Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Rac1 (Rac family small GTPase 1) Rattus norvegicus
Symbol: Rac1
Name: Rac family small GTPase 1
RGD ID: 619755
Description: Exhibits several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including Rac protein signal transduction; bone resorption; and regulation of cellular biosynthetic process. Localizes to several cellular components, including Golgi membrane; cytosol; and dendritic spine. Predicted to colocalize with actin filament. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; INTERACTS WITH (R)-mevalonic acid; 11-deoxycorticosterone; 17beta-estradiol.
Type: protein-coding
Also known as: p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1
Homo sapiens (human) : RAC1 (Rac family small GTPase 1)  HGNC  Alliance
Mus musculus (house mouse) : Rac1 (Rac family small GTPase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rac1 (Rac family small GTPase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RAC1 (Rac family small GTPase 1)
Canis lupus familiaris (dog) : RAC1 (Rac family small GTPase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rac1 (Rac family small GTPase 1)
Sus scrofa (pig) : RAC1 (Rac family small GTPase 1)
Chlorocebus sabaeus (African green monkey) : RAC1 (Rac family small GTPase 1)
Heterocephalus glaber (naked mole-rat) : Rac1 (Rac family small GTPase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Rac1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619755
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.