Rgs12 (regulator of G-protein signaling 12) - Rat Genome Database

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Gene: Rgs12 (regulator of G-protein signaling 12) Rattus norvegicus
Analyze
Symbol: Rgs12
Name: regulator of G-protein signaling 12
RGD ID: 3564
Description: Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in termination of G protein-coupled receptor signaling pathway. Located in several cellular components, including apical dendrite; neuronal cell body; and nucleus. Part of protein-containing complex. Colocalizes with synapse. Orthologous to human RGS12 (regulator of G protein signaling 12); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: regulator of G-protein signalling 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,940,561 - 80,048,637 (-)NCBIGRCr8
mRatBN7.21475,715,925 - 75,824,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,715,934 - 75,794,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,175,876 - 80,263,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,416,503 - 81,503,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,861,725 - 77,949,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,975,239 - 81,069,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,975,322 - 81,053,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,664,122 - 81,771,788 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,363,542 - 81,436,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,365,932 - 81,438,585 (-)NCBI
Celera1474,648,755 - 74,720,676 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical dendrite  (IDA)
cytoplasm  (IBA,IDA,IEA)
cytosol  (IEA,ISO)
dendrite  (IDA,IEA)
neuronal cell body  (IDA)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA)
plasma membrane  (IBA,IEA)
protein-containing complex  (IDA)
synapse  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. Kimple RJ, etal., J Biol Chem. 2001 Aug 3;276(31):29275-81. Epub 2001 May 31.
3. Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain. Lopez-Aranda MF, etal., Eur J Neurosci. 2006 Jun;23(11):2971-82.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. Schiff ML, etal., Nature. 2000 Dec 7;408(6813):723-7.
10. Molecular cloning and expression analysis of rat Rgs12 and Rgs14. Snow BE, etal., Biochem Biophys Res Commun 1997 Apr 28;233(3):770-7.
11. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. Snow BE, etal., J Biol Chem 1998 Jul 10;273(28):17749-55.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation. Willard MD, etal., EMBO J. 2007 Apr 18;26(8):2029-40. Epub 2007 Mar 22.
Additional References at PubMed
PMID:34674723  


Genomics

Comparative Map Data
Rgs12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,940,561 - 80,048,637 (-)NCBIGRCr8
mRatBN7.21475,715,925 - 75,824,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,715,934 - 75,794,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,175,876 - 80,263,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,416,503 - 81,503,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,861,725 - 77,949,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,975,239 - 81,069,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,975,322 - 81,053,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,664,122 - 81,771,788 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,363,542 - 81,436,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,365,932 - 81,438,585 (-)NCBI
Celera1474,648,755 - 74,720,676 (-)NCBICelera
Cytogenetic Map14q21NCBI
RGS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3843,285,891 - 3,439,913 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl43,293,021 - 3,439,913 (+)EnsemblGRCh38hg38GRCh38
GRCh3743,287,618 - 3,441,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,285,672 - 3,411,438 (+)NCBINCBI36Build 36hg18NCBI36
Build 3443,425,087 - 3,478,607NCBI
Celera43,227,025 - 3,352,526 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef43,253,766 - 3,378,780 (+)NCBIHuRef
CHM1_143,313,437 - 3,439,350 (+)NCBICHM1_1
T2T-CHM13v2.043,284,640 - 3,439,697 (+)NCBIT2T-CHM13v2.0
Rgs12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,106,273 - 35,196,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,106,789 - 35,196,988 (+)EnsemblGRCm39 Ensembl
GRCm38534,948,929 - 35,039,642 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,949,445 - 35,039,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv37535,292,097 - 35,376,244 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36535,266,308 - 35,350,456 (+)NCBIMGSCv36mm8
Celera532,423,269 - 32,508,385 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.96NCBI
Rgs12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,088,354 - 2,154,191 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,081,575 - 2,154,414 (+)NCBIChiLan1.0ChiLan1.0
RGS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,632,834 - 3,783,631 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,566,200 - 3,717,305 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,439,030 - 3,589,026 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,444,467 - 3,573,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,444,570 - 3,573,712 (+)Ensemblpanpan1.1panPan2
RGS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,917,033 - 61,011,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,917,072 - 61,009,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,567,210 - 63,619,308 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,392,603 - 61,512,294 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,392,635 - 61,512,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,884,355 - 61,003,999 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,090,461 - 61,208,240 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,446,826 - 61,566,535 (-)NCBIUU_Cfam_GSD_1.0
Rgs12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,544,669 - 66,706,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,257,965 - 20,278,434 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493647720,300,521 - 20,388,221 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,300,528 - 20,388,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,963,308 - 2,075,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,971,390 - 2,074,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,649,955 - 1,729,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,302,193 - 45,444,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660511,647,849 - 1,802,824 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,489,966 - 24,553,505 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,489,746 - 24,567,937 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgs12
301 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:414
Count of miRNA genes:136
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000040215, ENSRNOT00000045068
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat

Markers in Region
RH131193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,722,868 - 75,723,076 (+)MAPPERmRatBN7.2
Rnor_6.01480,982,183 - 80,982,390NCBIRnor6.0
Rnor_5.01481,671,066 - 81,671,273UniSTSRnor5.0
RGSC_v3.41481,363,563 - 81,363,770UniSTSRGSC3.4
Celera1474,648,776 - 74,648,983UniSTS
Cytogenetic Map14q21UniSTS
RH132578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21475,716,019 - 75,716,204 (+)MAPPERmRatBN7.2
Rnor_6.01480,975,334 - 80,975,518NCBIRnor6.0
Rnor_5.01481,664,217 - 81,664,401UniSTSRnor5.0
RGSC_v3.41481,356,714 - 81,356,898UniSTSRGSC3.4
Celera1474,641,927 - 74,642,111UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 26 18 16 18 65 18 40 11
Low 3 21 31 23 3 23 8 11 9 17 1 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006251353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF035151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U92280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000040215   ⟹   ENSRNOP00000045065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1475,715,934 - 75,794,596 (-)Ensembl
Rnor_6.0 Ensembl1480,975,322 - 81,053,906 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000045068   ⟹   ENSRNOP00000047497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1475,722,848 - 75,794,596 (-)Ensembl
Rnor_6.0 Ensembl1480,982,162 - 81,053,905 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081570   ⟹   ENSRNOP00000072476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1475,722,848 - 75,764,371 (-)Ensembl
Rnor_6.0 Ensembl1480,982,162 - 81,023,682 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093959   ⟹   ENSRNOP00000096510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1475,723,806 - 75,755,612 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096126   ⟹   ENSRNOP00000083247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1475,722,848 - 75,794,144 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098957   ⟹   ENSRNOP00000096951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1475,722,848 - 75,736,876 (-)Ensembl
RefSeq Acc Id: NM_019339   ⟹   NP_062212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,947,479 - 80,034,859 (-)NCBI
mRatBN7.21475,722,848 - 75,810,235 (-)NCBI
Rnor_6.01480,982,162 - 81,053,905 (-)NCBI
Rnor_5.01481,664,122 - 81,771,788 (-)NCBI
RGSC_v3.41481,363,542 - 81,436,194 (-)RGD
Celera1474,648,755 - 74,720,676 (-)RGD
Sequence:
RefSeq Acc Id: XM_006251351   ⟹   XP_006251413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 80,035,843 (-)NCBI
mRatBN7.21475,715,925 - 75,810,235 (-)NCBI
Rnor_6.01480,975,239 - 81,069,519 (-)NCBI
Rnor_5.01481,664,122 - 81,771,788 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251352   ⟹   XP_006251414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 80,035,843 (-)NCBI
mRatBN7.21475,715,925 - 75,810,203 (-)NCBI
Rnor_6.01480,975,239 - 81,069,519 (-)NCBI
Rnor_5.01481,664,122 - 81,771,788 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251353   ⟹   XP_006251415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 80,027,176 (-)NCBI
mRatBN7.21475,715,925 - 75,802,546 (-)NCBI
Rnor_6.01480,975,239 - 81,062,243 (-)NCBI
Rnor_5.01481,664,122 - 81,771,788 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770350   ⟹   XP_008768572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 80,027,176 (-)NCBI
mRatBN7.21475,715,925 - 75,802,546 (-)NCBI
Rnor_6.01480,975,239 - 81,062,243 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770351   ⟹   XP_008768573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 80,003,481 (-)NCBI
mRatBN7.21475,715,925 - 75,778,856 (-)NCBI
Rnor_6.01480,975,239 - 81,038,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599342   ⟹   XP_017454831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 79,968,347 (-)NCBI
mRatBN7.21475,715,925 - 75,743,725 (-)NCBI
Rnor_6.01480,975,239 - 81,000,733 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092337   ⟹   XP_038948265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 80,048,637 (-)NCBI
mRatBN7.21475,715,925 - 75,824,012 (-)NCBI
RefSeq Acc Id: XM_039092338   ⟹   XP_038948266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,941,077 - 80,035,843 (-)NCBI
mRatBN7.21475,716,449 - 75,810,235 (-)NCBI
RefSeq Acc Id: XM_039092339   ⟹   XP_038948267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,947,475 - 80,035,843 (-)NCBI
mRatBN7.21475,724,293 - 75,810,235 (-)NCBI
RefSeq Acc Id: XM_039092340   ⟹   XP_038948268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 80,003,349 (-)NCBI
mRatBN7.21475,715,925 - 75,778,737 (-)NCBI
RefSeq Acc Id: XM_063273512   ⟹   XP_063129582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81479,940,561 - 79,980,985 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062212   ⟸   NM_019339
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot),   G3V9H1 (UniProtKB/TrEMBL),   A6IK12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251413   ⟸   XM_006251351
- Peptide Label: isoform X1
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot),   D4AB55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251414   ⟸   XM_006251352
- Peptide Label: isoform X1
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot),   D4AB55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251415   ⟸   XM_006251353
- Peptide Label: isoform X1
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot),   D4AB55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768572   ⟸   XM_008770350
- Peptide Label: isoform X1
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot),   D4AB55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768573   ⟸   XM_008770351
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K326 (UniProtKB/TrEMBL),   A6IK13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454831   ⟸   XM_017599342
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GAJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000047497   ⟸   ENSRNOT00000045068
RefSeq Acc Id: ENSRNOP00000072476   ⟸   ENSRNOT00000081570
RefSeq Acc Id: ENSRNOP00000045065   ⟸   ENSRNOT00000040215
RefSeq Acc Id: XP_038948265   ⟸   XM_039092337
- Peptide Label: isoform X1
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot),   D4AB55 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948268   ⟸   XM_039092340
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GAJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948266   ⟸   XM_039092338
- Peptide Label: isoform X2
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038948267   ⟸   XM_039092339
- Peptide Label: isoform X3
- UniProtKB: O88383 (UniProtKB/Swiss-Prot),   O08774 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000096510   ⟸   ENSRNOT00000093959
RefSeq Acc Id: ENSRNOP00000096951   ⟸   ENSRNOT00000098957
RefSeq Acc Id: ENSRNOP00000083247   ⟸   ENSRNOT00000096126
RefSeq Acc Id: XP_063129582   ⟸   XM_063273512
- Peptide Label: isoform X7
Protein Domains
GoLoco   PDZ   PID   RBD   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08774-F1-model_v2 AlphaFold O08774 1-1387 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699399
Promoter ID:EPDNEW_R9918
Type:single initiation site
Name:Rgs12_1
Description:regulator of G-protein signaling 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,023,588 - 81,023,648EPDNEW
RGD ID:13699402
Promoter ID:EPDNEW_R9919
Type:single initiation site
Name:AC114393_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01481,043,430 - 81,043,490EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3564 AgrOrtholog
BioCyc Gene G2FUF-15311 BioCyc
Ensembl Genes ENSRNOG00000030568 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040215.6 UniProtKB/TrEMBL
  ENSRNOT00000045068 ENTREZGENE
  ENSRNOT00000045068.4 UniProtKB/TrEMBL
  ENSRNOT00000081570.2 UniProtKB/TrEMBL
  ENSRNOT00000093959.1 UniProtKB/TrEMBL
  ENSRNOT00000096126.1 UniProtKB/TrEMBL
  ENSRNOT00000098957.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GoLoco_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS10/12/14-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS12_RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54292 UniProtKB/Swiss-Prot
NCBI Gene 54292 ENTREZGENE
PANTHER REGULATOR OF G-PROTEIN SIGNALING 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATOR OF G-PROTEIN SIGNALING LOCO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GoLoco UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS12_us1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS12_us2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS12_usC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgs12 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GOLOCO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030568 RatGTEx
SMART GoLoco UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218673
UniProt A0A0G2K326 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AQL0_RAT UniProtKB/TrEMBL
  A0A8I6ARZ6_RAT UniProtKB/TrEMBL
  A0A8I6GAJ3 ENTREZGENE, UniProtKB/TrEMBL
  A6IK11_RAT UniProtKB/TrEMBL
  A6IK12 ENTREZGENE, UniProtKB/TrEMBL
  A6IK13 ENTREZGENE, UniProtKB/TrEMBL
  D4AB55 ENTREZGENE, UniProtKB/TrEMBL
  G3V9H1 ENTREZGENE, UniProtKB/TrEMBL
  O08774 ENTREZGENE
  O88383 ENTREZGENE
  RGS12_RAT UniProtKB/Swiss-Prot
UniProt Secondary O88383 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rgs12  regulator of G-protein signaling 12      Name updated 70584 APPROVED