Plcd1 (phospholipase C, delta 1) - Rat Genome Database

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Gene: Plcd1 (phospholipase C, delta 1) Rattus norvegicus
Analyze
Symbol: Plcd1
Name: phospholipase C, delta 1
RGD ID: 3346
Description: Enables several functions, including calcium-dependent phospholipid binding activity; ion binding activity; and phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of inositol trisphosphate biosynthetic process; positive regulation of norepinephrine secretion; and response to prostaglandin F. Located in mitochondrial membrane. Used to study congestive heart failure and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1); PARTICIPATES IN G protein mediated signaling pathway; calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; INTERACTS WITH (R)-noradrenaline; 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-delta-1; phospholipase C delta 1 long form; phospholipase C-delta-1; Phospholipase C-delta1; phospholipase C-III; PLC-delta-1; PLC-III; Plc1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp331
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,672,955 - 127,695,939 (-)NCBIGRCr8
mRatBN7.28118,795,196 - 118,818,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,795,201 - 118,818,186 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,397,003 - 124,419,829 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,595,953 - 122,618,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,428,662 - 120,451,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,753,514 - 127,782,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,753,539 - 127,782,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,970,643 - 126,991,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,023,090 - 124,052,193 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,042,827 - 124,071,930 (-)NCBI
Celera8117,968,204 - 117,991,136 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
acrylonitrile  (EXP)
aluminium atom  (EXP)
aluminium(0)  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cerium trichloride  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
Cuprizon  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
methamphetamine  (ISO)
morphine  (EXP)
N-nitrosodiethylamine  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
potassium chromate  (ISO)
prazosin  (EXP)
prostaglandin F2alpha  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
U-73122  (EXP,ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (ISO)
mitochondrial membrane  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Identification of the changes in phospholipase C isozymes in ischemic-reperfused rat heart. Asemu G, etal., Arch Biochem Biophys 2003 Mar 15;411(2):174-82.
2. Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta. Essen LO, etal., Nature. 1996 Apr 18;380(6575):595-602.
3. Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signaling. Feng JF, etal., J Biol Chem. 1996 Jul 12;271(28):16451-4.
4. Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain. Flesch FM, etal., Biochem J. 2005 Jul 15;389(Pt 2):435-41.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Catalysis by phospholipase C delta1 requires that Ca2+ bind to the catalytic domain, but not the C2 domain. Grobler JA and Hurley JH, Biochemistry. 1998 Apr 7;37(14):5020-8.
8. Phospholipase C-delta1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes. Hwang KC, etal., J Steroid Biochem Mol Biol. 2004 Jul;91(3):131-8.
9. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Kang SK, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):383-90.
10. Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats. Kato H, etal., J Biol Chem. 1992 Apr 5;267(10):6483-7.
11. Hypotensive effect associated with a phospholipase C-delta 1 gene mutation in the spontaneously hypertensive rat. Katsuya T, etal., Biochem Biophys Res Commun. 1992 Sep 30;187(3):1359-66.
12. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. Kavran JM, etal., J Biol Chem. 1998 Nov 13;273(46):30497-508.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Assignment of the rat phospholipase C-delta1 gene (Plcd1) to rat chromosome band 8q32 by fluorescence in situ hybridization and radiation hybrid mapping. Kim H, etal., Cytogenet Cell Genet 2001;94(1-2):86-7.
15. Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation. Kim YH, etal., J Biol Chem. 1999 Sep 10;274(37):26127-34.
16. Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake. Knox CD, etal., Am J Physiol Gastrointest Liver Physiol 2004 Sep;287(3):G533-40. Epub 2004 Apr 23.
17. A novel follicle-stimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx. Lin YF, etal., Mol Endocrinol. 2006 Oct;20(10):2514-27. Epub 2006 May 18.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain. Nagasawa K, etal., Life Sci 2003 Aug 1;73(11):1453-62.
20. Phospholipase Cdelta1 is required for skin stem cell lineage commitment. Nakamura Y, etal., EMBO J 2003 Jun 16;22(12):2981-91.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Novel regulation of PLCzeta activity via its XY-linker. Nomikos M, etal., Biochem J. 2011 Sep 15;438(3):427-32. doi: 10.1042/BJ20110953.
23. Phospholipase Cdelta1 associates with importin beta1 and translocates into the nucleus in a Ca2+-dependent manner. Okada M, etal., FEBS Lett. 2005 Sep 12;579(22):4949-54.
24. Carboxyl-terminal basic amino acids in the X domain are essential for the nuclear import of phospholipase C delta1. Okada M, etal., Genes Cells 2002 Sep;7(9):985-96.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Increased expression and activity of phospholipase C in renal arterioles of young spontaneously hypertensive rats. Peng Z, etal., Am J Hypertens. 2007 Jan;20(1):38-43.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Signal transduction mechanisms in Alzheimer disease. Shimohama S and Matsushima H, Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22.
32. Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array. Stocco C, etal., Endocrinology. 2001 Sep;142(9):4158-61.
33. Cloning and sequence of multiple forms of phospholipase C. Suh PG, etal., Cell 1988 Jul 15;54(2):161-9.
34. Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains. Tanino H, etal., Biochem Biophys Res Commun. 2000 May 19;271(3):620-5.
35. Depressed responsiveness of phospholipase C isoenzymes to phosphatidic acid in congestive heart failure. Tappia PS, etal., J Mol Cell Cardiol. 2001 Mar;33(3):431-40.
36. Oscillations of phospholipase C activity triggered by depolarization and Ca2+ influx in insulin-secreting cells. Thore S, etal., J Biol Chem 2004 May 7;279(19):19396-400. Epub 2004 Mar 25.
37. Structure and dynamics of the phospholipase C-delta1 pleckstrin homology domain located at the lipid bilayer surface. Tuzi S, etal., J Biol Chem 2003 Jul 25;278(30):28019-25. Epub 2003 May 7.
38. Phospholipase Cdelta(1) does not mediate Ca(2+) responses in neonatal rat cardiomyocytes. Woodcock EA, etal., FEBS Lett 2003 Jul 10;546(2-3):325-8.
39. Phosphoinositide-specific phospholipase C delta1 activity toward micellar substrates, inositol 1,2-cyclic phosphate, and other water-soluble substrates: a sequential mechanism and allosteric activation. Wu Y, etal., Biochemistry. 1997 Sep 16;36(37):11223-33.
40. Recruitment and activation of phospholipase C (PLC)-delta1 in lipid rafts by muscarinic stimulation of PC12 cells: contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCdelta1 binding protein. Yamaga M, etal., Adv Enzyme Regul. 2008;48:41-54. Epub 2007 Nov 19.
Additional References at PubMed
PMID:1313009   PMID:1684614   PMID:8521504   PMID:8784353   PMID:9062102   PMID:9565585   PMID:11001876   PMID:15506980   PMID:15702972   PMID:15817490   PMID:15899900   PMID:16314520  
PMID:18063675   PMID:18359940   PMID:18434237   PMID:18567701   PMID:19056867   PMID:19681039   PMID:19826432   PMID:19850006   PMID:22710061   PMID:22833565   PMID:23376485   PMID:23892088  
PMID:24235144   PMID:24810051   PMID:27783455  


Genomics

Comparative Map Data
Plcd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,672,955 - 127,695,939 (-)NCBIGRCr8
mRatBN7.28118,795,196 - 118,818,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,795,201 - 118,818,186 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,397,003 - 124,419,829 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,595,953 - 122,618,783 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,428,662 - 120,451,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,753,514 - 127,782,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,753,539 - 127,782,070 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,970,643 - 126,991,422 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,023,090 - 124,052,193 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,042,827 - 124,071,930 (-)NCBI
Celera8117,968,204 - 117,991,136 (-)NCBICelera
Cytogenetic Map8q32NCBI
PLCD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,007,496 - 38,029,642 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,007,496 - 38,029,642 (-)EnsemblGRCh38hg38GRCh38
GRCh37338,048,987 - 38,071,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,023,991 - 38,059,068 (-)NCBINCBI36Build 36hg18NCBI36
Build 34338,024,010 - 38,046,119NCBI
Celera337,983,370 - 38,005,535 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef337,991,684 - 38,013,851 (-)NCBIHuRef
CHM1_1338,000,639 - 38,022,806 (-)NCBICHM1_1
T2T-CHM13v2.0338,011,677 - 38,033,823 (-)NCBIT2T-CHM13v2.0
Plcd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,900,595 - 118,922,570 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,900,595 - 118,922,570 (-)EnsemblGRCm39 Ensembl
GRCm389119,071,527 - 119,093,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,071,527 - 119,093,502 (-)EnsemblGRCm38mm10GRCm38
MGSCv379118,980,645 - 119,002,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369118,920,225 - 118,942,194 (-)NCBIMGSCv36mm8
Celera9119,539,423 - 119,561,381 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.32NCBI
Plcd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554214,856,366 - 4,880,309 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554214,856,366 - 4,880,309 (-)NCBIChiLan1.0ChiLan1.0
PLCD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2237,961,770 - 37,984,008 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1337,966,534 - 37,988,753 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0337,906,359 - 37,928,564 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,189,496 - 38,211,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,189,496 - 38,206,886 (-)Ensemblpanpan1.1panPan2
PLCD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,782,495 - 7,804,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,781,787 - 7,805,336 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,824,568 - 7,846,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,071,728 - 8,094,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,071,740 - 8,094,243 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1237,886,045 - 7,908,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,027,176 - 8,049,514 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,019,585 - 8,041,935 (-)NCBIUU_Cfam_GSD_1.0
Plcd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,225,831 - 194,248,765 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,364,389 - 27,387,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,364,404 - 27,387,337 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1322,851,584 - 22,872,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11322,851,581 - 22,872,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21324,826,459 - 24,847,853 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLCD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1151,372,874 - 1,395,475 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl151,373,234 - 1,395,711 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606310,103,145 - 10,125,488 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477320,108,004 - 20,130,630 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477320,108,383 - 20,130,630 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plcd1
304 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:61
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000045493
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 10 6 2 6 2 4 35 20 38 11 2
Low 6 47 35 17 35 6 7 39 15 3 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000045493   ⟹   ENSRNOP00000042824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,795,221 - 118,818,186 (-)Ensembl
Rnor_6.0 Ensembl8127,753,539 - 127,782,070 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110954   ⟹   ENSRNOP00000090035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,795,201 - 118,812,531 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113471   ⟹   ENSRNOP00000076591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8118,795,221 - 118,818,186 (-)Ensembl
RefSeq Acc Id: NM_017035   ⟹   NP_058731
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,672,959 - 127,695,939 (-)NCBI
mRatBN7.28118,795,200 - 118,818,186 (-)NCBI
Rnor_6.08127,753,518 - 127,782,070 (-)NCBI
Rnor_5.08126,970,643 - 126,991,422 (-)NCBI
RGSC_v3.48124,023,090 - 124,052,193 (-)RGD
Celera8117,968,204 - 117,991,136 (-)RGD
Sequence:
RefSeq Acc Id: XM_006244063   ⟹   XP_006244125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,672,955 - 127,695,818 (-)NCBI
mRatBN7.28118,795,196 - 118,818,078 (-)NCBI
Rnor_6.08127,753,514 - 127,781,969 (-)NCBI
Rnor_5.08126,970,643 - 126,991,422 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080826   ⟹   XP_038936754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,672,955 - 127,690,298 (-)NCBI
mRatBN7.28118,795,196 - 118,812,536 (-)NCBI
RefSeq Acc Id: XM_039080827   ⟹   XP_038936755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,675,417 - 127,690,312 (-)NCBI
mRatBN7.28118,797,655 - 118,812,552 (-)NCBI
RefSeq Acc Id: XM_039080828   ⟹   XP_038936756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,672,955 - 127,677,489 (-)NCBI
mRatBN7.28118,795,196 - 118,799,730 (-)NCBI
RefSeq Acc Id: XM_039080829   ⟹   XP_038936757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88127,675,417 - 127,695,818 (-)NCBI
mRatBN7.28118,797,655 - 118,818,078 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_058731   ⟸   NM_017035
- UniProtKB: Q9QVD5 (UniProtKB/Swiss-Prot),   Q9QVD4 (UniProtKB/Swiss-Prot),   Q9QVD3 (UniProtKB/Swiss-Prot),   Q80WI4 (UniProtKB/Swiss-Prot),   P10688 (UniProtKB/Swiss-Prot),   G3V9D1 (UniProtKB/TrEMBL),   A6I3V0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244125   ⟸   XM_006244063
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y0I7 (UniProtKB/TrEMBL),   A6Y857 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042824   ⟸   ENSRNOT00000045493
RefSeq Acc Id: XP_038936754   ⟸   XM_039080826
- Peptide Label: isoform X2
- UniProtKB: Q9QVD5 (UniProtKB/Swiss-Prot),   Q9QVD4 (UniProtKB/Swiss-Prot),   Q9QVD3 (UniProtKB/Swiss-Prot),   Q80WI4 (UniProtKB/Swiss-Prot),   P10688 (UniProtKB/Swiss-Prot),   A0A8I6GIK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936756   ⟸   XM_039080828
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038936757   ⟸   XM_039080829
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038936755   ⟸   XM_039080827
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000076591   ⟸   ENSRNOT00000113471
RefSeq Acc Id: ENSRNOP00000090035   ⟸   ENSRNOT00000110954
Protein Domains
C2   EF-hand   PH   PI-PLC X-box   PI-PLC Y-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10688-F1-model_v2 AlphaFold P10688 1-756 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696367
Promoter ID:EPDNEW_R6890
Type:multiple initiation site
Name:Plcd1_1
Description:phospholipase C, delta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08127,781,949 - 127,782,009EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3346 AgrOrtholog
BioCyc Gene G2FUF-28808 BioCyc
Ensembl Genes ENSRNOG00000032238 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045493 ENTREZGENE
  ENSRNOT00000045493.6 UniProtKB/TrEMBL
  ENSRNOT00000110954.1 UniProtKB/TrEMBL
  ENSRNOT00000113471.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-delta1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-delta1_EF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24655 UniProtKB/Swiss-Prot
NCBI Gene 24655 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plcd1 PhenoGen
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_X_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032238 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0I7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIK0 ENTREZGENE, UniProtKB/TrEMBL
  A6I3V0 ENTREZGENE, UniProtKB/TrEMBL
  A6Y857 ENTREZGENE, UniProtKB/TrEMBL
  G3V9D1 ENTREZGENE, UniProtKB/TrEMBL
  P10688 ENTREZGENE, UniProtKB/Swiss-Prot
  Q80WI4 ENTREZGENE
  Q9QVD3 ENTREZGENE
  Q9QVD4 ENTREZGENE
  Q9QVD5 ENTREZGENE
UniProt Secondary Q80WI4 UniProtKB/Swiss-Prot
  Q9QVD3 UniProtKB/Swiss-Prot
  Q9QVD4 UniProtKB/Swiss-Prot
  Q9QVD5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Plcd1  phospholipase C, delta 1    Phospholipase C-delta1  Name updated 625702 APPROVED
2002-06-10 Plcd1  Phospholipase C-delta1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a pleckstrin homology (PH) domain at the lipid bilayer surface 1299011
gene_expression protein levels altered by hyperoxia 1299008
gene_function involved in cell signalling and cytoskeletal functions 1299011
gene_physical_interaction interacts with high affinity and specificity with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) 1299011
gene_transcript contains a TGII (transglutaminase II) binding site in promoter 634393