Gene: Serpine1 (serpin family E member 1) Rattus norvegicus
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Symbol: Serpine1
Name: serpin family E member 1
Description: ENCODES a protein that exhibits protease binding; serine-type endopeptidase inhibitor activity; signaling receptor binding (ortholog); INVOLVED IN cellular response to aldosterone; cellular response to angiotensin; cellular response to ATP; PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; ASSOCIATED WITH decreased metastatic potential; ASSOCIATED WITH abdominal aortic aneurysm; Acquired Protein C Deficiency; Acute Lung Injury; FOUND IN chromaffin granule; cytoplasm; extracellular region; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-colchicine; (S)-naringenin
AGR Description: Exhibits protease binding activity and serine-type endopeptidase inhibitor activity; involved in several processes, including cellular response to growth factor stimulus, cellular response to hormone stimulus, and cellular response to organic cyclic compound; localizes to the chromaffin granule and extracellular space; used to study several diseases, including artery disease (multiple), cerebrovascular disease (multiple), disseminated intravascular coagulation, end stage renal failure, and glucose metabolism disease (multiple); biomarker of several diseases, including asthma, disseminated intravascular coagulation, glomerulonephritis (multiple), lung disease (multiple), and middle cerebral artery infarction; orthologous to human SERPINE1 (serpin family E member 1).
Merged Description: Exhibits protease binding activity and serine-type endopeptidase inhibitor activity; involved in several processes, including cellular response to growth factor stimulus, cellular response to hormone stimulus, and cellular response to organic cyclic compound; localizes to the chromaffin granule and extracellular space; used to study several diseases, including artery disease (multiple), cerebrovascular disease (multiple), disseminated intravascular coagulation, end stage renal failure, and glucose metabolism disease (multiple); biomarker of several diseases, including asthma, disseminated intravascular coagulation, glomerulonephritis (multiple), lung disease (multiple), and middle cerebral artery infarction; orthologous to human SERPINE1 (serpin family E member 1); PARTICIPATES IN oxygen homeostasis pathway; fibrinolysis pathway; hypoxia inducible factor pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-colchicine; (S)-naringenin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; Pai1; PAI1A; Pai1aa; Planh; Plasminogen activator inhibitor; plasminogen activator inhibitor 1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Orthologs:
Homo sapiens (human) : SERPINE1 (serpin family E member 1)  HGNC  Alliance
Mus musculus (house mouse) : Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpine1 (serpin family E member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINE1 (serpin family E member 1)
Canis lupus familiaris (dog) : SERPINE1 (serpin family E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpine1 (serpin family E member 1)
Sus scrofa (pig) : SERPINE1 (serpin family E member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01222,641,104 - 22,651,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,653,385 - 24,663,763 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,931,996 - 20,942,374 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11220,921,607 - 20,931,986 (-)NCBI
Celera1221,377,028 - 21,387,410 (+)NCBICelera
Cytogenetic Map12q12NCBI
RH 3.4 Map12277.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Strain Sequence Variants (Rnor 5.0)