Sult1e1 (sulfotransferase family 1E member 1) - Rat Genome Database

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Gene: Sult1e1 (sulfotransferase family 1E member 1) Rattus norvegicus
Analyze
Symbol: Sult1e1
Name: sulfotransferase family 1E member 1
RGD ID: 3776
Description: Enables estrone sulfotransferase activity. Predicted to be involved in several processes, including 3'-phosphoadenosine 5'-phosphosulfate metabolic process; estrogen catabolic process; and ethanol catabolic process. Predicted to act upstream of or within female pregnancy. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in breast cancer and endometrial cancer. Orthologous to human SULT1E1 (sulfotransferase family 1E member 1); PARTICIPATES IN estradiol biosynthetic pathway; paracetamol pharmacokinetics pathway; sulfite oxidase deficiency pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EST-1; EST-2; EST-3; EST-6; estrogen sulfotransferase; estrogen sulfotransferase, isoform 1; estrogen sulfotransferase, isoform 3; estrone sulfotransferase; ESTSUL; rEST-6; ST1E1; Ste; Ste1; ste2; sulfotransferase 1E1; sulfotransferase family 1E, estrogen-preferring, member 1; sulfotransferase family 1E, member 1; sulfotransferase, estrogen preferring; sulfotransferase, estrogen-preferring
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,700,444 - 20,718,719 (+)NCBIGRCr8
mRatBN7.21420,422,324 - 20,439,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,422,324 - 20,439,275 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,610,541 - 20,627,768 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,929,454 - 21,946,681 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,684,867 - 20,702,117 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,070,861 - 22,089,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,072,024 - 22,089,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01421,985,847 - 22,004,150 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1419,831,652 - 19,842,299 (+)NCBICelera
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-ropivacaine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-hydroxy-17beta-estradiol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-Hydroxybenzo[a]pyrene  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
acetonitrile  (ISO)
adenosine 3',5'-bismonophosphate  (ISO)
aflatoxin B1  (ISO)
Aloe emodin  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (EXP)
biochanin A  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
butylated hydroxyanisole  (ISO)
Butylparaben  (EXP)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
chrysin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
colforsin daropate hydrochloride  (ISO)
coumarin  (EXP)
cyanocob(III)alamin  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dienestrol  (ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
estriol  (ISO)
estrone  (ISO)
estrone 3-sulfate  (ISO)
ethanol  (EXP,ISO)
fenofibrate  (EXP)
fipronil  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glycine betaine  (ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
Heliotrine  (ISO)
hexachlorobenzene  (EXP)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indole-3-methanol  (EXP)
ketoconazole  (ISO)
kojic acid  (EXP,ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
meclofenamic acid  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulindac  (EXP,ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
triadimefon  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP)
vitamin E  (EXP)
zaragozic acid A  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO,ISS)
nuclear membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer. Choi JY, etal., Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1090-5.
2. Estrogen sulfotransferase of the rat liver: complementary DNA cloning and age- and sex-specific regulation of messenger RNA. Demyan WF, etal., Mol Endocrinol 1992 Apr;6(4):589-97.
3. Isolation and expression of an isoform of rat estrogen sulfotransferase. Falany JL, etal., J Steroid Biochem Mol Biol 1995 Jan;52(1):35-44.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility. Hirata H, etal., Cancer. 2008 May 1;112(9):1964-73.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Purohit A, etal., Mol Cell Endocrinol. 2011 Jul 4;340(2):154-60. Epub 2011 Jun 30.
14. Pairwise combinations of estrogen metabolism genotypes in postmenopausal breast cancer etiology. Rebbeck TR, etal., Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):444-50.
15. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Structural relationships among members of the mammalian sulfotransferase gene family. Rikke BA and Roy AK, Biochim Biophys Acta 1996 Jul 17;1307(3):331-8.
20. Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers. Sun H, etal., J Pharmacol Exp Ther. 2006 Nov;319(2):818-31. Epub 2006 Aug 8.
21. Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches. Svetlov SI, etal., Biomarkers. 2006 Jul-Aug;11(4):355-69.
Additional References at PubMed
PMID:1299062   PMID:9348232   PMID:9765259   PMID:10519119   PMID:11884392   PMID:12173467   PMID:12477932   PMID:12765521   PMID:15685171   PMID:18054434   PMID:19548878   PMID:20056724  
PMID:23207770   PMID:24567372  


Genomics

Comparative Map Data
Sult1e1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81420,700,444 - 20,718,719 (+)NCBIGRCr8
mRatBN7.21420,422,324 - 20,439,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,422,324 - 20,439,275 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1420,610,541 - 20,627,768 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01421,929,454 - 21,946,681 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01420,684,867 - 20,702,117 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,070,861 - 22,089,264 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,072,024 - 22,089,248 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01421,985,847 - 22,004,150 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1419,831,652 - 19,842,299 (+)NCBICelera
Cytogenetic Map14p21NCBI
SULT1E1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38469,821,122 - 69,860,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl469,841,212 - 69,860,145 (-)EnsemblGRCh38hg38GRCh38
GRCh37470,706,930 - 70,725,863 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36470,741,519 - 70,760,459 (-)NCBINCBI36Build 36hg18NCBI36
Build 34470,887,690 - 70,906,630NCBI
Celera468,060,253 - 68,079,193 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef466,504,780 - 66,523,720 (-)NCBIHuRef
CHM1_1470,743,366 - 70,762,280 (-)NCBICHM1_1
T2T-CHM13v2.0473,176,039 - 73,194,989 (-)NCBIT2T-CHM13v2.0
Sult1e1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39587,723,827 - 87,739,470 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl587,723,828 - 87,739,453 (-)EnsemblGRCm39 Ensembl
GRCm38587,575,968 - 87,591,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl587,575,969 - 87,591,594 (-)EnsemblGRCm38mm10GRCm38
MGSCv37588,004,993 - 88,020,636 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36588,650,530 - 88,666,155 (-)NCBIMGSCv36mm8
Celera584,792,542 - 84,808,207 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
SULT1E1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2360,230,334 - 60,249,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1460,433,324 - 60,452,868 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0454,377,681 - 54,396,619 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,714,305 - 60,733,229 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl460,713,392 - 60,733,229 (+)Ensemblpanpan1.1panPan2
LOC482182
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11359,323,430 - 59,343,745 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1359,052,730 - 59,072,999 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01360,119,719 - 60,140,008 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1360,120,936 - 60,140,217 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11359,734,248 - 59,754,528 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01359,195,062 - 59,214,797 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01360,339,614 - 60,359,890 (-)NCBIUU_Cfam_GSD_1.0
SULT1E1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl866,811,550 - 66,834,473 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1866,811,536 - 66,838,181 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SULT1E1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1718,313,510 - 18,330,768 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl718,313,238 - 18,330,741 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660844,599,800 - 4,616,560 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Sult1e1
1025 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141762256142337007Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat

Markers in Region
D14Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21420,439,207 - 20,439,526 (+)MAPPERmRatBN7.2
Rnor_6.01422,088,911 - 22,089,228NCBIRnor6.0
Rnor_5.01422,003,797 - 22,004,114UniSTSRnor5.0
RGSC_v3.41421,965,205 - 21,965,523RGDRGSC3.4
RGSC_v3.41421,965,206 - 21,965,523UniSTSRGSC3.4
RGSC_v3.11421,965,205 - 21,965,523RGD
Celera1419,841,948 - 19,842,265UniSTS
FHH x ACI Map1421.7599RGD
FHH x ACI Map1421.7599UniSTS
Cytogenetic Map14p21UniSTS
Cytogenetic Map14p21.3-p21.2UniSTS
D14Wox31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21420,421,607 - 20,421,896 (+)MAPPERmRatBN7.2
Rnor_6.01422,071,307 - 22,071,596NCBIRnor6.0
Rnor_5.01421,986,193 - 21,986,482UniSTSRnor5.0
RGSC_v3.41421,947,758 - 21,948,047UniSTSRGSC3.4
Cytogenetic Map14p21.3-p21.2UniSTS
Cytogenetic Map14p21UniSTS
D14Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21420,439,378 - 20,439,524 (+)MAPPERmRatBN7.2
Rnor_6.01422,089,082 - 22,089,226NCBIRnor6.0
Rnor_5.01422,003,968 - 22,004,112UniSTSRnor5.0
RGSC_v3.41421,965,377 - 21,965,521UniSTSRGSC3.4
Celera1419,842,119 - 19,842,263UniSTS
Cytogenetic Map14p21UniSTS
Cytogenetic Map14p21.3-p21.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5 5 5
Medium 4 4 4 1
Low 7 2 4 2 1 1 2 2 16 4 1
Below cutoff 1 6 21 10 13 10 5 7 9 12 16 4 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ131835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ298109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ306223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ306224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ306225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ306226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ306227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ306228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ312318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S76490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000002680   ⟹   ENSRNOP00000002680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1420,422,324 - 20,439,275 (+)Ensembl
Rnor_6.0 Ensembl1422,072,024 - 22,089,248 (+)Ensembl
RefSeq Acc Id: NM_012883   ⟹   NP_037015
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,701,480 - 20,718,719 (+)NCBI
mRatBN7.21420,422,324 - 20,439,562 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063273309   ⟹   XP_063129379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81420,700,444 - 20,718,719 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000002680   ⟸   ENSRNOT00000002680
RefSeq Acc Id: NP_037015   ⟸   NM_012883
- UniProtKB: Q9QWS0 (UniProtKB/Swiss-Prot),   P52845 (UniProtKB/Swiss-Prot),   P52844 (UniProtKB/Swiss-Prot),   P49890 (UniProtKB/Swiss-Prot),   P49889 (UniProtKB/Swiss-Prot),   F7FNI2 (UniProtKB/TrEMBL),   Q99ND5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063129379   ⟸   XM_063273309
- Peptide Label: isoform X1
Protein Domains
Sulfotransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49889-F1-model_v2 AlphaFold P49889 1-295 view protein structure
AF-P49890-F1-model_v2 AlphaFold P49890 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699249
Promoter ID:EPDNEW_R9774
Type:multiple initiation site
Name:Sult1e1_1
Description:sulfotransferase family 1E member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,072,015 - 22,072,075EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3776 AgrOrtholog
BioCyc Gene G2FUF-16121 BioCyc
Ensembl Genes ENSRNOG00000001957 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002680 ENTREZGENE
  ENSRNOT00000002680.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7323209 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360268 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108739 IMAGE-MGC_LOAD
NCBI Gene Sult1e1 ENTREZGENE
PANTHER SULFOTRANSFERASE 1E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SULFOTRANSFERASE SULT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SULT1E1 RGD
PhenoGen Sult1e1 PhenoGen
RatGTEx ENSRNOG00000001957 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F7FNI2 ENTREZGENE, UniProtKB/TrEMBL
  P49889 ENTREZGENE
  P49890 ENTREZGENE
  P52844 ENTREZGENE
  P52845 ENTREZGENE
  Q99ND5 ENTREZGENE, UniProtKB/TrEMBL
  Q9QWS0 ENTREZGENE
  ST1E1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P49889 UniProtKB/Swiss-Prot
  P49890 UniProtKB/Swiss-Prot
  P52845 UniProtKB/Swiss-Prot
  Q9QWS0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-25 Sult1e1  sulfotransferase family 1E member 1  ste2  estrogen sulfotransferase  Data merged from RGD:1597142 737654 PROVISIONAL
2015-11-12 Sult1e1  sulfotransferase family 1E member 1  Sult1e1  sulfotransferase family 1E, estrogen-preferring, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Sult1e1  sulfotransferase family 1E, estrogen-preferring, member 1  Sult1e1  sulfotransferase family 1E, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Sult1e1  sulfotransferase family 1E, member 1  Ste  sulfotransferase, estrogen preferring  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 ste2  estrogen sulfotransferase      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ste  sulfotransferase, estrogen preferring      Symbol and Name status set to approved 70586 APPROVED
2001-07-23 Ste  sulfotransferase, estrogen preferring      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Ste  Estrogen sulfotransferase      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 1299062