Serpine1 (serpin family E member 1) - Rat Genome Database

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Gene: Serpine1 (serpin family E member 1) Rattus norvegicus
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Symbol: Serpine1
Name: serpin family E member 1
RGD ID: 3249
Description: Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; INTERACTS WITH (S)-colchicine; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; Pai1; PAI1A; Pai1aa; Planh; Plasminogen activator inhibitor; plasminogen activator inhibitor 1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,601,272 - 19,611,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,601,272 - 19,611,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,739,113 - 20,749,506 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01221,351,819 - 21,362,213 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01220,416,358 - 20,426,756 (+)NCBIRnor_WKY
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IMP)
Acquired Protein C Deficiency  (IEP)
Acute Lung Injury  (IDA,IEP)
acute necrotizing pancreatitis  (IEP,ISO)
adult respiratory distress syndrome  (ISO)
Aggressive Fibromatosis  (ISO)
Albuminuria  (ISO)
Alcoholic Fatty Liver  (IEP)
alcoholic liver cirrhosis  (ISO)
allergic rhinitis  (ISO)
amyloidosis  (ISO)
Animal Disease Models  (ISO)
anterolateral myocardial infarction  (ISO)
aortic aneurysm  (IMP)
Aortic Remodeling  (IDA)
Arterial Thrombosis  (IEP)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (IDA)
breast cancer  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Cardiac Fibrosis  (IDA,IEP)
Carotid Artery Injuries  (IEP)
Central Serous Chorioretinopathy  (ISO)
cerebral infarction  (IDA)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Choroidal Neovascularization, Experimental  (IDA,ISO)
Chronic Allograft Nephropathy  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISS)
Dermal Fibrosis  (ISO)
diabetes mellitus  (IDA)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IDA,IEP,ISO)
diabetic retinopathy  (ISO)
disseminated intravascular coagulation  (IDA,IEP)
end stage renal disease  (IDA,ISO)
Endotoxemia  (IDA,IEP)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
familial hypercholesterolemia  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
fibrosarcoma  (ISO)
focal segmental glomerulosclerosis  (IEP,ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (IDA,IEP)
Graft vs Host Disease  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematopoietic system disease  (IDA)
Hemorrhage  (IDA,IEP)
hemorrhagic disease  (ISO)
high grade glioma  (ISO)
Hyaline Membrane Disease  (ISO)
hypertension  (IDA,IEP,ISO)
hyperthyroidism  (ISO)
Insulin Resistance  (IDA,IEP)
interstitial lung disease  (ISO)
Intestinal Polyps  (ISO)
Intestinal Reperfusion Injury  (IDA)
ischemic colitis  (ISO)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (IEP)
lung disease  (ISO)
Lung Reperfusion Injury  (IDA,ISO)
macular degeneration  (ISO)
Metabolic Syndrome  (IDA)
middle cerebral artery infarction  (IEP)
Multiple Organ Failure  (IDA)
Multiple Trauma  (IEP)
muscular atrophy  (IEP)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
Neointima  (IMP,ISO)
Neovascularization, Pathologic  (ISO)
nephrotic syndrome  (ISO)
nervous system disease  (ISO)
neurilemmoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (ISO)
Oxygen-Induced Retinopathy  (IEP,ISO)
Penetrating Wounds  (IEP)
peripheral artery disease  (ISO)
Peritoneal Adhesions  (IDA,IEP)
Peritoneal Fibrosis  (ISO)
placental insufficiency  (ISO)
Plasminogen Activator Inhibitor-1 Deficiency  (ISO)
platelet-type bleeding disorder 10  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
polycythemia  (IEP)
polyneuropathy  (ISO)
portal vein thrombosis  (ISO)
Postoperative Atrial Fibrillation  (ISO)
pre-eclampsia  (ISO)
Pregnancy Complications  (ISO)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
pulmonary hypertension  (IDA,ISO)
Radiation Nephropathy  (IEP)
relapsing-remitting multiple sclerosis  (ISO)
renal fibrosis  (IDA,IEP)
respiratory allergy  (ISO)
retinal vein occlusion  (ISO)
retinopathy of prematurity  (ISO)
rhinitis  (ISO)
Rhinosinusitis  (ISO)
sciatic neuropathy  (IDA)
Sepsis  (IDA,ISO)
sleep apnea  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Sudden Hearing Loss  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IDA)
type 2 diabetes mellitus  (IDA,IEP,ISO)
ureteral obstruction  (IDA,IEP,ISO)
urinary bladder cancer  (ISO)
uveal melanoma  (ISO)
Vascular Depression  (IDA)
Vascular Remodeling  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (IEP,IMP,ISO)
Ventilator-Induced Lung Injury  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-aminophenol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (ISO)
adenine  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
aminoguanidine  (EXP,ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
apocynin  (ISO)
arecoline  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
aspalathin  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
Aurin  (ISO)
azathioprine  (ISO)
barium chloride  (EXP)
benazepril  (EXP,ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP)
busulfan  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camostat  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
Clofop  (ISO)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
efavirenz  (ISO)
emodin  (ISO)
enalapril  (EXP)
enalaprilat dihydrate  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
eplerenone  (EXP)
eprosartan  (EXP)
Ethyl icosapentate  (EXP)
ethyl methanesulfonate  (ISO)
famotidine  (EXP)
fenofibrate  (EXP,ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fructose  (EXP)
fulvestrant  (ISO)
fumonisin B1  (ISO)
geldanamycin  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
gestodene  (ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Goe 6976  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
guanethidine  (ISO)
GW 501516  (ISO)
heparin  (EXP)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (EXP)
Honokiol  (EXP)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxychloroquine  (ISO)
hydroxyl  (ISO)
hypochlorous acid  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (ISO)
ionomycin  (EXP)
iron(III) citrate  (ISO)
isobutanol  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
levonorgestrel  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
LY 364947  (ISO)
magnesium atom  (ISO)
magnesium dichloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (EXP)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (ISO)
meglumine amidotrizoate  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metaproterenol  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
mitoxantrone  (EXP)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N-acetylsphingosine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nonanedioic acid  (ISO)
Nonidet P-40  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
orciprenaline  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
pentane-2,3-dione  (EXP)
Pentoxifylline  (EXP)
perfluorobutyric acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Phenelzine  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phosphane  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pioglitazone  (EXP,ISO)
pirfenidone  (EXP,ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
potassium chloride  (EXP)
potassium dichromate  (ISO)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salvianolic acid B  (ISO)
saralasin  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
tartrazine  (ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiacloprid  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
tibolone  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
trans-caffeic acid  (ISO)
triadimefon  (ISO)
triamterene  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
undecane  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
cellular response to aldosterone  (IEP)
cellular response to angiotensin  (IEP)
cellular response to ATP  (IEP)
cellular response to cAMP  (IEP)
cellular response to cGMP  (IEP)
cellular response to cycloheximide  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to fibroblast growth factor stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to glucagon stimulus  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to gravity  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-1  (IDA)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to lipopolysaccharide  (IEA,IEP,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to metal ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to nicotine  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to potassium ion  (IEP)
cellular response to resveratrol  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP,ISO)
cellular response to xenobiotic stimulus  (IDA)
decidualization  (IEP)
defense response to Gram-negative bacterium  (IEA,ISO)
dentinogenesis  (IEA,ISO)
female gonad development  (IDA)
glucose homeostasis  (IEP)
mast cell activation  (IEP)
negative regulation of cell adhesion mediated by integrin  (IEA,ISO)
negative regulation of cell migration  (IDA,IMP,ISO)
negative regulation of endopeptidase activity  (IBA,IC,IDA,IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of fibrinolysis  (IEA,ISO)
negative regulation of gene expression  (IMP)
negative regulation of plasminogen activation  (IBA,IEA,ISO)
negative regulation of smooth muscle cell migration  (IEA,ISO)
negative regulation of smooth muscle cell-matrix adhesion  (IEA,ISO)
negative regulation of vascular wound healing  (IBA,IEA,ISO)
placenta development  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of blood coagulation  (ISO)
positive regulation of calcium ion import  (IMP)
positive regulation of coagulation  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of epithelium regeneration  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of keratinocyte migration  (IMP)
positive regulation of leukotriene production involved in inflammatory response  (IEA,ISO)
positive regulation of monocyte chemotaxis  (IEA,ISO)
positive regulation of odontoblast differentiation  (IEA,ISO)
positive regulation of receptor-mediated endocytosis  (IEA,IMP,ISO)
regulation of angiogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of signaling receptor activity  (IEA,ISO)
replicative senescence  (IEA,ISO,ISS)
response to cytokine  (IEP)
response to epidermal growth factor  (IEP)
response to estrogen  (IEP)
response to hyperoxia  (IEP)
response to laminar fluid shear stress  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to reactive oxygen species  (IEP)
response to starvation  (IEP)
response to transforming growth factor beta  (IEP)
tissue regeneration  (IEP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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99. Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. Kobayashi N, etal., J Pharmacol Exp Ther. 2002 May;301(2):459-66.
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102. Plasmin system regulation in an ovalbumin-induced rat model of asthma. Kucharewicz I, etal., Int Arch Allergy Immunol. 2008;147(3):190-6. Epub 2008 Jul 2.
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109. Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. Laudes IJ, etal., Am J Pathol. 2002 May;160(5):1867-75.
110. Plasminogen activator inhibitor-1 is expressed in cultured rat Sertoli cells. Le Magueresse-Battistoni B, etal., Biol Reprod. 1998 Sep;59(3):591-8.
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115. Receptor-associated protein promotes t-PA expression, reduces PAI-1 expression and improves neurorecovery after acute ischemic stroke. Li DD, etal., J Neurol Sci. 2015 Mar 15;350(1-2):84-9. doi: 10.1016/j.jns.2015.02.022. Epub 2015 Feb 17.
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118. Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection. Liu X, etal., World J Gastroenterol. 2014 Dec 28;20(48):18249-59. doi: 10.3748/wjg.v20.i48.18249.
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120. Plasminogen enhances the secretion of plasminogen activator inhibitor-1 from cultured rat astrocytes. Liu Y, etal., Neurosci Lett. 2000 Mar 24;282(3):137-40.
121. Studies on the role of plasminogen activators and plasminogen activator inhibitor type-1 in rat corpus luteum of pregnancy. Liu YX, etal., Biol Reprod. 1995 Nov;53(5):1131-8.
122. Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities. Liu Z, etal., J Diabetes. 2016 May;8(3):324-335. doi: 10.1111/1753-0407.12296. Epub 2015 May 6.
123. Basic mechanisms and regulation of fibrinolysis. Longstaff C and Kolev K, J Thromb Haemost. 2015 Jun;13 Suppl 1:S98-105. doi: 10.1111/jth.12935.
124. Peritoneal effluent MMP-2 and PAI-1 in encapsulating peritoneal sclerosis. Lopes Barreto D, etal., Am J Kidney Dis. 2015 May;65(5):748-53. doi: 10.1053/j.ajkd.2014.10.022. Epub 2014 Dec 17.
125. Inhibition of metastasis of intraocular melanomas by adenovirus-mediated gene transfer of plasminogen activator inhibitor type 1 (PAI-1) in an athymic mouse model. Ma D, etal., Blood. 1997 Oct 1;90(7):2738-46.
126. 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. Madach K, etal., Crit Care. 2010;14(2):R79. Epub 2010 Apr 29.
127. Urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1) are potential predictive biomarkers in early stage oral squamous cell carcinomas (OSCC). Magnussen S, etal., PLoS One. 2014 Jul 7;9(7):e101895. doi: 10.1371/journal.pone.0101895. eCollection 2014.
128. Polymorphisms of the plasminogen activator inhibitor-1 gene in type 1 and type 2 diabetes, and in patients with diabetic retinopathy. Mansfield MW, etal., Thromb Haemost. 1994 Jun;71(6):731-6.
129. Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing. Maquerlot F, etal., Am J Pathol. 2006 Nov;169(5):1624-32.
130. The PAI-1 gene locus 4G/5G polymorphism is associated with a family history of coronary artery disease. Margaglione M, etal., Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):152-6.
131. Do tissue plasminogen activator-plasminogen activator inhibitor-1 complexes relate to the complications of insulin-dependent diabetes mellitus? Pittsburgh Epidemiology of Diabetes Complications Study. Maser RE, etal., J Diabetes Complications. 1997 Jul-Aug;11(4):243-9.
132. Effects of combination PPARgamma agonist and angiotensin receptor blocker on glomerulosclerosis. Matsushita K, etal., Lab Invest. 2016 Mar 21. doi: 10.1038/labinvest.2016.42.
133. Plasminogen activator inhibitor-1 is elevated, but not essential, in the development of bleomycin-induced murine scleroderma. Matsushita M, etal., Clin Exp Immunol. 2005 Mar;139(3):429-38.
134. Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland Family Study. Mehra R, etal., Am J Respir Crit Care Med. 2010 Sep 15;182(6):826-33. Epub 2010 May 27.
135. Imbalance of plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) activity in patients with Noonan syndrome. Mehta P and Parker RI, J Pediatr Hematol Oncol. 2010 Oct;32(7):532-6. doi: 10.1097/MPH.0b013e3181e0d152.
136. PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample. Meigs JB, etal., Obesity (Silver Spring). 2006 May;14(5):753-8.
137. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
138. Aortic Length Changes During Abdominal Aortic Aneurysm Formation, Expansion and Stabilisation in a Rat Model. Michineau S, etal., Eur J Vasc Endovasc Surg. 2010 Jun 14.
139. Prevalence and significance of coagulation abnormalities in community-acquired pneumonia. Milbrandt EB, etal., Mol Med. 2009 Nov-Dec;15(11-12):438-45. Epub 2009 Sep 8.
140. TGF-beta1 and Serpine 1 expression changes in traumatic deep vein thrombosis. Mo JW, etal., Genet Mol Res. 2015 Oct 30;14(4):13835-42. doi: 10.4238/2015.October.29.3.
141. Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves blood coagulation abnormalities and dysfunction of vascular endothelial cells in Otsuka Long-Evans Tokushima fatty rats. Mori Y, etal., Endocr J. 2003 Oct;50(5):603-11.
142. The induction of the immediate-early-genes Egr-1, PAI-1 and PRL-1 during liver regeneration in surgical models is related to increased portal flow. Mueller L, etal., J Hepatol. 2002 Nov;37(5):606-12.
143. Transcriptional regulation of plasminogen activator inhibitor-1 by transforming growth factor-beta, activin A and microphthalmia-associated transcription factor. Murakami M, etal., Cell Signal. 2006 Feb;18(2):256-65. Epub 2005 Jun 14.
144. Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Mutoh M, etal., Carcinogenesis. 2008 Apr;29(4):824-9. doi: 10.1093/carcin/bgn028. Epub 2008 Feb 6.
145. Plasminogen activator inhibitor type 1 up-regulation is associated with skeletal muscle atrophy and associated fibrosis. Naderi J, etal., Am J Pathol. 2009 Aug;175(2):763-71. Epub 2009 Jul 2.
146. Protective effects of vascular endothelial growth factor on intestinal epithelial apoptosis and bacterial translocation in experimental severe acute pancreatitis. Nakajima T, etal., Pancreas. 2007 May;34(4):410-6.
147. Shear stress induces hepatocyte PAI-1 gene expression through cooperative Sp1/Ets-1 activation of transcription. Nakatsuka H, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G26-34. Epub 2006 Feb 23.
148. Characterization of recombinant rat plasminogen activator inhibitor-1 and development of immunological tools for its quantitation. Ngo TH, etal., J Pharm Belg. 1997 Jul-Aug;52(4):165-6.
149. Monoclonal antibody-based immunoassays for the specific quantitation of rat PAI-1 antigen and activity in biological samples. Ngo TH, etal., Thromb Haemost. 1998 Apr;79(4):808-12.
150. Long-term administration of highly purified eicosapentaenoic acid ethyl ester prevents diabetes and abnormalities of blood coagulation in male WBN/Kob rats. Nobukata H, etal., Metabolism. 2000 Jul;49(7):912-9.
151. Urokinase plasminogen activator and plasminogen activator inhibitor type-1 in nonsmall-cell lung cancer: relation to prognosis and angiogenesis. Offersen BV, etal., Lung Cancer. 2007 Apr;56(1):43-50. Epub 2007 Jan 17.
152. Upregulated expression of transforming growth factor-beta, type IV collagen, and plasminogen activator inhibitor-1 mRNA are decreased after release of unilateral ureteral obstruction. Ogata Y, etal., Tohoku J Exp Med. 2002 Jul;197(3):159-68.
153. Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition. Oikawa T, etal., Kidney Int. 1997 Jan;51(1):164-72.
154. Extinguishing Egr-1-dependent inflammatory and thrombotic cascades after lung transplantation. Okada M, etal., FASEB J. 2001 Dec;15(14):2757-9. Epub 2001 Oct 15.
155. Role of microthrombus formation in the development of ischemia/reperfusion-induced liver injury in rats. Okajima K, etal., Thromb Haemost. 2002 Sep;88(3):473-80.
156. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
157. Elevated plasma level of plasminogen activator inhibitor-1 (PAI-1) in patients with relapsing-remitting multiple sclerosis. Onodera H, etal., Tohoku J Exp Med. 1999 Dec;189(4):259-65.
158. Lp(a) lipoprotein levels as a predictor of risk for thrombogenic events in patients with Behcet's disease. Orem A, etal., Ann Rheum Dis. 1995 Sep;54(9):726-9.
159. Plasminogen activator inhibitor-1 gene 4G/5G polymorphism in Turkish children with asthma and allergic rhinitis. Ozbek OY, etal., Allergy Asthma Proc. 2009 Jan-Feb;30(1):41-6. Epub 2008 Dec 6.
160. Plasma levels of free tissue factor pathway inhibitor in patients with various thyroid disorders. Ozcan MA, etal., Thromb Res. 2003 Jun 1;110(4):243-7.
161. Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats. Pan F, etal., Chin J Integr Med. 2015 May 13.
162. Effects of Kaixinjieyu, a Chinese herbal medicine preparation, on neurovascular unit dysfunction in rats with vascular depression. Pan J, etal., BMC Complement Altern Med. 2015 Aug 19;15:291. doi: 10.1186/s12906-015-0808-z.
163. Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity. Penn JS and Rajaratnam VS, Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5423-9.
164. The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. Penn JS, etal., Invest Ophthalmol Vis Sci. 2001 Jan;42(1):283-90.
165. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
166. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
167. Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathy. Pontrelli P, etal., Transplantation. 2008 Jan 15;85(1):125-34. doi: 10.1097/01.tp.0000296831.91303.9a.
168. Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury. Prabhakaran P, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L20-8. Epub 2003 May 2.
169. Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass. Pretorius M, etal., Circulation. 2007 Sep 11;116(11 Suppl):I1-7.
170. PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair. Providence KM and Higgins PJ, J Cell Physiol. 2004 Aug;200(2):297-308.
171. Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model. Qiu P, etal., J Infect Dis. 2013 Sep;208(6):978-89. doi: 10.1093/infdis/jit247. Epub 2013 Jun 3.
172. Disorders of hemostasis during the surgical management of severe necrotizing pancreatitis. Radenkovic D, etal., Pancreas. 2004 Aug;29(2):152-6.
173. Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia. Renckens R, etal., Blood. 2007 Feb 15;109(4):1593-601. Epub 2006 Oct 10.
174. Chronic allograft nephropathy: expression and localization of PAI-1 and PPAR-gamma. Revelo MP, etal., Nephrol Dial Transplant. 2005 Dec;20(12):2812-9. Epub 2005 Oct 12.
175. GOA pipeline RGD automated data pipeline
176. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
177. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
178. Fibrinolytic inhibitor levels and polymorphisms in Behcet disease and their association with thrombosis. Ricart JM, etal., Br J Haematol. 2008 May;141(5):716-9. doi: 10.1111/j.1365-2141.2008.07078.x. Epub 2008 Mar 12.
179. Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response. Richardson MA, etal., J Pharmacol Exp Ther. 2008 Apr;325(1):17-26. doi: 10.1124/jpet.107.130609. Epub 2008 Jan 8.
180. Involvement of RAGE, NADPH oxidase, and Ras/Raf-1 pathway in glycated LDL-induced expression of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells. Sangle GV, etal., Endocrinology. 2010 Sep;151(9):4455-66. doi: 10.1210/en.2010-0323. Epub 2010 Jul 14.
181. 4G/5G polymorphism of plasminogen activator inhibitor-1 gene is associated with mortality in intensive care unit patients with severe pneumonia. Sapru A, etal., Anesthesiology. 2009 May;110(5):1086-91.
182. Elevated PAI-1 is associated with poor clinical outcomes in pediatric patients with acute lung injury. Sapru A, etal., Intensive Care Med. 2010 Jan;36(1):157-63. Epub 2009 Oct 24.
183. The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia. Sartori MT, etal., Clin Appl Thromb Hemost. 2003 Oct;9(4):299-307.
184. Local intravascular coagulation and fibrin deposition on intestinal ischemia-reperfusion in rats. Schoots IG, etal., Surgery. 2003 Apr;133(4):411-9.
185. Genetic and plasma markers of venous thromboembolism in patients with high grade glioma. Sciacca FL, etal., Clin Cancer Res. 2004 Feb 15;10(4):1312-7.
186. The EGF-inducible protein EIP-1 of migrating normal and malignant rat liver epithelial cells is identical to plasminogen activator inhibitor 1 and is a component of the ECM migration tracks. Seebacher T, etal., Exp Cell Res. 1992 Dec;203(2):504-7.
187. Increased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis. Seferovic MD and Gupta MB, Dis Markers. 2016;2016:7124186. doi: 10.1155/2016/7124186. Epub 2016 Jan 19.
188. The expression of fibrinolytic components in chronic paranasal sinus disease. Sejima T, etal., Am J Rhinol Allergy. 2011 Jan-Feb;25(1):1-6.
189. Tissue-specific PAI-1 gene expression and glycosylation pattern in insulin-resistant old rats. Serrano R, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1563-9. doi: 10.1152/ajpregu.00093.2009. Epub 2009 Sep 23.
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192. The prevalence of 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene in central serous chorioretinopathy and its association with plasma PAI-1 levels. Sogutlu Sari E, etal., Cutan Ocul Toxicol. 2014 Jan 22.
193. Plasminogen activation inhibitor concentrations in bronchoalveolar lavage fluid distinguishes ventilator-associated pneumonia from colonization in mechanically ventilated pediatric patients. Srinivasan R, etal., Pediatr Crit Care Med. 2010 May 13.
194. Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. Stefansson S, etal., J Biol Chem. 1996 Apr 5;271(14):8215-20.
195. Plasminogen activator inhibitor-1 promoter 4G/5G genotype is not a risk factor for myocardial infarction in a Japanese population. Sugano T, etal., Blood Coagul Fibrinolysis. 1998 Mar;9(2):201-4.
196. Glucose upregulates plasminogen activator inhibitor-1 gene expression in vascular smooth muscle cells. Suzuki M, etal., Life Sci. 2002 Nov 22;72(1):59-66.
197. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
198. Platelet activation independent of pulmonary inflammation contributes to diesel exhaust particulate-induced promotion of arterial thrombosis. Tabor CM, etal., Part Fibre Toxicol. 2016 Feb 9;13(1):6. doi: 10.1186/s12989-016-0116-x.
199. Changes in fibrinolytic parameters in male patients with type 2 (non-insulin-dependent) diabetes mellitus. Takada Y, etal., Thromb Res. 1993 Sep 1;71(5):405-15.
200. Thiamine attenuates the hypertension and metabolic abnormalities in CD36-defective SHR: uncoupling of glucose oxidation from cellular entry accompanied with enhanced protein O-GlcNAcylation in CD36 deficiency. Tanaka T, etal., Mol Cell Biochem. 2007 May;299(1-2):23-35.
201. Plasminogen activator inhibitor-1 and apolipoprotein E gene polymorphisms and diabetic angiopathy. Tarnow L, etal., Nephrol Dial Transplant. 2000 May;15(5):625-30.
202. Coordinated induction of extracellular proteolysis systems during experimental autoimmune encephalomyelitis in mice. Teesalu T, etal., Am J Pathol. 2001 Dec;159(6):2227-37.
203. Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril. Toblli JE, etal., Heart. 2005 Jan;91(1):80-6.
204. Regulation of plasminogen activator inhibitor-1 mRNA accumulation by basic fibroblast growth factor and transforming growth factor-beta1 in cultured rat astrocytes. Treichel JA, etal., J Neurochem. 1998 Nov;71(5):1944-52.
205. Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis. Tsai HJ, etal., Blood Coagul Fibrinolysis. 2015 Mar;26(2):175-84. doi: 10.1097/MBC.0000000000000214.
206. Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis. A meta-analysis. Tsantes AE, etal., Thromb Haemost. 2007 Jun;97(6):907-13.
207. The role of hypercoagulability in ischemic colitis. Tsimperidis AG, etal., Scand J Gastroenterol. 2015 Jul;50(7):848-55. doi: 10.3109/00365521.2015.1010568. Epub 2015 Feb 5.
208. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
209. Graves' orbitopathy results in profound changes in tear composition: a study of plasminogen activator inhibitor-1 and seven cytokines. Ujhelyi B, etal., Thyroid. 2012 Apr;22(4):407-14. doi: 10.1089/thy.2011.0248. Epub 2012 Mar 2.
210. Impaired fibrinolysis in hypertension and obesity due to high plasminogen activator inhibitor-1 level in plasma. Urano T, etal., Jpn J Physiol. 1993;43(2):221-8.
211. Candidate genetic markers and the risk of restenosis after coronary angioplasty. Volzke H, etal., Clin Sci (Lond). 2004 Jan;106(1):35-42.
212. Increased adipose tissue secretion of interleukin-6, but not of leptin, plasminogen activator inhibitor-1 or tumour necrosis factor alpha, in Graves' hyperthyroidism. Wahrenberg H, etal., Eur J Endocrinol. 2002 May;146(5):607-11.
213. The LOC387715 polymorphism, inflammatory markers, smoking, and age-related macular degeneration. A population-based case-control study. Wang JJ, etal., Ophthalmology. 2008 Apr;115(4):693-9. Epub 2007 Aug 2.
214. Presence of urokinase plasminogen activator and plasminogen activator inhibitor-1 messenger ribonucleic acids in rat endometrium during decidualization in vivo. Wang S, etal., Biol Reprod. 1996 Sep;55(3):493-7.
215. Aldosterone and TGF-beta(1) synergistically increase PAI-1 expression in hepatic stellate cells of rats. Wang SL, etal., Int J Clin Exp Pathol. 2015 Sep 1;8(9):9845-53. eCollection 2015.
216. Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Ware LB, etal., Crit Care Med. 2007 Aug;35(8):1821-8.
217. Glucocorticoids activate TGF-beta induced PAI-1 and CTGF expression in rat hepatocytes. Wickert L, etal., Comp Hepatol. 2007 May 2;6:5.
218. A DNA enzyme against plasminogen activator inhibitor- type 1 (PAI-1) limits neointima formation after angioplasty in an obese diabetic rodent model. Witkowski P, etal., J Cardiovasc Pharmacol. 2007 Dec;50(6):633-40.
219. Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia. Wu J, etal., Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1565-70. doi: 10.1161/ATVBAHA.109.189514. Epub 2009 Jul 2.
220. Procoagulant and fibrinolytic activity after polytrauma in rat. Wu X, etal., Am J Physiol Regul Integr Comp Physiol. 2016 Feb 15;310(4):R323-9. doi: 10.1152/ajpregu.00401.2015. Epub 2015 Dec 2.
221. Downregulated expression of plasminogen activator inhibitor-1 augments myocardial neovascularization and reduces cardiomyocyte apoptosis after acute myocardial infarction. Xiang G, etal., J Am Coll Cardiol. 2005 Aug 2;46(3):536-41.
222. Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors. Xiang G, etal., J Exp Med. 2004 Dec 20;200(12):1657-66. Epub 2004 Dec 13.
223. Resveratrol ameliorates renal injury in spontaneously hypertensive rats by inhibiting renal micro-inflammation. Xue H, etal., Biosci Rep. 2016 Apr 19. pii: BSR20160035.
224. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. Yamada Y, etal., N Engl J Med. 2002 Dec 12;347(24):1916-23.
225. Bactericidal/permeability-increasing protein ameliorates hypercoagulability after hemorrhagic shock. Yamashita M Thromb Res. 1997 Aug 1;87(3):323-9.
226. Effect of intra-abdominal administration of ligustrazine nanoparticles nano spray on postoperative peritoneal adhesion in rat model. Yan S, etal., J Obstet Gynaecol Res. 2015 Dec;41(12):1942-50. doi: 10.1111/jog.12807. Epub 2015 Sep 30.
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229. The 4G/5G genetic polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial infarction in the ECTIM study. Etude CasTemoins de I'nfarctus du Mycocarde. Ye S, etal., Thromb Haemost. 1995 Sep;74(3):837-41.
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233. A Selective TGFbeta Ligand Trap Attenuates Pulmonary Hypertension. Yung LM, etal., Am J Respir Crit Care Med. 2016 Apr 26.
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237. Plasminogen activator inhibitor-1 4G/5G polymorphism and retinopathy risk in type 2 diabetes: a meta-analysis. Zhang T, etal., BMC Med. 2013 Jan 2;11:1. doi: 10.1186/1741-7015-11-1.
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241. Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. Zhao G, etal., Neuroreport. 2003 Sep 15;14(13):1689-92.
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Additional References at PubMed
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PMID:31257474   PMID:32748313   PMID:33450132  


Genomics

Comparative Map Data
Serpine1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21219,601,272 - 19,611,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,601,272 - 19,611,657 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,739,113 - 20,749,506 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01221,351,819 - 21,362,213 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01220,416,358 - 20,426,756 (+)NCBIRnor_WKY
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
RH 3.4 Map12277.5RGD
Cytogenetic Map12q12NCBI
SERPINE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,127,104 - 101,139,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7101,127,104 - 101,139,247 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,770,385 - 100,782,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,557,172 - 100,569,026 (+)NCBINCBI36Build 36hg18NCBI36
Build 347100,363,886 - 100,375,741NCBI
Celera795,778,744 - 95,790,926 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,363,553 - 95,375,745 (+)NCBIHuRef
CHM1_17100,700,705 - 100,712,867 (+)NCBICHM1_1
T2T-CHM13v2.07102,449,908 - 102,462,056 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,128,757 - 100,140,934 (+)NCBI
Serpine1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,090,358 - 137,101,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,090,358 - 137,101,122 (-)EnsemblGRCm39 Ensembl
GRCm385137,061,504 - 137,072,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,061,504 - 137,072,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,537,374 - 137,548,142 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,346,135 - 137,356,886 (-)NCBIMGSCv36mm8
Celera5134,078,340 - 134,089,224 (-)NCBICelera
Cytogenetic Map5G2NCBI
Serpine1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545616,145,944 - 16,157,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545616,147,523 - 16,157,040 (-)NCBIChiLan1.0ChiLan1.0
SERPINE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17106,511,539 - 106,518,605 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,510,130 - 106,518,450 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0793,267,517 - 93,279,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SERPINE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.168,719,547 - 8,727,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl68,720,825 - 8,726,301 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,418,147 - 10,423,482 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,538,810 - 8,546,429 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,540,391 - 8,550,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,500,159 - 8,505,509 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,470,611 - 8,475,963 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,635,341 - 8,640,693 (-)NCBIUU_Cfam_GSD_1.0
Serpine1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344132,997,052 - 133,003,714 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365431,032,543 - 1,040,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,863,695 - 8,871,547 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,863,738 - 8,871,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SERPINE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,047,520 - 12,060,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,047,529 - 12,060,202 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660704,295,672 - 4,308,796 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpine1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,128,059 - 16,137,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,128,145 - 16,136,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpine1
57 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:814
Count of miRNA genes:305
Interacting mature miRNAs:394
Transcripts:ENSRNOT00000001916
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat

Markers in Region
D12Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,870 - 19,611,091 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,702 - 22,650,918NCBIRnor6.0
Rnor_5.01224,662,983 - 24,663,199UniSTSRnor5.0
RGSC_v3.41220,932,560 - 20,932,776UniSTSRGSC3.4
RGSC_v3.41220,932,559 - 20,932,776RGDRGSC3.4
RGSC_v3.11220,922,171 - 20,922,388RGD
Celera1221,386,630 - 21,386,846UniSTS
RH 3.4 Map12280.3RGD
RH 3.4 Map12280.3UniSTS
RH 2.0 Map12205.1RGD
SHRSP x BN Map1222.7RGD
FHH x ACI Map129.01RGD
Cytogenetic Map12q11-q12UniSTS
D12Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,886 - 19,611,090 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,718 - 22,650,917NCBIRnor6.0
Rnor_5.01224,662,999 - 24,663,198UniSTSRnor5.0
RGSC_v3.41220,932,561 - 20,932,760UniSTSRGSC3.4
RGSC_v3.41220,932,560 - 20,932,760RGDRGSC3.4
RGSC_v3.11220,922,172 - 20,922,372RGD
Celera1221,386,646 - 21,386,845UniSTS
RH 3.4 Map12277.7UniSTS
RH 3.4 Map12277.7RGD
RH 2.0 Map12206.8RGD
Cytogenetic Map12q11-q12UniSTS
D12Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,889 - 19,611,095 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,721 - 22,650,922NCBIRnor6.0
Rnor_5.01224,663,002 - 24,663,203UniSTSRnor5.0
RGSC_v3.41220,932,556 - 20,932,757UniSTSRGSC3.4
RGSC_v3.41220,932,555 - 20,932,757RGDRGSC3.4
RGSC_v3.11220,922,167 - 20,922,369RGD
Celera1221,386,649 - 21,386,850UniSTS
RH 3.4 Map12277.5UniSTS
RH 3.4 Map12277.5RGD
RH 2.0 Map12197.1RGD
Cytogenetic Map12q11-q12UniSTS
D12Arb4   No map positions available.
RH129692  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,611,385 - 19,611,585 (+)MAPPERmRatBN7.2
Rnor_6.01222,651,211 - 22,651,410NCBIRnor6.0
Rnor_5.01224,663,492 - 24,663,691UniSTSRnor5.0
RGSC_v3.41220,932,068 - 20,932,267UniSTSRGSC3.4
Celera1221,387,139 - 21,387,338UniSTS
RH 3.4 Map12277.5UniSTS
Cytogenetic Map12q11-q12UniSTS
RH142420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,610,381 - 19,610,594 (+)MAPPERmRatBN7.2
Rnor_6.01222,650,213 - 22,650,425NCBIRnor6.0
Rnor_5.01224,662,494 - 24,662,706UniSTSRnor5.0
RGSC_v3.41220,933,053 - 20,933,265UniSTSRGSC3.4
Celera1221,386,141 - 21,386,353UniSTS
RH 3.4 Map12277.5UniSTS
Cytogenetic Map12q11-q12UniSTS
RH94577  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,611,229 - 19,611,407 (+)MAPPERmRatBN7.2
Rnor_6.01222,651,055 - 22,651,232NCBIRnor6.0
Rnor_5.01224,663,336 - 24,663,513UniSTSRnor5.0
RGSC_v3.41220,932,246 - 20,932,423UniSTSRGSC3.4
Celera1221,386,983 - 21,387,160UniSTS
Cytogenetic Map12q11-q12UniSTS
PMC15197P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,609,566 - 19,610,072 (+)MAPPERmRatBN7.2
Rnor_6.01222,649,398 - 22,649,903NCBIRnor6.0
Rnor_5.01224,661,679 - 24,662,184UniSTSRnor5.0
RGSC_v3.41220,933,575 - 20,934,080UniSTSRGSC3.4
Celera1221,385,326 - 21,385,831UniSTS
Cytogenetic Map12q11-q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 16 3 3 9 5
Low 2 27 48 35 19 35 8 11 66 32 32 6 8
Below cutoff 6 6 6 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001916   ⟹   ENSRNOP00000001916
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,601,272 - 19,611,657 (+)Ensembl
Rnor_6.0 Ensembl1222,641,104 - 22,651,482 (+)Ensembl
RefSeq Acc Id: NM_012620   ⟹   NP_036752
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21219,601,272 - 19,611,657 (+)NCBI
Rnor_6.01222,641,104 - 22,651,482 (+)NCBI
Rnor_5.01224,653,385 - 24,663,763 (+)NCBI
RGSC_v3.41220,931,996 - 20,942,374 (-)RGD
Celera1221,377,028 - 21,387,410 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036752 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41796 (Get FASTA)   NCBI Sequence Viewer  
  AAA56856 (Get FASTA)   NCBI Sequence Viewer  
  EDM13286 (Get FASTA)   NCBI Sequence Viewer  
  P20961 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036752   ⟸   NM_012620
- Peptide Label: precursor
- UniProtKB: F1LM16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001916   ⟸   ENSRNOT00000001916
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20961-F1-model_v2 AlphaFold P20961 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698524
Promoter ID:EPDNEW_R9049
Type:multiple initiation site
Name:Serpine1_1
Description:serpin family E member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,641,079 - 22,641,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3249 AgrOrtholog
BioCyc Gene G2FUF-19678 BioCyc
Ensembl Genes ENSRNOG00000001414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001916 ENTREZGENE
  ENSRNOP00000001916.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001916 ENTREZGENE
  ENSRNOT00000001916.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Serpin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24617 UniProtKB/Swiss-Prot
NCBI Gene 24617 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Serpin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SERPINE1 RGD
PhenoGen Serpine1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SERPIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP<