Gene: Prkn (parkin RBR E3 ubiquitin protein ligase) Rattus norvegicus
Symbol: Prkn
Name: parkin RBR E3 ubiquitin protein ligase
Description: ENCODES a protein that exhibits protein kinase binding; protein-containing complex binding; actin binding (ortholog); INVOLVED IN autophagy of mitochondrion; brain development; cellular response to hydrogen sulfide; PARTICIPATES IN altered mitochondrial autophagy pathway; mitochondrial autophagy pathway; Parkinson's disease pathway; ASSOCIATED WITH Liver Cirrhosis, Experimental; Parkinson's Disease; Subarachnoid Hemorrhage; FOUND IN axon; cytoplasm; cytoplasmic vesicle; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; androgen antagonist
Type: protein-coding
Also known as: E3 ubiquitin-protein ligase parkin; Park; Park2; parkin; parkin RBR E3 ubiquitin protein ligase 2; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein ligase
Homo sapiens (human) : PRKN (parkin RBR E3 ubiquitin protein ligase)  HGNC  Alliance
Mus musculus (house mouse) : Park2 (Parkinson disease (autosomal recessive, juvenile) 2, parkin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkn (parkin RBR E3 ubiquitin protein ligase)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Canis lupus familiaris (dog) : PRKN (parkin RBR E3 ubiquitin protein ligase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkn (parkin RBR E3 ubiquitin protein ligase)
more info ...
Allele / Splice: Prknem1Sage  
Genetic Models: LE-Prknem1Sage-/- LE-Prknem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0148,880,015 - 50,069,998 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0149,684,308 - 50,875,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4143,151,265 - 44,374,470 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1143,154,209 - 44,377,415 (-)NCBI
Celera144,478,407 - 45,666,902 (-)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Prkn
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61797
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2018-04-17
Status: ACTIVE