Klrb1b (killer cell lectin like receptor B1B) - Rat Genome Database

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Gene: Klrb1b (killer cell lectin like receptor B1B) Rattus norvegicus
Analyze
Symbol: Klrb1b
Name: killer cell lectin like receptor B1B (Ensembl:killer cell lectin-like receptor subfamily B member 1B)
RGD ID: 2975
Description: Predicted to enable signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1); PARTICIPATES IN malaria pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD161 antigen-like family member B; killer cell lectin-like receptor subfamily B member 1B; killer cell lectin-like receptor subfamily B member 1B allele A; killer cell lectin-like receptor subfamily B member 1B allele C; natural killer cell surface protein NKR-P1B; natural killer cell surface protein NKR-P1B allele RNK/SD/BN/F344; natural killer cell surface protein NKR-P1B allele TO; Nkr-p1b; Nkrp1b
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84163,634,357 - 163,647,629 (-)NCBIGRCr8
mRatBN7.24161,948,259 - 161,961,537 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,890,577 - 161,961,675 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4168,183,930 - 168,196,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04186,737,909 - 186,750,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04162,600,915 - 162,613,354 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04162,012,653 - 162,025,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,949,817 - 162,025,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04227,212,758 - 227,225,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44165,699,490 - 165,711,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4150,650,284 - 150,662,721 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NKR-P1, a signal transduction molecule on natural killer cells. Giorda R, etal., Science 1990 Sep 14;249(4974):1298-300.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17462921   PMID:19130483  


Genomics

Comparative Map Data
Klrb1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84163,634,357 - 163,647,629 (-)NCBIGRCr8
mRatBN7.24161,948,259 - 161,961,537 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4161,890,577 - 161,961,675 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4168,183,930 - 168,196,369 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04186,737,909 - 186,750,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04162,600,915 - 162,613,354 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04162,012,653 - 162,025,090 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4161,949,817 - 162,025,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04227,212,758 - 227,225,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44165,699,490 - 165,711,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4150,650,284 - 150,662,721 (-)NCBICelera
Cytogenetic Map4q42NCBI
KLRF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38129,881,489 - 9,895,833 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl129,881,489 - 9,895,833 (+)EnsemblGRCh38hg38GRCh38
GRCh371210,034,088 - 10,048,432 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera1215,195,471 - 15,209,811 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef129,776,992 - 9,791,335 (+)NCBIHuRef
CHM1_11210,003,106 - 10,017,446 (+)NCBICHM1_1
T2T-CHM13v2.0129,767,714 - 9,782,051 (+)NCBIT2T-CHM13v2.0
Klrb1c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396128,755,448 - 128,765,514 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6128,755,448 - 128,766,178 (-)EnsemblGRCm39 Ensembl
GRCm386128,778,485 - 128,788,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6128,778,485 - 128,789,215 (-)EnsemblGRCm38mm10GRCm38
MGSCv376128,728,503 - 128,738,659 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366128,744,104 - 128,754,199 (-)NCBIMGSCv36mm8
Celera6130,474,176 - 130,494,006 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.09NCBI
KLRF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,371,824 - 15,386,576 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,368,582 - 15,383,334 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0129,929,162 - 9,943,917 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,178,501 - 10,192,800 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,178,501 - 10,192,800 (+)Ensemblpanpan1.1panPan2
KLRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,765,192 - 9,781,662 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,766,837 - 9,781,420 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660891,843,081 - 1,856,211 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Klrb1b
533 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:36
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000009904
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat

Markers in Region
RH128601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24161,890,619 - 161,890,806 (+)MAPPERmRatBN7.2
mRatBN7.24161,948,776 - 161,948,966 (+)MAPPERmRatBN7.2
Rnor_6.04162,012,369 - 162,012,558NCBIRnor6.0
Rnor_6.04161,950,313 - 161,950,499NCBIRnor6.0
Rnor_5.04227,212,474 - 227,212,663UniSTSRnor5.0
Rnor_5.04227,151,567 - 227,151,753UniSTSRnor5.0
RGSC_v3.44165,637,521 - 165,637,707UniSTSRGSC3.4
RGSC_v3.44165,699,206 - 165,699,395UniSTSRGSC3.4
Celera4150,650,000 - 150,650,189UniSTS
Celera4150,591,777 - 150,591,963UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 1
Low 3 14 45 29 12 29 4 11 21 10
Below cutoff 27 12 12 12 8 11 70 24 20 8

Sequence


Reference Sequences
RefSeq Acc Id: NM_173292   ⟹   NP_775414
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84163,634,357 - 163,647,629 (-)NCBI
mRatBN7.24161,948,259 - 161,961,537 (-)NCBI
Rnor_6.04162,012,653 - 162,025,090 (-)NCBI
Rnor_5.04227,212,758 - 227,225,195 (-)NCBI
RGSC_v3.44165,699,490 - 165,711,927 (-)RGD
Celera4150,650,284 - 150,662,721 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_775414   ⟸   NM_173292
- UniProtKB: Q62983 (UniProtKB/Swiss-Prot),   A4KWA1 (UniProtKB/Swiss-Prot),   B5U216 (UniProtKB/TrEMBL),   A0A8I6AB27 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A4KWA1-F1-model_v2 AlphaFold A4KWA1 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2975 AgrOrtholog
BioCyc Gene G2FUF-42840 BioCyc
Ensembl Genes ENSRNOG00000007310 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055001275 UniProtKB/Swiss-Prot
  ENSRNOG00055011174 UniProtKB/Swiss-Prot
  ENSRNOG00060020382 UniProtKB/Swiss-Prot
  ENSRNOG00065033887 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085887.2 UniProtKB/TrEMBL
  ENSRNOT00000104988.1 UniProtKB/TrEMBL
  ENSRNOT00000111200 ENTREZGENE
  ENSRNOT00000111200.1 UniProtKB/Swiss-Prot
  ENSRNOT00000113391.1 UniProtKB/TrEMBL
  ENSRNOT00055002106 UniProtKB/Swiss-Prot
  ENSRNOT00055018957 UniProtKB/Swiss-Prot
  ENSRNOT00060035309 UniProtKB/Swiss-Prot
  ENSRNOT00065058178 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25192 ENTREZGENE
PANTHER KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 UniProtKB/Swiss-Prot
  KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 UniProtKB/Swiss-Prot
  KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 UniProtKB/TrEMBL
  KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klrb1b PhenoGen
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007310 RatGTEx
  ENSRNOG00055001275 RatGTEx
  ENSRNOG00055011174 RatGTEx
  ENSRNOG00060020382 RatGTEx
  ENSRNOG00065033887 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2KAQ0_RAT UniProtKB/TrEMBL
  A0A8I6A029_RAT UniProtKB/TrEMBL
  A0A8I6AB27 ENTREZGENE, UniProtKB/TrEMBL
  A4KWA1 ENTREZGENE
  B5U216 ENTREZGENE, UniProtKB/TrEMBL
  KRBBA_RAT UniProtKB/Swiss-Prot
  KRBBC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62983 ENTREZGENE
UniProt Secondary Q62983 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-30 Klrb1b  killer cell lectin like receptor B1B  Klrb1b  killer cell lectin-like receptor subfamily B member 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Klrb1b  Killer cell lectin-like receptor subfamily B, member 1b      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may be involved in activating NK cell activity 1298974