Kcnmb1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1) - Rat Genome Database

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Gene: Kcnmb1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1) Rattus norvegicus
Analyze
Symbol: Kcnmb1
Name: potassium calcium-activated channel subfamily M regulatory beta subunit 1
RGD ID: 2961
Description: Enables potassium channel regulator activity. Involved in several processes, including cellular response to bile acid; cellular response to ethanol; and cellular response to hypoxia. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Used to study hypertension. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BK channel subunit beta-1; BKbeta; BKbeta1; calcium-activated potassium channel beta subunit; calcium-activated potassium channel subunit beta; calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel, subfamily M subunit beta-1; charybdotoxin receptor subunit beta-1; k(VCA)beta-1; LOC60591; maxi K channel subunit beta-1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slo-beta; slo-beta-1; slowpoke-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Kcnmb1em1Mcwi   Kcnmb1em3Mcwi  
Genetic Models: SS-Kcnmb1em3Mcwi SS-Kcnmb1em1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81019,062,014 - 19,119,005 (+)NCBIGRCr8
mRatBN7.21018,557,510 - 18,614,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1018,557,904 - 18,565,798 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1023,312,979 - 23,320,935 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01022,801,535 - 22,809,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01018,280,331 - 18,288,287 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,910,586 - 18,922,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,906,010 - 18,919,639 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01018,790,595 - 18,800,957 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,904,902 - 18,912,604 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11018,905,950 - 18,913,652 (+)NCBI
Celera1018,189,045 - 18,196,906 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Downregulation of the BK channel beta1 subunit in genetic hypertension. Amberg GC and Santana LF, Circ Res 2003 Nov 14;93(10):965-71. Epub 2003 Oct 9.
2. Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning. Bautista L, etal., Circ Res. 2009 Jun 19;104(12):1364-72. doi: 10.1161/CIRCRESAHA.108.190645. Epub 2009 May 21.
3. The BK channel accessory beta1 subunit determines alcohol-induced cerebrovascular constriction. Bukiya AN, etal., FEBS Lett. 2009 Sep 3;583(17):2779-84. doi: 10.1016/j.febslet.2009.07.019. Epub 2009 Jul 17.
4. Cerebrovascular dilation via selective targeting of the cholane steroid-recognition site in the BK channel beta1-subunit by a novel nonsteroidal agent. Bukiya AN, etal., Mol Pharmacol. 2013 May;83(5):1030-44. doi: 10.1124/mol.112.083519. Epub 2013 Mar 1.
5. The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory beta1 subunit. Bukiya AN, etal., Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20207-12. doi: 10.1073/pnas.1112901108. Epub 2011 Nov 28.
6. Differential expression of the alpha and beta subunits of the large-conductance calcium-activated potassium channel: implication for channel diversity. Chang CP, etal., Brain Res Mol Brain Res 1997 Apr;45(1):33-40.
7. High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel. Chang H, etal., J Cell Physiol. 2011 Jun;226(6):1660-75. doi: 10.1002/jcp.22497.
8. Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats. Chang T, etal., Am J Hypertens. 2006 Jul;19(7):678-85.
9. Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvbeta 1.1 subunit. Falk T, etal., Neuroscience 2003;120(2):387-404.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Human and rodent MaxiK channel beta-subunit genes: cloning and characterization. Jiang Z, etal., Genomics 1999 Jan 1;55(1):57-67.
13. Reduction of large-conductance Ca(2)(+) -activated K(+) channel with compensatory increase of nitric oxide in insulin resistant rats. Li S, etal., Diabetes Metab Res Rev. 2011 Jul;27(5):461-9. doi: 10.1002/dmrr.1196.
14. Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Lu T, etal., Biophys J. 2008 Dec;95(11):5165-77. doi: 10.1529/biophysj.108.138339. Epub 2008 Sep 12.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Protective effect of the KCNMB1 E65K genetic polymorphism against diastolic hypertension in aging women and its relevance to cardiovascular risk. Senti M, etal., Circ Res. 2005 Dec 9;97(12):1360-5. Epub 2005 Nov 17.
22. Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of alpha- and beta1-subunit expression. Shi L, etal., Mech Ageing Dev. 2013 Sep;134(9):416-25. doi: 10.1016/j.mad.2013.09.001. Epub 2013 Sep 16.
23. E65 K polymorphism in KCNMB1 gene is not associated with ischaemic heart disease in Spanish patients. Via M, etal., J Hum Genet. 2005;50(11):604-6. Epub 2005 Sep 10.
24. [Ca(2+)-activated K(+) channel switching in smooth muscle participates in atherosclerosis development in diabetic rats]. Wang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):188-92.
Additional References at PubMed
PMID:12388098   PMID:14966080   PMID:16113069   PMID:17209121   PMID:17293477   PMID:19321803   PMID:19940072   PMID:20139169   PMID:20334613   PMID:20443052   PMID:20936291   PMID:21438011  
PMID:22660813   PMID:25371198   PMID:28487419   PMID:29040972   PMID:29093563   PMID:30012867   PMID:31738403   PMID:32967457   PMID:33556372   PMID:36717168  


Genomics

Comparative Map Data
Kcnmb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81019,062,014 - 19,119,005 (+)NCBIGRCr8
mRatBN7.21018,557,510 - 18,614,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1018,557,904 - 18,565,798 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1023,312,979 - 23,320,935 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01022,801,535 - 22,809,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01018,280,331 - 18,288,287 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,910,586 - 18,922,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,906,010 - 18,919,639 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01018,790,595 - 18,800,957 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,904,902 - 18,912,604 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11018,905,950 - 18,913,652 (+)NCBI
Celera1018,189,045 - 18,196,906 (+)NCBICelera
Cytogenetic Map10q12NCBI
KCNMB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385170,374,671 - 170,389,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5170,374,671 - 170,389,634 (-)EnsemblGRCh38hg38GRCh38
GRCh375169,801,675 - 169,816,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365169,737,745 - 169,749,216 (-)NCBINCBI36Build 36hg18NCBI36
Build 345169,737,744 - 169,749,216NCBI
Celera5165,837,099 - 165,848,570 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5164,904,047 - 164,915,563 (-)NCBIHuRef
CHM1_15169,238,046 - 169,249,557 (-)NCBICHM1_1
T2T-CHM13v2.05170,913,506 - 170,928,202 (-)NCBIT2T-CHM13v2.0
Kcnmb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,912,955 - 33,923,641 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,913,013 - 33,923,641 (+)EnsemblGRCm39 Ensembl
GRCm381133,962,955 - 33,973,641 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,963,013 - 33,973,641 (+)EnsemblGRCm38mm10GRCm38
MGSCv371133,863,013 - 33,873,638 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,863,286 - 33,871,275 (+)NCBIMGSCv36mm8
Celera1136,374,009 - 36,384,630 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.32NCBI
Kcnmb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540823,325,225 - 23,335,298 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540823,306,286 - 23,335,170 (-)NCBIChiLan1.0ChiLan1.0
KCNMB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24165,531,886 - 165,545,457 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15163,669,031 - 163,685,000 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05165,712,588 - 165,747,948 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15172,495,762 - 172,507,318 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5172,495,762 - 172,507,318 (-)Ensemblpanpan1.1panPan2
KCNMB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1441,536,841 - 41,545,523 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl441,537,225 - 41,545,344 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha441,491,752 - 41,497,517 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0441,912,957 - 41,922,108 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl441,912,853 - 41,921,446 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1441,733,152 - 41,738,919 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0441,919,686 - 41,925,451 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0442,430,404 - 42,436,172 (+)NCBIUU_Cfam_GSD_1.0
Kcnmb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721395,728,790 - 95,736,033 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366094,451,492 - 4,458,712 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366094,451,526 - 4,458,665 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNMB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1653,618,603 - 53,631,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11653,616,532 - 53,631,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21657,959,628 - 57,972,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNMB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12372,580,617 - 72,591,070 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2372,577,813 - 72,591,588 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660346,070,733 - 6,081,816 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnmb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473319,582,489 - 19,597,722 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473319,582,646 - 19,593,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnmb1
369 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:155
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000007393, ENSRNOT00000007408
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101724551319388279Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat

Markers in Region
RH142383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21018,565,193 - 18,565,369 (+)MAPPERmRatBN7.2
Rnor_6.01018,919,035 - 18,919,210NCBIRnor6.0
Rnor_5.01018,797,692 - 18,797,867UniSTSRnor5.0
RGSC_v3.41018,911,999 - 18,912,174UniSTSRGSC3.4
Celera1018,196,301 - 18,196,476UniSTS
Cytogenetic Map10q12UniSTS


Genetic Models
This gene Kcnmb1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 6
Low 2 35 2 4 2 2 1 28 18 11 2
Below cutoff 8 17 4 15 4 6 7 52 7 16 6

Sequence


RefSeq Acc Id: ENSRNOT00000007393   ⟹   ENSRNOP00000007393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,912,865 - 18,919,458 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000007408   ⟹   ENSRNOP00000007408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1018,557,904 - 18,565,798 (+)Ensembl
Rnor_6.0 Ensembl1018,911,938 - 18,919,639 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090659   ⟹   ENSRNOP00000071161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1018,559,526 - 18,565,576 (+)Ensembl
Rnor_6.0 Ensembl1018,906,010 - 18,919,261 (+)Ensembl
RefSeq Acc Id: NM_019273   ⟹   NP_062146
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81019,062,099 - 19,069,991 (+)NCBI
mRatBN7.21018,557,904 - 18,565,799 (+)NCBI
Rnor_6.01018,911,938 - 18,919,640 (+)NCBI
Rnor_5.01018,790,595 - 18,800,957 (+)NCBI
RGSC_v3.41018,904,902 - 18,912,604 (+)RGD
Celera1018,189,045 - 18,196,906 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246089   ⟹   XP_006246151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81019,062,036 - 19,073,207 (+)NCBI
mRatBN7.21018,558,206 - 18,569,015 (+)NCBI
Rnor_6.01018,910,586 - 18,922,856 (+)NCBI
Rnor_5.01018,790,595 - 18,800,957 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085796   ⟹   XP_038941724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81019,062,014 - 19,119,005 (+)NCBI
mRatBN7.21018,557,510 - 18,614,824 (+)NCBI
RefSeq Acc Id: XM_039085797   ⟹   XP_038941725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81019,062,034 - 19,073,207 (+)NCBI
mRatBN7.21018,557,519 - 18,569,015 (+)NCBI
RefSeq Acc Id: XM_063268844   ⟹   XP_063124914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81019,062,303 - 19,073,207 (+)NCBI
RefSeq Acc Id: NP_062146   ⟸   NM_019273
- UniProtKB: Q9ESK7 (UniProtKB/Swiss-Prot),   O88805 (UniProtKB/Swiss-Prot),   O35337 (UniProtKB/Swiss-Prot),   Q9QWI7 (UniProtKB/Swiss-Prot),   P97678 (UniProtKB/Swiss-Prot),   A6HDH5 (UniProtKB/TrEMBL),   B5U130 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246151   ⟸   XM_006246089
- Peptide Label: isoform X1
- UniProtKB: Q9ESK7 (UniProtKB/Swiss-Prot),   O88805 (UniProtKB/Swiss-Prot),   O35337 (UniProtKB/Swiss-Prot),   Q9QWI7 (UniProtKB/Swiss-Prot),   P97678 (UniProtKB/Swiss-Prot),   A6HDH5 (UniProtKB/TrEMBL),   B5U130 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071161   ⟸   ENSRNOT00000090659
RefSeq Acc Id: ENSRNOP00000007408   ⟸   ENSRNOT00000007408
RefSeq Acc Id: ENSRNOP00000007393   ⟸   ENSRNOT00000007393
RefSeq Acc Id: XP_038941724   ⟸   XM_039085796
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941725   ⟸   XM_039085797
- Peptide Label: isoform X3
- UniProtKB: A6HDH4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124914   ⟸   XM_063268844
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97678-F1-model_v2 AlphaFold P97678 1-191 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697097
Promoter ID:EPDNEW_R7622
Type:initiation region
Name:Kcnmb1_1
Description:potassium calcium-activated channel subfamily M regulatory betasubunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01018,912,187 - 18,912,247EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2961 AgrOrtholog
BioCyc Gene G2FUF-25591 BioCyc
Ensembl Genes ENSRNOG00000005465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055002934 UniProtKB/Swiss-Prot
  ENSRNOG00060002803 UniProtKB/Swiss-Prot
  ENSRNOG00065009520 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007408 ENTREZGENE
  ENSRNOT00000007408.7 UniProtKB/Swiss-Prot
  ENSRNOT00000090659.2 UniProtKB/Swiss-Prot
  ENSRNOT00055004591 UniProtKB/Swiss-Prot
  ENSRNOT00060004514 UniProtKB/Swiss-Prot
  ENSRNOT00065015241 UniProtKB/Swiss-Prot
InterPro K_chnl_Ca-activ_BK_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29747 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29747 ENTREZGENE
PANTHER CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10258 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CaKB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnmb1 PhenoGen
PRINTS BKCHANNELB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005465 RatGTEx
  ENSRNOG00055002934 RatGTEx
  ENSRNOG00060002803 RatGTEx
  ENSRNOG00065009520 RatGTEx
UniProt A6HDH4 ENTREZGENE, UniProtKB/TrEMBL
  A6HDH5 ENTREZGENE, UniProtKB/TrEMBL
  B5U130 ENTREZGENE, UniProtKB/TrEMBL
  KCMB1_RAT UniProtKB/Swiss-Prot
  O35337 ENTREZGENE
  O88805 ENTREZGENE
  P97678 ENTREZGENE
  Q9ESK7 ENTREZGENE
  Q9QWI7 ENTREZGENE
UniProt Secondary O35337 UniProtKB/Swiss-Prot
  O88805 UniProtKB/Swiss-Prot
  Q9ESK7 UniProtKB/Swiss-Prot
  Q9QWI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-04-26 Kcnmb1  potassium large conductance calcium-activated channel, subfamily M, beta member 1  LOC60591  calcium-activated potassium channel beta subunit  Data merged from RGD:708570 737654 APPROVED
2002-06-10 Kcnmb1  potassium large conductance calcium-activated channel, subfamily M, beta member 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease expression is decreased during hypertension 1298970
gene_expression expressed in a few discrete populations of neurons 1298969
gene_process modulates the channel activity 1298969