Creb1 (cAMP responsive element binding protein 1) - Rat Genome Database

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Gene: Creb1 (cAMP responsive element binding protein 1) Rattus norvegicus
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Symbol: Creb1
Name: cAMP responsive element binding protein 1
RGD ID: 620218
Description: Enables several functions, including Hsp70 protein binding activity; arrestin family protein binding activity; and histone acetyltransferase binding activity. Involved in several processes, including learning or memory; regulation of apoptotic process; and regulation of gene expression. Located in axon; mitochondrial matrix; and nucleus. Part of chromatin and transcription regulator complex. Used to study several diseases, including alcohol use disorder; cerebrovascular disease (multiple); cocaine abuse; obsessive-compulsive disorder; and substance dependence (multiple). Biomarker of several diseases, including Huntington's disease; alcohol dependence; alcohol use disorder; amphetamine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; adenosine signaling pathway; follicle-stimulating hormone signaling pathway; INTERACTS WITH (R)-adrenaline; (R)-lipoic acid; (R)-salsolinol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP response element binding protein 1; cAMP-responsive element-binding protein 1; Creb; CREB-1; cyclic AMP-responsive element-binding protein 1; Y protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Memor11
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,397,333 - 73,466,339 (+)NCBIGRCr8
mRatBN7.2965,903,511 - 65,972,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,903,547 - 65,970,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,423,783 - 74,487,123 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,554,383 - 79,617,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,958,854 - 78,022,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,229,753 - 71,298,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,230,108 - 71,293,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,277,171 - 71,346,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,170,785 - 63,234,727 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,317,766 - 63,381,709 (+)NCBI
Celera963,310,784 - 63,374,139 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (IDA,IEP,ISO)
alcohol use disorder  (IDA,IEP)
amnestic disorder  (IDA,ISO)
amphetamine abuse  (IEP,ISO)
Angiomatoid Fibrous Histiocytoma  (ISO)
anxiety disorder  (IEP,ISO)
autism spectrum disorder  (IDA)
brain ischemia  (IEP)
cocaine abuse  (IDA,ISO)
cocaine dependence  (IDA,IEP,ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (IDA)
depressive disorder  (IDA,IEP)
Diabetic Nephropathies  (IEP)
dilated cardiomyopathy  (ISO)
drug dependence  (IEP)
Experimental Liver Cirrhosis  (IMP)
genetic disease  (ISO)
heroin dependence  (IDA,ISO)
holoprosencephaly  (ISO)
Huntington's disease  (IEP,ISO)
hypertension  (IDA)
hypoglycemia  (ISO)
Memory Disorders  (IDA,IEP,ISO)
middle cerebral artery infarction  (IDA)
morphine dependence  (IDA,IEP,ISO)
morphine withdrawal syndrome  (IDA)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
Neurodevelopmental Disorders  (ISO)
nicotine dependence  (ISO)
non-alcoholic fatty liver  (ISO)
obsessive-compulsive disorder  (IDA)
opioid abuse  (IEP,ISO)
Parkinson's disease  (ISO)
Pick's disease  (ISO)
Postoperative Cognitive Dysfunction  (IDA,ISO)
Prenatal Exposure Delayed Effects  (IDA)
primary pulmonary hypertension  (ISO)
Pulmonary Arterial Hypertension  (IDA)
schizophrenia  (ISO)
sciatic neuropathy  (IDA,IEP)
Spinal Cord Reperfusion Injury  (IEP)
steatotic liver disease  (ISO)
substance dependence  (IDA)
transient cerebral ischemia  (IDA)
vascular dementia  (IDA)
Ventricular Dysfunction, Right  (IEP)
withdrawal disorder  (IDA,IEP,IMP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dichloroethane  (ISO)
1,2-naphthoquinone  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP,ISO)
2-naphthylamine  (ISO)
23-epi-26-deoxyactein  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methoxynobiletin  (EXP)
3-methylcholanthrene  (EXP)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-aminobenzoic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
adenosine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP,ISO)
allethrin  (EXP)
alpha-pinene  (ISO)
alpha-Solamarine  (ISO)
alternariol  (ISO)
AM-251  (ISO)
amino acid  (ISO)
aminoguanidine  (ISO)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP,ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony(0)  (EXP,ISO)
antimycin A  (ISO)
apocynin  (ISO)
arachidonic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atenolol  (ISO)
atosiban  (ISO)
Atractylone  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
baclofen  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (ISO)
Bay-K-8644  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP)
beryllium difluoride  (ISO)
beryllium sulfate  (ISO)
beta-naphthoflavone  (ISO)
betaxolol  (EXP)
bicuculline  (EXP)
bilobalide  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bortezomib  (EXP)
brimonidine tartrate  (EXP)
bucladesine  (ISO)
buprenorphine  (EXP)
butan-1-ol  (EXP)
cabergoline  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
Calphostin C  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (EXP)
carbon dioxide  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
celecoxib  (ISO)
CGS-21680  (EXP)
chaetocin  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
cilostazol  (EXP,ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (EXP)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinous acid  (ISO)
diosmin  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP,ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxycycline  (ISO)
elemental selenium  (EXP,ISO)
emetine  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
Erythropoietin  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eticlopride(1+)  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
fisetin  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
furan  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
Geniposide  (ISO)
genistein  (EXP)
Ginkgolide C  (ISO)
ginsenoside Rg1  (ISO)
glucagon  (EXP)
glucose  (EXP,ISO)
glycidol  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
GW 1929  (ISO)
GYKI 52466  (EXP)
haloperidol  (EXP,ISO)
heroin  (EXP)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
icariin  (ISO)
imipramine  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
ketoconazole  (EXP,ISO)
KN-93  (EXP)
kojic acid  (ISO)
KT 5823  (ISO)
Kukoamine B  (ISO)
L-methionine  (ISO)
L-mimosine  (EXP)
lanthanum atom  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
liraglutide  (EXP)
lithium chloride  (EXP,ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
losartan  (EXP)
lovastatin  (EXP)
LY294002  (EXP,ISO)
lycopene  (EXP)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mecamylamine  (EXP)
melatonin  (ISO)
melittin  (ISO)
memantine  (EXP)
menadione  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methyl salicylate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
Mitotane  (ISO)
MK-2206  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP,ISO)
mycophenolic acid  (ISO)
N(6)-butyryl-cAMP  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimodipine  (ISO)
nitroprusside  (EXP)
Nonylphenol  (EXP,ISO)
o-anisidine  (ISO)
okadaic acid  (EXP,ISO)
olanzapine  (EXP)
oleuropein  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (EXP)
Panaxynol  (EXP)
papaverine  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
paxilline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
peroxynitrous acid  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phenylpropanolamine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium atom  (EXP)
potassium chloride  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prasugrel hydrochloride  (EXP)
prazosin  (EXP)
proanthocyanidin  (ISO)
progesterone  (EXP)
propranolol  (EXP)
prostaglandin E2  (ISO)
puerarin  (ISO)
pyrethrins  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (EXP,ISO)
Ro 31-8220  (EXP,ISO)
roflumilast  (EXP)
rolipram  (EXP)
rotenone  (EXP,ISO)
rubimaillin  (ISO)
ryanodine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
SB 203580  (EXP,ISO)
SB 415286  (EXP,ISO)
SCH 23390  (EXP)
SCH772984  (EXP)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
selumetinib  (ISO)
serotonin  (ISO)
sertraline  (EXP)
sevoflurane  (EXP,ISO)
sildenafil citrate  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
SKF 38393  (EXP)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
suramin  (ISO)
suvorexant  (ISO)
T-2 toxin  (EXP)
tacrine  (ISO)
tadalafil  (ISO)
tamibarotene  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (EXP)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (EXP)
tetrodotoxin  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
toluene  (ISO)
topiramate  (EXP)
tramadol  (EXP)
tranylcypromine  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (EXP,ISO)
umbelliferone  (EXP)
urethane  (ISO)
Ursonic acid  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (EXP)
wortmannin  (ISO)
Xamoterol  (ISO)
xanthohumol  (ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
XL147  (ISO)
Yessotoxin  (ISO)
zebularine  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (ISO)
cAMP-mediated signaling  (ISO)
cell differentiation  (IMP)
cellular response to fatty acid  (IEP)
cellular response to forskolin  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to insulin-like growth factor stimulus  (IEP)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to retinoic acid  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to zinc ion  (ISO)
chemotaxis to arachidonic acid  (IMP)
circadian rhythm  (IEP,ISO)
hormone secretion  (ISO)
lactation  (ISO)
lung epithelium development  (ISO)
lung saccule development  (ISO)
mammary gland development  (ISO)
memory  (IMP,ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of apoptotic process  (IMP,ISO)
negative regulation of gene expression  (IMP)
negative regulation of transcription by competitive promoter binding  (ISO)
osteoclast differentiation  (ISO)
pituitary gland development  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of cardiac muscle tissue development  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of fat cell differentiation  (ISO,ISS)
positive regulation of hormone secretion  (ISO)
positive regulation of lipid biosynthetic process  (ISO,ISS)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of membrane depolarization  (IMP)
positive regulation of multicellular organism growth  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (IMP)
protein stabilization  (ISO,ISS)
regulation of apoptotic process  (IDA)
regulation of cell size  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fibroblast proliferation  (IMP)
regulation of glial cell proliferation  (IMP)
regulation of testosterone biosynthetic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to activity  (IEP)
response to cocaine  (IEP)
response to dehydroepiandrosterone  (IEP)
response to erythropoietin  (IDA)
response to ethanol  (IDA,IEP)
response to glucagon  (ISO,ISS)
response to hypobaric hypoxia  (IEP)
response to hypoxia  (IEP)
response to inorganic substance  (ISO)
response to L-glutamate  (IEP)
response to nicotine  (IEP)
response to organic substance  (ISO)
response to purine-containing compound  (ISO)
response to xenobiotic stimulus  (IEP,ISO)
secretory granule organization  (ISO)
transcription by RNA polymerase II  (IMP)
transforming growth factor beta receptor signaling pathway  (IMP)
type I pneumocyte differentiation  (ISO)
visual learning  (IMP)

Cellular Component

References

References - curated
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110. Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. Tischkau SA, etal., J Biol Chem 2003 Jan 10;278(2):718-23.
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114. Inhibition of ERK/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats. Wang H, etal., J Mol Med (Berl). 2023 Mar;101(3):265-278. doi: 10.1007/s00109-023-02285-9. Epub 2023 Jan 23.
115. PDGF-induced proliferation of smooth muscular cells is related to the regulation of CREB phosphorylation and Nur77 expression. Wang L, etal., J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):169-73. doi: 10.1007/s11596-011-0245-2. Epub 2011 Apr 20.
116. [Protective effects of Lovastatin on early diabetic renal tissue and the possible mechanism]. Wang LH, etal., Wei Sheng Yan Jiu. 2005 Jan;34(1):70-3.
117. p-CREB-1 promotes hepatic fibrosis through the transactivation of transforming growth factor-β1 expression in rats. Wang P, etal., Int J Mol Med. 2016 Aug;38(2):521-8. doi: 10.3892/ijmm.2016.2630. Epub 2016 Jun 8.
118. Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. Wang WS, etal., J Neurosci. 2012 Oct 3;32(40):13763-75. doi: 10.1523/JNEUROSCI.1991-12.2012.
119. Dexmedetomidine promotes the recovery of neurogenesis in aged mouse with postoperative cognitive dysfunction. Wang WX, etal., Neurosci Lett. 2018 Jun 11;677:110-116. doi: 10.1016/j.neulet.2018.03.043. Epub 2018 Mar 20.
120. Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway. Wang X, etal., Eur J Pharmacol. 2021 Apr 15;897:173945. doi: 10.1016/j.ejphar.2021.173945. Epub 2021 Feb 14.
121. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Wang Y, etal., Autophagy. 2013 Dec;9(12):2069-86. doi: 10.4161/auto.26447. Epub 2013 Nov 1.
122. cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory. Warburton EC, etal., J Neurosci. 2005 Jul 6;25(27):6296-303.
123. Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles. Watson PA, etal., Endocrinology 2002 Aug;143(8):2922-9.
124. Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism. Wu H, etal., Psychopharmacology (Berl). 2018 Mar;235(3):873-886. doi: 10.1007/s00213-017-4805-4. Epub 2017 Dec 7.
125. κ Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca2+-SERCA2a. Wu T, etal., Oxid Med Cell Longev. 2021 Jul 30;2021:7328437. doi: 10.1155/2021/7328437. eCollection 2021.
126. CREB down-regulation in the laterodorsal thalamic nucleus deteriorates memory consolidation in rats. Xiang W, etal., Learn Mem. 2019 May 15;26(6):182-186. doi: 10.1101/lm.049742.119. Print 2019 Jun.
127. Transcriptional regulation of the promoter of the rat frizzled related protein gene by CREB. Yam JW, etal., Oncogene 2003 Jun 19;22(25):3901-10.
128. Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin. Yan D, etal., Brain Behav Immun. 2018 Jul;71:66-80. doi: 10.1016/j.bbi.2018.04.014. Epub 2018 Apr 26.
129. The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line. Yang GM, etal., Neurotox Res. 2020 Apr;37(4):926-935. doi: 10.1007/s12640-019-00150-7. Epub 2020 Jan 4.
130. Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine-addicted mother: Beneficial effect of dextromethorphan. Yang SN, etal., Hippocampus. 2006;16(6):521-30. doi: 10.1002/hipo.20179.
131. Chronic ethanol exposure impairs phosphorylation of CREB and CRE-binding activity in rat striatum. Yang X, etal., Alcohol Clin Exp Res. 1998 Apr;22(2):382-90.
132. Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian granulosa cells. Yazawa T, etal., Endocrinology. 2003 May;144(5):1920-30.
133. TOX3 regulates calcium-dependent transcription in neurons. Yuan SH, etal., Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2909-14. doi: 10.1073/pnas.0805555106. Epub 2009 Feb 5.
134. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. Zhang H, etal., Sci Rep. 2018 Jul 10;8(1):10376. doi: 10.1038/s41598-018-28415-9.
135. Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Zhang J, etal., Neurosci Lett. 2016 Sep 6;630:70-76. doi: 10.1016/j.neulet.2016.07.047. Epub 2016 Jul 25.
136. Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. Zhang L, etal., Brain Res Bull. 2013 Jul;96:45-53. doi: 10.1016/j.brainresbull.2013.04.009. Epub 2013 May 2.
137. Effects of morphine-dependent and withdrawal on activation of the distal cerebrospinal fluid contacting neurons' phosphorylation CREB in rat brain. Zhang L, etal., Neurol Res. 2009 Sep;31(7):738-42. doi: 10.1179/174313209X382386. Epub 2008 Dec 23.
138. [Effect of manual acupuncture on expression of BDNF/TrkB/ERK/CREB signaling in infarcted tissue of cerebral ischemia rats]. Zhong LY, etal., Zhen Ci Yan Jiu. 2022 Feb 25;47(2):135-40. doi: 10.13702/j.1000-0607.20210048.
Additional References at PubMed
PMID:1396344   PMID:1646483   PMID:1655749   PMID:7565774   PMID:7958915   PMID:8621702   PMID:8798441   PMID:9065434   PMID:9098922   PMID:10222196   PMID:11354513   PMID:11688998  
PMID:11739747   PMID:11988169   PMID:12015964   PMID:12086646   PMID:12114502   PMID:12114522   PMID:12121497   PMID:12151796   PMID:12220541   PMID:12244210   PMID:12477932   PMID:12609977  
PMID:12715102   PMID:12805315   PMID:12843242   PMID:12849998   PMID:12853429   PMID:12871976   PMID:12969258   PMID:14517290   PMID:14519530   PMID:14594818   PMID:14604761   PMID:14604762  
PMID:14622123   PMID:14659479   PMID:15030764   PMID:15076716   PMID:15112319   PMID:15135945   PMID:15229233   PMID:15262987   PMID:15263086   PMID:15371543   PMID:15381254   PMID:15390165  
PMID:15511237   PMID:15652982   PMID:15689550   PMID:15739190   PMID:15753290   PMID:15817708   PMID:15905095   PMID:15923261   PMID:15927180   PMID:16088955   PMID:16141355   PMID:16159392  
PMID:16168389   PMID:16230783   PMID:16251435   PMID:16298471   PMID:16299502   PMID:16330542   PMID:16359811   PMID:16410315   PMID:16421965   PMID:16510265   PMID:16520736   PMID:16632469  
PMID:16782881   PMID:16801951   PMID:16891269   PMID:16897752   PMID:16923323   PMID:16952356   PMID:16973918   PMID:16990276   PMID:16997391   PMID:17022948   PMID:17074386   PMID:17164818  
PMID:17325033   PMID:17505916   PMID:17610355   PMID:17638387   PMID:17680988   PMID:17692820   PMID:17920195   PMID:17925456   PMID:17977028   PMID:18055458   PMID:18063565   PMID:18063805  
PMID:18095593   PMID:18172855   PMID:18213625   PMID:18250056   PMID:18252718   PMID:18378685   PMID:18381242   PMID:18386196   PMID:18559891   PMID:18566605   PMID:18586506   PMID:18636983  
PMID:18639611   PMID:18669938   PMID:18710651   PMID:18922788   PMID:19046951   PMID:19047462   PMID:19151710   PMID:19164762   PMID:19183266   PMID:19223597   PMID:19272413   PMID:19342597  
PMID:19357264   PMID:19360104   PMID:19416748   PMID:19426786   PMID:19540313   PMID:19545278   PMID:19601643   PMID:19602869   PMID:19664625   PMID:19851832   PMID:19861239   PMID:19891990  
PMID:19921094   PMID:19945407   PMID:19968712   PMID:20080871   PMID:20102225   PMID:20127074   PMID:20145658   PMID:20150559   PMID:20168088   PMID:20346417   PMID:20361314   PMID:20439489  
PMID:20534813   PMID:20573957   PMID:20613834   PMID:20688914   PMID:20818076   PMID:20824729   PMID:20852621   PMID:20876357   PMID:20926146   PMID:21072211   PMID:21123217   PMID:21155252  
PMID:21156158   PMID:21338685   PMID:21367774   PMID:21382451   PMID:21396965   PMID:21408140   PMID:21414930   PMID:21448293   PMID:21605499   PMID:21728997   PMID:21740234   PMID:21762679  
PMID:21808064   PMID:21819464   PMID:21826657   PMID:21835234   PMID:21890628   PMID:22079318   PMID:22305649   PMID:22419107   PMID:22445851   PMID:22505719   PMID:22509362   PMID:22543102  
PMID:22553039   PMID:22569987   PMID:22616931   PMID:22632974   PMID:22796763   PMID:22841916   PMID:22932066   PMID:22974552   PMID:23052195   PMID:23110949   PMID:23150431   PMID:23160045  
PMID:23223304   PMID:23292070   PMID:23381906   PMID:23382074   PMID:23395171   PMID:23704876   PMID:23716681   PMID:23749289   PMID:23950594   PMID:24062441   PMID:24064350   PMID:24106266  
PMID:24114393   PMID:24121025   PMID:24222346   PMID:24277525   PMID:24292370   PMID:24316406   PMID:24364879   PMID:24597568   PMID:24773364   PMID:24965890   PMID:25154887   PMID:25170769  
PMID:25193019   PMID:25201604   PMID:25231482   PMID:25609649   PMID:25687488   PMID:25931508   PMID:25986861   PMID:26296331   PMID:26365342   PMID:26397995   PMID:26398857   PMID:26440419  
PMID:26473326   PMID:26492285   PMID:26546462   PMID:26554229   PMID:26926964   PMID:26996991   PMID:27010597   PMID:27132084   PMID:27530066   PMID:27611779   PMID:27761593   PMID:27771283  
PMID:27815155   PMID:27840939   PMID:28051768   PMID:28160495   PMID:28222740   PMID:28230177   PMID:28236215   PMID:28327356   PMID:28429887   PMID:28469203   PMID:28638088   PMID:28666847  
PMID:28743894   PMID:28763438   PMID:28866293   PMID:29330129   PMID:29427172   PMID:29559698   PMID:29806529   PMID:30507144   PMID:30964189   PMID:31253357   PMID:32043504   PMID:32189593  
PMID:32417176   PMID:32553080   PMID:32554860   PMID:32569665   PMID:32725625   PMID:33277644   PMID:33290797   PMID:33359781   PMID:33420884   PMID:33421503   PMID:33530478   PMID:34374467  
PMID:34635097   PMID:34696976   PMID:34787820   PMID:35217880   PMID:35769142   PMID:36143887   PMID:36324232   PMID:36933848   PMID:37392026   PMID:37406926   PMID:37572160   PMID:37863169  


Genomics

Comparative Map Data
Creb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8973,397,333 - 73,466,339 (+)NCBIGRCr8
mRatBN7.2965,903,511 - 65,972,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl965,903,547 - 65,970,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx974,423,783 - 74,487,123 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0979,554,383 - 79,617,717 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0977,958,854 - 78,022,149 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0971,229,753 - 71,298,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,230,108 - 71,293,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,277,171 - 71,346,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,170,785 - 63,234,727 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1963,317,766 - 63,381,709 (+)NCBI
Celera963,310,784 - 63,374,139 (+)NCBICelera
Cytogenetic Map9q32NCBI
CREB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382207,529,962 - 207,605,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2207,529,737 - 207,605,988 (+)EnsemblGRCh38hg38GRCh38
GRCh372208,394,686 - 208,470,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362208,102,931 - 208,171,818 (+)NCBINCBI36Build 36hg18NCBI36
Build 342208,220,191 - 208,289,074NCBI
Celera2202,156,105 - 202,231,803 (+)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2200,237,266 - 200,313,048 (+)NCBIHuRef
CHM1_12208,400,466 - 208,476,105 (+)NCBICHM1_1
T2T-CHM13v2.02208,003,958 - 208,080,006 (+)NCBIT2T-CHM13v2.0
Creb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39164,571,963 - 64,643,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl164,571,804 - 64,643,707 (+)EnsemblGRCm39 Ensembl
GRCm38164,532,794 - 64,604,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl164,532,645 - 64,604,548 (+)EnsemblGRCm38mm10GRCm38
MGSCv37164,579,378 - 64,651,122 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36164,467,080 - 64,538,824 (+)NCBIMGSCv36mm8
Celera165,034,311 - 65,105,954 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.74NCBI
Creb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554577,431,736 - 7,491,149 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554577,424,403 - 7,490,630 (-)NCBIChiLan1.0ChiLan1.0
CREB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213110,136,747 - 110,210,159 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B110,151,726 - 110,225,138 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B94,762,796 - 94,836,304 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B212,891,261 - 212,963,584 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B212,891,261 - 212,958,130 (+)Ensemblpanpan1.1panPan2
CREB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13715,921,214 - 15,978,492 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3715,939,138 - 15,977,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3716,804,994 - 16,867,966 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03715,856,953 - 15,919,649 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3715,856,946 - 15,919,150 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13715,802,749 - 15,865,587 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03715,775,840 - 15,838,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03715,785,052 - 15,847,761 (+)NCBIUU_Cfam_GSD_1.0
Creb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303164,086,248 - 164,150,269 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366313,721,313 - 3,780,892 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366313,721,307 - 3,785,346 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CREB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15110,705,496 - 110,771,728 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115110,705,548 - 110,773,037 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215122,245,218 - 122,278,060 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CREB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11093,316,774 - 93,395,187 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1093,316,840 - 93,388,832 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040105,980,378 - 106,058,783 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Creb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247658,374,160 - 8,436,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Creb1
240 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1596
Count of miRNA genes:327
Interacting mature miRNAs:449
Transcripts:ENSRNOT00000018326, ENSRNOT00000049654
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)94996854671098346Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

Markers in Region
D9Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2965,941,759 - 65,942,010 (+)MAPPERmRatBN7.2
Rnor_6.0971,268,192 - 71,268,442NCBIRnor6.0
Rnor_5.0971,307,519 - 71,307,769UniSTSRnor5.0
RGSC_v3.4963,208,873 - 63,209,124RGDRGSC3.4
RGSC_v3.4963,208,874 - 63,209,124UniSTSRGSC3.4
RGSC_v3.1963,355,855 - 63,356,106RGD
Celera963,348,896 - 63,349,146UniSTS
RH 3.4 Map9538.0UniSTS
RH 3.4 Map9538.0RGD
RH 2.0 Map9608.1RGD
Cytogenetic Map9q32UniSTS
RH140745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2965,966,992 - 65,967,117 (+)MAPPERmRatBN7.2
mRatBN7.21824,212,055 - 24,212,180 (-)MAPPERmRatBN7.2
mRatBN7.2965,966,992 - 65,967,117 (-)MAPPERmRatBN7.2
mRatBN7.21824,212,055 - 24,212,180 (+)MAPPERmRatBN7.2
Rnor_6.0971,293,425 - 71,293,549NCBIRnor6.0
Rnor_6.01825,363,262 - 25,363,386NCBIRnor6.0
Rnor_5.01825,078,973 - 25,079,097UniSTSRnor5.0
Rnor_5.0971,282,616 - 71,282,740UniSTSRnor5.0
RGSC_v3.41825,027,665 - 25,027,789UniSTSRGSC3.4
RGSC_v3.4963,234,717 - 63,234,841UniSTSRGSC3.4
Celera963,374,129 - 63,374,253UniSTS
Celera1823,961,591 - 23,961,715UniSTS
Cytogenetic Map9q32UniSTS
RH139083  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2965,970,480 - 65,970,612 (+)MAPPERmRatBN7.2
mRatBN7.21824,208,576 - 24,208,709 (+)MAPPERmRatBN7.2
mRatBN7.21824,208,576 - 24,208,709 (-)MAPPERmRatBN7.2
Rnor_6.0971,296,913 - 71,297,044NCBIRnor6.0
Rnor_6.01825,359,783 - 25,359,915NCBIRnor6.0
Rnor_5.01825,075,494 - 25,075,626UniSTSRnor5.0
Rnor_5.0971,279,121 - 71,279,252UniSTSRnor5.0
Celera1823,958,102 - 23,958,234UniSTS
Celera963,377,610 - 63,377,742UniSTS
Cytogenetic Map9q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 27 34 18 19 18 2 2 74 28 41 11 2
Low 1 16 23 23 23 6 9 7 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063267771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010054634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC097311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X60002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018326   ⟹   ENSRNOP00000018326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,903,547 - 65,970,816 (+)Ensembl
Rnor_6.0 Ensembl971,230,108 - 71,293,435 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000049654   ⟹   ENSRNOP00000049369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,903,572 - 65,946,526 (+)Ensembl
Rnor_6.0 Ensembl971,247,781 - 71,293,414 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114810   ⟹   ENSRNOP00000077567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,944,840 - 65,970,278 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115911   ⟹   ENSRNOP00000087190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl965,903,582 - 65,970,816 (+)Ensembl
RefSeq Acc Id: NM_031017   ⟹   NP_112279
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,397,509 - 73,460,780 (+)NCBI
mRatBN7.2965,903,728 - 65,967,003 (+)NCBI
Rnor_6.0971,230,108 - 71,293,435 (+)NCBI
Rnor_5.0971,277,171 - 71,346,198 (-)NCBI
RGSC_v3.4963,170,785 - 63,234,727 (+)RGD
Celera963,310,784 - 63,374,139 (+)RGD
Sequence:
RefSeq Acc Id: NM_134443   ⟹   NP_604392
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,415,228 - 73,460,759 (+)NCBI
mRatBN7.2965,921,450 - 65,966,982 (+)NCBI
Rnor_6.0971,247,781 - 71,293,414 (+)NCBI
Rnor_5.0971,277,171 - 71,346,198 (-)NCBI
RGSC_v3.4963,170,785 - 63,234,727 (+)RGD
Celera963,328,586 - 63,374,118 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245070   ⟹   XP_006245132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,437,033 - 73,466,339 (+)NCBI
mRatBN7.2965,943,255 - 65,972,562 (+)NCBI
Rnor_6.0971,269,740 - 71,298,994 (+)NCBI
Rnor_5.0971,277,171 - 71,346,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084245   ⟹   XP_038940173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,397,333 - 73,466,339 (+)NCBI
mRatBN7.2965,903,511 - 65,972,562 (+)NCBI
RefSeq Acc Id: XM_039084247   ⟹   XP_038940175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,415,215 - 73,439,188 (+)NCBI
mRatBN7.2965,903,621 - 65,945,464 (+)NCBI
RefSeq Acc Id: XM_063267770   ⟹   XP_063123840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,422,277 - 73,466,339 (+)NCBI
RefSeq Acc Id: XM_063267771   ⟹   XP_063123841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,423,142 - 73,466,339 (+)NCBI
RefSeq Acc Id: XR_005488972
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,415,215 - 73,466,339 (+)NCBI
mRatBN7.2965,903,621 - 65,972,562 (+)NCBI
RefSeq Acc Id: XR_010054634
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8973,415,215 - 73,466,339 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112279   ⟸   NM_031017
- Peptide Label: isoform B
- UniProtKB: A6IPH8 (UniProtKB/TrEMBL),   A0A8L2QQ18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_604392   ⟸   NM_134443
- Peptide Label: isoform A
- UniProtKB: P15337 (UniProtKB/Swiss-Prot),   A6IPH9 (UniProtKB/TrEMBL),   A0A8L2QQ18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245132   ⟸   XM_006245070
- Peptide Label: isoform X4
- UniProtKB: A0A8I5YBW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018326   ⟸   ENSRNOT00000018326
RefSeq Acc Id: ENSRNOP00000049369   ⟸   ENSRNOT00000049654
RefSeq Acc Id: XP_038940173   ⟸   XM_039084245
- Peptide Label: isoform X1
- UniProtKB: A6IPH8 (UniProtKB/TrEMBL),   A0A8L2QQ18 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940175   ⟸   XM_039084247
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000087190   ⟸   ENSRNOT00000115911
RefSeq Acc Id: ENSRNOP00000077567   ⟸   ENSRNOT00000114810
RefSeq Acc Id: XP_063123840   ⟸   XM_063267770
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063123841   ⟸   XM_063267771
- Peptide Label: isoform X3
Protein Domains
bZIP   KID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15337-F1-model_v2 AlphaFold P15337 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620218 AgrOrtholog
BioCyc Gene G2FUF-27319 BioCyc
Ensembl Genes ENSRNOG00000013412 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022525 UniProtKB/Swiss-Prot
  ENSRNOG00060018985 UniProtKB/Swiss-Prot
  ENSRNOG00065026624 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018326.6 UniProtKB/Swiss-Prot
  ENSRNOT00000049654 ENTREZGENE
  ENSRNOT00000049654.5 UniProtKB/TrEMBL
  ENSRNOT00000114810.1 UniProtKB/TrEMBL
  ENSRNOT00000115911.1 UniProtKB/TrEMBL
  ENSRNOT00055038699 UniProtKB/Swiss-Prot
  ENSRNOT00060032877 UniProtKB/Swiss-Prot
  ENSRNOT00065046001 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Coactivator_CBP_pKID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_CREB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81646 UniProtKB/Swiss-Prot
NCBI Gene 81646 ENTREZGENE
PANTHER PTHR45879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45879:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  pKID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CREB1 RGD
PhenoGen Creb1 PhenoGen
PRINTS LEUZIPPRCREB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013412 RatGTEx
  ENSRNOG00055022525 RatGTEx
  ENSRNOG00060018985 RatGTEx
  ENSRNOG00065026624 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YBW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7B3_RAT UniProtKB/TrEMBL
  A0A8L2QQ18 ENTREZGENE, UniProtKB/TrEMBL
  A6IPH8 ENTREZGENE, UniProtKB/TrEMBL
  A6IPH9 ENTREZGENE, UniProtKB/TrEMBL
  A6IPI0_RAT UniProtKB/TrEMBL
  A6IPI1_RAT UniProtKB/TrEMBL
  CREB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Creb1  cAMP responsive element binding protein 1    cAMP response element binding protein 1  Name updated 625702 APPROVED
2002-08-07 Creb1  cAMP response element binding protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process regulates transcription of Period 1 (Per1) 633667
gene_process decreases platelet-derived growth factor- receptor alpha (Pdgfra) gene expression in vascular smooth muscle cells (SMCs) 625715
gene_process may mediate SMC activation during diabetes 625715
gene_regulation regulates transcription of liver carnitine palmitoyltransferase 633650