Gene: Zap70 (zeta chain of T cell receptor associated protein kinase 70) Rattus norvegicus
Symbol: Zap70
Name: zeta chain of T cell receptor associated protein kinase 70
Description: ENCODES a protein that exhibits ATP binding (ortholog); phosphotyrosine residue binding (ortholog); protein kinase activity (ortholog); INVOLVED IN beta selection (ortholog); immune response (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; primary immunodeficiency disease pathway; T cell receptor signaling pathway; ASSOCIATED WITH autoimmune disease, multisystem, infantile-onset, 2 (ortholog); CD8 Deficiency, Familial (ortholog); IMMUNODEFICIENCY 48 (ortholog); FOUND IN cell-cell junction (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; 2,3,4,7,8-Pentachlorodibenzofuran
Type: protein-coding
Also known as: MGC108902; Srk; syk-related protein tyrosine kinase; tyrosine-protein kinase ZAP-70; Zap70_mapped; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70 (mapped); zeta-chain (TCR) associated protein kinase 70kDa
Homo sapiens (human) : ZAP70 (zeta chain of T cell receptor associated protein kinase 70)  HGNC  AGR
Mus musculus (house mouse) : Zap70 (zeta-chain (TCR) associated protein kinase)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Zap70 (zeta-chain (TCR) associated protein kinase 70kDa)
Pan paniscus (bonobo/pygmy chimpanzee) : ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa)
Canis lupus familiaris (dog) : ZAP70 (tyrosine-protein kinase ZAP-70)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101971458 (tyrosine-protein kinase ZAP-70)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0943,331,149 - 43,353,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0942,980,050 - 43,002,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,693,089 - 35,715,071 (+)NCBIRGSC3.4rn4RGSC3.4
Celera936,755,106 - 36,777,088 (+)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Zap70
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3983
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE