCh38
GRCh381256,470,952 - 56,488,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,864,736 - 56,881,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,151,003 - 55,168,448 (-)NCBINCBI36hg18NCBI36
Celera1256,518,105 - 56,535,542 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1253,903,771 - 53,921,163 (-)NCBIHuRef
CHM1_11256,832,389 - 56,849,813 (-)NCBICHM1_1
Gls2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,030,504 - 128,045,873 (+)NCBIGRCm39mm39
GRCm39 Ensembl10128,030,326 - 128,045,873 (+)Ensembl
GRCm3810128,194,635 - 128,210,004 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,194,457 - 128,210,004 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,631,691 - 127,647,060 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610127,597,639 - 127,612,883 (+)NCBImm8
Celera10130,589,515 - 130,604,841 (+)NCBICelera
Cytogenetic Map10D3NCBI
Gls2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554584,050,674 - 4,065,322 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554584,055,088 - 4,065,307 (-)NCBIChiLan1.0ChiLan1.0
GLS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11232,678,814 - 32,696,694 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,678,814 - 32,696,694 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,426,264 - 32,443,690 (+)NCBIMhudiblu_PPA_v0panPan3
GLS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110722,105 - 737,857 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10722,202 - 737,753 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10785,318 - 800,983 (-)NCBI
ROS_Cfam_1.010731,085 - 746,763 (-)NCBI
UMICH_Zoey_3.110708,149 - 723,814 (-)NCBI
UNSW_CanFamBas_1.010951,254 - 966,922 (-)NCBI
UU_Cfam_GSD_1.0101,074,979 - 1,090,642 (-)NCBI
Gls2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,028,150 - 58,044,275 (+)NCBI
SpeTri2.0NW_004936646825,957 - 842,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,806,406 - 21,820,001 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,806,405 - 21,820,001 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,529,902 - 23,543,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GLS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,430,345 - 52,448,572 (-)NCBI
ChlSab1.1 Ensembl1152,427,919 - 52,448,463 (-)Ensembl
Vero_WHO_p1.0NW_023666037193,533,565 - 193,552,090 (+)NCBI
Gls2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480211,545,196 - 11,559,851 (+)NCBI

Position Markers
RH130821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27633,186 - 633,377 (+)MAPPER
Rnor_6.072,621,616 - 2,621,806NCBIRnor6.0
Rnor_5.072,600,492 - 2,600,682UniSTSRnor5.0
RGSC_v3.471,495,050 - 1,495,240UniSTSRGSC3.4
Celera7511,734 - 511,924UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:48
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000018737
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 27 27 23 11
Low 3 43 29 14 19 14 8 11 51 35 41 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_138904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR610318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L76175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018737   ⟹   ENSRNOP00000018737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl72,605,719 - 2,621,852 (+)Ensembl
RefSeq Acc Id: NM_001270786   ⟹   NP_001257715
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,288 - 633,424 (+)NCBI
Rnor_6.072,605,719 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Celera7495,890 - 511,971 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270787   ⟹   NP_001257716
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,288 - 633,424 (+)NCBI
Rnor_6.072,605,719 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Celera7495,890 - 511,971 (+)NCBI
Sequence:
RefSeq Acc Id: NM_138904   ⟹   NP_620259
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27622,534 - 633,424 (+)NCBI
Rnor_6.072,610,963 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
RGSC_v3.471,484,397 - 1,495,283 (+)RGD
Celera7501,081 - 511,971 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240728   ⟹   XP_006240790
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,484 - 633,157 (+)NCBI
Rnor_6.072,605,679 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240730   ⟹   XP_006240792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,559 - 633,424 (+)NCBI
Rnor_6.072,605,991 - 2,621,853 (+)NCBI
Rnor_5.072,584,594 - 2,600,729 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594652   ⟹   XP_017450141
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,252 - 633,424 (+)NCBI
Rnor_6.072,605,679 - 2,621,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594653   ⟹   XP_017450142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,568 - 633,424 (+)NCBI
Rnor_6.072,606,053 - 2,621,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594654   ⟹   XP_017450143
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,612,305 - 2,621,853 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078385   ⟹   XP_038934313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,746 - 633,424 (+)NCBI
RefSeq Acc Id: XM_039078386   ⟹   XP_038934314
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,568 - 633,424 (+)NCBI
RefSeq Acc Id: XM_039078387   ⟹   XP_038934315
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,570 - 633,424 (+)NCBI
RefSeq Acc Id: XM_039078388   ⟹   XP_038934316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27617,933 - 633,424 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_620259   ⟸   NM_138904
- Peptide Label: isoform 3
- UniProtKB: P28492 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257716   ⟸   NM_001270787
- Peptide Label: isoform 2
- UniProtKB: P28492 (UniProtKB/Swiss-Prot),   A0A0H2UHL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257715   ⟸   NM_001270786
- Peptide Label: isoform 1
- UniProtKB: P28492 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006240790   ⟸   XM_006240728
- Peptide Label: isoform X1
- UniProtKB: A0A0S2EF05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240792   ⟸   XM_006240730
- Peptide Label: isoform X5
- UniProtKB: P28492 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450141   ⟸   XM_017594652
- Peptide Label: isoform X2
- UniProtKB: A0A0S2EF12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450142   ⟸   XM_017594653
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017450143   ⟸   XM_017594654
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000018737   ⟸   ENSRNOT00000018737
RefSeq Acc Id: XP_038934314   ⟸   XM_039078386
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038934315   ⟸   XM_039078387
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038934313   ⟸   XM_039078385
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038934316   ⟸   XM_039078388
- Peptide Label: isoform X6
Protein Domains
ANK_REP_REGION

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694925
Promoter ID:EPDNEW_R5450
Type:initiation region
Name:Gls2_1
Description:glutaminase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5451  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,605,688 - 2,605,748EPDNEW
RGD ID:13694926
Promoter ID:EPDNEW_R5451
Type:multiple initiation site
Name:Gls2_2
Description:glutaminase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5450  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,605,879 - 2,605,939EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620359 AgrOrtholog
Ensembl Genes ENSRNOG00000031612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018737 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018737 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.710.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7326030 IMAGE-MGC_LOAD
  IMAGE:7369495 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-lactam/transpept-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase_EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192268 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108591 IMAGE-MGC_LOAD
  MGC:124940 IMAGE-MGC_LOAD
NCBI Gene 192268 ENTREZGENE
PANTHER PTHR12544 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaminase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gls2 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs Gln_ase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHL2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2EF05 ENTREZGENE, UniProtKB/TrEMBL
  A0A0S2EF12 ENTREZGENE, UniProtKB/TrEMBL
  GLSL_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3MHS6 UniProtKB/Swiss-Prot
  Q5FVU0 UniProtKB/Swiss-Prot
  Q64606 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Gls2  glutaminase 2  Gls2  glutaminase 2 (liver, mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gls2  glutaminase 2 (liver, mitochondrial)  Ga  liver mitochondrial glutaminase  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ga  liver mitochondrial glutaminase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the mitochondrial matrix, possibly in loose association with the inner membrane 728635
gene_regulation expressed only after birth and restricted to a small periportal population of hepatocytes 728635