Ankrd1 (ankyrin repeat domain 1) - Rat Genome Database

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Gene: Ankrd1 (ankyrin repeat domain 1) Rattus norvegicus
Analyze
Symbol: Ankrd1
Name: ankyrin repeat domain 1
RGD ID: 61989
Description: Predicted to enable several functions, including R-SMAD binding activity; cytoskeletal protein binding activity; and transcription coregulator activity. Involved in several processes, including cellular response to hypoxia; negative regulation of transcription by RNA polymerase II; and positive regulation of neuron projection development. Located in I band and nucleus. Human ortholog(s) of this gene implicated in congenital structural myopathy; dilated cardiomyopathy; hypertrophic cardiomyopathy; nemaline myopathy; and spinal muscular atrophy. Orthologous to human ANKRD1 (ankyrin repeat domain 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Alrp; ankyrin repeat domain 1 (cardiac muscle); ankyrin repeat domain-containing protein 1; ankyrin-like repeat protein; cardiac adriamycin-responsive protein; cardiac ankyrin repeat protein; cardiac responsive adriamycin protein; Carp; Crap; LOC102552909; MARP; muscle ankyrin repeat protein; uncharacterized LOC102552909
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,228,460 - 243,237,014 (-)NCBIGRCr8
mRatBN7.21233,815,851 - 233,834,891 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,815,851 - 233,834,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,212,709 - 242,221,290 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,129,677 - 249,138,264 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,967,834 - 241,976,421 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01254,726,985 - 254,745,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,726,969 - 254,735,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01262,038,137 - 262,046,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,316,123 - 240,324,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11240,490,005 - 240,498,684 (-)NCBI
Celera1230,914,960 - 230,923,398 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
andrographolide  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Botulinum toxin type A  (EXP)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
daunorubicin  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
Heliotrine  (EXP)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
Muraglitazar  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
Platyphylline  (EXP)
propanal  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
verteporfin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter. Aihara Y, etal., Hypertension. 2000 Jul;36(1):48-53.
2. Doxorubicin represses CARP gene transcription through the generation of oxidative stress in neonatal rat cardiac myocytes: possible role of serine/threonine kinase-dependent pathways. Aihara Y, etal., J Mol Cell Cardiol. 2000 Aug;32(8):1401-14.
3. Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. Arimura T, etal., J Am Coll Cardiol. 2009 Jul 21;54(4):334-42.
4. Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies. Bang ML, etal., J Cell Biol. 2001 Apr 16;153(2):413-27.
5. Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy. Duboscq-Bidot L, etal., Eur Heart J. 2009 Sep;30(17):2128-36. Epub 2009 Jun 12.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Involvement of GADD153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of H9c2 cells. Han XJ, etal., J Biol Chem. 2005 Jun 17;280(24):23122-9. Epub 2005 Apr 12.
9. Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury. Lee MJ, etal., Exp Mol Med. 2009 Apr 30;41(4):243-52.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Carotid surgery. Munro E, Eur J Vasc Endovasc Surg. 1998 Aug;16(2):170-1.
12. Cardiac ankyrin repeat protein is preferentially induced in atrophic myofibers of congenital myopathy and spinal muscular atrophy. Nakada C, etal., Pathol Int. 2003 Oct;53(10):653-8.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue. Shi Y, etal., Am J Pathol. 2005 Jan;166(1):303-12.
17. Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury. Stam FJ, etal., Eur J Neurosci. 2007 Jun;25(12):3629-37.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, etal., BMC Cell Biol. 2011 May 10;12:18. doi: 10.1186/1471-2121-12-18.
21. CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Zou Y, etal., Development. 1997 Feb;124(4):793-804.
Additional References at PubMed
PMID:7730328   PMID:9278441   PMID:9382869   PMID:11139470   PMID:12054667   PMID:14583192   PMID:14741210   PMID:15489334   PMID:15698842   PMID:15805281   PMID:16322914   PMID:17239933  
PMID:18310072   PMID:19500504   PMID:19608030   PMID:20599664   PMID:22147266   PMID:22532871   PMID:22892129   PMID:23811403   PMID:25089522   PMID:27353086  


Genomics

Comparative Map Data
Ankrd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,228,460 - 243,237,014 (-)NCBIGRCr8
mRatBN7.21233,815,851 - 233,834,891 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,815,851 - 233,834,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,212,709 - 242,221,290 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,129,677 - 249,138,264 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,967,834 - 241,976,421 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01254,726,985 - 254,745,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1254,726,969 - 254,735,548 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01262,038,137 - 262,046,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,316,123 - 240,324,804 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11240,490,005 - 240,498,684 (-)NCBI
Celera1230,914,960 - 230,923,398 (-)NCBICelera
Cytogenetic Map1q53NCBI
ANKRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381090,912,096 - 90,921,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1090,912,096 - 90,921,087 (-)EnsemblGRCh38hg38GRCh38
GRCh371092,671,853 - 92,680,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361092,661,837 - 92,671,012 (-)NCBINCBI36Build 36hg18NCBI36
Build 341092,661,836 - 92,671,012NCBI
Celera1086,418,314 - 86,427,472 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1086,300,878 - 86,309,941 (-)NCBIHuRef
CHM1_11092,949,704 - 92,958,879 (-)NCBICHM1_1
T2T-CHM13v2.01091,795,773 - 91,804,766 (-)NCBIT2T-CHM13v2.0
Ankrd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,089,365 - 36,097,244 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1936,089,361 - 36,097,499 (-)EnsemblGRCm39 Ensembl
GRCm381936,111,965 - 36,119,844 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,111,961 - 36,120,099 (-)EnsemblGRCm38mm10GRCm38
MGSCv371936,186,455 - 36,194,334 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361936,177,109 - 36,184,988 (-)NCBIMGSCv36mm8
Celera1936,887,384 - 36,895,221 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1930.52NCBI
Ankrd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554252,258,392 - 2,267,878 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554252,258,554 - 2,267,699 (+)NCBIChiLan1.0ChiLan1.0
ANKRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28102,942,181 - 102,951,190 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110102,948,133 - 102,956,491 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01087,652,254 - 87,661,173 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11091,179,325 - 91,188,414 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1091,180,034 - 91,188,165 (-)Ensemblpanpan1.1panPan2
ANKRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,569,120 - 5,578,393 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl285,569,501 - 5,601,956 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha285,736,579 - 5,745,849 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,789,401 - 5,799,972 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,789,403 - 5,823,534 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1285,546,460 - 5,555,716 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0285,585,466 - 5,594,725 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0285,750,959 - 5,760,237 (-)NCBIUU_Cfam_GSD_1.0
Ankrd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721341,870,291 - 41,878,306 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366013,502,844 - 3,511,003 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366013,502,844 - 3,510,919 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14102,603,777 - 102,612,839 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114102,603,777 - 102,612,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214111,714,967 - 111,724,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANKRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1984,248,133 - 84,257,276 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl984,247,241 - 84,257,170 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604844,957,846 - 44,966,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ankrd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247372,127,267 - 2,136,347 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247372,127,253 - 2,136,181 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ankrd1
187 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:85
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000025258
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat

Markers in Region
RH128736  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,815,953 - 233,816,154 (+)MAPPERmRatBN7.2
Rnor_6.01254,727,088 - 254,727,288NCBIRnor6.0
Rnor_5.01262,046,397 - 262,046,597UniSTSRnor5.0
RGSC_v3.41240,316,217 - 240,316,417UniSTSRGSC3.4
Celera1230,915,054 - 230,915,254UniSTS
RH 3.4 Map11586.6UniSTS
Cytogenetic Map1q53UniSTS
RH130311  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,815,948 - 233,816,148 (+)MAPPERmRatBN7.2
Rnor_6.01254,727,083 - 254,727,282NCBIRnor6.0
Rnor_5.01262,046,403 - 262,046,602UniSTSRnor5.0
RGSC_v3.41240,316,212 - 240,316,411UniSTSRGSC3.4
Celera1230,915,049 - 230,915,248UniSTS
RH 3.4 Map4511.12UniSTS
Cytogenetic Map1q53UniSTS
RH134094  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,825,496 - 233,825,716 (+)MAPPERmRatBN7.2
Rnor_6.01254,736,633 - 254,736,852NCBIRnor6.0
Rnor_5.01262,036,833 - 262,037,052UniSTSRnor5.0
RGSC_v3.41240,325,889 - 240,326,108UniSTSRGSC3.4
Celera1230,924,483 - 230,924,702UniSTS
RH 3.4 Map11584.7UniSTS
Cytogenetic Map1q53UniSTS
AI556107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,816,132 - 233,816,269 (+)MAPPERmRatBN7.2
Rnor_6.01254,727,267 - 254,727,403NCBIRnor6.0
Rnor_5.01262,046,282 - 262,046,418UniSTSRnor5.0
RGSC_v3.41240,316,396 - 240,316,532UniSTSRGSC3.4
Celera1230,915,233 - 230,915,369UniSTS
RH 3.4 Map11586.91UniSTS
Cytogenetic Map1q53UniSTS
RH140168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,820,715 - 233,820,928 (+)MAPPERmRatBN7.2
Rnor_6.01254,731,853 - 254,732,065NCBIRnor6.0
Rnor_5.01262,041,620 - 262,041,832UniSTSRnor5.0
RGSC_v3.41240,321,109 - 240,321,321UniSTSRGSC3.4
Celera1230,919,703 - 230,919,915UniSTS
Cytogenetic Map1q53UniSTS
Ankrd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,820,013 - 233,821,266 (+)MAPPERmRatBN7.2
Rnor_6.01254,731,151 - 254,732,403NCBIRnor6.0
Rnor_5.01262,041,282 - 262,042,534UniSTSRnor5.0
Celera1230,919,001 - 230,920,253UniSTS
Cytogenetic Map1q53UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 18
Medium 25 2 2 2 3 11 2
Low 3 55 41 17 41 6 8 53 35 36 6
Below cutoff 21 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025258   ⟹   ENSRNOP00000025258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,815,853 - 233,824,410 (-)Ensembl
Rnor_6.0 Ensembl1254,726,969 - 254,735,548 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097402   ⟹   ENSRNOP00000084263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,815,854 - 233,824,597 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108356   ⟹   ENSRNOP00000083877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,815,851 - 233,824,403 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108831   ⟹   ENSRNOP00000088225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,815,851 - 233,824,403 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117221   ⟹   ENSRNOP00000097020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,815,853 - 233,834,919 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120144   ⟹   ENSRNOP00000097010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,815,857 - 233,824,289 (-)Ensembl
RefSeq Acc Id: NM_013220   ⟹   NP_037352
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,228,460 - 243,237,014 (-)NCBI
mRatBN7.21233,815,860 - 233,824,412 (-)NCBI
Rnor_6.01254,726,994 - 254,735,548 (-)NCBI
Rnor_5.01262,038,137 - 262,046,691 (+)NCBI
RGSC_v3.41240,316,123 - 240,324,804 (-)RGD
Celera1230,914,960 - 230,923,398 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_037352   ⟸   NM_013220
- UniProtKB: Q8R560 (UniProtKB/Swiss-Prot),   Q9Z1F0 (UniProtKB/Swiss-Prot),   A6I150 (UniProtKB/TrEMBL),   A0A8I6GLV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025258   ⟸   ENSRNOT00000025258
RefSeq Acc Id: ENSRNOP00000097010   ⟸   ENSRNOT00000120144
RefSeq Acc Id: ENSRNOP00000088225   ⟸   ENSRNOT00000108831
RefSeq Acc Id: ENSRNOP00000097020   ⟸   ENSRNOT00000117221
RefSeq Acc Id: ENSRNOP00000083877   ⟸   ENSRNOT00000108356
RefSeq Acc Id: ENSRNOP00000084263   ⟸   ENSRNOT00000097402

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R560-F1-model_v2 AlphaFold Q8R560 1-319 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690871
Promoter ID:EPDNEW_R1396
Type:single initiation site
Name:Ankrd1_1
Description:ankyrin repeat domain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01254,735,550 - 254,735,610EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61989 AgrOrtholog
BioCyc Gene G2FUF-55831 BioCyc
Ensembl Genes ENSRNOG00000018598 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055030495 UniProtKB/Swiss-Prot
  ENSRNOG00065030408 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025258.7 UniProtKB/TrEMBL
  ENSRNOT00000097402.1 UniProtKB/TrEMBL
  ENSRNOT00000108356 ENTREZGENE
  ENSRNOT00000108356.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108831.1 UniProtKB/TrEMBL
  ENSRNOT00000117221.1 UniProtKB/TrEMBL
  ENSRNOT00000120144.1 UniProtKB/TrEMBL
  ENSRNOT00055052971 UniProtKB/Swiss-Prot
  ENSRNOT00065052450 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105899 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:27064 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91764 IMAGE-MGC_LOAD
NCBI Gene 27064 ENTREZGENE
PANTHER ANKYRIN REPEAT CONTAINING UniProtKB/TrEMBL
  ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED UniProtKB/TrEMBL
  L-ASPARAGINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ankrd1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018598 RatGTEx
  ENSRNOG00055030495 RatGTEx
  ENSRNOG00065030408 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204620
UniProt A0A8I6A0X3_RAT UniProtKB/TrEMBL
  A0A8I6A7L7_RAT UniProtKB/TrEMBL
  A0A8I6ARV8_RAT UniProtKB/TrEMBL
  A0A8I6GLV4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QDJ7_RAT UniProtKB/TrEMBL
  A6I149_RAT UniProtKB/TrEMBL
  A6I150 ENTREZGENE, UniProtKB/TrEMBL
  ANKR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z1F0 ENTREZGENE
UniProt Secondary Q9Z1F0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ankrd1  ankyrin repeat domain 1  LOC102552909  uncharacterized LOC102552909  Data merged from RGD:7602717 737654 PROVISIONAL
2013-12-18 LOC102552909  uncharacterized LOC102552909      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-05 Ankrd1  ankyrin repeat domain 1 (cardiac muscle)  Alrp  ankyrin-like repeat protein  Symbol and name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-06-10 Alrp  ankyrin-like repeat protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus 634545
gene_drugs expression is inhibited by the antineoplastic drug doxorubicin 634545
gene_expression expressed in cardiomyocytes 634545