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Gene: P4hb (prolyl 4-hydroxylase subunit beta) Rattus norvegicus
Symbol: P4hb
Name: prolyl 4-hydroxylase subunit beta
RGD ID: 3244
Description: Exhibits enzyme binding activity and protein disulfide isomerase activity. Predicted to contribute to procollagen-proline 4-dioxygenase activity. Predicted to be involved in several processes, including peptidyl-proline hydroxylation to 4-hydroxy-L-proline; positive regulation of substrate adhesion-dependent cell spreading; and positive regulation of viral entry into host cell. Predicted to localize to several cellular components, including endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cellular thyroid hormone-binding protein; PDI; PDIR; prolyl 4-hydroxylase, beta polypeptide; protein disulfide isomerase; protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); protein disulfide-isomerase
Homo sapiens (human) : P4HB (prolyl 4-hydroxylase subunit beta)  HGNC  Alliance
Mus musculus (house mouse) : P4hb (prolyl 4-hydroxylase, beta polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P4hb (prolyl 4-hydroxylase subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : P4HB (prolyl 4-hydroxylase subunit beta)
Canis lupus familiaris (dog) : P4HB (prolyl 4-hydroxylase subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P4hb (prolyl 4-hydroxylase subunit beta)
Sus scrofa (pig) : P4HB (prolyl 4-hydroxylase subunit beta)
Chlorocebus sabaeus (African green monkey) : P4HB (prolyl 4-hydroxylase subunit beta)
Heterocephalus glaber (naked mole-rat) : P4hb (prolyl 4-hydroxylase subunit beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Celera10104,380,384 - 104,391,995 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on P4hb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3244
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.