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Gene: Hdac2 (histone deacetylase 2) Rattus norvegicus
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Symbol: Hdac2
Name: histone deacetylase 2
Description: Exhibits several functions, including enzyme binding activity; promoter-specific chromatin binding activity; and transcription factor binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of neurogenesis; and response to alkaloid. Localizes to the chromatin; cytoplasm; and nucleus. Used to study Peyronie's disease; alcohol use disorder; and anxiety disorder. Biomarker of bronchitis; chronic obstructive pulmonary disease; endometriosis; pulmonary emphysema; and visual epilepsy. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; histone modification pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: VALIDATED
Orthologs:
Homo sapiens (human) : HDAC2 (histone deacetylase 2)  HGNC  Alliance
Mus musculus (house mouse) : Hdac2 (histone deacetylase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac2 (histone deacetylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC2 (histone deacetylase 2)
Canis lupus familiaris (dog) : HDAC2 (histone deacetylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac2 (histone deacetylase 2)
Sus scrofa (pig) : HDAC2 (histone deacetylase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02043,084,870 - 43,108,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02044,811,967 - 44,835,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,162,093 - 41,186,492 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12041,204,917 - 41,209,275 (+)NCBI
Celera2041,298,790 - 41,322,159 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hdac2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619976
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.