Sv2a (synaptic vesicle glycoprotein 2a) - Rat Genome Database

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Gene: Sv2a (synaptic vesicle glycoprotein 2a) Rattus norvegicus
Analyze
Symbol: Sv2a
Name: synaptic vesicle glycoprotein 2a
RGD ID: 619715
Description: Predicted to enable protein kinase binding activity. Involved in regulation of gamma-aminobutyric acid secretion. Located in several cellular components, including neuronal cell body; presynaptic active zone; and synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105346; Sv2; synaptic vesicle glycoprotein 2 a; synaptic vesicle protein 2; synaptic vesicle protein 2A; synaptic vesicle transmembrane transporter (SV2) RNA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Sv2am1Kyo  
Genetic Models: F344-Sv2am1Kyo
Is Marker For: Strains:   F344-Sv2am1Kyo  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,430,363 - 186,446,161 (+)NCBIGRCr8
mRatBN7.22183,741,489 - 183,757,290 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,741,547 - 183,756,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,405,136 - 191,420,924 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,209,456 - 189,225,293 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,037,670 - 184,053,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,321,100 - 198,336,889 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,321,142 - 198,336,913 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,808,165 - 217,823,872 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,989,187 - 191,000,859 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,948,188 - 190,963,566 (+)NCBI
Celera2176,272,713 - 176,284,621 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Bajjalieh SM, etal., Science 1992 Aug 28;257(5074):1271-3.
2. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Formation of Golgi-derived active zone precursor vesicles. Maas C, etal., J Neurosci. 2012 Aug 8;32(32):11095-108. doi: 10.1523/JNEUROSCI.0195-12.2012.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain. Nensa FM, etal., Mol Cell Proteomics. 2014 Feb;13(2):475-88. doi: 10.1074/mcp.M113.029280. Epub 2013 Nov 27.
8. Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain. Pellet JB, etal., Eur J Neurosci. 2000 Feb;12(2):621-32.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin. Schivell AE, etal., J Biol Chem. 1996 Nov 1;271(44):27770-5.
14. Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A. Strotmeier J, etal., FEBS Lett. 2014 Apr 2;588(7):1087-93. doi: 10.1016/j.febslet.2014.02.034. Epub 2014 Feb 25.
15. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
16. Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy. Tejero R, etal., Hum Mol Genet. 2016 Aug 29. pii: ddw297.
17. Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission. Tokudome K, etal., Sci Rep. 2016 Jun 6;6:27420. doi: 10.1038/srep27420.
18. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:1355409   PMID:1426240   PMID:10455054   PMID:10624962   PMID:10625067   PMID:10747945   PMID:12074840   PMID:12477932   PMID:12687700   PMID:15210974   PMID:15489334   PMID:15713258  
PMID:15866046   PMID:16306227   PMID:16543415   PMID:18524768   PMID:19176798   PMID:20410110   PMID:21307259   PMID:21664258   PMID:22871113   PMID:23530581   PMID:24035762   PMID:25205164  
PMID:26489628   PMID:29476059   PMID:30336420   PMID:30905653   PMID:32407277   PMID:32538280   PMID:34435329  


Genomics

Comparative Map Data
Sv2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,430,363 - 186,446,161 (+)NCBIGRCr8
mRatBN7.22183,741,489 - 183,757,290 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,741,547 - 183,756,927 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,405,136 - 191,420,924 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,209,456 - 189,225,293 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,037,670 - 184,053,458 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,321,100 - 198,336,889 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,321,142 - 198,336,913 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,808,165 - 217,823,872 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,989,187 - 191,000,859 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,948,188 - 190,963,566 (+)NCBI
Celera2176,272,713 - 176,284,621 (+)NCBICelera
Cytogenetic Map2q34NCBI
SV2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,903,318 - 149,917,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,903,318 - 149,917,844 (-)EnsemblGRCh38hg38GRCh38
GRCh371149,874,870 - 149,889,396 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,141,859 - 148,156,054 (-)NCBINCBI36Build 36hg18NCBI36
Celera1122,990,840 - 123,005,404 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,255,354 - 121,269,918 (-)NCBIHuRef
CHM1_11151,271,444 - 151,286,008 (-)NCBICHM1_1
T2T-CHM13v2.01149,027,459 - 149,041,985 (-)NCBIT2T-CHM13v2.0
Sv2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,088,543 - 96,102,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,088,467 - 96,102,837 (+)EnsemblGRCm39 Ensembl
GRCm38396,181,227 - 96,195,183 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,181,151 - 96,195,521 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,985,150 - 95,999,106 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,266,632 - 96,280,588 (+)NCBIMGSCv36mm8
Celera397,620,657 - 97,631,186 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.65NCBI
Sv2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413834,743 - 851,023 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955413834,743 - 849,176 (+)NCBIChiLan1.0ChiLan1.0
SV2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,921,893 - 99,936,495 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,676,850 - 99,691,458 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,247,429 - 125,262,041 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11128,904,140 - 128,918,829 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1128,904,151 - 128,918,829 (-)Ensemblpanpan1.1panPan2
SV2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,185,715 - 59,195,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,187,244 - 59,195,888 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,633,794 - 58,647,878 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,182,727 - 60,196,808 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,182,738 - 60,196,859 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,032,197 - 59,046,284 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,115,941 - 59,130,018 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,843,004 - 59,857,105 (-)NCBIUU_Cfam_GSD_1.0
Sv2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,213,447 - 21,227,353 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580243,792 - 257,760 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580243,829 - 257,708 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SV2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,138,342 - 99,153,149 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,138,319 - 99,153,153 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,567,034 - 108,581,274 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SV2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603813,389,665 - 13,404,056 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sv2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,681,299 - 17,696,884 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,684,061 - 17,698,728 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sv2a
79 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:330
Count of miRNA genes:214
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000028760
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
D2Got117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,743,287 - 183,743,468 (+)MAPPERmRatBN7.2
Rnor_6.02198,322,923 - 198,323,103NCBIRnor6.0
Rnor_5.02217,809,906 - 217,810,086UniSTSRnor5.0
RGSC_v3.42190,987,175 - 190,987,356RGDRGSC3.4
RGSC_v3.42190,987,176 - 190,987,356UniSTSRGSC3.4
RGSC_v3.12190,949,930 - 190,950,110RGD
Celera2176,270,702 - 176,270,882UniSTS
RH 3.4 Map21221.5UniSTS
RH 3.4 Map21221.5RGD
RH 2.0 Map2901.2RGD
Cytogenetic Map2q34UniSTS
D2Wox49  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,756,199 - 183,756,468 (+)MAPPERmRatBN7.2
Rnor_6.02198,335,799 - 198,336,067NCBIRnor6.0
Rnor_5.02217,822,782 - 217,823,050UniSTSRnor5.0
RGSC_v3.42191,000,085 - 191,000,353UniSTSRGSC3.4
Celera2176,283,847 - 176,284,115UniSTS
Cytogenetic Map2q34UniSTS
AI746429  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,756,723 - 183,756,829 (+)MAPPERmRatBN7.2
Rnor_6.02198,336,323 - 198,336,428NCBIRnor6.0
Rnor_5.02217,823,306 - 217,823,411UniSTSRnor5.0
RGSC_v3.42191,000,609 - 191,000,714UniSTSRGSC3.4
Celera2176,284,371 - 176,284,476UniSTS
Cytogenetic Map2q34UniSTS
RH129295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,757,052 - 183,757,232 (+)MAPPERmRatBN7.2
Rnor_6.02198,336,652 - 198,336,831NCBIRnor6.0
Rnor_5.02217,823,635 - 217,823,814UniSTSRnor5.0
RGSC_v3.42191,000,938 - 191,001,117UniSTSRGSC3.4
Celera2176,284,700 - 176,284,879UniSTS
RH 3.4 Map21221.6UniSTS
Cytogenetic Map2q34UniSTS
RH143796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,754,422 - 183,754,565 (+)MAPPERmRatBN7.2
Rnor_6.02198,334,022 - 198,334,164NCBIRnor6.0
Rnor_5.02217,821,005 - 217,821,147UniSTSRnor5.0
RGSC_v3.42190,998,308 - 190,998,450UniSTSRGSC3.4
Celera2176,282,070 - 176,282,212UniSTS
RH 3.4 Map21221.4UniSTS
Cytogenetic Map2q34UniSTS
BE119349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,740,816 - 183,740,982 (+)MAPPERmRatBN7.2
Rnor_6.02198,320,452 - 198,320,617NCBIRnor6.0
Rnor_5.02217,807,435 - 217,807,600UniSTSRnor5.0
RGSC_v3.42190,984,705 - 190,984,870UniSTSRGSC3.4
Celera2176,268,103 - 176,268,268UniSTS
RH 3.4 Map21221.5UniSTS
Cytogenetic Map2q34UniSTS


Related Rat Strains
The following Strains have been annotated to Sv2a
F344-Sv2am1Kyo    


Genetic Models
This gene Sv2a is modified in the following models/strains:
F344-Sv2am1Kyo    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 2 2 2 68 22 17
Low 3 27 53 37 19 37 7 10 6 13 19 11 7
Below cutoff 2 2 2 1 1 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028760   ⟹   ENSRNOP00000028760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,741,547 - 183,756,927 (+)Ensembl
Rnor_6.0 Ensembl2198,321,142 - 198,336,913 (+)Ensembl
RefSeq Acc Id: NM_057210   ⟹   NP_476558
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,430,363 - 186,446,161 (+)NCBI
mRatBN7.22183,741,489 - 183,757,290 (+)NCBI
Rnor_6.02198,324,934 - 198,336,573 (+)NCBI
Rnor_5.02217,808,165 - 217,823,872 (+)NCBI
RGSC_v3.42190,989,187 - 191,000,859 (+)RGD
Celera2176,272,713 - 176,284,621 (+)RGD
Sequence:
RefSeq Acc Id: XM_039101598   ⟹   XP_038957526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,436,362 - 186,446,161 (+)NCBI
mRatBN7.22183,747,488 - 183,757,290 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_476558   ⟸   NM_057210
- UniProtKB: Q58DZ8 (UniProtKB/Swiss-Prot),   Q02563 (UniProtKB/Swiss-Prot),   A6K354 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028760   ⟸   ENSRNOT00000028760
RefSeq Acc Id: XP_038957526   ⟸   XM_039101598
- Peptide Label: isoform X1
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02563-F1-model_v2 AlphaFold Q02563 1-742 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691569
Promoter ID:EPDNEW_R2093
Type:initiation region
Name:Sv2a_1
Description:synaptic vesicle glycoprotein 2a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02198,321,138 - 198,321,198EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619715 AgrOrtholog
BioCyc Gene G2FUF-52050 BioCyc
Ensembl Genes ENSRNOG00000021182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055032256 UniProtKB/Swiss-Prot
  ENSRNOG00060013977 UniProtKB/Swiss-Prot
  ENSRNOG00065031025 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028760 ENTREZGENE
  ENSRNOT00000028760.5 UniProtKB/Swiss-Prot
  ENSRNOT00055055705 UniProtKB/Swiss-Prot
  ENSRNOT00060023914 UniProtKB/Swiss-Prot
  ENSRNOT00065053497 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
  E3 ubiquitin-protein ligase SopA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS general substrate transporter like domains UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314271 IMAGE-MGC_LOAD
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_sugar_transport-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SV2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117559 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105346 IMAGE-MGC_LOAD
NCBI Gene 117559 ENTREZGENE
PANTHER SYNAPTIC VESICLE GLYCOPROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPTIC VESICLE GLYCOPROTEIN 2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_tr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sv2a PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR_TRANSPORT_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021182 RatGTEx
  ENSRNOG00055032256 RatGTEx
  ENSRNOG00060013977 RatGTEx
  ENSRNOG00065031025 RatGTEx
Superfamily-SCOP MFS general substrate transporter UniProtKB/TrEMBL
  Pentapeptide repeat-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF103473 UniProtKB/Swiss-Prot
UniProt A6K354 ENTREZGENE, UniProtKB/TrEMBL
  Q02563 ENTREZGENE
  Q58DZ8 ENTREZGENE
  SV2A_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q58DZ8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Sv2a  synaptic vesicle glycoprotein 2a    synaptic vesicle glycoprotein 2 a  Name updated 1299863 APPROVED
2002-08-07 Sv2a  synaptic vesicle glycoprotein 2 a      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains has 12 transmembrane domains 634182
gene_expression expressed in the endocrine cells and in the secretory vesicles in neurons 634182