Smad3 (SMAD family member 3) - Rat Genome Database

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Gene: Smad3 (SMAD family member 3) Rattus norvegicus
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Symbol: Smad3
Name: SMAD family member 3
RGD ID: 3032
Description: Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of cellular component biogenesis; regulation of cellular biosynthetic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in nucleus. Part of transcription regulator complex. Used to study pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAD (mothers against decapentaplegic Drosophila) homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD homolog 3; MAD homolog 3 (Drosophila); mad3; Madh3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; Smad 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-O-oleoyl-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
20-HETE  (ISO)
3,4-dihydroxybenzaldehyde  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-Methoxynobiletin  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
aconitic acid  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
AM-251  (ISO)
Ammothamnine  (ISO)
amphetamine  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
azithromycin  (ISO)
azoxystrobin  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
benzophenone  (ISO)
betulin  (EXP)
betulinic acid  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
casticin  (ISO)
celastrol  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
CGS-21680  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cytochalasin D  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
diminazene diaceturate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
ebselen  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
ferulic acid  (EXP)
fipronil  (EXP)
fluoranthene  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
gallic acid  (EXP)
Ganoderic acid A  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heptachlor  (ISO)
hexachlorobenzene  (ISO)
Honokiol  (EXP,ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
irbesartan  (EXP)
irinotecan  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
leptomycin B  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
LY-2157299  (EXP,ISO)
lycopene  (ISO)
melphalan  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methoxychlor  (EXP)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mirtazapine  (ISO)
monocrotaline  (ISO)
Muraglitazar  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP)
niclosamide  (EXP,ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
nitrofen  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
oridonin  (ISO)
osthole  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
patulin  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Phyllanthin  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (ISO)
SB 203580  (ISO)
SB 431542  (EXP,ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (EXP)
streptozocin  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vitamin D  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (IMP)
activin receptor signaling pathway  (IBA,IEA,ISO)
adrenal gland development  (IDA)
anatomical structure morphogenesis  (IBA,IEA)
apoptotic process  (ISO)
cell differentiation  (IBA,IEA)
cell population proliferation  (ISO)
cell-cell junction organization  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to transforming growth factor beta stimulus  (IEP,ISO)
cellular response to virus  (ISO)
developmental growth  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic pattern specification  (ISO)
endoderm development  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
gastrulation  (ISO)
heart looping  (ISO)
immune response  (ISO)
immune system development  (ISO)
in utero embryonic development  (ISO)
JNK cascade  (ISO)
lens fiber cell differentiation  (ISO)
liver development  (ISO)
MAPK cascade  (ISO)
mesoderm formation  (ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of cardiac muscle hypertrophy in response to stress  (IGI)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IDA,ISO)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of fat cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of lung blood pressure  (IGI)
negative regulation of miRNA transcription  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of protein catabolic process  (IDA,IMP)
negative regulation of transcription by RNA polymerase II  (IMP,ISO)
negative regulation of wound healing  (ISO)
nodal signaling pathway  (ISO)
osteoblast development  (ISO)
osteoblast differentiation  (ISO)
paraxial mesoderm morphogenesis  (ISO)
pericardium development  (ISO)
positive regulation of alkaline phosphatase activity  (IDA)
positive regulation of bone mineralization  (IDA)
positive regulation of canonical Wnt signaling pathway  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of focal adhesion assembly  (IDA)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of nitric oxide biosynthetic process  (IGI,ISO)
positive regulation of positive chemotaxis  (IDA)
positive regulation of stress fiber assembly  (IDA)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,IMP,ISO)
positive regulation of transforming growth factor beta3 production  (IMP)
protein stabilization  (IMP)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of immune response  (ISO)
regulation of striated muscle tissue development  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to angiotensin  (ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (ISO)
signal transduction involved in regulation of gene expression  (IMP)
skeletal system development  (ISO)
SMAD protein signal transduction  (IBA,IEA,IMP,ISO)
somitogenesis  (ISO)
T cell activation  (ISO)
thyroid gland development  (ISO)
transdifferentiation  (IDA)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,IMP,ISO)
ureteric bud development  (ISO)

Cellular Component

Molecular Function
beta-catenin binding  (IDA)
bHLH transcription factor binding  (ISO)
chromatin binding  (ISO)
chromatin DNA binding  (ISO)
cis-regulatory region sequence-specific DNA binding  (ISO,ISS)
co-SMAD binding  (ISO)
collagen binding  (ISO)
DEAD/H-box RNA helicase binding  (ISO)
DNA binding  (ISO)
DNA-binding transcription activator activity, RNA polymerase II-specific  (ISO)
DNA-binding transcription factor activity  (IDA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IBA,IEA,ISO)
DNA-binding transcription factor binding  (ISO)
DNA-binding transcription repressor activity  (ISO)
double-stranded DNA binding  (ISO)
enzyme binding  (IPI)
I-SMAD binding  (IBA,IEA)
identical protein binding  (ISO)
metal ion binding  (IEA)
nuclear glucocorticoid receptor binding  (ISO)
nuclear mineralocorticoid receptor binding  (ISO)
nuclear receptor binding  (ISO)
phosphatase binding  (ISO)
promoter-specific chromatin binding  (ISO)
protein binding  (IPI,ISO)
protein homodimerization activity  (ISO)
protein kinase binding  (ISO)
R-SMAD binding  (ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IBA,IEA,ISO)
RNA polymerase II transcription regulatory region sequence-specific DNA binding  (IDA,ISO)
RNA polymerase II-specific DNA-binding transcription factor binding  (ISO)
sequence-specific DNA binding  (IDA,ISO)
sterol response element binding  (ISO)
transcription cis-regulatory region binding  (ISO)
transcription coactivator binding  (ISO)
transcription corepressor binding  (ISO)
transcription factor binding  (IDA,IPI)
transforming growth factor beta receptor binding  (ISO)
ubiquitin binding  (ISO)
ubiquitin protein ligase binding  (ISO)
zinc ion binding  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Aoki H, etal., Am J Physiol Cell Physiol. 2006 Apr;290(4):C1100-8. Epub 2005 Dec 21.
2. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
3. Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins. Chen Y, etal., Proc Natl Acad Sci U S A 1996 Nov 12;93(23):12992-7.
4. Cited2 modulates TGF-beta-mediated upregulation of MMP9. Chou YT, etal., Oncogene. 2006 Sep 7;25(40):5547-60. Epub 2006 Apr 17.
5. Ovarian follicle populations of the rat express TGF-beta signalling pathways. Drummond AE, etal., Mol Cell Endocrinol. 2003 Apr 28;202(1-2):53-7.
6. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, etal., PLoS One. 2018 Oct 22;13(10):e0206130. doi: 10.1371/journal.pone.0206130. eCollection 2018.
7. p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Furukawa F, etal., Hepatology. 2003 Oct;38(4):879-89.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Pharmacological application of caffeine inhibits TGF-beta-stimulated connective tissue growth factor expression in hepatocytes via PPARgamma and SMAD2/3-dependent pathways. Gressner OA, etal., J Hepatol. 2008 Nov;49(5):758-67. Epub 2008 Apr 30.
10. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
11. Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Hu B, etal., Am J Respir Cell Mol Biol 2003 Sep;29(3 Pt 1):397-404. Epub 2003 Apr 17.
12. Gut-enriched Kruppel-like factor interaction with Smad3 inhibits myofibroblast differentiation. Hu B, etal., Am J Respir Cell Mol Biol. 2007 Jan;36(1):78-84. Epub 2006 Jul 20.
13. Role of Smad3 in the regulation of rat telomerase reverse transcriptase by TGFbeta. Hu B, etal., Oncogene. 2006 Feb 16;25(7):1030-41.
14. Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-beta Induced Smad3 activation in vascular smooth muscle cell. Huang D, etal., PLoS One. 2011;6(10):e27123. doi: 10.1371/journal.pone.0027123. Epub 2011 Oct 31.
15. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
16. Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Kim BC, etal., Mol Cell Biol. 2002 Mar;22(5):1369-78.
17. Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways. Li CY, etal., J Cardiovasc Transl Res. 2021 Aug;14(4):636-646. doi: 10.1007/s12265-020-10089-2. Epub 2021 Jan 6.
18. Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes. Li TF, etal., J Biol Chem. 2006 Jul 28;281(30):21296-304. doi: 10.1074/jbc.M600514200. Epub 2006 May 10.
19. Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGF beta) induction of TGF beta 3 secretion. Liu G, etal., J Biol Chem. 2006 Oct 6;281(40):29479-90. Epub 2006 Aug 4.
20. Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells. Liu L, etal., Am J Physiol Gastrointest Liver Physiol 2003 Nov;285(5):G1056-67. Epub 2003 Jul 10.
21. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
22. MiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3. Liu Y, etal., Biochem Biophys Res Commun. 2016 May 13;473(4):859-66. doi: 10.1016/j.bbrc.2016.03.140. Epub 2016 Mar 30.
23. Smad3 is overexpressed in advanced human prostate cancer and necessary for progressive growth of prostate cancer cells in nude mice. Lu S, etal., Clin Cancer Res. 2007 Oct 1;13(19):5692-702.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Expression and intracellular localization of Smad proteins in human endometrial cancer. Piestrzeniewicz-Ulanska D, etal., Oncol Rep. 2003 Sep-Oct;10(5):1539-44.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
35. Reversible Smad-dependent signaling between tumor suppression and oncogenesis. Sekimoto G, etal., Cancer Res. 2007 Jun 1;67(11):5090-6.
36. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
37. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. Song K, etal., EMBO J. 2006 Jan 11;25(1):58-69. Epub 2005 Dec 15.
38. Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. Sowa H, etal., J Biol Chem. 2003 Dec 26;278(52):52240-52. Epub 2003 Sep 29.
39. Smad3 promotes alkaline phosphatase activity and mineralization of osteoblastic MC3T3-E1 cells. Sowa H, etal., J Bone Miner Res 2002 Jul;17(7):1190-9.
40. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Uemura M, etal., Mol Biol Cell. 2005 Sep;16(9):4214-24. Epub 2005 Jun 29.
43. Activin signal transduction in the fetal rat adrenal gland and in human H295R cells. Wang EY, etal., J Endocrinol 2003 Jul;178(1):137-48.
44. FOSL2 positively regulates TGF-beta1 signalling in non-small cell lung cancer. Wang J, etal., PLoS One. 2014 Nov 6;9(11):e112150. doi: 10.1371/journal.pone.0112150. eCollection 2014.
45. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
46. Stage-specific expression of Smad2 and Smad3 during folliculogenesis. Xu J, etal., Biol Reprod 2002 Jun;66(6):1571-8.
47. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
48. Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway. Zhang L, etal., J Mol Histol. 2020 Feb;51(1):77-87. doi: 10.1007/s10735-020-09859-8. Epub 2020 Feb 17.
49. Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. Zhang M, etal., J Biol Chem. 2010 Mar 19;285(12):8703-10. doi: 10.1074/jbc.M109.093526. Epub 2010 Jan 22.
50. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
51. Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling. Zhao X, etal., J Biol Chem. 2008 Feb 8;283(6):3272-80. doi: 10.1074/jbc.M708033200. Epub 2007 Nov 30.
52. Regulation of Smad3 expression in bleomycin-induced pulmonary fibrosis: a negative feedback loop of TGF-beta signaling. Zhao Y and Geverd DA, Biochem Biophys Res Commun 2002 Jun 7;294(2):319-23.
Additional References at PubMed
PMID:8774881   PMID:9111321   PMID:9311995   PMID:9679056   PMID:9702197   PMID:9732876   PMID:9759503   PMID:10064594   PMID:10559937   PMID:10647776   PMID:10708948   PMID:10708949  
PMID:10823886   PMID:11160896   PMID:11278251   PMID:11585338   PMID:11711431   PMID:11937490   PMID:12411310   PMID:12446380   PMID:12543979   PMID:12686552   PMID:12845704   PMID:12874272  
PMID:12876289   PMID:12902338   PMID:12943993   PMID:14555988   PMID:14559231   PMID:14617288   PMID:14623893   PMID:14656760   PMID:14754879   PMID:15084457   PMID:15107418   PMID:15150273  
PMID:15150278   PMID:15183723   PMID:15239668   PMID:15282343   PMID:15326485   PMID:15334054   PMID:15464984   PMID:15489334   PMID:15647271   PMID:15761025   PMID:15799969   PMID:16007207  
PMID:16224064   PMID:16266486   PMID:16696323   PMID:16751101   PMID:16777850   PMID:16785237   PMID:16807527   PMID:16824956   PMID:16886151   PMID:16931807   PMID:16980030   PMID:17038494  
PMID:17159989   PMID:17215516   PMID:17251190   PMID:17392319   PMID:17541159   PMID:17723189   PMID:18022758   PMID:18057996   PMID:18395914   PMID:18466073   PMID:18505915   PMID:18548003  
PMID:18679024   PMID:18729074   PMID:18794808   PMID:18832382   PMID:19122240   PMID:19197123   PMID:19525370   PMID:19555739   PMID:19667256   PMID:19816956   PMID:19834880   PMID:19959709  
PMID:20129061   PMID:20182310   PMID:20226149   PMID:20375011   PMID:20404057   PMID:20423827   PMID:20739403   PMID:20874717   PMID:20943464   PMID:21035443   PMID:21158069   PMID:21307346  
PMID:21354414   PMID:21429339   PMID:21468608   PMID:21498085   PMID:21560355   PMID:21724602   PMID:21749980   PMID:21828274   PMID:21852586   PMID:21937600   PMID:21947082   PMID:22045334  
PMID:22338217   PMID:22384127   PMID:22447946   PMID:22674034   PMID:22926646   PMID:23056222   PMID:23064763   PMID:23176567   PMID:23291610   PMID:23390484   PMID:23403244   PMID:23690627  
PMID:24086569   PMID:24290497   PMID:24356887   PMID:24500776   PMID:24718260   PMID:24914373   PMID:24964035   PMID:25010983   PMID:25065622   PMID:25245272   PMID:25416030   PMID:25422985  
PMID:25538336   PMID:25867402   PMID:25893292   PMID:26138247   PMID:26153982   PMID:26253398   PMID:26276823   PMID:26311719   PMID:26483344   PMID:26738448   PMID:26945889   PMID:26946943  
PMID:26954391   PMID:27155082   PMID:27217701   PMID:27239849   PMID:27282665   PMID:27340942   PMID:27422367   PMID:27453280   PMID:27530924   PMID:27633729   PMID:28035691   PMID:28041981  
PMID:28125630   PMID:28193525   PMID:28230313   PMID:28539652   PMID:28552397   PMID:28586069   PMID:28623783   PMID:28647476   PMID:28943431   PMID:29102631   PMID:29104873   PMID:29215718  
PMID:29309309   PMID:29505748   PMID:29704604   PMID:30053527   PMID:30055965   PMID:30066831   PMID:30317638   PMID:30549198   PMID:31521890   PMID:31582430   PMID:31813251   PMID:31917288  
PMID:31960436   PMID:32169420   PMID:32274619   PMID:32949699   PMID:33448318   PMID:33577033   PMID:33769459   PMID:34175710   PMID:34834085   PMID:34898379   PMID:34938805   PMID:36030021  
PMID:37187923   PMID:38122948  


Genomics

Comparative Map Data
Smad3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8873,022,204 - 73,132,324 (-)NCBIGRCr8
mRatBN7.2864,126,829 - 64,236,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx869,641,910 - 69,752,073 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,914,370 - 68,024,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,784,499 - 65,894,665 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,569,530 - 68,678,349 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0868,290,927 - 68,397,727 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,803,909 - 67,952,056 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,822,964 - 67,971,110 (-)NCBI
Celera863,537,497 - 63,647,062 (-)NCBICelera
Cytogenetic Map8q24NCBI
SMAD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381567,065,602 - 67,195,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,063,763 - 67,195,173 (+)EnsemblGRCh38hg38GRCh38
GRCh371567,357,940 - 67,487,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,145,249 - 65,274,587 (+)NCBINCBI36Build 36hg18NCBI36
Build 341565,145,248 - 65,274,586NCBI
Celera1544,246,635 - 44,375,039 (+)NCBICelera
Cytogenetic Map15q22.33NCBI
HuRef1544,193,465 - 44,321,904 (+)NCBIHuRef
CHM1_11567,476,260 - 67,605,488 (+)NCBICHM1_1
T2T-CHM13v2.01564,885,345 - 65,017,070 (+)NCBIT2T-CHM13v2.0
Smad3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,554,048 - 63,665,276 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,554,049 - 63,665,276 (-)EnsemblGRCm39 Ensembl
GRCm38963,646,766 - 63,757,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,646,767 - 63,757,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,494,574 - 63,605,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36963,444,773 - 63,556,000 (-)NCBIMGSCv36mm8
Celera960,869,117 - 60,980,879 (-)NCBICelera
Cytogenetic Map9CNCBI
cM Map934.22NCBI
Smad3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,747,651 - 8,842,136 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,747,651 - 8,842,003 (-)NCBIChiLan1.0ChiLan1.0
SMAD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21656,319,096 - 56,448,455 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,491,695 - 60,621,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,013,764 - 46,143,126 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,284,949 - 64,414,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,284,949 - 64,414,185 (+)Ensemblpanpan1.1panPan2
SMAD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,246,313 - 31,360,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,245,657 - 31,363,337 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,175,971 - 31,289,442 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03031,444,224 - 31,557,937 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,444,224 - 31,561,176 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,371,657 - 31,485,227 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,431,846 - 31,545,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03031,673,713 - 31,787,293 (+)NCBIUU_Cfam_GSD_1.0
Smad3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,232,767 - 109,341,735 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,080,575 - 27,189,793 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,080,662 - 27,185,861 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1164,998,103 - 165,124,449 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11164,998,457 - 165,124,455 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21182,902,348 - 182,926,370 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12616,319,959 - 16,446,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2616,320,933 - 16,446,527 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048125,021,354 - 125,151,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247815,795,652 - 5,890,371 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247815,795,652 - 5,890,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smad3
482 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:512
Count of miRNA genes:253
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000039730
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat

Markers in Region
Madh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,236,564 - 64,236,759 (+)MAPPERmRatBN7.2
Rnor_6.0868,677,954 - 68,678,148NCBIRnor6.0
Rnor_5.0868,397,332 - 68,397,526UniSTSRnor5.0
RGSC_v3.4867,951,661 - 67,951,855UniSTSRGSC3.4
Celera863,646,667 - 63,646,861UniSTS
Cytogenetic Map8q24UniSTS
RH130799  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,235,228 - 64,235,441 (+)MAPPERmRatBN7.2
Rnor_6.0868,676,610 - 68,676,822NCBIRnor6.0
Rnor_5.0868,396,418 - 68,396,630UniSTSRnor5.0
RGSC_v3.4867,950,063 - 67,950,275UniSTSRGSC3.4
Celera863,645,365 - 63,645,577UniSTS
RH 3.4 Map8810.0UniSTS
Cytogenetic Map8q24UniSTS
RH143351  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,162,995 - 64,163,140 (+)MAPPERmRatBN7.2
Rnor_6.0868,605,604 - 68,605,748NCBIRnor6.0
Rnor_5.0868,327,124 - 68,327,268UniSTSRnor5.0
RGSC_v3.4867,856,537 - 67,856,681UniSTSRGSC3.4
Celera863,573,666 - 63,573,810UniSTS
RH 3.4 Map8805.0UniSTS
Cytogenetic Map8q24UniSTS
RH143448  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,126,996 - 64,127,126 (+)MAPPERmRatBN7.2
Rnor_6.0868,569,698 - 68,569,827NCBIRnor6.0
Rnor_5.0868,291,095 - 68,291,224UniSTSRnor5.0
RGSC_v3.4867,820,872 - 67,821,001UniSTSRGSC3.4
Celera863,537,665 - 63,537,794UniSTS
RH 3.4 Map8809.9UniSTS
Cytogenetic Map8q24UniSTS
RH138729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,126,876 - 64,127,014 (+)MAPPERmRatBN7.2
Rnor_6.0868,569,578 - 68,569,715NCBIRnor6.0
Rnor_5.0868,290,975 - 68,291,112UniSTSRnor5.0
RGSC_v3.4867,820,752 - 67,820,889UniSTSRGSC3.4
Celera863,537,545 - 63,537,682UniSTS
RH 3.4 Map8810.0UniSTS
Cytogenetic Map8q24UniSTS
PE5L-LSB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2864,216,656 - 64,217,035 (+)MAPPERmRatBN7.2
Rnor_6.0868,658,300 - 68,658,678NCBIRnor6.0
Rnor_5.0868,379,536 - 68,379,914UniSTSRnor5.0
RGSC_v3.4867,931,905 - 67,932,283UniSTSRGSC3.4
Celera863,626,945 - 63,627,323UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 28 12 19 12 8 11 65 35 40 11 8
Low 17 29 29 29 9 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039730   ⟹   ENSRNOP00000037346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,110,039 - 64,236,960 (-)Ensembl
Rnor_6.0 Ensembl868,569,530 - 68,678,349 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099327   ⟹   ENSRNOP00000081624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl864,110,039 - 64,181,174 (-)Ensembl
RefSeq Acc Id: NM_013095   ⟹   NP_037227
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,132,324 (-)NCBI
mRatBN7.2864,126,829 - 64,236,960 (-)NCBI
Rnor_6.0868,569,530 - 68,678,349 (-)NCBI
Rnor_5.0868,290,927 - 68,397,727 (-)NCBI
RGSC_v3.4867,803,909 - 67,952,056 (-)RGD
Celera863,537,497 - 63,647,062 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008766216   ⟹   XP_008764438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,042,099 (-)NCBI
mRatBN7.2864,126,829 - 64,146,730 (-)NCBI
Rnor_6.0868,569,530 - 68,589,751 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080896   ⟹   XP_038936824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,078,810 (-)NCBI
mRatBN7.2864,126,829 - 64,183,523 (-)NCBI
RefSeq Acc Id: XM_039080897   ⟹   XP_038936825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8873,022,204 - 73,099,691 (-)NCBI
mRatBN7.2864,126,829 - 64,191,240 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037227   ⟸   NM_013095
- UniProtKB: P84025 (UniProtKB/Swiss-Prot),   A6J5A4 (UniProtKB/TrEMBL),   A0A8I5ZS20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764438   ⟸   XM_008766216
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000037346   ⟸   ENSRNOT00000039730
RefSeq Acc Id: XP_038936825   ⟸   XM_039080897
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZS20 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936824   ⟸   XM_039080896
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS20 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081624   ⟸   ENSRNOT00000099327
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P84025-F1-model_v2 AlphaFold P84025 1-425 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696062
Promoter ID:EPDNEW_R6587
Type:multiple initiation site
Name:Smad3_1
Description:SMAD family member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0868,678,414 - 68,678,474EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3032 AgrOrtholog
BioCyc Gene G2FUF-30124 BioCyc
Ensembl Genes ENSRNOG00000008620 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023531 UniProtKB/Swiss-Prot
  ENSRNOG00060018232 UniProtKB/Swiss-Prot
  ENSRNOG00065007937 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039730 ENTREZGENE
  ENSRNOT00000039730.5 UniProtKB/Swiss-Prot
  ENSRNOT00000099327.1 UniProtKB/TrEMBL
  ENSRNOT00055040461 UniProtKB/Swiss-Prot
  ENSRNOT00060031345 UniProtKB/Swiss-Prot
  ENSRNOT00065012522 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599910 IMAGE-MGC_LOAD
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72529 IMAGE-MGC_LOAD
NCBI Gene 25631 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad3 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008620 RatGTEx
  ENSRNOG00055023531 RatGTEx
  ENSRNOG00060018232 RatGTEx
  ENSRNOG00065007937 RatGTEx
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC221903
UniProt A0A8I5ZS20 ENTREZGENE, UniProtKB/TrEMBL
  A6J5A4 ENTREZGENE, UniProtKB/TrEMBL
  P84025 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O09064 UniProtKB/Swiss-Prot
  O09144 UniProtKB/Swiss-Prot
  O14510 UniProtKB/Swiss-Prot
  O35273 UniProtKB/Swiss-Prot
  Q92940 UniProtKB/Swiss-Prot
  Q93002 UniProtKB/Swiss-Prot
  Q9GKR4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Smad3  SMAD family member 3  Smad3  MAD homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Smad3  MAD homolog 3 (Drosophila)  Madh3    Symbol updated 1299863 APPROVED
2002-06-10 Madh3  MAD homolog 3 (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization translocated to the nucleus 727374
gene_disease may be involved in pulmonary fibrosis 625421
gene_drugs bleomycin at a dose of 9U/kg body weight causes down regulation of mRNA 625421
gene_process an essential downstream intracellular target of the TGF-beta receptor signaling pathway 625421
gene_process plays an important role in osteoblastic bone formation 727387
gene_process involved in folliculogenesis 727374
gene_product member of the family of Smad proteins 625421
gene_regulation phosphorylated by activated TGF-beta type 1 receptor which induces the translocation of the protein from the cytoplasm to the nucleus 625421