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Gene: Il6r (interleukin 6 receptor) Rattus norvegicus
Symbol: Il6r
Name: interleukin 6 receptor
Description: Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to ethanol; and response to gamma radiation. Localizes to extracellular space and neuronal cell body membrane. Biomarker of several diseases, including congestive heart failure; mental depression; orchitis; sciatic neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor); PARTICIPATES IN interleukin-6 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL6R1; Il6ra; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha
Homo sapiens (human) : IL6R (interleukin 6 receptor)  HGNC  Alliance
Mus musculus (house mouse) : Il6ra (interleukin 6 receptor, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il6r (interleukin 6 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IL6R (interleukin 6 receptor)
Canis lupus familiaris (dog) : IL6R (interleukin 6 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il6r (interleukin 6 receptor)
Sus scrofa (pig) : IL6R (interleukin 6 receptor)
Chlorocebus sabaeus (African green monkey) : IL6R (interleukin 6 receptor)
Heterocephalus glaber (naked mole-rat) : Il6r (interleukin 6 receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02189,196,180 - 189,255,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,205,701 - 189,254,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,619,391 - 208,679,233 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42182,078,049 - 182,128,135 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12182,028,156 - 182,078,238 (-)NCBI
Celera2169,240,233 - 169,289,575 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Il6r
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2902
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.