Rbp1 (retinol binding protein 1) - Rat Genome Database

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Gene: Rbp1 (retinol binding protein 1) Rattus norvegicus
Analyze
Symbol: Rbp1
Name: retinol binding protein 1
RGD ID: 3543
Description: Enables retinol binding activity. Involved in response to benzoic acid; response to retinoic acid; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1); PARTICIPATES IN retinoic acid metabolic pathway; retinoid cycle metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cellular retinol-binding protein I; CRBP; CRBP-I; retinol binding protein 1, cellular; Retinol-binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88107,904,589 - 107,926,109 (+)NCBIGRCr8
mRatBN7.2899,025,218 - 99,046,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,025,206 - 99,046,743 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8104,694,098 - 104,715,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08102,893,354 - 102,914,875 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08100,735,862 - 100,757,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08106,449,321 - 106,470,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8106,449,321 - 106,470,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08105,891,160 - 105,912,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48103,605,870 - 103,627,390 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18103,625,419 - 103,646,845 (+)NCBI
Celera898,434,714 - 98,456,228 (+)NCBICelera
RH 3.4 Map81051.49RGD
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
ammonium chloride  (EXP)
arotinoid acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrazine  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell body  (IDA)
cytosol  (IBA,ISO)
lipid droplet  (ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange. Careri M, etal., Rapid Commun Mass Spectrom. 2006;20(13):1973-80.
2. Uptake and esterification of vitamin A by RCS rat retinal pigment epithelial cells in primary culture. Cia D, etal., Vision Res. 2004 Feb;44(3):247-55.
3. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
4. Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution. Franzoni L, etal., J Biol Chem 2002 Jun 14;277(24):21983-97.
5. New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers. Franzoni L, etal., J Lipid Res. 2010 Jun;51(6):1332-43. Epub 2009 Nov 25.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Localizations of visual cycle components in retinal pigment epithelium. Huang J, etal., Mol Vis. 2009;15:223-34. Epub 2009 Jan 26.
9. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
10. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, etal., Biochim Biophys Acta. 2012 Jan;1821(1):137-51. Epub 2011 Apr 5.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility. Lu J, etal., J Mol Biol. 2003 Jul 18;330(4):799-812.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
20. Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA. Sherman DR, etal., Proc Natl Acad Sci U S A 1987 May;84(10):3209-13.
21. All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate. Spade DJ, etal., Toxicol Sci. 2019 Feb 1;167(2):546-558. doi: 10.1093/toxsci/kfy260.
22. All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity. Spade DJ, etal., Toxicol Sci. 2019 Mar 1;168(1):149-159. doi: 10.1093/toxsci/kfy283.
Additional References at PubMed
PMID:2054343   PMID:3584109   PMID:4039728   PMID:6541654   PMID:6942701   PMID:7683727   PMID:11222375   PMID:12631600   PMID:15193143   PMID:15632377   PMID:15765518   PMID:18503097  
PMID:22230368   PMID:22944241   PMID:28057518   PMID:31746385  


Genomics

Comparative Map Data
Rbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88107,904,589 - 107,926,109 (+)NCBIGRCr8
mRatBN7.2899,025,218 - 99,046,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,025,206 - 99,046,743 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8104,694,098 - 104,715,613 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08102,893,354 - 102,914,875 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08100,735,862 - 100,757,379 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08106,449,321 - 106,470,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8106,449,321 - 106,470,842 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08105,891,160 - 105,912,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48103,605,870 - 103,627,390 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18103,625,419 - 103,646,845 (+)NCBI
Celera898,434,714 - 98,456,228 (+)NCBICelera
RH 3.4 Map81051.49RGD
Cytogenetic Map8q31NCBI
RBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383139,517,438 - 139,539,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3139,517,434 - 139,539,829 (-)EnsemblGRCh38hg38GRCh38
GRCh373139,236,280 - 139,258,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363140,718,970 - 140,741,175 (-)NCBINCBI36Build 36hg18NCBI36
Build 343140,718,977 - 140,741,188NCBI
Celera3137,659,177 - 137,681,571 (-)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3136,611,722 - 136,634,115 (-)NCBIHuRef
CHM1_13139,199,741 - 139,222,138 (-)NCBICHM1_1
T2T-CHM13v2.03142,264,863 - 142,287,171 (-)NCBIT2T-CHM13v2.0
Rbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,305,014 - 98,328,604 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl998,305,014 - 98,328,628 (+)EnsemblGRCm39 Ensembl
GRCm38998,422,961 - 98,446,551 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl998,422,961 - 98,446,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37998,323,380 - 98,346,970 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36998,232,313 - 98,255,903 (+)NCBIMGSCv36mm8
Celera997,975,569 - 97,999,047 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.36NCBI
Rbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555086,046,316 - 6,072,288 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555086,046,738 - 6,072,202 (+)NCBIChiLan1.0ChiLan1.0
RBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,431,555 - 137,453,940 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13137,436,285 - 137,458,668 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03136,554,315 - 136,576,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13144,153,937 - 144,176,209 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3144,153,937 - 144,176,209 (-)Ensemblpanpan1.1panPan2
RBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12335,677,844 - 35,698,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2335,679,176 - 35,698,363 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2335,665,589 - 35,686,876 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02336,214,587 - 36,235,924 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12335,896,788 - 35,918,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02335,970,311 - 35,991,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02336,212,783 - 36,234,124 (-)NCBIUU_Cfam_GSD_1.0
Rbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560274,860,890 - 74,886,796 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365401,600,398 - 1,626,652 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365401,600,673 - 1,626,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1380,380,962 - 80,407,458 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11380,380,958 - 80,407,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21388,047,841 - 88,073,765 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11551,011,664 - 51,033,963 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604123,988,481 - 24,010,687 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473016,091,863 - 16,119,591 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473016,091,863 - 16,119,591 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbp1
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000018622
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Markers in Region
RH94499  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2899,046,615 - 99,046,698 (+)MAPPERmRatBN7.2
Rnor_6.08106,470,718 - 106,470,800NCBIRnor6.0
Rnor_5.08105,912,557 - 105,912,639UniSTSRnor5.0
RGSC_v3.48103,627,266 - 103,627,348UniSTSRGSC3.4
Celera898,456,104 - 98,456,186UniSTS
RH 3.4 Map81051.49UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 50 41 16 41 1 1 73 35 41 11 1
Low 1 7 3 7 10 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018622   ⟹   ENSRNOP00000018622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl899,025,206 - 99,046,743 (+)Ensembl
Rnor_6.0 Ensembl8106,449,321 - 106,470,842 (+)Ensembl
RefSeq Acc Id: NM_012733   ⟹   NP_036865
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88107,904,589 - 107,926,109 (+)NCBI
mRatBN7.2899,025,218 - 99,046,740 (+)NCBI
Rnor_6.08106,449,321 - 106,470,842 (+)NCBI
Rnor_5.08105,891,160 - 105,912,681 (+)NCBI
RGSC_v3.48103,605,870 - 103,627,390 (+)RGD
Celera898,434,714 - 98,456,228 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40962 (Get FASTA)   NCBI Sequence Viewer  
  AAA42021 (Get FASTA)   NCBI Sequence Viewer  
  EDL77465 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018622
  ENSRNOP00000018622.2
  ENSRNOP00055023881
  ENSRNOP00060011617
  ENSRNOP00065007405
GenBank Protein P02696 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036865   ⟸   NM_012733
- UniProtKB: P02696 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018622   ⟸   ENSRNOT00000018622

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02696-F1-model_v2 AlphaFold P02696 1-135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696201
Promoter ID:EPDNEW_R6726
Type:initiation region
Name:Rbp1_1
Description:retinol binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08106,449,337 - 106,449,397EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3543 AgrOrtholog
BioCyc Gene G2FUF-29419 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
  PWY-6861 [the visual cycle I (vertebrates)] BioCyc
  PWY-6872 [retinoate biosynthesis I] BioCyc
  PWY-6875 [retinoate biosynthesis II] BioCyc
BioCyc Pathway Image PWY-6857 BioCyc
  PWY-6861 BioCyc
  PWY-6872 BioCyc
  PWY-6875 BioCyc
Ensembl Genes ENSRNOG00000013794 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055017567 UniProtKB/Swiss-Prot
  ENSRNOG00060008934 UniProtKB/Swiss-Prot
  ENSRNOG00065006568 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018622 ENTREZGENE
  ENSRNOT00000018622.5 UniProtKB/Swiss-Prot
  ENSRNOT00055029720 UniProtKB/Swiss-Prot
  ENSRNOT00060014974 UniProtKB/Swiss-Prot
  ENSRNOT00065010140 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro Calycin UniProtKB/Swiss-Prot
  CRBP1 UniProtKB/Swiss-Prot
  Fatty_acid-bd UniProtKB/Swiss-Prot
  ILBP UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:25056 UniProtKB/Swiss-Prot
NCBI Gene 25056 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot
  PTHR11955:SF56 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PhenoGen Rbp1 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot
PROSITE FABP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013794 RatGTEx
  ENSRNOG00055017567 RatGTEx
  ENSRNOG00060008934 RatGTEx
  ENSRNOG00065006568 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
UniProt A6I2B2_RAT UniProtKB/TrEMBL
  P02696 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Rbp1  retinol binding protein 1  Rbp1  retinol binding protein 1, cellular  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rbp1  retinol binding protein 1, cellular    retinol binding protein 1  Name updated 1299863 APPROVED
2002-06-10 Rbp1  Retinol-binding protein 1      Symbol and Name status set to approved 70586 APPROVED