Map3k12 (mitogen activated protein kinase kinase kinase 12) - Rat Genome Database

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Gene: Map3k12 (mitogen activated protein kinase kinase kinase 12) Rattus norvegicus
Analyze
Symbol: Map3k12
Name: mitogen activated protein kinase kinase kinase 12
RGD ID: 3988
Description: Predicted to enable several functions, including JUN kinase kinase kinase activity; protein homodimerization activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including JNK cascade; positive regulation of DNA-templated transcription; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within negative regulation of motor neuron apoptotic process. Predicted to be located in cytosol; growth cone; and plasma membrane. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DLK; dual leucine zipper bearing kinase; dual leucine zipper kinase; leucine-zipper protein kinase; MAPK-upstream kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); mitogen-activated protein kinase kinase kinase 12; mixed lineage kinase; MUK; PK; Zipper (leucine) protein kinase; Zpk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,507,082 - 135,527,396 (-)NCBIGRCr8
mRatBN7.27133,630,267 - 133,648,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,630,835 - 133,640,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,386,026 - 135,403,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,615,393 - 137,632,865 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,601,642 - 137,619,118 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,102,275 - 144,120,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,102,680 - 144,109,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,894,406 - 141,912,301 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,254,451 - 141,264,979 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,330,887 - 141,341,418 (-)NCBI
Celera7130,056,875 - 130,075,370 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-tert-Octylphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carboplatin  (EXP)
cefaloridine  (EXP)
cisplatin  (EXP,ISO)
clozapine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
haloperidol  (EXP)
indometacin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
triticonazole  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)
growth cone  (IEA,ISO)
plasma membrane  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo. Hirai S, etal., Development 2002 Oct;129(19):4483-95.
4. Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Hirai S, etal., Oncogene 1996 Feb 1;12(3):641-50.
5. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7983011   PMID:8663324   PMID:14690535   PMID:14697235   PMID:15567716   PMID:18031680   PMID:19146952   PMID:23431148   PMID:25100604   PMID:26719418   PMID:27511108   PMID:28111074  
PMID:32189007  


Genomics

Comparative Map Data
Map3k12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,507,082 - 135,527,396 (-)NCBIGRCr8
mRatBN7.27133,630,267 - 133,648,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,630,835 - 133,640,789 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,386,026 - 135,403,498 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,615,393 - 137,632,865 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,601,642 - 137,619,118 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,102,275 - 144,120,306 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,102,680 - 144,109,116 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,894,406 - 141,912,301 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,254,451 - 141,264,979 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,330,887 - 141,341,418 (-)NCBI
Celera7130,056,875 - 130,075,370 (-)NCBICelera
Cytogenetic Map7q36NCBI
MAP3K12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,479,669 - 53,501,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,479,669 - 53,500,063 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,873,453 - 53,893,242 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,160,547 - 52,179,538 (-)NCBINCBI36Build 36hg18NCBI36
Build 341252,160,546 - 52,179,538NCBI
Celera1253,524,658 - 53,543,802 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,914,162 - 50,933,025 (-)NCBIHuRef
CHM1_11253,841,326 - 53,860,500 (-)NCBICHM1_1
T2T-CHM13v2.01253,445,716 - 53,466,177 (-)NCBIT2T-CHM13v2.0
Map3k12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,406,079 - 102,425,311 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,406,081 - 102,425,499 (-)EnsemblGRCm39 Ensembl
GRCm3815102,497,647 - 102,517,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,497,646 - 102,517,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715102,328,078 - 102,347,435 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,325,683 - 102,344,846 (-)NCBIMGSCv36mm8
Celera15104,655,611 - 104,674,768 (-)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.63NCBI
Map3k12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458774,478 - 785,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955458774,478 - 793,654 (-)NCBIChiLan1.0ChiLan1.0
MAP3K12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,684,755 - 40,704,150 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,681,825 - 40,700,914 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,253,814 - 35,273,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,038,595 - 36,058,210 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,038,634 - 36,058,200 (+)Ensemblpanpan1.1panPan2
MAP3K12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,721,484 - 1,736,204 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,726,310 - 1,734,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,514,739 - 44,529,820 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,724,391 - 1,739,470 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,725,365 - 1,739,450 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,742,889 - 1,756,986 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,725,190 - 1,740,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,916,419 - 44,931,520 (-)NCBIUU_Cfam_GSD_1.0
Map3k12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,391,586 - 62,409,177 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,754,510 - 10,773,625 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,755,653 - 10,773,321 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,699,385 - 18,717,199 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,699,123 - 18,717,209 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2519,134,847 - 19,152,725 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,581,601 - 49,600,359 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,582,291 - 49,600,335 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,453,652 - 196,473,011 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249041,578,986 - 1,598,939 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249041,579,792 - 1,598,595 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k12
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:98
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000020437
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
RH134302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,630,949 - 133,631,163 (+)MAPPERmRatBN7.2
Rnor_6.07144,103,361 - 144,103,574NCBIRnor6.0
Rnor_5.07141,895,495 - 141,895,708UniSTSRnor5.0
RGSC_v3.47141,255,132 - 141,255,345UniSTSRGSC3.4
Celera7130,057,556 - 130,057,769UniSTS
RH 3.4 Map71062.1UniSTS
Cytogenetic Map7q36UniSTS
AA924752  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,630,698 - 133,630,816 (+)MAPPERmRatBN7.2
Rnor_6.07144,103,110 - 144,103,227NCBIRnor6.0
Rnor_5.07141,895,244 - 141,895,361UniSTSRnor5.0
RGSC_v3.47141,254,881 - 141,254,998UniSTSRGSC3.4
Celera7130,057,305 - 130,057,422UniSTS
RH 3.4 Map71064.5UniSTS
Cytogenetic Map7q36UniSTS
PMC87148P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,630,958 - 133,631,880 (+)MAPPERmRatBN7.2
Rnor_6.07144,103,370 - 144,104,291NCBIRnor6.0
Rnor_5.07141,895,504 - 141,896,425UniSTSRnor5.0
RGSC_v3.47141,255,141 - 141,256,062UniSTSRGSC3.4
Celera7130,057,565 - 130,058,486UniSTS
Cytogenetic Map7q36UniSTS
AA924752  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X111,939,024 - 111,939,212 (+)MAPPERmRatBN7.2
mRatBN7.2X111,933,167 - 111,933,355 (+)MAPPERmRatBN7.2
mRatBN7.27133,630,584 - 133,630,773 (+)MAPPERmRatBN7.2
mRatBN7.2X111,923,266 - 111,923,454 (+)MAPPERmRatBN7.2
Rnor_6.07144,102,996 - 144,103,184NCBIRnor6.0
Rnor_6.0X119,209,198 - 119,209,385NCBIRnor6.0
Rnor_5.0X119,351,534 - 119,351,721UniSTSRnor5.0
Rnor_5.07141,895,130 - 141,895,318UniSTSRnor5.0
RGSC_v3.4X29,755,783 - 29,755,971UniSTSRGSC3.4
RGSC_v3.47141,254,767 - 141,254,955UniSTSRGSC3.4
Celera7130,057,191 - 130,057,379UniSTS
RH 3.4 Map71064.5UniSTS
Cytogenetic MapXq13UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 23 18 4 18 4 3 74 29 41 11
Low 20 39 37 1 37 8 8 6 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006242382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063263042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY240864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D49785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000020437   ⟹   ENSRNOP00000020437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,630,835 - 133,640,789 (-)Ensembl
Rnor_6.0 Ensembl7144,102,680 - 144,109,116 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100256   ⟹   ENSRNOP00000090908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,630,835 - 133,640,789 (-)Ensembl
RefSeq Acc Id: NM_013055   ⟹   NP_037187
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,508,790 - 135,526,272 (-)NCBI
mRatBN7.27133,630,269 - 133,647,752 (-)NCBI
Rnor_6.07144,102,680 - 144,120,306 (-)NCBI
Rnor_5.07141,894,406 - 141,912,301 (-)NCBI
RGSC_v3.47141,254,451 - 141,264,979 (-)RGD
Celera7130,056,875 - 130,075,370 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242381   ⟹   XP_006242443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,525,901 (-)NCBI
mRatBN7.27133,630,267 - 133,642,093 (-)NCBI
Rnor_6.07144,102,275 - 144,115,336 (-)NCBI
Rnor_5.07141,894,406 - 141,912,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242382   ⟹   XP_006242444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,527,269 (-)NCBI
mRatBN7.27133,630,267 - 133,648,133 (-)NCBI
Rnor_6.07144,102,275 - 144,120,142 (-)NCBI
Rnor_5.07141,894,406 - 141,912,301 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063263032   ⟹   XP_063119102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,525,901 (-)NCBI
RefSeq Acc Id: XM_063263034   ⟹   XP_063119104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,527,269 (-)NCBI
RefSeq Acc Id: XM_063263035   ⟹   XP_063119105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,527,396 (-)NCBI
RefSeq Acc Id: XM_063263036   ⟹   XP_063119106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,525,901 (-)NCBI
RefSeq Acc Id: XM_063263037   ⟹   XP_063119107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,527,269 (-)NCBI
RefSeq Acc Id: XM_063263038   ⟹   XP_063119108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,526,706 (-)NCBI
RefSeq Acc Id: XM_063263039   ⟹   XP_063119109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,525,901 (-)NCBI
RefSeq Acc Id: XM_063263040   ⟹   XP_063119110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,525,901 (-)NCBI
RefSeq Acc Id: XM_063263041   ⟹   XP_063119111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,507,082 - 135,527,269 (-)NCBI
RefSeq Acc Id: XM_063263042   ⟹   XP_063119112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,511,350 - 135,527,269 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037187   ⟸   NM_013055
- UniProtKB: Q63796 (UniProtKB/Swiss-Prot),   A0A8I6AF79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242444   ⟸   XM_006242382
- Peptide Label: isoform X1
- UniProtKB: F1LQ89 (UniProtKB/TrEMBL),   A0A8I6AF79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242443   ⟸   XM_006242381
- Peptide Label: isoform X1
- UniProtKB: F1LQ89 (UniProtKB/TrEMBL),   A0A8I6AF79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020437   ⟸   ENSRNOT00000020437
RefSeq Acc Id: ENSRNOP00000090908   ⟸   ENSRNOT00000100256
RefSeq Acc Id: XP_063119105   ⟸   XM_063263035
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119104   ⟸   XM_063263034
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119111   ⟸   XM_063263041
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119107   ⟸   XM_063263037
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119108   ⟸   XM_063263038
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119102   ⟸   XM_063263032
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119109   ⟸   XM_063263039
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119106   ⟸   XM_063263036
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119110   ⟸   XM_063263040
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119112   ⟸   XM_063263042
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63796-F1-model_v2 AlphaFold Q63796 1-888 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3988 AgrOrtholog
BioCyc Gene G2FUF-31933 BioCyc
Ensembl Genes ENSRNOG00000015134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020437 ENTREZGENE
  ENSRNOT00000020437.6 UniProtKB/TrEMBL
  ENSRNOT00000100256.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP3K12_MAP3K13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKKK12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25579 UniProtKB/Swiss-Prot
NCBI Gene 25579 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Map3k12 PhenoGen
PIRSF MAPKKK12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKKK12_MAPKKK13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015134 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216623
UniProt A0A8I6AF79 ENTREZGENE, UniProtKB/TrEMBL
  A6KCW1_RAT UniProtKB/TrEMBL
  A6KCW2_RAT UniProtKB/TrEMBL
  F1LQ89 ENTREZGENE, UniProtKB/TrEMBL
  M3K12_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Map3k12  mitogen activated protein kinase kinase kinase 12  Zpk  Zipper (leucine) protein kinase  Symbol and Name updated 629477 APPROVED
2002-06-10 Zpk  Zipper (leucine) protein kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activates JNK1 729296
gene_process may regulate neuronal radial cell migration 727427