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Gene: Ptprc (protein tyrosine phosphatase, receptor type, C) Rattus norvegicus
Symbol: Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Description: Exhibits protein tyrosine phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Localizes to cell surface and integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD45; L-CA; Lca; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; Protein tyrosine phosphatase, receptor-type, c polypeptide; receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein
Homo sapiens (human) : PTPRC (protein tyrosine phosphatase receptor type C)  HGNC  Alliance
Mus musculus (house mouse) : Ptprc (protein tyrosine phosphatase, receptor type, C)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptprc (protein tyrosine phosphatase receptor type C)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPRC (protein tyrosine phosphatase receptor type C)
Canis lupus familiaris (dog) : PTPRC (protein tyrosine phosphatase receptor type C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptprc (protein tyrosine phosphatase receptor type C)
Sus scrofa (pig) : PTPRC (protein tyrosine phosphatase receptor type C)
Chlorocebus sabaeus (African green monkey) : PTPRC (protein tyrosine phosphatase receptor type C)
Heterocephalus glaber (naked mole-rat) : Ptprc (protein tyrosine phosphatase receptor type C)
more info ...
Is Marker For: Strains:   BBDP.WF-(D13Rat124-D13Mgh5)/Sunn   BBDP.BBDR-Gimap5, WF-(D13Rat124-D13Mgh5)/Sunn  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01355,061,561 - 55,174,150 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1355,061,562 - 55,173,692 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01360,094,038 - 60,205,773 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41351,246,163 - 51,357,995 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11351,261,097 - 51,309,893 (-)NCBI
Celera1349,881,478 - 49,993,142 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ptprc
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3451
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.