Stxbp2 (syntaxin binding protein 2) - Rat Genome Database

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Gene: Stxbp2 (syntaxin binding protein 2) Rattus norvegicus
Analyze
Symbol: Stxbp2
Name: syntaxin binding protein 2
RGD ID: 619967
Description: Enables syntaxin-1 binding activity and syntaxin-3 binding activity. Involved in positive regulation of mast cell degranulation and response to acidic pH. Located in apical plasma membrane and lamellipodium. Part of protein-containing complex. Colocalizes with secretory granule. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 5. Orthologous to human STXBP2 (syntaxin binding protein 2); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: munc18-2; Munc18b; syntaxin binding protein Munc18-2; syntaxin-binding protein 2; unc-18 homolog 2; unc-18 homolog B; unc-18B; unc18-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,487,265 - 6,498,351 (+)NCBIGRCr8
mRatBN7.2121,689,364 - 1,701,145 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,689,410 - 1,700,458 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,356,029 - 2,367,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,979,598 - 2,990,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,750,571 - 1,761,558 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,180,101 - 2,191,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,180,150 - 2,191,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,342,202 - 4,353,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,511,793 - 2,522,818 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,511,792 - 2,522,818 (-)NCBI
Celera123,545,180 - 3,556,207 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)
syntaxin binding  (IPI)
syntaxin-1 binding  (IBA,IEA,IPI,ISO)
syntaxin-3 binding  (IBA,IEA,IPI,ISO)

References

References - curated
# Reference Title Reference Citation
1. Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation. Bin NR, etal., Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4610-5. doi: 10.1073/pnas.1214887110. Epub 2013 Mar 4.
2. Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis. Coppola T, etal., Mol Biol Cell 2002 Jun;13(6):1906-15.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. Hata Y and Sudhof TC, J Biol Chem 1995 Jun 2;270(22):13022-8.
6. Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Kim K, etal., Biochem J. 2012 Sep 15;446(3):383-94. doi: 10.1042/BJ20120057.
7. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
8. Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. Martin-Verdeaux S, etal., J Cell Sci. 2003 Jan 15;116(Pt 2):325-34.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Munc-18-2 regulates exocytosis of H(+)-ATPase in rat inner medullary collecting duct cells. Nicoletta JA, etal., Am J Physiol Cell Physiol. 2004 Nov;287(5):C1366-74. Epub 2004 Jul 7.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Munc18-2 regulates exocytotic membrane fusion positively interacting with syntaxin-3 in RBL-2H3 cells. Tadokoro S, etal., Mol Immunol. 2007 Jul;44(13):3427-33. Epub 2007 Apr 3.
Additional References at PubMed
PMID:7890599   PMID:10469351   PMID:11487543   PMID:12477932   PMID:12773094   PMID:12935901   PMID:16186111   PMID:17027648   PMID:18505797   PMID:18535671   PMID:18588921   PMID:19056867  
PMID:19144319   PMID:19487699   PMID:19804848   PMID:19812250   PMID:19884660   PMID:23376485   PMID:23423569   PMID:23533145   PMID:24323579   PMID:24835618   PMID:28163042   PMID:30127032  
PMID:34857632  


Genomics

Comparative Map Data
Stxbp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,487,265 - 6,498,351 (+)NCBIGRCr8
mRatBN7.2121,689,364 - 1,701,145 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,689,410 - 1,700,458 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,356,029 - 2,367,024 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,979,598 - 2,990,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,750,571 - 1,761,558 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,180,101 - 2,191,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,180,150 - 2,191,175 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,342,202 - 4,353,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,511,793 - 2,522,818 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,511,792 - 2,522,818 (-)NCBI
Celera123,545,180 - 3,556,207 (+)NCBICelera
Cytogenetic Map12p12NCBI
STXBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,629,793 - 7,647,873 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,636,772 - 7,647,873 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,701,996 - 7,712,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,608,011 - 7,618,707 (+)NCBINCBI36Build 36hg18NCBI36
Build 34197,608,020 - 7,618,697NCBI
Celera197,573,175 - 7,583,945 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,371,707 - 7,382,556 (+)NCBIHuRef
CHM1_1197,701,738 - 7,712,511 (+)NCBICHM1_1
T2T-CHM13v2.0197,630,676 - 7,648,756 (+)NCBIT2T-CHM13v2.0
Stxbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,680,960 - 3,693,998 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,680,955 - 3,693,644 (+)EnsemblGRCm39 Ensembl
GRCm3883,630,960 - 3,643,998 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,630,955 - 3,643,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,631,160 - 3,643,644 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,631,150 - 3,642,795 (+)NCBIMGSCv36mm8
Celera83,861,489 - 3,873,974 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Stxbp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,617,621 - 1,624,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,617,621 - 1,624,441 (-)NCBIChiLan1.0ChiLan1.0
STXBP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,307,265 - 12,318,536 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,424,774 - 11,436,107 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,926,833 - 6,937,385 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,781,830 - 7,792,038 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,781,830 - 7,792,038 (+)Ensemblpanpan1.1panPan2
STXBP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,413,174 - 52,421,525 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,413,191 - 52,421,517 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,217,265 - 52,225,592 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,942,478 - 52,950,859 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,941,323 - 52,950,851 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,146,293 - 52,154,615 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,589,880 - 52,598,195 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,820,884 - 52,829,229 (+)NCBIUU_Cfam_GSD_1.0
Stxbp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,138,708 - 213,146,587 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,687,834 - 4,696,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,688,221 - 4,696,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STXBP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,504,569 - 71,513,422 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,504,575 - 71,513,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,843,349 - 71,852,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STXBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,123,564 - 7,133,459 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,123,597 - 7,133,460 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081728,134 - 738,032 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stxbp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828718,485 - 725,483 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828718,728 - 725,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stxbp2
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:102
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000001322
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat

Markers in Region
RH126492  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,699,399 - 1,700,176 (+)MAPPERmRatBN7.2
Rnor_6.0122,190,117 - 2,190,893NCBIRnor6.0
Rnor_5.0124,352,215 - 4,352,991UniSTSRnor5.0
Celera123,555,149 - 3,555,925UniSTS
Cytogenetic Map12p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 10 51 36 19 36 12 35 41 11
Low 33 6 5 5 8 11 62 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001322   ⟹   ENSRNOP00000001322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,689,433 - 1,700,458 (+)Ensembl
Rnor_6.0 Ensembl122,180,150 - 2,191,175 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107607   ⟹   ENSRNOP00000083154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,689,410 - 1,700,196 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115749   ⟹   ENSRNOP00000081592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,690,165 - 1,700,458 (+)Ensembl
RefSeq Acc Id: NM_031126   ⟹   NP_112388
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,487,326 - 6,498,351 (+)NCBI
mRatBN7.2121,689,433 - 1,700,458 (+)NCBI
Rnor_6.0122,180,150 - 2,191,175 (+)NCBI
Rnor_5.0124,342,202 - 4,353,960 (+)NCBI
RGSC_v3.4122,511,793 - 2,522,818 (-)RGD
Celera123,545,180 - 3,556,207 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248783   ⟹   XP_006248845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,487,265 - 6,498,087 (+)NCBI
mRatBN7.2121,689,365 - 1,701,145 (+)NCBI
Rnor_6.0122,180,101 - 2,191,862 (+)NCBI
Rnor_5.0124,342,202 - 4,353,960 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063271697   ⟹   XP_063127767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,488,382 - 6,498,087 (+)NCBI
RefSeq Acc Id: XR_005491676
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,487,265 - 6,497,252 (+)NCBI
mRatBN7.2121,689,365 - 1,699,359 (+)NCBI
RefSeq Acc Id: XR_005491677
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,487,265 - 6,495,373 (+)NCBI
mRatBN7.2121,689,365 - 1,701,145 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112388   ⟸   NM_031126
- UniProtKB: Q62753 (UniProtKB/Swiss-Prot),   A0A8I5ZT02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248845   ⟸   XM_006248783
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZT02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001322   ⟸   ENSRNOT00000001322
RefSeq Acc Id: ENSRNOP00000081592   ⟸   ENSRNOT00000115749
RefSeq Acc Id: ENSRNOP00000083154   ⟸   ENSRNOT00000107607
RefSeq Acc Id: XP_063127767   ⟸   XM_063271697
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62753-F1-model_v2 AlphaFold Q62753 1-594 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698373
Promoter ID:EPDNEW_R8898
Type:multiple initiation site
Name:Stxbp2_1
Description:syntaxin binding protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,180,141 - 2,180,201EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619967 AgrOrtholog
BIND 134475
  134476
  134477
BioCyc Gene G2FUF-20386 BioCyc
Ensembl Genes ENSRNOG00000000994 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001322 ENTREZGENE
  ENSRNOT00000001322.5 UniProtKB/TrEMBL
  ENSRNOT00000107607.1 UniProtKB/TrEMBL
  ENSRNOT00000115749.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Sec-1-like_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec-1-like_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec-1-like_dom3a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81804 UniProtKB/Swiss-Prot
NCBI Gene 81804 ENTREZGENE
PANTHER PTHR11679 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNTAXIN-BINDING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sec1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stxbp2 PhenoGen
PIRSF VPS45_Sec1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000994 RatGTEx
Superfamily-SCOP SSF56815 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZT02 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZVB0_RAT UniProtKB/TrEMBL
  A6KQ26_RAT UniProtKB/TrEMBL
  A6KQ27_RAT UniProtKB/TrEMBL
  A6KQ28_RAT UniProtKB/TrEMBL
  G3V637_RAT UniProtKB/TrEMBL
  Q62753 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Stxbp2  syntaxin binding protein 2    syntaxin binding protein Munc18-2  Name updated 1299863 APPROVED
2002-08-07 Stxbp2  syntaxin binding protein Munc18-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in most tissues 730001
gene_physical_interaction binds granuphilin, binds SNARE complex 634125
gene_physical_interaction binds syntaxins 1A, 2 and 3 730001
gene_process may be important for pancreatic beta-cell exocytosis 634125