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Gene: Rb1 (RB transcriptional corepressor 1) Rattus norvegicus
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Symbol: Rb1
Name: RB transcriptional corepressor 1
Description: Exhibits transcription factor binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of protein kinase activity; and spermatogenesis. Localizes to the nucleus. Predicted to colocalize with the cyclin/CDK positive transcription elongation factor complex. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in several diseases, including malignant glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1); PARTICIPATES IN ceramide signaling pathway; G1/S transition pathway; RNA polymerase III transcription pathway; INTERACTS WITH (Z)-3-butylidenephthalide; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: pp105; pRb; rb; retinoblastoma 1; Retinoblastoma 1 (including osteosarcoma); retinoblastoma-associated protein
Orthologs:
Homo sapiens (human) : RB1 (RB transcriptional corepressor 1)  HGNC  Alliance
Mus musculus (house mouse) : Rb1 (RB transcriptional corepressor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rb1 (RB transcriptional corepressor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RB1 (RB transcriptional corepressor 1)
Canis lupus familiaris (dog) : RB1 (RB transcriptional corepressor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rb1 (RB transcriptional corepressor 1)
Sus scrofa (pig) : RB1 (RB transcriptional corepressor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01555,081,582 - 55,209,060 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01558,804,731 - 58,931,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41553,828,881 - 53,962,099 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11553,844,684 - 53,977,640 (-)NCBI
Celera1548,020,828 - 48,147,805 (-)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Rb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3540
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.