Ppat (phosphoribosyl pyrophosphate amidotransferase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ppat (phosphoribosyl pyrophosphate amidotransferase) Rattus norvegicus
Analyze
Symbol: Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
RGD ID: 620237
Description: Enables amidophosphoribosyltransferase activity and identical protein binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; glutamine catabolic process; and lactation. Biomarker of hepatocellular carcinoma and renal cell carcinoma. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amidophosphoribosyltransferase; Atase; glutamine phosphoribosylpyrophosphate amidotransferase; GPAT; MGC93251
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,570,010 - 31,604,410 (+)NCBIGRCr8
mRatBN7.21431,215,741 - 31,250,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,593,072 - 31,627,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,901,403 - 32,935,708 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,386,077 - 31,420,375 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,580,541 - 33,614,919 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,580,541 - 33,614,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01433,371,454 - 33,405,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,509,364 - 33,543,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,509,363 - 33,543,743 (+)NCBI
Celera1430,529,492 - 30,563,868 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dioxygen  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
glutathione  (EXP)
ivermectin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorone  (EXP)
pinosylvin  (ISO)
pirinixic acid  (EXP,ISO)
rotenone  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trans-pinosylvin  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes. Beardsley S, etal., Biochem J. 1988 Mar 1;250(2):395-9.
2. Pediatric neurological syndromes and inborn errors of purine metabolism. Camici M, etal., Neurochem Int. 2010 Feb;56(3):367-78. Epub 2009 Dec 11.
3. Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma. Denton JE, etal., Life Sci. 1982 Mar 29;30(13):1073-80.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Increased rate of de novo purine synthesis and its mechanism in regenerating rat liver. Itakura M, etal., Am J Physiol. 1986 Nov;251(5 Pt 1):G585-90.
7. Malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) increases liver de novo purine synthesis and amidophosphoribosyltransferase activity. Itakura M, etal., J Pharmacol Exp Ther. 1986 Jun;237(3):794-8.
8. Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes. Iwahana H, etal., Biochim Biophys Acta 1995 Apr 26;1261(3):369-80.
9. An end-trimming method to amplify adjacent cDNA fragments by PCR. Iwahana H, etal., Biotechniques 1994 Jan;16(1):94-8.
10. Molecular cloning of rat amidophosphoribosyltransferase. Iwahana H, etal., J Biol Chem 1993 Apr 5;268(10):7225-37.
11. Renal hypertrophy in experimental diabetes. The activity of the 'de novo' and salvage pathways of purine synthesis. Kunjara S, etal., Biochem J. 1988 Feb 1;249(3):911-4.
12. Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues. Natsumeda Y, etal., Cancer Res. 1984 Jun;44(6):2475-9.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. Glutamine-phosphoribosylpyrophosphate amidotransferase (amidophosphoribosyltransferase, EC 2.4.2.14) activity in normal, differentiating, and neoplastic kidney. Prajda N, etal., Cancer Res. 1979 Oct;39(10):3909-14.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Increased de novo purine synthesis by insulin through selective enzyme induction in primary cultured rat hepatocytes. Tsuchiya M, etal., Am J Physiol. 1990 May;258(5 Pt 1):C841-8.
20. Rat liver glutamine 5-phosphoribosyl-1-pyrophosphate amidotransferase [EC 2.4.2.14]. Purification and properties. Tsuda M, etal., J Biochem. 1979 May;85(5):1347-54.
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Ppat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,570,010 - 31,604,410 (+)NCBIGRCr8
mRatBN7.21431,215,741 - 31,250,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1431,593,072 - 31,627,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01432,901,403 - 32,935,708 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01431,386,077 - 31,420,375 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01433,580,541 - 33,614,919 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,580,541 - 33,614,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01433,371,454 - 33,405,854 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41433,509,364 - 33,543,743 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11433,509,363 - 33,543,743 (+)NCBI
Celera1430,529,492 - 30,563,868 (+)NCBICelera
Cytogenetic Map14p11NCBI
PPAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,393,362 - 56,435,615 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,393,362 - 56,435,615 (-)EnsemblGRCh38hg38GRCh38
GRCh37457,259,528 - 57,301,781 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36456,954,285 - 56,996,602 (-)NCBINCBI36Build 36hg18NCBI36
Build 34457,100,458 - 57,142,773NCBI
Celera454,765,911 - 54,808,216 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef453,213,663 - 53,255,937 (-)NCBIHuRef
CHM1_1457,294,641 - 57,336,915 (-)NCBICHM1_1
T2T-CHM13v2.0459,881,364 - 59,923,605 (-)NCBIT2T-CHM13v2.0
Ppat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39577,061,096 - 77,099,425 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl577,061,096 - 77,099,425 (-)EnsemblGRCm39 Ensembl
GRCm38576,913,249 - 76,951,578 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl576,913,249 - 76,951,578 (-)EnsemblGRCm38mm10GRCm38
MGSCv37577,342,274 - 77,380,603 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36577,987,920 - 78,026,353 (-)NCBIMGSCv36mm8
Celera574,190,125 - 74,219,445 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.45NCBI
Ppat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,574,407 - 14,607,416 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544714,552,846 - 14,607,416 (+)NCBIChiLan1.0ChiLan1.0
PPAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2373,347,602 - 73,390,036 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,553,280 - 73,595,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0467,491,407 - 67,533,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1474,059,967 - 74,102,002 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl474,059,966 - 74,102,002 (+)Ensemblpanpan1.1panPan2
PPAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11348,618,460 - 48,656,164 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1348,620,714 - 48,655,780 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1348,509,175 - 48,546,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01349,233,071 - 49,270,374 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,207,789 - 49,270,306 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11348,904,984 - 48,942,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,433,951 - 48,471,441 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,380,077 - 49,417,387 (-)NCBIUU_Cfam_GSD_1.0
Ppat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,649,519 - 27,693,748 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648218,606,124 - 18,648,681 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648218,606,124 - 18,648,989 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl855,654,377 - 55,701,077 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1855,652,194 - 55,701,077 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,820,418 - 57,896,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1712,201,434 - 12,242,418 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl712,191,784 - 12,243,488 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606612,869,154 - 12,912,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476112,980,513 - 13,019,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476112,980,508 - 13,017,818 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppat
155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1313
Count of miRNA genes:350
Interacting mature miRNAs:483
Transcripts:ENSRNOT00000002905
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143076702539153750Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat

Markers in Region
RH141568  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,249,660 - 31,249,860 (+)MAPPERmRatBN7.2
Rnor_6.01433,614,458 - 33,614,657NCBIRnor6.0
Rnor_5.01433,405,371 - 33,405,570UniSTSRnor5.0
RGSC_v3.41433,543,282 - 33,543,481UniSTSRGSC3.4
Celera1430,563,407 - 30,563,606UniSTS
RH 3.4 Map14382.98UniSTS
Cytogenetic Map14p11UniSTS
PMC312758P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,216,183 - 31,216,360 (+)MAPPERmRatBN7.2
Rnor_6.01433,580,984 - 33,581,160NCBIRnor6.0
Rnor_5.01433,371,897 - 33,372,073UniSTSRnor5.0
RGSC_v3.41433,509,807 - 33,509,983UniSTSRGSC3.4
Celera1430,529,935 - 30,530,111UniSTS
Cytogenetic Map14p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 10 74 35 35 11 8
Low 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002905   ⟹   ENSRNOP00000002905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)Ensembl
Rnor_6.0 Ensembl1433,580,541 - 33,614,919 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100016   ⟹   ENSRNOP00000087004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1431,216,165 - 31,250,144 (+)Ensembl
RefSeq Acc Id: NM_057198   ⟹   NP_476546
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,570,010 - 31,604,388 (+)NCBI
mRatBN7.21431,215,741 - 31,250,122 (+)NCBI
Rnor_6.01433,580,541 - 33,614,919 (+)NCBI
Rnor_5.01433,371,454 - 33,405,854 (+)NCBI
RGSC_v3.41433,509,364 - 33,543,743 (+)RGD
Celera1430,529,492 - 30,563,868 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091566   ⟹   XP_038947494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,570,565 - 31,604,410 (+)NCBI
mRatBN7.21431,216,234 - 31,250,144 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_476546   ⟸   NM_057198
- UniProtKB: P35433 (UniProtKB/Swiss-Prot),   A6JCX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002905   ⟸   ENSRNOT00000002905
RefSeq Acc Id: XP_038947494   ⟸   XM_039091566
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2E8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087004   ⟸   ENSRNOT00000100016
Protein Domains
Glutamine amidotransferase type-2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35433-F1-model_v2 AlphaFold P35433 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699271
Promoter ID:EPDNEW_R9796
Type:single initiation site
Name:Ppat_1
Description:phosphoribosyl pyrophosphate amidotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9798  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01433,580,527 - 33,580,587EPDNEW
RGD ID:13699273
Promoter ID:EPDNEW_R9798
Type:initiation region
Name:Ppat_2
Description:phosphoribosyl pyrophosphate amidotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9796  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01433,580,995 - 33,581,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620237 AgrOrtholog
BioCyc Gene G2FUF-15963 BioCyc
Ensembl Genes ENSRNOG00000002128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005127 UniProtKB/Swiss-Prot
  ENSRNOG00060017990 UniProtKB/Swiss-Prot
  ENSRNOG00065020270 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002905 ENTREZGENE
  ENSRNOT00000002905.4 UniProtKB/Swiss-Prot
  ENSRNOT00000100016.1 UniProtKB/TrEMBL
  ENSRNOT00055008218 UniProtKB/Swiss-Prot
  ENSRNOT00060030904 UniProtKB/Swiss-Prot
  ENSRNOT00065034250 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189259 IMAGE-MGC_LOAD
InterPro GATase_2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ntn_hydrolases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PurF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PurF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117544 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93251 IMAGE-MGC_LOAD
NCBI Gene 117544 ENTREZGENE
PANTHER AMIDOPHOSPHORIBOSYLTRANSFERASE UniProtKB/Swiss-Prot
  AMIDOPHOSPHORIBOSYLTRANSFERASE UniProtKB/Swiss-Prot
  AMIDOPHOSPHORIBOSYLTRANSFERASE UniProtKB/TrEMBL
  AMIDOPHOSPHORIBOSYLTRANSFERASE UniProtKB/TrEMBL
Pfam GATase_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PPAT RGD
PhenoGen Ppat PhenoGen
PIRSF Amd_phspho_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GATASE_TYPE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PUR_PYR_PR_TRANSFER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002128 RatGTEx
  ENSRNOG00055005127 RatGTEx
  ENSRNOG00060017990 RatGTEx
  ENSRNOG00065020270 RatGTEx
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2E8 ENTREZGENE, UniProtKB/TrEMBL
  A6JCX0 ENTREZGENE, UniProtKB/TrEMBL
  P35433 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ppat  phosphoribosyl pyrophosphate amidotransferase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ppat  phosphoribosyl pyrophosphate amidotransferase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression ubiquitously expressed; enriched in brain, heart, liver, and stomach 633710
gene_protein 517 amino acids; 57.4 kDa 633710